Steve Ottersberg - Physiological Basis of the Endocannabinoid System, and Phytocannabinoids

Steve Ottersberg - Physiological Basis of the Endocannabinoid System, and Phytocannabinoids - AHS19

Рет қаралды 19,172

4 жыл бұрын

The purpose of this talk is to provide a physiological basis for understanding the function of the ECS and how genetics and diet influence endocannabinoid tone. From the physiological basis of the ECS this presentation will build upon the pharmacology and pharmacogenomics to provide rationale for determining the most effective clinical approach to endocannabinoid therapies. Polymorphisms in the genes for the component enzymes and receptors of the ECS can influence the clinical outcome of cannabinoid therapies. One poignant example of this are ultra-fast variants of CYP2C9 are poor candidates for oral consumption of Delta-9-THC due to the rapid conversion of Delta-9-THC into 11-OH-THC. 11-OH-THC is poorly tolerated due to intensity of euphoric effect and long terminal plasma half-life (up to 72 hours).

Пікірлер: 46

@medicinaverde8852 4 жыл бұрын

Thanks for this video, and thanks Steve for your work on this topic. Cheers from Chile!

@AmirZenOfficial 4 жыл бұрын

Wow this was such an informative lecture!

@CarlosRodriguez-db6sb 4 жыл бұрын

💯🔥great lecture , soon we will know more

@Thomas-ic4gk 5 ай бұрын

It is also amazing that much higher doses of ThC release AEA that jump backwards across the synapse to close the CA+ channel which prevents ROS from destroying our cells. Your diagram is missing the last half of the process.

@The_MissJarvis Жыл бұрын

As a cannabis user of over 25 years I truly appreciate this. Highly informative lecture and I’m glad he’s ditching grow bro science for real science. Let’s hope some funding for cannabis research starts here and not just in places like Israel.

@ahamed143 2 жыл бұрын

Excellent talk. Can we have a separate lecture on endocannabinoid degrading enzymes?

@Thomas-ic4gk 5 ай бұрын

You should listen to someone else who isn’t kinda wrong for political purposes lol. He skipped over the second half of the neuronal response of CB1. Once the neurotransmitters/modulators attach to the dentrites of the next neuron, that neuron release AEA which travels backwards across the synapse to close the CA+ channels of the firing cells. This prevents ROS from getting into the cells and destroying them.

@thomastousant7178 3 жыл бұрын

Informative, would like to know more. Believe more happens in the body that is natural homeostasis , what does missing part of the intestinal tract due to the equation?

@MedicallyFit 3 жыл бұрын

I believe Dr. Dedi Meiri would strongly disagree with the statement of "Cannabis does not kill cancer" and "its broscience" because of his research in Israel.

@sharronwells4946 3 жыл бұрын

Do people with the MTHFR gene mutation have a hard time with CBD and cannibus?

@Healingandchoices 9 ай бұрын

Never tried the thc version just the hemp variety....cbd. I have been finding cbd a godsend. Pain pain pain and started to really overdue on aleve. Cbd oil works for me so much better and faster and has reduced anxiety too. I have cf and mthfr.

@mistersir3020 Жыл бұрын

7:04 still valid

@thecannabisdoc 7 ай бұрын

I wish the speaker made less mistakes, would be much easier to follow but great talk overall

@REAlREAction 4 жыл бұрын

Gods creation is amazing.

@NoName-fp3jk 4 жыл бұрын

Nature creations....nature my friend...no need for invisible friends in the sky ...educate yourself!

@pwnage783 3 жыл бұрын

@@NoName-fp3jk if an invisible friend in the sky is what you believe god is then you either need to stop talking religion or actually study it

@larrytate1657 2 жыл бұрын

@@NoName-fp3jk yeah your DNA with a language in it more complex than any computer program formed on its own from nothing. The universe also started on its own and came from nothing. And all the exact measurements for life came from an explosion that created an endless exact order through the universe for life. Yeah ……. Evolution is more of a stretch than creation. If you don’t like God, call it Aliens. Aliens created us. That’s less of a stretch than evolution once you truly look into it.

@larrytate1657 2 жыл бұрын

Explosions create disorder not perfect divine order.

@tyupp77 4 жыл бұрын

THC = THICC

@Cannabinol 4 жыл бұрын

I like this presentation. However I think the stance on cannabis science as potential cancer treatment is a little needlessly negative. Dr. David (Dedi) Meiri and his team in Israel have demonstrated that certain strains of cannabis are more effective at killing cancer cells than current practiced methods. Not 'bro' science and you shouldn't walk away if someone wants to discuss it, that's just childish and ignorant.

