"ApoB is the new way of saying your total cholesterol is too high, without saying your total cholesterol is too high". Thank you soooo much for clarifying. I always felt it was pompous and not significant. First time I listen to you and I already like your content.

My doc tried to put me on statins because of high cholesterol, even though I had high hdl & low triglycerides , ratio 0.6 & a recent angiogram & ultrasound confirmed no plague build-up in coronary arteries. I am 62 , 1.84m, 70kg,type 1 diabetic, do 10 hours cycling/gym every week & have been on a keto diet for 3 years together with intermittent fasting ,20/4. And this was after he advised me that Type 2 diabetes could not be reversed!! I almost reported him to the GMC ! Keep up the good work.

Finally someone who agrees with me. I am so tired of arguing with doctors. How refreshing!

Its good to see more and more doctors coming out with the real information. Congratulations.

Finally! A doc who explains things in straight forward, understandable terms. I'm a retired RN and have been on a quest to get solid answers to my questions about my meds & side effects, plus healthiest diet choices. Long story short, you have confirmed in simple terms that the studies I've been wading through are correct. In recent months, I've quit the statins and cleaned out all the processed foods from my house. I got off the vegan diet & switched to a whole foods, low carbohydrates, ketogenic diet. Also quit the antacid I've been on for years that was likely interfering with nutient absorption. My god, I feel so much better & my brain fog has cleared. This is my new favorite go-to channel for health information! Thanks, so much, Dr. Jay!

Started the carnivore diet and all of a sudden life is worth living.

It is difficult to believe anyone. The only sensible thing to do is eat minimally processed foods, a balanced diet, and stay as active or physically fit as you can and let genetics fall where they may.

Had to have a stent in 5 years ago. They put me on an 80 mg huge daily statin. Did some homework. I am PROUD to say that my total cholesterol is UP to 304. Tryglcerides are 63, fasting glucose 79, fasting insulin 3.3, 13% body fat, great ratios ...5'7', 140 lbs, 60 years old.I quit the 80mg and take a 10mg statin every three days bc I heard it can help solidify any soft plaque and help prevent it from rupture/clot/heart attack. Great video Dr.J

Refreshingly straightforward and well-informed content. This is one of the best videos I’ve seen on this subject matter. Thank you for helping us navigate what can be very confusing and often contradictory information on cholesterol et al.

Thanks. Because I run on ketones, my ApoB is high, 116. Today, my internist tried to use that to warn me off my high fat (low carb) diet because it might cause my heart disease to worsen. He thought he had a point. My calcium score had come in at 1908 a few years ago, so a fair amount of disease (and he wanted me on PCSK9 Inhibitors: I said no). Anyway, from your video, I knew that the ApoB just means "high cholesterol," and my research showed it helps unlock blood fats so that cells can use them, either to fight inflammation and disease, or to use as fuel. I'm the latter: I metabolise them. I showed him that my HS CRP is 0.6, so I have very low inflammation. If the ApoB was marking cholesterol used to fight inflammation, my HS CRP would have reflected the fire in my endothelium, and my doc would have a point. But, no. I also had a new calcium score, 1394, down 500 points (not supposed to happen), and my carotid is also less congested than four years ago (when I started low carb/carnivore). I'm apparently fixing "permanent and debilitating heart disease." And not taking a poison (statin) to do it.

This popped up on my recommended list, and I didn't know what to expect. I have to say I am pleasantly surprised by the content of this video. 👍

I am so glad to find you. This is great information and I feel crazy when my doctor pushes statins. I have a bit of arterial calcification and I hope I can stabilize it with a lchf diet. I’m 75. Good to meet you.

Drs. Brown and Goldstein were 2 of my professors when they won the Nobel Prize for their work with cholesterol. I do believe they would not agree with much of the teaching that is out there about cholesterol and its (dubious) direct connection to heart disease. We've known for over 30 years that inflammation is a (or the) pivotal issue. Thank you for staying up to date with the literature and sharing it with all of us.

Anthony is exactly correct on the APO B scam. Anyone with high LDL has high APO B; anyone with high APO B has high LDL. This is a scam. They are trying to convey that they have moved on from the LDL focus, while they are just trying to extend the LDL focus.

