The Promise of Two Anti-Aging Molecules [10 Studies]

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7 ай бұрын

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References (Copy & Paste into Search)
[1] doi:10.1210/endrev/bnaa023
[2] doi:10.1111/dom.12354
[3] doi: 10.1093/ije/dyac200
[4] doi:10.1038/ncomms3192
[5] doi:10.1007/s11357-020-00274-1
[6] doi:10.1101/cshperspect.a025924
[7] doi: 10.1038/nature08221
[8] doi: 10.7554/eLife.16351
[9] doi: 10.1007/s11357-019-00113-y
[10] doi: 10.1016/j.exger.2017.12.026
First Video in this Series: • Is forever food restri...
Economist Video: • Longevity: can ageing ...
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#antiaging #agingbackwards #antiagingtreatment

Пікірлер: 196

@Physionic 7 ай бұрын

1 AMENDMENT This is the last video in the 5 part Anti-Aging series! I hope you enjoyed and learned. All the videos are linked below: Calorie and Protein Restriction for Longer Life: kzfaq.info/get/bejne/bKp7hNOX1rWodZs.html Genes that extend Lifespan: kzfaq.info/get/bejne/l9ODf5eFyarNg4U.html The Microbiome & Young Blood on Lifespan: kzfaq.info/get/bejne/n7hxg8eKqrPUmXU.html Senolytics: kzfaq.info/get/bejne/mt6Sh5CLvJrKiHU.html AMENDMENT: @3:33, that should read 'LKB', not 'LBK'

@RealitikDaily 7 ай бұрын

Hi Nicolas, your videos have to be some of the most professional / research paper and science-backed regarding aging molecules. Could you do a video regarding astaxanthin and sulforaphane please? 😊

@beckyerb9941 7 ай бұрын

Great content! Do you think Metformin will be a banned substance for athletes do to its competitive advantage?

@Beans-great 7 ай бұрын

I have to say, out of all the people I look to, to get the-most precise unbiased data, you are it! Keep up the great work!

@markmartin2292 7 ай бұрын

Old Chinese saying- one illness long life. People who have a health condition take better care of themselves. They don’t stay out all night smoking and drinking

@Sh0n0 7 ай бұрын

Wow. That’s a good one

@oolala53 7 ай бұрын

Sometimes. I had a client years ago who had had open heart surgery in his late 50s/early 60s. I asked him if he had also changed his lifestyle. He said yes, but that meant eating one less slice of bacon at breakfast or the like. That kind of surgery on its own extends life about 10 years. The buildup can happen again and sure enough he died about 10 years later. I will say that I think he enjoyed the time he had. Also, I hear of plenty of people with diabetes not eating to lose weight which reverses it in many people. They’ve often said their doctors say it’s a lifelong condition that can only be managed with meds. It does have to be managed, but changing eating and exercise is a great first step, yet many claim it’s too hard. It IS hard, but so is living with risk.

@whitewolf6730 7 ай бұрын

I don’t smoke or drink anyway. Only have arthritis. Never smoked, drank, or smoked “The Hootch”

@jellybeanvinkler4878 7 ай бұрын

@@oolala53Dr's tell diabetics not to change. The meds now control sugar processing. I know a few and they eat a shit ton of sugary carbs. But get thinner. It's very hard for someone like me (no meds, struggles with weight, struggles to stay low carb)to hang out with these old friends...😢

@shantinaturechild3239 7 ай бұрын

@@jellybeanvinkler4878 find a new crowd who has common interests and doesn't just stuff their faces and kills themselves with refined junk! Try eating raw ripe fresh organic alkaline produce to heal and lose weight IF YOU WANT!!! It's YOUR body and YOUR life! Check Sergei Boutenko who healed type 1 diabetes within 1 month eating raw. Transition slowly! Arnold Ehret's mucusless diet healing system book can help as a start. Be well!!!

@aldifortuner278 7 ай бұрын

What about methylene blue you promise to dig down? Im looking forward on that subject. Thanks nic

@deliveroobandit 7 ай бұрын

I am med student and I keep watching your videos since your first.... Maybe.. I wanna tell you something... Keep making videos and you'll hit 1mill follower in the future... Your content is way under appreciated... It's technically accurate , still understandable. Please keep doing it. If I can afford in the future I will donate your Channel! Since then I support you with my words and thoughts! :)

@Physionic 7 ай бұрын

Words and thoughts are enough support from you, ATM. Thank you. All the best with medical school!

