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RNAi: Slicing, dicing and serving your cells - Alex Dainis

  Рет қаралды 366,081

TED-Ed

TED-Ed

11 жыл бұрын

View full lesson: ed.ted.com/less...
RNA, the genetic messenger, makes sure the DNA recipe gives your cells exactly what they ordered. But sometimes that means inhibiting some other RNA that got the recipe wrong. This process is called RNA interference (RNAi), and it acts as a self-correcting system within the complicated genetic kitchen of your body. Alex Dainis explains the importance -- and exciting potential -- of RNAi.
Lesson by Alex Dainis, animation by Cinematic Sweden.

Пікірлер: 184
@secondjoint
@secondjoint 10 жыл бұрын
The quality of the animation is sooo good! I'm used to seeing amateurish work in these edutainment animations. This animator actually understands stretch, correct physics, motion blur etc.
@KnakuanaRka
@KnakuanaRka 6 жыл бұрын
secondjoint Great animations, but I do think that the metaphor shown by those animations only manages to confuse the matter instead of clarifying.
@toobaaaapi
@toobaaaapi 5 ай бұрын
Quality of animation is good but the content was not upto mark, ended confusing the topic more than clarifying it.
@ichliebemeinfunt
@ichliebemeinfunt 8 жыл бұрын
I couldn't understand RNAi well, but this lecture is very clever and help my study so much! Thanks!!! Before then, I was a little confused by technical terms of this phenomenon.
@halcyonparade
@halcyonparade 11 жыл бұрын
The cooking metaphor sorta makes it a bit more confusing for me
@valeriesze
@valeriesze 10 жыл бұрын
I wish to contribute myself in creating this kind of educative videos when I grow up. This is so much meaningful.
@justagreekinternetuser8998
@justagreekinternetuser8998 Жыл бұрын
so, did you?
@jack171380
@jack171380 5 жыл бұрын
Moral of the story, Chop up unsatisfied customers.
@XENOS1010
@XENOS1010 7 жыл бұрын
Great video , best metaphor ever and I like the cute animation
@beartheburn3863
@beartheburn3863 3 жыл бұрын
Let me summarize everything in one shot ( actually this is the project that I've been assigned) So rna interference is basically used to prevent gene expression ( prevention of translation and hence production of proteins ) So to do it artificially we use vectors and introduce the desired dna . Now this dna produces both sense and anti sense strand these being complementary to each other bind together . Dicer proteins sense these and chop them and these thereby approach the m rna and slicer protein comes and chops down the m rna too So , viola ! We've successfully prevented the gene expression
@Sapnakolira
@Sapnakolira 2 жыл бұрын
So in eukaryotes these double stranded rnas are created in response to an attack by viruses???
@lemonade4865
@lemonade4865 2 жыл бұрын
Wait aren't you supposed to use desired Double Stranded RNA and not DNA for the vector?
@justagreekinternetuser8998
@justagreekinternetuser8998 Жыл бұрын
@@Sapnakolira no. Sometimes, viruses have genetic material in the form of double stranded RNA, instead of DNA that we have. So, they insert it in cells and manipulate their cell functions, in order to replicate their dsRNA and move to close cells and infect them too.
@kristiabondoc6681
@kristiabondoc6681 9 жыл бұрын
This is the best explanation out there. Thanks a bunch! Really appreciate it.
@vineethvishnu9975
@vineethvishnu9975 7 жыл бұрын
woww........difficult topic explained in very easy way.......thanks a lotttt
@veryawful861
@veryawful861 3 жыл бұрын
That RNA decking the other RNA caught me off guard and had me bustin up!
@knosis
@knosis 2 жыл бұрын
What a classic video. I watched this video when I was studying for my MCAT and now I am in medical school, studying for USMLE Step 1 and came across an RNA question and it reminded me of this. Thank you so much for these videos!
@asapelliott
@asapelliott 3 жыл бұрын
Amazing communication of science in this video!
@jakeshmohapatra6956
@jakeshmohapatra6956 2 жыл бұрын
The voice has perfect timing to understanding.