You are one of the only doctors I trust.

Looks like I just found a New Doctor to subscribe to who is BOTH Knowledgable And SANE...!!! A Great and RARE Combination in our Society 😊 👍 -70SomethingGuy

Loved your podcast. I appreciate what you’re doing. I’m actually the first MD in America to base their practice off the Paleo diet starting in 1997 after hearing a lecture by doctor, Lauren Cordain a few months before his published paper came out. I am now carnivore for about 11 months and have been against use of Statin drugs for over 25years. I heard Peter Peter Attia, speak at the A4 lecture several years ago, and was unimpressed. He’s a late comer with poor understanding how things work, but has promoted himself as an expert. Thanks for calling him out.

I'm so happy I stumbled on your channel!! Finally a REAL honest and educated doctor confirming my thoughts for years!!!

If IT admins worked like doctors, they would tell people with apple computers to install Windows patches, because research shows this helps with most computer problems.

SUGAR. get rid of it from your diet

What a fantastic and most refreshing presentation; thank you. I am a LMHR and have no concerns in carrying high quantities of the "other good cholesterol" - LDL - in my blood.

I had a heart attack 4 years ago at 48yrs old. 3 stents right side. I was is good physical health otger than I smoked. So I stopped. Then they gave me statins and blood thinners and a year later I had gained pounds and Type 2. Know that pre heart attack I never was diagnosed with Type 2 and regularly went to my doctor. I did have a lot of stress, physical and mental. I switched to a clean Keto. My cholesterol went up but everything else went down. A1C 7.4 to 5.3. I stopped taking the statins. I believe they caused the carnage after my heart attack. I eat a clean Keto. Feel better than ever

I just found your channel and was pleasantly surprised. Thank you for quiting the Mayo Clinic. Their lose is definitely our gain! We need more people like you.

A bigger problem than oxidized cholesterol and, btw, oxidized PUFAs, is glycated ApoB, which leads to the formation of sdLDL. It is *not* ApoB itself that is the problem, but the glycation of this protein caused by chronically elevated blood glucose. This is part of the connection between diabetes and elevated CVD risk. What they are really trying to do by reducing ApoB is to reduce the LDL particle count, which can be accomplished by reducing sdLDL and shifting "pattern B" toward "pattern A".

Not sure why you came into my feed but I am grateful. I needed this video. Thank you 🙏🏼

Your video showed up on my feed, probably because of the many health related channels I listen to. Your information is so refreshing to hear and wish more doctors would research beyond big pharma training in med school. ‘Diagnosis an issue, refer to the pharmacology books for an answer’. Instead of researching diet, nutrient deficiencies and lifestyle factors leading to most diseases. Looking forward to hearing more of your videos.

THANK YOU!! An educated consumer/patient is in charge of their own destiny. My GP wanted to put me on a statin bc my LDL is "high" (125) and Tot Chol was 201 at the time. I declined. I've had 2 CCTA's and both ZERO blockages! I eat a little bit of everything.

I've been through three doctors as I changed my nutrition life style ... I don't like calling it a diet as in today's world a diet is a temporary thing people "try". I was brain washed over the years with the nutrition pyramid that is designed to make a person sick IMHO. I really appreciate the time you take to break things down so us who only speak "normal English" can grasp all of this. Thanks

Doctor Jay, you are a breath of fresh air and I hope you will never change. It's so easy to "hear what we want to hear and see what we want to see". This is especially true in our political evaluation of candidates.

I appreciate you calling out that peer review is politicized

Man, you've pretty much summarized everything so well in this one video. Everyone on KZfaq is selling something and pushing an agenda. Your open ness comes thru . Subbed

Surprised this guy never hit my algorithm before.

Just found your video and really appreciate what you say. New follower here.

Great vid, doc! I’m a 69yo ex- rugby player (18 yrs) and, before that, wrestled for 12 years. My CAC score is 1200. My dad died of an MI at 42. But I told a guy at the gym just recently that inflammation is the root cause of not only cardiovascular disease, but also the majority of chronic and degenerative diseases that are prevalent in the ‘modern’ world. Nice job, PLEASE keep up the good fight!

