Serotonin Receptors | Types of Serotonin Receptors and Serotonin Receptor Pharmacology

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Күн бұрын

This video focuses on the serotonin receptors and their molecular biology, pharmacology, and psychological effects when stimulated.
Serotonin (also known as 5-hydroxytryptamine or 5-HT) is a neurotransmitter molecule used in a huge variety of neurobiological processes. There are 14 different 5-HT receptors in the brain and body, each with a fairly unique intracellular signaling mechanism and distinct psychological effects.
What do you think of Sense of Mind’s new style (more visuals, shorter videos)? Let me know in the comments.
This is the first in a miniseries on the neurobiology of the serotonin system. Link to the rest of the serotonin videos: • Serotonin Miniseries
Chapters:
00:00 Serotonin (5-HT) is NOT just the happiness molecule
00:35 The goals and approach of this video and miniseries on serotonin
01:36 This is a new style for Sense of Mind’s neuroscience videos
02:18 Part 1: Mechanism of serotonin synaptic transmission
03:05 How SSRIs work
03:28 The “need-to-know” of synaptic transmission
03:57 Serotonin is a “neuromodulator” that can work extra synaptically
04:44 Part 2: Families and subtypes of 5-HT receptors
05:20 Most 5-HT receptors are GPCRs
06:00 5-HT1 and 5 receptor inhibitory mechanisms
06:30 5-HT2, 4, 6, and 7 receptors excitatory mechanisms
07:02 5-HT3 receptor excitatory mechanism
07:33 Please sign up for the video newsletter and podcast!
08:16 Part 3: What do the different receptors do to the brain?
09:28 Some effects of stimulating 5-HT receptors in the human brain
10:28 Resolving some paradoxes of 5-HT pharmacology (presynaptic receptors and biased agonism)
12:25 Examples of bodily effects of 5-HT stimulation
13:10 How can one neurotransmitter do so much?
13:59 Conclusion: Some remaining questions
14:35 - Please like and subscribe! Thank you!
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Sources Cited:
1. Sharp, T., & Barnes, N. M. (2020). Central 5-HT receptors and their function; present and future. Neuropharmacology, 177, 108155. pubmed.ncbi.nlm.nih.gov/32522...
2. Di Giovanni, G., & De Deurwaerdère, P. (2020). Serotonin research: Crossing scales and boundaries. doi.org/10.1016/j.neuropharm....
3. Hoyer, D. (2020). Targeting the 5-HT system: Potential side effects. Neuropharmacology, 108233. pubmed.ncbi.nlm.nih.gov/32805...
4. Mosienko, V., Bader, M., & Alenina, N. (2020). The serotonin-free brain: behavioral consequences of Tph2 deficiency in animal models. In Handbook of Behavioral Neuroscience (Vol. 31, pp. 601-607). Elsevier.
5. Carhart-Harris, R. L., & Nutt, D. J. (2017). Serotonin and brain function: a tale of two receptors. Journal of Psychopharmacology, 31(9), 1091-1120. pubmed.ncbi.nlm.nih.gov/28858...
6. Bacqué-Cazenave, J., Bharatiya, R., Barrière, G., Delbecque, J. P., Bouguiyoud, N., Di Giovanni, G., ... & De Deurwaerdère, P. (2020). Serotonin in animal cognition and behavior. International journal of molecular sciences, 21(5), 1649. pubmed.ncbi.nlm.nih.gov/32121...
7. Carvajal-Oliveros, A., & Campusano, J. M. (2021). Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?. Frontiers in Behavioral Neuroscience, 14, 262. www.frontiersin.org/articles/...
8. Dingman M. Know Your Brain: Raphe Nuclei. Neuroscientifically Challenged. neuroscientificallychallenged.... Published October 27, 2017.
9. JJ Medicine. “Serotonin and Melatonin Synthesis | Tryptophan Metabolism” • Serotonin and Melatoni... .

Пікірлер: 71

@senseofmindshow 9 ай бұрын

⚠ CORRECTION!!! In this video, I said "this video is brought to you by the Diamond Mind Foundation." Well, as of December 2022, that is no longer the case. Sense of Mind is now 100% dependent on viewers like you. So if you value this content, please go to www.patreon.com/senseofmind. For less than $5 a month, you'll get exclusive content and the satisfaction of knowing you're helping to keep Sense of Mind alive! 🧠

@ArchieMackintoosh 2 жыл бұрын

Just have to comment again to say that you are ridiculously good at explaining this stuff, it's so easy to follow and understand - I really hope this channel gets the growth it deserves

@senseofmindshow 2 жыл бұрын

Very much appreciate the compliment.

