GABA - The Inhibitory Neurotransmitter (+ Alcohol in the Brain) (Level 3

GABA - The Inhibitory Neurotransmitter (+ Alcohol in the Brain) (Level 3 - Advanced)

Рет қаралды 27,310

Күн бұрын

Explains how GABA (and GABA receptors), the brain's main inhibitory neurotransmitter works at the level of synapses, as well as the role of inhibition in the brain, how certain drugs affect the GABAa receptor (such as alcohol, barbiturates, and benzodiazepines), and how alcohol effects various brain regions.
If you want shorter, less technical explanations of this topic, check out my other videos:
Level 1 (30 seconds): • GABA - The Inhibitory ...
Level 2 (16 mins): • GABA - The Inhibitory ...
--
Chapters:
00:00 Why is your brain not constantly having seizures?
01:40 The answer? GABA inhibition
02:19 Me, this channel, this introduciton to neuroscience series.
03:48 I also release less technical, less sciencey videos
04:24 GABA is the brain's main inhibitory neurotransmitter
05:11 GABA is used commonly throughout the brain
06:03 GABA's functions
07:36 The role of inhibition in the brain: the neuronal brakes.
10:00 Review of how glutamate affects neurons
10:36 Terminology: EPSP and IPSP (excitation and inhibition)
12:13 How GABA affects its receptors
12:29 The GABAa ionotropic receptor mechanism: chlorine influx
14:40 The GABAb metabotropic receptor mechanism: potassium efflux
16:42 A neuron weighs up thousands of inputs to decide whether it will fire.
18:42 The closer to the axon hillock, the stronger the inhibitory input.
21:17 Alcohol, barbiturates, and benzodiazepines bind to the GABAa receptor
23:00 Why do these drugs have different effects?
24:58 Some ways that alcohol affects the brain
30:35 Please like, comment, and subscribe. Thank you!!
--
Connect with Sense of Mind on social media!
Instagram: / sense.ofmind
Facebook: / senseofmindshow
Join the newsletter: mailchi.mp/d76edf98390b/sense...
--
Sources and Recommended Readings:
Kandel, E. R., Koester, J. D., Mack, S. H., & Siegelbaum, S. A. (2021). 13 Synaptic Integration in the Central Nervous System. In Principles of neural science (6th ed., pp. 277-287). essay, McGraw-Hill.
Banich, M. T., & Compton, R. J. (2018). Cognitive neuroscience. Chapter 1: Introduction to the Nervous system. Cambridge University Press.
Sullivan, E. V., Harris, R. A., & Pfefferbaum, A. (2010). Alcohol's effects on brain and behavior. Alcohol Research & Health.
--
Music:
Happy Electronic Beat | FLOWERS by Alex-Productions | kzfaq.info/love/x0_...
Music promoted by www.free-stock-music.com
Creative Commons Attribution 3.0 Unported License
creativecommons.org/licenses/...
#gaba #neuroscience #alcoholandthebrain

Пікірлер: 83

@tiffanykennedy788 7 ай бұрын

Great work! My background is chemical engineering, biochem tech elective, master's public health, recovering alcoholic, permanently &total disabled veteran with a mental condition and I have been drinking kava for three years wondering if I have relapsed as an alcoholic. I immensely appreciate how wonderfully you present this topic. I just moved home to Ohio where there were zero kava locations from Florida where kava is abundant. Ohio just opened it's first Kava location outside of Cleveland and I have resumed drinking kava. I think Kava increases GABA receptors. FYI Kava research is swiftly increasing if you could bring this topic to your channel soon. Thank you.

@rodrigoalmanza66 Ай бұрын

Yes, you relapsed because it's GABA, No KAVA.

@zane003 6 күн бұрын

This is great. would be helpful to have a level 4 or a separate video diving deeper into the details of alcohol, barbiturates, and benzodiazepines. I think your content will show up in more search results especially to people who need this the most and are looking up the specific drugs

@alanfiddler Жыл бұрын

I have been thinking of glutamate and GABA as being corollaries of Chochma and Binah respectively , in the kabbalistic system, of how both the body and universe works . I would be glad to carry on this conversation with those who are curious

@Horsechemist Жыл бұрын

THANK YOU! First one of your vids and I’m thrilled it was an advanced enough video. Love the way you separate topics into the levels in general and this was really well explained. I’ll definitely be back and share it!