You’re awesome bro, spittin facts for the people. God I hate these corrupt industries.

Thanks, I really enjoyed this video. When you started and mentioned 5 years working on a phd, my initial thought was that you would be in the same camp as all the traditionally trained doctors, I was pleasantly surprised. When I first came across PA, I admit I was a fan, but have gotten to the point I don't listen to anything he has to say. He loves to say everything with such authority and if it is 100% proven fact. He was a big proponent of taking Metformin and would point out that it was not available to the average person, but since he is a doctor that he can take it. Turns out he was very wrong about that. When I hear any doctor spouting off about Apob, all I hear is, "we were right all along about cholesterol, but we were a little off about exactly what to measure, now we have it figured out and you still need to take a statin. I like that when you talk about certain lab levels you simply state the number. PA and others feel the need to always express the units of measurement, I suppose they think it makes them sound smarter.

My great grandmother is 82 and has high LDL. She still drives, lives alone, and cooks all her own meals including meat and veg. My gramps is 75 and despite smoking, has always been active and cuts down trees and splits firewood, reroofed his house on his own the other year. Being active and eating real food, with adequate protien to retain muscle is essential. They probably also have decent genes, which I hope I inherited. Both have full heads of hair still. My other family members that haven't eaten so well and have much more processed food have beer bellies showing up in middle age

Oh thank you so much! As a practitioner following this game, this is huge for me to see more and more of the facts pointing away from ApoB, and toward inflammation (what about iron/copper? That’s another interesting set of factors affecting inflammation, isn’t it?) Thank you! Oh, and you are awesome. 🙏 Let’s see the science-speak on the CT-angiogram. ❤️

Thank you DR. You make the most sense of all the drs I have watched. 👍🏻

Awesome information. Can you do a video on ways that one can lower arterial inflammation using methods such as intermittent fasting?

Excellent information. Thank you, Dr. Anthony.

God Bless you Dr. Jay. We appreciate the truth on youtube. Rare nowadays!

Thank you! Really clears up the apo b trend for me!

I appreciate your review AND thank you for sharing this knowledge with us. My total :) is at 290 and due to those trustworthy like you I listen, I am not concerned. I eat meat mostly for about 2 years, some carbs and chocolate way too often (Special days, or religious celebrations). I know “meat only” will improve because that is when I feel the best. Simple.

Great video. I like this guy. I listen to Peter Attia but I have a weird vibe that he may work with the pharmaceutical company. Anthony seems more like a guy who knows the science behind it all.

Good timing. I just got my bloodwork back this morning. I'll be 58 in July and I'm menopausal. I've always eaten healthy, organic when possible. A few weeks ago I started low carb and no sugar and added more protein to my diet. I'm trying to only eat "healthy" fats. We only use EVOO and avocado oils in my house. Recently switched to grass fed butter in moderation. I'm still finding the best foods to eat, but all of my cholesterol numbers are showing in red. Total chol 233; LDL 152 and HDL 65; Trig 67. My fasting glucose was 95 and my A1c was 5.6. I had not had bloodwork in 2 years and my numbers are only a tick up. I'm also about 4 months now on an estradiol patch. I'm feeling pretty good. Never been on any medications and take vitamins sparingly. Since I changed my diet a few weeks ago, I've even felt my mood lift. I think I'm on the right track. :)

Can you do a video describing the "if this, then that" of blood lipid tests? As in, if you have high total or LDL cholesterol, get a CAC scan to determine if you have plaque. And if you have plaque- then? Or if not then what? Don't worry? Change diet to get under 280? Thanks for all the great info!

Thanks for the honesty and for your expertise and time.

Thank you so much. This video was so important for me.

Hey Dr Jay! This is the first time I have visited your channel. I clicked on the video thinking "oh boy I bet we got another biased doctor who can't objectively evaluate data quality or interpret quality data results". I was very wrong, and I am very glad. Please keep doing what you are doing. You have earned a new subscriber!