@shantinaturechild3239 7 ай бұрын

@@juliantreidiii if he promotes drugs like Metformin they will even pay him 😉

@OTatime 7 ай бұрын

Great channel. I love your evidence-based approach and your humor.

@Physionic 7 ай бұрын

Thank you :) appreciate having you here.

@marksamarin8536 7 ай бұрын

Not sure I agree on the humor part 🤣

@zhilahaghbin4766 7 ай бұрын

Thanks Nick, appreciate your work and analysis and your super productivity:)

@nerdinium 7 ай бұрын

For the financially challenged (or cheap) - creatine and collagen - eat a cheap steak or burgers. Omega 3 - eat some wild caught fish - canned is fine. Curcumin - put curry sauce on the steak, fish, or low carb veggies. Profit!

@arihaviv8510 4 ай бұрын

Salmon skin is a good source of collagen/glycine and salmon is also a good source of creatine

@arihaviv8510 4 ай бұрын

Herring is an even better creatine source than beef

@theshadow8008 7 ай бұрын

Nice longevity lecture nick, learned a lot🤔!

@TheFarmacySeedsNetwork 7 ай бұрын

Thanks for another great video!

@RandomGuyOnYoutube601 7 ай бұрын

The most important question still unanswered. Does rapamicin cause mice to rap?

@Physionic 7 ай бұрын

A major side effect, unfortunately.

@jp7357 7 ай бұрын

I’ve been going back and forth about microdosing rapamycin, the scales were dipping to “yes” until I heard on Peter Attia’s show that “he knew it was working because he was getting mouth ulcers .. and there are meds for the ulcers” .. that swung the scales way the f back again.

@youranonymousyoutuber4051 7 ай бұрын

Can you make a summary of most effective supplements

@squamish4244 Ай бұрын

I have gotten incredible effects from intravenous NAD+ use. Emphasis on intravenous. I do not know if taking NAD in pill form sublingually, which I do, is having any effect, but I am 100% certain IV drips are doing all sorts of good stuff - joint healing, relief from back pain caused by really tight muscles, gut cleansing and a few weeks of increased stamina. Enormously increased stamina for the 24 hours after the infusion. Cognitive improvemets. Greater flexibility. I didn't know NAD+ had these effects, and used it to get off a horrible benzo dependency in a matter of a few weeks, without withdrawal symptoms. It repairs exhausted receptors in the brain and works against ANY chemical dependency or addiction. Finding out about all the other stuff it was doing was pretty cool.

@johnallen7230 7 ай бұрын

Yet another excellent video

@tempcadoganenright 7 ай бұрын

Very competent. Good job

@DanaVastman 7 ай бұрын

Always enjoy your evidence based wit and charm❤️

@HealthyLife4Me 7 ай бұрын

Metformin? Naw…better to use Berberine or Magnesium Malate & Chromium Polynicotinate

@williamhenry3337 7 ай бұрын

I heard you need a prescription to get Metformin. The last time I was at a doctors office was in 1969 so I take berberine.

@leighnapier4505 6 ай бұрын

You are smart ! Stay away from the medical industrial complex.

@lozocodo 7 ай бұрын

Love this channel! Honest and to the point! E retuning us backed up with scientific data and nobody is trying to scam you.

@westfield90 7 ай бұрын

Really enjoying your channel as of late.

@beyerch 7 ай бұрын

Now the real question : How to get Rapamycin and Metformin? Also, what are Berberine as a alternative for Metformin?

@desireisfundamental 7 ай бұрын

I would say the most potent natural compound for age reversal is curcumin, just not sure what is the best way to use it. There isn't a compound I have found that can at the same time affect the reversal of so many aging-related mechanisms like : acting as a GSK-3β inhibitor; inhibiting TGF-β receptor I/ALK5(part of cellular senescence); inhibiting MAO-B( neuroprotection by inhibiting the breakdown of neurotransmitters); increasing cyclic AMP (cAMP currently confirmed only in muscles I think); inducing the expression of TET enzymes; activating both canonical and autophagy-mediated Wnt signaling..

@myofasciatherapy8191 7 ай бұрын

Hope I will see many many answers/ ideas from all on this! Also from Physionic ☀️

@CraigHocker 6 ай бұрын

Without any clinical evidence, it's not at all convincing to argue only from mechanistic claims that are based purely on in vitro data.