@DanielSRosehill Жыл бұрын

Thanks for the deep dive! Really excellent stuff!

@kaylagonzalez3465 8 ай бұрын

Honestly, soooooo good! Just what I was looking for!!

@theemilbarna 2 жыл бұрын

This is great! I like the way you don't assume that people know exactly what you're talking about and provide context and links where required. Keep up the good work!

@senseofmindshow 2 жыл бұрын

Thank you! I'm so glad it made sense. Keep it up with your channel too! 💪

@azclepius Жыл бұрын

I had been searching how does few Serotonin Antagonist drugs help in increasing Serotonin levels, (but could not find it anywhere on internet) but you answered that specifically in your video. Thanks!

@msmventures799 5 ай бұрын

Love the timestamps organization. Subscribed!

@user-dc8sk4em8b 23 күн бұрын

Brilliant video which explains basics of serotonin receptors (?Hats off to the creative brain behind ) - If a small area can include 5 HT1 A disinhibition, when explaining SSRI actions , that would pretty much cover basic psychopharmacology in connection to serotonin receptor function ( usually explained as the cause of delay in clinical response of most SSRI ‘s ) 👍👍👍👍

@curious.biochemist 11 ай бұрын

This video is underrated!

@SM-lh2rm 2 жыл бұрын

Your team’s explanations are so clear it awesome. I can’t see how this channel won’t blow up with views

@senseofmindshow 2 жыл бұрын

Thank you so much!

@Kuffyeyo-HonestWeirdo 2 жыл бұрын

Underrated video production value. I’ll browse your page more later. Love neuroscience

@senseofmindshow 2 жыл бұрын

Thanks so much for the compliment and for checking it out! 🙌

@jojo1865 2 жыл бұрын

The video was highly informative and very well put together I really enjoyed it. Thanks bro !

@senseofmindshow 2 жыл бұрын

Thanks for checking it out!!

@isabeladunlap5866 Жыл бұрын

so happy I came across your channel! Definitely subscribed. I'm doing research for a research paper & presentation on the effectivity of SSRIs and MAOIs for one of my senior biochemistry theses. This series (and your references) has been so helpful, as I am have very little background in neurochemistry. Super organized, clear, and interesting, thank you and great work!!!

@senseofmindshow Жыл бұрын

Thank you very much! I'm glad to hear it could be of help.

@bellabee8235 Жыл бұрын

Thank you for helping me study for my RANZCP exams x

@126geminis 5 ай бұрын

Thank you so much! I finally understood!

@senseofmindshow 5 ай бұрын

Great to hear!

@Doraemon-wc2nn 4 ай бұрын

Great or glad😜@@senseofmindshow

@PauloRLustosa Жыл бұрын

Excelente trabalho. Obrigado

@senseofmindshow Жыл бұрын

obrigado por assistir o video!

@Elena-tt6gs 2 жыл бұрын

I'm so happy I found you. I love neuroscience and will definitely watch some more videos.

@senseofmindshow 2 жыл бұрын

I'm so glad to hear that! Just curious, are you a student? I'm just interested in learning about where people are coming from. Thanks for being here!

@Elena-tt6gs 2 жыл бұрын

@@senseofmindshow Yes, I am a psychology student. We talked about the serotonin system in a course and I wanted to know more. That's how I found you.

@senseofmindshow 2 жыл бұрын

@@Elena-tt6gs Very cool. Good luck in your degree! And never hesitate to reach out if you want to suggest topics for future videos!

@opio2204 10 ай бұрын

Thanks!

@senseofmindshow 10 ай бұрын

Thank you so much!!

@ahmedmemon7756 Жыл бұрын

Excellent

@senseofmindshow Жыл бұрын

Thank you!

@zacharyzheng3610 Жыл бұрын

Clear explanation❤❤❤

@senseofmindshow Жыл бұрын

Thanks so much for watching!

@deelupriyadarsh7305 Жыл бұрын

Will Get Back... With Gratitude, Deelu Priyadarsh

@jeremydeane7057 Жыл бұрын

Great job

@senseofmindshow Жыл бұрын

Thank you!