@senseofmindshow Жыл бұрын

That's great to hear, thank you!

@tjfSIM 4 ай бұрын

This is absolutely fascinating. I learned a lot of stuff, and your method of presentation is really clear and easy to follow. I think anyone who drinks regularly should watch this, as it really is scary what alcohol does to the brain and body. Thanks so much for taking the time to put this together.

@TE-7302- 3 ай бұрын

Can you do one focused only on benzodiazepines? Lots of people are tapering off once their body hits tolerance after taking as prescribed for years. Not addicts, but regular people who work, have families, never abused and had their lives ruined by rapid cold turkey tapers. There is now a black box warning stating these should never be used for more than 4 weeks. Tough for those who were prescribed for decades because of a few anxiety attacks.

@richardhenry9844 2 ай бұрын

I was diagnosed with PTSD, so I regularly deal with anxiety attacks. Since my father was addicted to alcohol and Xanax, and was the main cause of my PTSD. I have always avoided benzo's like Xanax, they terrify me. I found a natural drug called Kanna. It's a succulent that the people of Africa have been using for thousands of years. This stuff wipes out an anxiety within 10 minutes, without the worry of withdrawal. Many are cautious about it, rightfully so, the original method of using the powder is to snort it, which makes you feel like you're doing something much harder. I personally leave it under my tongue until my anxiety starts to fade, and then I swallow it. I highly recommend looking into it as an alternative, that way you can taper without the worry of anxiety attacks coming back.

@CentaCo 10 ай бұрын

Awesome...so well explained!

@dundonism 2 жыл бұрын

Fascinating presentation - thank you.

@senseofmindshow 2 жыл бұрын

Thank you very much for watching.

@stevenking8923 Жыл бұрын

I've suffered with anxiety and depression my whole life. Which led to migraines every week and back pain. I've been taking gaba for 5 weeks and I haven't had a migraine and no back pain. I started with 200 mg a day and after 5 weeks I have to increase the dose. I'm so happy with the results but my concern is that I'm just going to constantly have to increase the dose. If anyone's had similar experience with pain and using Gabba and have used it long term I'd love to hear from you.😊 I would also add it doesn't seem to mix well with alcohol for me. Even just having a couple beers with Gabba in my system seems to put me in a haze. So I haven't had a drink in over 3 weeks.

@deltalady33 4 ай бұрын

Can you offer advice I have been prescribed gabapentin for nerve damage as I was in constant pain all day 24 hours a day I was trying to do it natural for the first 2 years but this January I had to go to the doctor he prescribed Gabapentin March 18th and on the 5th day no pain so looking at the prefix Gaba coupled with the fact that I don't want to be on this the rest of my life do you think Gabapentin can help me

@deltalady33 4 ай бұрын

It's just so do you think Gaba could help me

@stevenking8923 4 ай бұрын

@@deltalady33 yes I think Gabba can help you but it will be a temporary fix. I recommend you reading the book unlearn your pain. My pain is gone way down since starting this book

@deltalady33 4 ай бұрын

@@stevenking8923 thank you so much

@courtlandcreekmore1421 2 жыл бұрын

Excellent content, thanks for posting.

@senseofmindshow 2 жыл бұрын

Much appreciated. And thanks for watching!

@matthewnicholson2699 Күн бұрын

I love benzo's so much! I wish I could take them every day

@VersifyVMR1028 16 күн бұрын

Thank you man you explained this very well I understand

@lambissol7423 Жыл бұрын

Great video! Thanks 🙏

@wendydenny9686 2 жыл бұрын

Really great presentation, I learned a lot. Thank you!

@senseofmindshow 2 жыл бұрын

Thank you for watching!!

@robertbendik1364 11 ай бұрын

@@senseofmindshowi use gabapentin.

@geraldineallen 2 жыл бұрын

thank you for this really helpful and informative video

@senseofmindshow 2 жыл бұрын

Thank you so much for checking it out!

@derocco4888 11 ай бұрын

thank you

@muiz1889 9 ай бұрын

Thanks mate i learnd in half houre what i havent learnd in three weeks from my teacher 😅😅😅

@dustygatrell-ru7tg 2 ай бұрын

You deffently do your homework brother. Thanks for the info.