You have become my favorite you tube Dr.

i think biochemists are the BOMB...keep it up,we can't afford for you to keep your knowledge to yourself.

immediately subscribed ❤ wonderful content! Thanks, Dr.Jay.Blessings 🙏

Great talk. I just converted mine from UK to US reading and got to 272. My doc has been pushing statins even though my trigs are 0.8. I won’t take them.

Brilliant presentation! Thank you!

Enjoyed the presentation so much. On the question of people with hypercholesterolemia dying earlier as a result of high LDL-C, there has been some questions concerning the cause. Briefly, it has been noted that *SOME* of the people with gene mutations that produce less effective LDL receptors (that hinder the removal of LDL particles from the blood stream and give them high cholesterol levels ). . . ALSO have genetic disorders of the blood coagulation system (which are likely to lead to atherosclerosis and early heart attacks). Those that suffer BOTH conditions typically die early because of the blood coagulation problems (usually < 30y of age) . Those that make it beyond 30, all things being equal, may expect to live a normal lifespan. In fact, a number of studies have shown that high cholesterol in the elderly is positively associated with longevity and slower cognitive decline. I must say that at the age of 73 I need all the cholesterol I can get. A paper "Importance of Coagulation Factors as Critical Components of Premature Cardiovascular Disease in Familial Hypercholesterolemia" Uffe Ravnskov, 2022 is worth a read.

Such a generous guy! I'm so glad to discover this channel!! Thank you for sharing your knowledge! 🙏

I like this doc he's making sense

Many doctors no longer believe saturated fat increases LDL. Like Dr Mason says, what's the biochemical pathway showing saturated fat to LDL?

ApoB is about the same as LDL it's just to sell more tests. "Remarkably, one-quarter of the centenarians had high Lp(a) serum levels even though they never suffered from atherosclerosis-related diseases." 1998 G. Baggio. High Lp(a) is in your genetics to make you live a long healthy life but low Lipoprotein(a) is bad news. 2012 article title: Low Lipoprotein(a) Concentration Is Associated with Cancer and All-Cause Deaths: A Population-Based Cohort Study (The JMS Cohort Study) The Lp(a) levels were inversely correlated with the CIMT in this population, suggesting that subjects with a low Lp(a) level may have a predisposition to carotid atherosclerosis. This finding was preliminary and should be investigated further in larger studies and in additional settings. 2012 article title, CIMT thickness in asymptomatic subjects with low Lipoprotein(a) levels.

What is your take on the Ference et al large Mendelian randomization study showing LDL as such a distinct risk factor? Based on what I’ve heard from Attia, that is the study which most concerned him. Also thanks for the great video.

Just got my labs back and had high ApoB (90) and high LDL (116)- all the LDL labs were high including particle #, small, medium. LDL peak size and Large HDL were below range. All other heart labs were within normal range. Total C was 196, Triglycerides 75, Lpa

Cracking of the arteries. Lysine + Vit C are required also Proline is beneficial. Cholesterol fills cracks in arteries attempting to repair the wounds. Linus Pauling Protocol. 2 times Nobel prize winner 👌

Thank you, your explanation of ApoB was reassuring. I tested for it among other things, and your video helped put it in perspective. I'm 65, BMI of 19 (135 lb / 61kg), total cholesterol 553, LDL 474 (large or Pattern A), HDL 86, trig 56, VLDL volume too low for size to be measured, Lp(a) 18, HS-CRP 0.95 and insulin of 6.7. The ApoB was 256, so I came to YT looking for you, Dave Feldman, Nadir Ali and some others. Found the reassurance I needed. Yes, I'm keto, under 20 grams total carbs a day.

Great video very informative best regards from United Kingdom 😺👍🙏

I have binged watched so many cholesterol videos. But I'm done for the nite with this one. You put my mind at ease by mentioning that that the acceptabe # of 300 for total use to be the standard. At 241 my doctor is hell bent on me starting a statin. I have told her NO 5 times. I'm about ready to find a new doc! Any way thanks for your research and the easy way you deliver it.