@johnlemmo681 7 ай бұрын

Love your channel, any studies on Boron and cartilage repair ?

@adamrieckel5597 7 ай бұрын

Can you please do a deep dive into Spirmidine supplements??🙏

@darelsmith2825 7 ай бұрын

I've been taking Metformin for years. I got off the extended release daily and take a double dose every other day now because it makes me sleepy and farty. Off day, I carry a 75 pound field sack 5-10 miles. On day, I pig out on tacos and fruit and if I feel like I have accomplished much, I might have a slice of pie or some ice cream. Thoughts? Doc says my A1C scores are improved.

@amj864 7 ай бұрын

Rapamycin indeed is one of the most exciting ones, though there are the concerns about the muscle-building ability and short term memory interruptions.

@MasterofPlay7 7 ай бұрын

just take taurine, much safer

@AUniqueHandleName444 7 ай бұрын

There are some concerns, but not really/significantly for muscle building ability or short term memory. The larger concern mostly seems to revolve around immosuppression.

@wildcsgotactics 7 ай бұрын

First time I hear about short term memory interruptions in regard to rapamycin (and I'm not on rapamycin yet).

@beyerch 7 ай бұрын

@@wildcsgotactics or maybe you ARE on rapamycin and you forgot. :) :)

@jellybeanvinkler4878 7 ай бұрын

It's hard to fathom any of these problems when listening to the Drive. Dr Attia is sharp as a tack and physically a #10. Though his moral compass seems to go off kilter occasionally.

@SilverFan21k 7 ай бұрын

Great video. came up on my recommended

@Physionic 7 ай бұрын

Thanks!

@user-xd6ep4xv7e 7 ай бұрын

You sir are a very good teacher 😊

@michaelzumpano7318 7 ай бұрын

Is there any data to support the idea that Metformin may increase the rate of diagnosis of dementia? I live near UCDavis and there was a buzz about that several years ago, but I never got any specifics. Could it have something to do with transport of sugar into brain cells?

@bigbear7567 7 ай бұрын

can you take a guess as to how long before we will be able to purchase medication to reverse ageing please.

@thomasfurman6052 6 ай бұрын

Creatine activates mTORC1, It would be interesting to hear your thoughts on aging, creatine, rapamycin, and mTorC1 since creatine seems to have many benefits.

@NobodyAnon-rm7li 7 ай бұрын

A deep dive on each of these on each of these drugs/ molecules for anti aging please ❤❤

@jmc8076 7 ай бұрын

Interesting. When it comes to drugs/med treatments ideally NNH/NNT and relative vs absolute data are avail. Thx Nic.

@keithdow8327 7 ай бұрын

Thanks!

@Physionic 7 ай бұрын

Thanks, Keith! I appreciate it.

@Beans-great 7 ай бұрын

Haha. This was entertaining my friend!

@Itisrealtalk 7 ай бұрын

I have Cytomegalovirus (CMV) that I contracted from my ex. Since then i'm super scared if it's gonna cause any harm to my body in the long run. Currently, i'm in my late 20s. I had mono due to the primary infection with CMV but since then i'm asymptomatic. I have read in so many varied published research papers online that CMV causes latent persistent infection inside the body that might cause low grade inflammation. I was considering taking Rapamycin but it's an immunosuppressant which I guess won't be a good idea to take in my case because I need properly functioning immunity to keep the virus in remission. Any advice on the same would be truly appreciated.

@V_Dgt 7 ай бұрын

Nicolas, could you tell about ornithine? Is it a good stuff for taking as a supplement?

@V_Dgt 7 ай бұрын

@@pramuanchutham7355 yep

@ImaJunkyoBell 7 ай бұрын

Questions - (a) What are the positive functions of mTOR a person would miss in the event rapamycin suppresses it? (b) fasting also stimulates autophagy so to what extent would rapamycin be redundant for a person who regularly fasts? (c) is there an age breakpoint where it becomes more useful than not to take rapamycin to inhibit growth to potentially suppress cancer?

@jj900 7 ай бұрын

Mtor in simplistic terms is pro growth, protein synthesis, muscle building. You can't suppress it all the time, itll lead to sarcopenia. It's that balance between fasting and muscle, feast and famine etc...