@manoranjitha2969 Жыл бұрын

I think the pace is soothing, if I don’t understand anything, I Can go back and listen again, your explanation is really helpful and your calming energy is just like GABA too!

@senseofmindshow Жыл бұрын

Thanks so much!

@nickk6763 9 ай бұрын

@@senseofmindshow Thanks you for the useful information about GABA and neurotransmitter it is very useful. I have a question now as you said “Benzodiazepines enhance the binding of GABA to its receptor” now after we consume Benzodiazepines medication for 2 weeks and then stop consuming further will “enhance binding of GABA to its receptor” also fade away or will enhance binding continues if so for how long ? Thanks in advance

@ulyluna8084 Жыл бұрын

next time i drink im going to sit and over think about the molecular process in response to alcohol

@alexandergyr4563 2 жыл бұрын

This guy KNOWS when to remind us to subscribe. Pretty fun to think about ;)

@alexandergyr4563 2 жыл бұрын

Great content by the way, I had this sudden urge to subscribe!

@senseofmindshow 2 жыл бұрын

Haha much appreciated. I know I went a little overboard with the subscribe requests in this one 😅 I’ve toned it down in newer videos 😎. Thanks for watching!

@MrWeb49 Жыл бұрын

im taking gaba in hopes to help my tinnitus your thoughts

@watchful4087 2 ай бұрын

This is an amazingly informative video. Do you have any videos on cbd used for aura headaches.

@aliceimhof1082 9 ай бұрын

Do you have any info on pituitary and it’s emotional or other relationship to adenomas?

@Snowbird39 Жыл бұрын

My son has OCD... What really seems to help him. Is benzodiazopines or alcohol? Which means maybe increasing Gaba for Would help him. Your thoughts?

@msgirl01 2 жыл бұрын

More on dopamine and etoh please!

@senseofmindshow 2 жыл бұрын

Noted! Thank you so much for the suggestion!

@marcyg321 16 күн бұрын

I have discovered that my body is making antibodies to the enzyme GAD - glutamic acid decarboxylase. Have you ever heard of anyone taking GABA with positive results to help calm the excitatory symptoms such as tremors. Thanks for any thoughts.

@brucesuchman1253 2 жыл бұрын

Great explanation of the mechanics of why and how alcohol affects ppl the way it does. This makes me think bartenders need similar training as police officers, in regards to spotting alcohol intoxication levels.

@senseofmindshow 2 жыл бұрын

That's a great point. Although I bet that bartenders get a pretty good intuition for it, considering how often they see highly intoxicated people.

@pamalatrynovich4817 8 ай бұрын

They say GABA supplement does not cross the blood brain. If that be the case then what good is that supplement ?

@marke.8334 3 ай бұрын

Take it with vitamin c and b vitamin complex You could also add magnesium it'll get across

@uranodas 2 ай бұрын

Gabapentin don't but gavipintin does easy to get it keeps you from anxiety it keeps glutamate down phenibut works real good I'm on kolonipin and the pharmacy ran out i ordered phenibut and thank God it helped

@Vvvrr89 2 жыл бұрын

Do you think gaba supplements and 5htp supplements are safer to use than ssri and benzodiazepines while nursing?

@senseofmindshow 2 жыл бұрын

I’m not sure and since I’m not a medical professional, I don’t give any medical advice. I would recommend consulting a doctor who knows your particular situation.

@nyabutoobare3914 Жыл бұрын

The presentation is great, but I wanted to know if it's possible to come up with a way to hinder the activities of alcohol to the brain, if possible, how will it be?

@robertschrum5496 7 ай бұрын

Drink water.

@Snowbird39 Жыл бұрын

How can this help OCD?

@georgeelgin3903 6 ай бұрын

Thanks! I did take a clip before 10:30 , and while i enjoy your `lecture` style i am not clear on the physics post vesicle. Positive ions don't really flow; negative electrons do leaving behind the positive ion which is why it is voltage and NOT current.

@senseofmindshow 6 ай бұрын

First of all, thanks so much for your generous support and thoughtful comment. If I understand your question correctly, I think it may stem from a slight misunderstanding. In neurons, both positive and negative ions move (i.e. flow) back and forth across the membrane through ion channels, contributing to the voltage changes. Unlike in electrical wires where only electrons flow, in neurons it's these ion movements that create the electrical signals. Does that answer your question?