@ume7739
@ume7739 2 жыл бұрын
Where were you when I was looking all over KZfaq to understand rnai for my biology test yesterday 😭😭😭😭😭😭😭😭😭😭😭
@thetypewriterbtch8763
@thetypewriterbtch8763 Ай бұрын
Trying to make it relatable, you guys screwed with the explanation 100 times more!
@SciFiles
@SciFiles 11 жыл бұрын
This video is awesome! Its so informative! Good job alex!
@FrankyFiks
@FrankyFiks 11 жыл бұрын
this video is 4 weeks to late. tried to understand it for an exam, but the information given was too confusing. this video sums it up perfectly :)
@nguyentuandangkhoi
@nguyentuandangkhoi 11 жыл бұрын
Something along those lines, but NO, no one volunteers. Neuroscientists study patients who already had an accident or a stroke, which lead to damage in certain localities in the brain. During and after preliminary treatment by ER physicians and/or neurosurgeons, scans are done, including MRI, fMRI, CT, PET, etc. which help localize the injured parts. After doing whatever they can, the patients are assessed behaviorally and compared to before the accident, etc., as well as normal brain scans.
@kirtikasaxena3097
@kirtikasaxena3097 8 жыл бұрын
too good difficult concept discussed very easily
@farhanahmed2508
@farhanahmed2508 7 жыл бұрын
kirtika Saxena Good evening, Ma'am...
@Andy-km1xp
@Andy-km1xp 6 жыл бұрын
Farhan Ahmed lol Creepy
@Owlnuss
@Owlnuss 2 ай бұрын
I'm shocked when I saw that this video is 10 years old! I'm currently working as a research physician with a pharma company developing RNAi drug to treat obesity.
@aminoddindomado9963
@aminoddindomado9963 7 ай бұрын
Wow I didn't know Alex Dainis narrated a Ted-Ed video !
@SamuelSamuelSamuel1
@SamuelSamuelSamuel1 4 жыл бұрын
Ribosome: what can I get for you Red blood cell: S-Sugar Ribosome: so glucose? Red blood cell: S-S-Sugar Ribosome: I don’t have the full ingredients for that Red blood cell: rolls on the floor screaming
@runforestrun406
@runforestrun406 5 жыл бұрын
This video is absolutely amazing
@mLBB-x-HoK22savg
@mLBB-x-HoK22savg 5 ай бұрын
Thanks I'm good at learning this way
@hustletime1632
@hustletime1632 7 ай бұрын
Oh man that was impressive I understand everything. ❤thank you
@BlueyTheCheese
@BlueyTheCheese 10 жыл бұрын
AHHH this is so addictive.
@nitinnarwade4075
@nitinnarwade4075 4 жыл бұрын
what was that at 2:18, wooallaaaa....!! 🤣🤣🤣🤣🤣🤣🤣. Nice animation and correctly explained with an example of a kitchen. Pretty helpful for explaining to the students. 👍 👍 👍
@masonacton9868
@masonacton9868 9 жыл бұрын
The animation was awesome
@PeterDosRamos
@PeterDosRamos 11 жыл бұрын
Congratulations Alex! What an accomplishment...
@dingovory
@dingovory 7 жыл бұрын
I'm sure I'd understand it better without the metaphor lol
@alineangel3210
@alineangel3210 6 жыл бұрын
dingovory I'm almost sure that you wouldn't. I've tried to understand this for half a hour by biology videos, this video gets the information a lot easier... ;-)
@LegeFles
@LegeFles 6 жыл бұрын
Aline Oliveira yeah no
@judonomobic
@judonomobic 11 жыл бұрын
wow Alex! That is way cool. You are certainly making an impact! Thank you!
@omni100won
@omni100won 11 жыл бұрын
Nice animation! I liked it a lot
@SetsunaKai5
@SetsunaKai5 8 жыл бұрын
Best TED video, ever!
@johnizer
@johnizer 11 жыл бұрын
Wow! So complex yet so organized and it all happened by chance?...At least that's what some people believe. This is what science must be all about. Things we can observe, study and test.
@ludiwang1172
@ludiwang1172 8 жыл бұрын
I read that RNAi is also being used to deal with the varroa destructor mites that are devastating beehives.