Great video. As I shifted to a more carnivore-based diet with IF, my overall and LDL cholesterol jumped up as expected by many. I paid for the advanced lipid panel (insurance doesn't pay for it because it's "unproven") and found I was pattern A with low lp(a). I do have elevated ApoB from the "standard" level, but I have argued that my increased overall numbers would directly impact that and not necessarily be a negative. I've maintained a weight over 90lbs from my high back in 2013 with low carb, then keto and now carnivore. My fasting glucose is below 85, HDL 79, TG 71, but that LDL of 250 has the doc panicked that I won't take a statin. At 43 I had a CAC done that showed zero and that fended him off a bit. I know people will say that soft plaque could still be an issue, but if I have restored my metabolic health, so I highly doubt there's plaque building up with no arterial damage from chronic inflammation. I'm now 45 and take zero prescription drugs and I plan to keep it that way.

I am SO glad that the algorithm sent THIS video to my feed. You have a new subscriber in ME. It is RARE to see doctors act like actuaries, and THAT is what I see in this pathologist, or dead person surgeon. I am blown AWAY by his astonishing GRIP on information statistics, with a touch of humor. 😊 Wow 😳, just WOW. 🎉 Thanks.

FWIW I understood what he was reading out of the medical textbook and I hold the opinion that Anthony Jay is a Legend.

This is fantastic Dr. Jay. Thank you for clarifying this all - your message is very much needed in the world. Maybe this could be your next book topic? ;-)

Love the fact that you think outside the box

I have been doing keto for 3 months to lower triglycerides, as well as taking a lot of Berberine and phosphatidylcholine. My triglycerides did drop from 169 to 147, but my ApoB went up from 119 to 120, and my A1c went up from 5.6 to 5.8. My LDL went from 118 to 134. My Omega 3 is high, and my Omega 6 is within normal range. I have also been intermittent fasting for a couple years, with an eating window between 10:00 a.m. to 6:00 p.m. I am an athlete with under 10% body fat and work out 7 days a week in one form or another, so I do eat a lot of calories. The past few months I have doubled the Salmon, Cod, tuna and sardines. I eat 4 eggs per day and eat lean bison and elk 2-3 days per week, along with non starchy vegetables; i.e. broccoli, culliflower, cabbage, brussell sprouts, spinach, mixed greens, carrots, onions and mushrooms. Any thoughts on why my ApoB and A1c are going up while my triclycerides are going down with out carbs?

Great 👍 information Doctor 👨‍⚕️ thank you 😊

Thank you Doc Anthony Jay...You have a special skill in taking a lot of technical medical gibberish and making it easier to understand...Still watching your video...again...again...and making notes...My Doctor and Cardiologist here in Canada are ignorant about almost everything that you have discussed here...Free ? Canadian Government-run Healthcare is a disaster....

can plaques (hard or soft) in arteries go away with diet? exercise? medication? or is it here to stay and all you can do is mitigate more damage?

I like this Guy! He is sharp and alert. I'm gonna email him.

Fabulous as always!

Liked and subscribed! I follow a number of medical doctors who state the same as you. Good information.

The Nutrition Made Simple channel notes that lower cholesterol doesn't cause deaths, rather it's that numerous diseases, like cancer, cause cholesterol to drop, which skews the data. The host of that channel is an MD and a PhD.

How do you stop LDL becoming oxidized? 🤔

We need mucher longer term studies to understand the effect of high fat and how it damages the endothelium

That was really a great and clarifying presentation. Thanks a lot!

Thank you Dr. Jay! I'm 52 and have been on an anti-inflammatory diet with IMF for a few years now. I've lost 50 pounds and have never felt healthier. However, my LDL and ApoB have gone up and my doctor wants me to get on a statin. Thus far I've refused but wasn't so sure when he started talking about ApoB. This clarifies things tremendously.

Dr. Jay - you’re the man! Very appreciative of the knowledge and the gene analysis you did a while ago.

Thank you so much for this great info and research that you learned and shared with us. I'm on stains right now and experiencing a lot of lower back pain which is preventing me from exercising like I should to Increase HDL and lower LDL and inflammation. Thanks 👍🏻

Such good information. Thank you, Dr.