@kadidra7760 2 жыл бұрын

You have a new subscriber June 30,2022!! So excited to learn from you..🥰

@senseofmindshow 2 жыл бұрын

Much appreciated!

@kadidra7760 2 жыл бұрын

@@senseofmindshow yup!!!

@eliskaosborn4897 Жыл бұрын

5HT1A receptor is an autoreceptor so it stops the release of serotonin from the cell if there is high accumulation of serotonin accumulation in the synapsis. Please correct me if I am wrong. You said that 5HT1A receptor removes serotonin from the synapsis back into cell. This is job of SERT. Maybe I am just misunderstanding your way of explaining it but I wanted to clarify?

@senseofmindshow Жыл бұрын

Thank you for pointing out my mistake. That was an unfortunate fumbling of words on my part. You’re correct that presynaptic 5HT1A autoreceptors do NOT function as reuptake pumps. They instead trigger a mechanism that inhibits further presynaptic release of 5HT.

@eliskaosborn4897 Жыл бұрын

@@senseofmindshow Thank you for your reply!

@tello7390 9 ай бұрын

Great video man , working with more diagrams would make it a plus maybe you could use an ipad to walk us through and you could include a few analogies to make us understand

@nazmulislam204 Жыл бұрын

Appreciate man! Do you also have a serotonin transporter series?

@senseofmindshow Жыл бұрын

Thanks for watching! And no I’m sorry I don’t right now… I will look into that for the future though.

@nazmulislam204 Жыл бұрын

@@senseofmindshow will wait for that 😁

@ntinos81 Ай бұрын

Good staff. But can you explain what happens during bipolar disorder syndrome? For example, a relative of mine is given leponex. The symptoms almost disappear. When the dose is reduced (leponex is co-given with haloperidol) the symptoms de-masked slowly. I have noticed that when he starts showing the initial symptoms slowly (not straight away in few days) he is acting like OCD with some signs of compulsions, like going out to have walk. What happens in such situation at that exact point? He has low serotonin or high (he is agitated a little)? Is there a possibility that his brain after usage of leponex and blockage of HT2 receptors starts to build up new HT2 receptors for compensation or making new serotonin. Thank you

@bluesquirrel2472 2 жыл бұрын

Great video! Do you recommend any pharmacology books?

@senseofmindshow 2 жыл бұрын

Thank you! And sorry I don’t. I wish I did! The articles I referenced are the best I can do on that front :)

@bluesquirrel2472 2 жыл бұрын

Okay! Thanks! :)

@Zahra00aftab 9 ай бұрын

Please tell me how to find this table.

@krishnavaddadi9829 2 жыл бұрын

Excellent video well explained Can you give us key reference papers please

@senseofmindshow 2 жыл бұрын

Thank you! For a full list of references, see the caption for this video. But, if I had to choose, I would say the most important paper is this one: pubmed.ncbi.nlm.nih.gov/32522572/

@majedmohammed6400 8 ай бұрын

Is there a difference between the word expressed and the word found? When we are talking about the presence of serotonin receptors or other NT

@petcgnstuff3959 2 жыл бұрын

Is there a video on synaptic pruning by any chance? 🥰

@senseofmindshow Жыл бұрын

Unfortunately, I haven't gotten to that topic in any detail yet (though I plan to eventually do a video on neurological development)... However, I VERY briefly discuss synaptic pruning in my video on neuroplasticity (kzfaq.info/get/bejne/p5OZhKqg3dO2m4E.html)

@thaisplouvier5403 Жыл бұрын

sex, digestion, LSD, emotions 4:00 neuromodulator. Relatively weak effects/ about 75 percent of serotonergic neurons also have glutamate receptors 15 subtypes of serotonine receptors 10:00 anti psychosis, antidepressant, antianxiety, sexual arousal in some women

@ArchieMackintoosh 2 жыл бұрын

I've been wanting to learn more about serotonin and this video literally gives everything I was trying to find out! Your videos are produced really well and the content is great, also you look so much like link from Good Mythical Morning! I've noticed you also post a lot of shorts, I think you'll find this video helpful: kzfaq.info/get/bejne/mNOeibyou6veoHk.html

@senseofmindshow 2 жыл бұрын

That's really great to hear! Thanks for checking it out and sending that video about yt shorts, I also post them on reels on IG, and they seem to do better there but I've definitely noticed less traffic on shorts lately. Also, that I look like Link is really funny. I had never heard of him before but I agree we could be long lost twins.