@056vatsalapandey3
@056vatsalapandey3 2 жыл бұрын
thank was sooooo amazing people
@linettelow
@linettelow 11 жыл бұрын
Succinctly narrated; wonderfully illustrated :)
@phuongho-ej1zt
@phuongho-ej1zt 7 жыл бұрын
this video is so amazing.
@atiiisa4047
@atiiisa4047 Жыл бұрын
such a nice video.
@tribenisharma1879
@tribenisharma1879 4 жыл бұрын
Best video on this topic...Thanks a lot😊
@adthakur638
@adthakur638 5 жыл бұрын
Perfect explanation
@XxwoodyleexX
@XxwoodyleexX 11 жыл бұрын
there are many kinds of rna, some sends message from dna to the ribosome to create proteins, some are attached to the ribosome used to create protein.
@yashrewaskar2902
@yashrewaskar2902 4 жыл бұрын
Thank you
@robly17
@robly17 11 жыл бұрын
Alex for the win!
@archanarn3884
@archanarn3884 8 жыл бұрын
superb..........saw genetic engineering class via kitchen mechanism
@katherineguzman5752
@katherineguzman5752 3 жыл бұрын
OMG what a great explanation!
@heivmnox
@heivmnox 3 жыл бұрын
imagine ur body housing silent assassins. lol
@ronmaest
@ronmaest 11 жыл бұрын
The body is [mostly, I think] reactive not active. Enough material is floating around inside to keep the process going even though the prices don't know where they're going.
@Suicidal_Muffin
@Suicidal_Muffin 11 жыл бұрын
Congrats Alex!
@imadnemeir9455
@imadnemeir9455 11 жыл бұрын
wonderfully done
@deanomuir
@deanomuir 11 жыл бұрын
Loved it .....well done Alex
@icarusozkavosh6573
@icarusozkavosh6573 5 жыл бұрын
Why good videos like this has so little watches?
@CallieSqueakz
@CallieSqueakz 8 жыл бұрын
Thank you for the lesson.
@SenapatiM96
@SenapatiM96 2 жыл бұрын
Lovely video. Thank you.
@CJonesApple
@CJonesApple 11 жыл бұрын
Aw well done Alex!
@Gracese0
@Gracese0 8 жыл бұрын
thank you for making wonderful video
@natpbs
@natpbs 11 жыл бұрын
Congratulations alex, this is cool!
@ThEKeeYs
@ThEKeeYs 11 жыл бұрын
very nice and simple
@JG-en8bg
@JG-en8bg 8 жыл бұрын
Wow, gruesome.
@siyacer
@siyacer 4 жыл бұрын
Drusome
@PerseusToons
@PerseusToons 7 жыл бұрын
The animation is hilariously violent!
@nopemeneither
@nopemeneither 11 жыл бұрын
A fantastic video, thank you for this
@alz123alz
@alz123alz 8 жыл бұрын
beautiful. thanks
@laylamedo
@laylamedo Жыл бұрын
That is stunning 😍 Thanks a lot 🙏 💓
@DudeWhoSaysDeez
@DudeWhoSaysDeez 6 жыл бұрын
How does our cells know which RNA is virus RNA vs our own good RNA
@litojonny
@litojonny 11 жыл бұрын
what a cute animation!
@liwazamemon918
@liwazamemon918 5 жыл бұрын
That video was great really love it 😍😍
@MustafaAHadid
@MustafaAHadid 5 жыл бұрын
well explained
@pornessianparrapio
@pornessianparrapio Жыл бұрын
Thx
@justinspykerman
@justinspykerman 2 жыл бұрын
How do you manipulate expression in gene expression, is this possible to do within yourself without any external help?
@lachlanmc2335
@lachlanmc2335 Жыл бұрын
yes like if u starve yourself the genes will express differently in response to lower levels of some proteins in blood to metabolize slower
@davidsweeney111
@davidsweeney111 11 жыл бұрын
superb video !