@evanwilliamson3602 2 жыл бұрын

Alcohol binds to dopaminergic receptors too..

@innosanto 6 ай бұрын

How do we treat ocd ? It is high glutamate and low gaba right? How do we improve situation on that?

@dallas44forlife65 2 ай бұрын

OCD is pathological primarily via the nigrostriatal pathway … SSRI help calm the anxiety via increased serotonin but some mild dopamine blockade can help That’s why there is some benefit to taking seroquel … its not as high potency as other D2 blockers but subtle enough to calm the brain

@julieete257 2 жыл бұрын

I got confused so does Gabba help with alcohol to stop a person from drinking

@senseofmindshow 2 жыл бұрын

Good question! I hadn’t looked into this specific question until just now. While it appears that there are no FDA-approved gaba-targeting drugs for the treatment of alcohol use disorder, there are some currently being investigated. They include “baclofen” and “topiramate”. Here’s a technical article with more info: www.science.org/doi/pdf/10.1126/sciadv.aax4043 As far as gaba itself goes, I’m not sure if there is any evidence that it helps someone stop drinking or not.

@julieete257 2 жыл бұрын

@@senseofmindshow Thank you

@RuboXing Жыл бұрын

Yesss

@kathydavis4925 2 жыл бұрын

Following

@senseofmindshow 2 жыл бұрын

Happy to hear it!!

@davidford761 3 ай бұрын

🎉❤Lovely work; clear & simple ~ in Oriental Medicine the Brain 🧠 is NOT in charge ~ rather it is a servant of the HEART 🧡 ~ the seat of KINDNESS & LOVE ~ in that state the mind / brain is CALM & its hormone -nerve-chemical balance is in harmony ❤🐝🙏‼️. David Ford DrOM

@asada7972 2 жыл бұрын

🧐🤔🤗😌

@completesalvation1755 9 ай бұрын

The first 5 min is superfluous information I prefer to skip to about 4:55 in the video. Additionally the playback flows much better at 1.25 vs normal speed.

@SvenAERTS Жыл бұрын

How on earth did certain humans discover all this? :) And ... then we have to remember all this while raising kids, finding a partner in life. I live in a world where mechanical stuff like my toilet breaks down, my car breaks down - the other day the extraction fan in the kitchen broke down-did you know it has a condensator with microfarads in them these days (?!), and I'm the one who has to repair all that stuff. I must be doing so much stuff wrong in life ...

@SvenAERTS Жыл бұрын

And in a country blessed with a enlightened dictator, the tiny % of their people who would be interested in all this are just send off into war, or thrown in jail, murdered, etc. 60% of humanity enjoys the privilege of living under a dictatorship .. and they are growing: en.wikipedia.org/wiki/Democracy_Index

@festerwalter 9 ай бұрын

Ghb is better than alcool

@OlafKeller 6 ай бұрын

At first. Then, you are addicted downregulating GABA B.

@unentangledentanglement 4 ай бұрын

Suggestion: Chloride (anion) not chlorine (molecule/element). The former is the flow of negative charge through the GABA-A chloride pore; the latter doesn't. Well done otherwise

@davidpingryn5628 2 ай бұрын

Interesting how this intricate system came about by accident over billions of years and not the result of some intelligent being creating it. Literally blows your mind doesn’t it?

@tracyhughes5092 Жыл бұрын

Thank you , however, I've watched a lot of videos on this topic. THIS is the most complicated and boring I've ever watched! It is more for biology students than the public guess that's why it says advanced

@trueblue450 2 ай бұрын

You must not be smart enough to understand the subject.

@judyrobin6911 2 жыл бұрын

I found your presentation extremely boring. Good information.

@senseofmindshow 2 жыл бұрын

Thanks for the feedback! I think you may find my newer videos more exciting :)

@judyrobin6911 2 жыл бұрын

@@senseofmindshow I just rewatch this one for reference. I need more information. I am about to find a new one you made.

@missseeingthesights 6 ай бұрын

I'm positive that cations do not flow down the axon once the action potential is reached, I think your diagram is misleading with the arrows (17:30 ish), might want rethink that whole electricity thing and focus on the electrons, enjoyed the video otherwise