@thegreenersidechannel 4 жыл бұрын

Exactly. Excellent comment

@davidvandeusen3424 Жыл бұрын

My closest friend was diagnosed with stage 1 rectal cancer. She did not do chemo,raciation, or surgery but took high THC concentrated,full spectrum cannabis oil, Host Defense Turkey Tail mycelium, and IV vit C. 19 months later her pet scan and biopsy revealed no cancer. Fact D

@native_earth916 Ай бұрын

Thats the way to do it! @davidvandeusen3424

@thegreenersidechannel 4 жыл бұрын

Disappointed by the anti cancer stance. How could he know that without more research? Certainly some things are still yet to be understood, right?

@jamesreid6526 4 жыл бұрын

I feel its more of a ass cover statement because MORE research needs to be done. I cant tell you how many times a pill got thru to help your heart burn but will give you cancer in 15 years. If we want to saw we do the opposite I want that statement to be tested. That being said I also feel like we can expedite cannabis as a true medication as we have plenty of people who have been smoking for 10+ years, no it wont be definitive because of the untracked variables of exatily what and how much will never be known . These people are still a valuable resource for our scientists to learn from and study.

@dana102083 3 жыл бұрын

Havent watched it yet but sounds like a conflict of interest. He works with a drug company that makes cancer drugs or something so had to stay in a lane.

@cannafitnessecstargetthera7857 4 жыл бұрын

I wonder why hemp seed has the perfect ratio of.Omega 3 and omega 6 fatty acid for the human body.

@Zyklon_B_still_and_know_God 4 жыл бұрын

Nothing perfect about it. ALA is poorly converted to true omega 3s.

@jamesreid6526 4 жыл бұрын

nothing but lube Steve even said it in the video.

@dana102083 3 жыл бұрын

@@Zyklon_B_still_and_know_God 100%. We poorly convert. We need DHA from animals and avoid seed and nut oils. 🖖

@killahills10304 2 жыл бұрын

@@jamesreid6526 hemp seed oil is not an industrial seed oil. He is referring to high omega 6 vegetable oils, sunflower oil etc. The machine lube oils.

@cannafitnessecstargetthera7857 4 жыл бұрын

that is why I am seed oil carries the perfect ratio of Omega 3 and 6 fatty acid for the human body is very essential for children hemp seed oil in their diet. I personally think a lot of mental illnesses today our direct result of deficient omega-3 fatty acid endocannabinoid system

@dana102083 3 жыл бұрын

I gree in concept but nuts in general have a much higher omega6 to 3 ratio. Pink fish would be a much better option and doesnt have antinutrients either. Then theres how its processed.. And how can you trust the stability of oils that knowingly break apart easily? (They have more weak double bonds). I think we need to be careful with nuts as it becomes the replacement for flour. Slightly more ancestrally appropriate but we ate mostly fatty meat.

@cannafitnessecstargetthera7857 3 жыл бұрын

@@dana102083 higher is not always better. But in the case of onega 3 we need all we can get. Great response

@jamisonhughes4593 3 жыл бұрын

🐈

@YouTubeSucks182 Жыл бұрын

16:30 Hacking in the middle of a speech. Great advertisement for weed (not).

@cannafitnessecstargetthera7857 4 жыл бұрын

You Are limited on your education. Next your going to say chemo therapy should be used with cannabis oil...

@cannafitnessecstargetthera7857 4 жыл бұрын

I refer to the perfect ratio of Omega 3 and 6 fatty acid I am referring to hemp seed oil that is not industrial seed oil but we'll work as a lubricant

@cannafitnessecstargetthera7857 4 жыл бұрын

Love the presentation but I'm very disappointed that you do not believe that phytocannabinoids play an essential role in curing cancer. So basically you're saying anyone that scared kid themselves of cancer and cannabis oil is what, lying or not telling the truth? I will inject myself with pure THC to the cancer site before I ever touch the chemotherapy. AKA mustard gas chemical medicine

@eddiem12eddiem12 Жыл бұрын

@@cannafitnessecstargetthera7857 Inject into your big toe mate will have same effect... The blood pump these things round at an intense rate WTF 🤣. Endocannabinoids may aid in some cancer survival but probably from them getting converted back to AA then specific prostagnadins, which can induce apoptosis, shift to Type 1 immune response and M1 macrophage shift... Bro PS I'll show you my education if you show me yours