Arterial turbulence from hypertension, inflammation, and oxidized seed oils causing the damage leads to plaque buildup if I'm thinking correctly. High cholesterol or high LDL does not cause it.

Peter Attia also seems to think people are poorly from a lack of vaccines. Now that you've pointed out the apo b stuff, I feel my instincts about him were correct. I had doubted myself. Very interesting video. Subscribed.

THIS HAS BEEN ENLIGHTENING. I WILL DIG THOSE STUDIES OUT

Grains turn to sugar immediately in the blood

Thought about cholesterol for 5 years but didnt wonder why cholesterol doesnt build up or plug up veins if its the claimed cause of cvd as per the cholesterol hypothesis. It should be obvious the majority of the damage is caused by high glucose/insulin and the repair mechanism is cholesterol.

I always thought that Metabolic syndrome was the key to everything, then I learned that insulin resistance is even more important, and then I learned that my glycemic index was the key to a long life. I guess I am going to have to go back to the drawing board. Just never enough blood work.

Don't smoke, normal blood work, low a1c, glucose, low lpa, etc. Extremely active, workout regularly. After 5 years of low carb diet and basically unchanged ldl/hdl/triglycerides, but my apoB went from 70 to 130...

As a medical doctor in primary care, I've been trying to get people to simply "live healthy". Don't smoke, avoid alcohol. exercise with short interval high intensity training and weightlifting, eat lots of green leafy vegetables and avoid hydrogenated fats like margarin and grain oils and low glycemic index foods like starchy fast foods and junk foods. eat good lean meats of all kinds. watch for the elevated sugar, triglycerides and metabolic syndrome as these people tend to develop heart disease. BUT.... people don't want to hear that. They want the easy quick fix and don't want to change to a healthy lifestyle. There's only so much I can do as a doctor.... I can lead the horse to water, but I can't make it drink.

Thanks

Thank you so very much for spending your time to explain these serious topics. I would love to hear more just about LPa and the bloodwork that needs to be done to determine LPa.

"Deficient in Pharma drugs;" that made my day. 🙂

ApoB may well be found in plaque but so is apoa, so the likely culprit is Lp(a) as the source. Lp(a) is a patch for endothelial damage, and inhibits clot dissolving while the repair continues. As new endothelial cells grow over the top, it all appears to be inside the arterial wall.

yes. so true. People, including researchers and doctors do not understand that correlation is not causation, and that measurement does not imply making the root cause visible. Both can be made to look very scientifically, but in fact measurement and correlations are abused in 99.9% of all scientific work. There are structural and historical reasons for that, which we can not discuss here. Measuring something means to fish in the dark like a racoon, grabbing some changes in the system to make it visible. Most measurements are targeting proxies, not the root cause... because in a metabolic network, the root cause is not detectable at all. Yet, I think you are wrong on Lp(a). Lp(a) itself is caused to rise in a a regulated response to an injury that creates a small clot. Lp(a) tells the whole erst of the system NOT to break down a clot. This is very helpful in preventing the continuous bleeding from a wound. that is, first you have the injury, then the normal reaction of building a clot. this triggers LP(a). if there is enough healing capacity, the injury will heal and the micro clot will disappear. Yet any of those they can grow if there are lots of micro-injuries, now affecting themselves mutually and preventing their break down. So, the micro-mechanics of injuring the vessels are important to understand. those go from malfunctioning glycocalyx, largely due to inflammatory factors, external and internal (homocysteine), ox stress, low gutathione, high BP, and stiffness of RBC ...which by the way is related to too much saturated fat, relatively to the level of O3, and pufas in the cell membranes

I’m 67, male, and went keto and IF, and stopped drinking in January 2023. Lost 60 pounds and 4 inches in my waist, (25% of my body weight); normalized BP; A1C in good range. Total cholesterol is 266 and my doctor stripped a gear and immediately prescribed Lipitor based solely on the cholesterol number. I had a stress echocardiogram yesterday and the cardiologist gave me a 100% clean bill….same as 7 years ago. But both he and my general practitioner INSIST that I am at a “very high risk for a heart attack.”