@dlbdlb3919 7 ай бұрын

thanks

@bradboustead1682 7 ай бұрын

Is Metformin only valuable to people with blood sugar problems and people who eat too much sugar?

@justdanny7252 7 ай бұрын

Have you heard of hyperbaric therapy for extending telemeres? 🤔 Was wondering if that was bogus or legit

@gettingstuffdoneright5332 3 ай бұрын

Really enjoy all your work, just wanted to point out that the image at 3:30 has a typo: you have Liver Kinase B (LKB) labeled as LBK. Maybe you were testing to see if anyone's actually paying attention? I'm certainly trying 🙏 take care

@sundiataq 7 ай бұрын

So, am I wrong for thinking that metformin is useless (or even detrimental) for people who manage to maintain an optimal blood glucose level without supplements/medication?

@boossersgarage3239 7 ай бұрын

I'm not going to get a RX and pay for dr visit . so what's your point..

@BradJames83 7 ай бұрын

The Economist really love their anti-aging videos.

@joebartles3986 7 ай бұрын

A lot of comments about Berberine. One question. Does Berberine blunt the impact of exercise? I think that metformin does.

@WilliamThirteen 7 ай бұрын

iirc - the blunting effect has to do with the MOA on AMPK and same detrimental effect is to be found with Berberine. I, too, would be pleased if you were to examine this question. I believe Dr. Stanfield has also addressed this question in the past few months.

@samuelgarcia1186 3 ай бұрын

Slight increase is most likely due to DHEA. Consistent use of DHEA can contribute to plaque build-up (foam cells) and raised levels re: liver (Pennison-Besnier 2008 meta study on females re: adrenal insufficiency)

@neutralnyy2855 5 ай бұрын

You should tell more about potential side effects of particucal substance as for example raphamacin and it's impact on blood cells. Small sugestion which you could introduction to your next videos

@manuelojeda9144 7 ай бұрын

Plus AKG in capsules also

@Elaba_ 7 ай бұрын

KZfaqr The road to 120 said Ashwaganda mimicks the effects of Metformin and Rapamycin on critical pathways. What's your vision about this?

@Philson 6 ай бұрын

Metformin vs Berberine tho? Which is better?

@CraigHocker 6 ай бұрын

Didn't mention Matt Kaeberlein's ongoing study of whether rapamycin can extend lifespan in healthy older dogs in the Dog Aging Project. That is something to keep an eye on.

@thoughtmocker 7 ай бұрын

im confused about Rapamycin. being a kidney transplant recipient , i understood Rapamycin to be an immunosuppressant. im on tacrolimus, which achieves the same end goal but wouldn't taking Rapamycin be dangerous ... my understanding is that by nature this drugs are toxic and constantly the dose needs to be monitored....

@mili7374 7 ай бұрын

Could you do a review on spirulina and chlorella please🙏

@cjstone8876 7 ай бұрын

Enjoying your videos. Thanks for all the hard work. Please remember "data" is a plural noun. You usually say "data is" when you should say "data are".

@Physionic 7 ай бұрын

Thanks for the tip :)

@jellybeanvinkler4878 7 ай бұрын

Thank you so much for the deep dive into the workings og metformin. But WHY does it block GPD?🤔 Oh, and THANK YOU THANK YOU THANK YOU for explaining the whole 'Metformin diabetics live longer than non metformin non diabetics' thing. I have heard this proclaimed over and over and could not understand this. THANK YOU for the explanation ❤

@adoarch 7 ай бұрын

Does GLP-1s do same as metformin? Also does MOTS-C peptide do same?

@Physionic 7 ай бұрын

@manuelojeda9144 7 ай бұрын

I am taking a break from Berberine, I will start taking it again. I don't know what you asked about migraines.❤

@isa-manuelaalbrecht2951 7 ай бұрын

No Metformin but better to go for Berberine or med.mushroom like coprinus extract..😏

@americanfreedom1777 7 ай бұрын

Hmm , I'm thinking about," Ionophores " to open pathways for uptake of --------- .

@bobmciver6437 7 ай бұрын

There is an underlying assumption (which seems valid) that activating or deactivating an enzyme in the body to modify how energy substrates signal and are utilized can create better mitochondrial outcomes.Fair,yes,no? Could you clarify if possible what is the % of electrons along The ETC contributed by food.I have read 30%,with the rest coming from water and factors such as UV light; Infrared;amount of deuterium in water,amount of oxygen and CO2 and electromagnetic properties of O2 and DHA, all contributing. Confusing...often in the food wars blogosphere it's 100% food?!? Aside:At 71,I would LUV to try a rapamycin skin cream😊.