@Ladiduify
@Ladiduify 8 жыл бұрын
I'm a bit depressed that the video isn't in german. It would be pretty perfect for my presentation tomorrow, but in fact its in english - most of my course wouldn't understand it directly :(
@tygonmaster
@tygonmaster 8 жыл бұрын
+Ladiduify There are German subtitles. :)
@incipio8068
@incipio8068 6 жыл бұрын
중간에 나오는 푸른빛집명나방이 아니라 예쁜꼬마선충(C.elegans)이 맞는거 같은데 ... I think that Korean subtitles are wrong. lI hear as [예쁜꼬마선충 - C.elegans] , but the Koean subtitle is [푸른빛집명나방Teliphasa elegans ] 영어 고수님들 이거 보시면 제대로된 영문으로 작성좀 해주세요.....ㅋㅋㅋㅋㅋㅋ
@Emoda3004
@Emoda3004 10 жыл бұрын
This is so cool and easy to remember now XD thanks
@sudedeniz3840
@sudedeniz3840 3 жыл бұрын
Turkce altyazi icin tesekkurler
@JungleJargon
@JungleJargon 11 жыл бұрын
Clearly many things chemicals could never do without being directed by a Maker.
@tybiblee
@tybiblee 5 жыл бұрын
THANKS!!!
@GozerB
@GozerB 11 жыл бұрын
Was just about to skip this on my sub list. Then I saw the name Alex Dainis. :-)
@kpacuBua
@kpacuBua 11 жыл бұрын
no that would be Bradford, UK
@dagwaddell4604
@dagwaddell4604 2 ай бұрын
We’re probably farther ahead not messing with this stuff
@banaalani7216
@banaalani7216 5 жыл бұрын
perfect!
@star666moon
@star666moon 11 жыл бұрын
cool video!
@MegaMGstudios
@MegaMGstudios 7 жыл бұрын
slice and dice
@Lizzi190
@Lizzi190 11 жыл бұрын
Not a lot of views:/ what's wrong with his world?!!?!!! Ashton kutchers video has more views than this informative, useful video. WHY?!!?! :'(
@adamsodhooq4463
@adamsodhooq4463 11 жыл бұрын
I like how she said volia
@laischristina8018
@laischristina8018 7 жыл бұрын
perfect
@k94koonce
@k94koonce 8 жыл бұрын
wow! amazing video
@user-hx5rc7zv7m
@user-hx5rc7zv7m 8 жыл бұрын
узбеккино
@user-hx5rc7zv7m
@user-hx5rc7zv7m 8 жыл бұрын
узбеки но х узбеккино
@areziqbal
@areziqbal 10 жыл бұрын
Plz explain this topic liteally
@raniabashar7955
@raniabashar7955 6 жыл бұрын
what's the difference of rna and dna?
@taeyang
@taeyang 8 жыл бұрын
wow just wow
@marioguts
@marioguts 8 жыл бұрын
+taeyang Same!!! I think people in general need a little bit more of previous knowledge to fully understand the video but it amazing nonetheless
@berzerius
@berzerius 11 жыл бұрын
Alexxxxx!
@user-us2di8go4m
@user-us2di8go4m 11 жыл бұрын
Hello TEDed. I love your videos. All your videos very interesting but in some case I try to understand without transcript as I'm not native speaker. Can I have this transcript from somewhere. Thanks.
@xlr1271
@xlr1271 11 жыл бұрын
nice
@na-is9xb
@na-is9xb 6 жыл бұрын
Very good:)
@ehe5669
@ehe5669 2 жыл бұрын
that brutally escalated quick.
@MrPoof15
@MrPoof15 11 жыл бұрын
This was awesomely violent.
@KnakuanaRka
@KnakuanaRka 6 жыл бұрын
Usually, TedEd does well at describing phenomena through metaphors, but here it was just distracting. Not as bad as the one about oil and water not mixing, but still.
@shannonlorraine7561
@shannonlorraine7561 7 жыл бұрын
😄 great job.
@BEV_shorts
@BEV_shorts 11 жыл бұрын
i may be wrong by the looks of the direction of this
@velstorios9473
@velstorios9473 6 жыл бұрын
You could have made the pieces of the double stranded RNA look alive like smaller living parts of it :P
@Qermaq
@Qermaq 11 жыл бұрын
Yay Alex! :)
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