Reversing APOE4 damage - what a hepatitis drug reveals about Alzheimer's and possible treatment
Рет қаралды 2,473
Күн бұрынPeople with at least one APOE4 allele are more susceptible to blood-brain barrier breakdown, which contributes to Alzheimer's disease development. APOE4 promotes the destruction of the blood-brain barrier by triggering the inflammatory cyclophilin A cascade. Dr. Montagne's animal research demonstrated that blocking cyclophilin A partially restored vascular function and cognition, suggesting that targeting the blood-brain barrier could be a promising avenue for Alzheimer's treatment. In this clip, Dr. Axel Montagne discusses the feasibility of pursuing cyclophilin A, MMP9, or blood-brain barrier proteins to develop new Alzheimer's disease therapies.
Interview published on Feb 28, 2023
Watch the full episode:
• Axel Montagne, PhD, on...
#aging #Alzheimer #brain
00:00 APOE4 and Alzheimer's disease
01:23 APOE4's influence on pericytes
03:18 Cyclophilin A and MMP9 in APOE4 carriers
05:27 Blocking cyclophilin A restores vascular function
09:27 Targeting MMP9 or other blood-brain barrier proteins
13:42 Potential therapeutic strategies for Alzheimer's disease
@EdwardsNH Жыл бұрын
I've got two APOe4 alleles... I'm crossing my fingers for an early fatal heart attack
@Runeakb 6 ай бұрын
My apoe4 grandfather popped his clogs at 64 from heart problems. Better way to go than my apoe4 mom who's 69 and has dementia. Have trust in that medical advancements will look our way
@jackonsville Жыл бұрын
Great clip as usual. Although I do not understand the detailed aspects of the discussion some of the basic ideas I can follow along with. The sheer complexity of the body inspires me to look after myself a bit more. Thank you.
@tolkienfan1972 Жыл бұрын
Amazing progress!
@sallyannbentham9073 Жыл бұрын
So what can one do for prevention - without medical drugs?
@ccamire Жыл бұрын
probably the best review on Alzheimer
@BuddhaBeanie 11 ай бұрын
This is far too technical for most people to understand. This must be made for genetic medical professionals.
@petexii 4 ай бұрын
Give it some time, rewatch and look up the key words. If you have ApoE4 it makes sense to spend the time to understand this.
@luckssj 11 ай бұрын
What about UCLA reversing Alzheimer disease
@appeal2nature Жыл бұрын
Wow, you've aged really fast!
@IvorMektin1701 Жыл бұрын
The French are going through a rough patch right
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