@jacklabonte6839 7 ай бұрын

Hi Nick. I know this is completely unrelated to this video(which is super interesting), but i was wondering if youve seen any of the work being done by Dave Feldman? He just released a study on cholesterol, specifically on L.M.H.R(Lean Mass Hyper Responder). Apologies if this isnt the right spot to post this. Just thought it was a very interesting study, and that you might have an interest. Be well👍

@Physionic 7 ай бұрын

Already recorded a video on the topic and it's ready to launch - I'm not exactly sure when I'll release it... maybe this coming week (on Wednesday)? What do you think?

@Mario-forall 7 ай бұрын

3:15 oh, would that explain why blood sugar spikes so high after eating carbs on a keto diet or when breaking prolonged fasting?

@miaya3898 7 ай бұрын

you should break fasting by eating only fat and or protein.

@Mario-forall 7 ай бұрын

@@miaya3898 yeah, cheese or peanuts, work pretty well for me. I was wondering about that transient insulin resistant state.

@miaya3898 7 ай бұрын

@@Mario-forall I wouldn't with cheese as it has lactose. you are better off with kefir milk to reintroduce gut flora. peanuts or peanut butter, avocado as it's mostly fat, eggs and bone broth with minimal salt to avoid bloating

@dtnuh 7 ай бұрын

Great information per usual! Also if I may very respectfully say, you are handsome! 🙂

@pavman42 7 ай бұрын

It's like there's an invisible person you're talking to. A little nutty, but I get it. It's ok, comedy is usually difficult for scientists.

@filippo85betti 7 ай бұрын

if metformin promotes sugar uptake from blood to tissues, won't adipocytes uptake it too, get larger and cause a weight increase? 😐

@rejiequimiguing3739 7 ай бұрын

Metformin affects the absorption of sugar in the intestines. So the food glycemix index is lower. you lose weight on metformin.

@Merzui-kg8ds 4 ай бұрын

metformin leaches b12 and b9 from the body, so needs to be taken w that concern in mind.

@beckyerb9941 7 ай бұрын

Smarty pants 😂

@djayjp 7 ай бұрын

NAD or NMN...?

@joeblow1748 7 ай бұрын

Is it realy that mystical? If a drug inhibits ypur shugar intake the tendensy would probably you live longer as evry1 knows shugar is bad for you.. I dont think in any shape or form it has anything to do with aging only the same old, health and fitness maintananse aka things we already know. Its probably a health supliment at best nothing more..

@marcjames3487 7 ай бұрын

My thinking too - if you don't eat sugar and practice intermittent fasting you're already well ahead health and longevity wise.

@larsnystrom6698 7 ай бұрын

@joeblow1748 Metformin inhibits the bodys own production of glucose. Too much of that is a problem for diabetics. Many diabetics eat low carbs, but still has high blood sugar. Especially while fasting. So That's not always a cure either. Low carb and fasting works better for pre-diabetes than for diabetics!

@miaya3898 7 ай бұрын

@@larsnystrom6698not according to bariatric surgery patients whose diabetes reversed.

@muzzletov 7 ай бұрын

but then, doesnt that allow for biases against metformin, if you include the low-end metformin users but dont account for the low-end general population?

@sunnyben2604 5 ай бұрын

Does this mean that healthy individual taking very low dosage of metformin may live longer.

@thomascorbett2936 7 ай бұрын

Wow this kid is smart , I thunk I'll listen .

@boossersgarage3239 7 ай бұрын

o2 , carbon. can't live without them.

@findingdori442 7 ай бұрын

💛

@manuelojeda9144 7 ай бұрын

I take ProHealth NMN, and TMG in powder form. Metaformin causes stomach issues. I took it for two years it's bad. I switched to Berberine instead.❤

@pattheplanter 7 ай бұрын

Doesn't berberine clear out your microbiome due to its antibiotic effect? I used to use it for stopping my migraines completely but I found my triggers so i don't have to anymore. I wonder if you take berberine regularly and stop, would you get migraines?

@manuelojeda9144 7 ай бұрын

I don't know about that. I'm taking a break from Berberine, but I will start taking it again.❤

@naguarachamo1 7 ай бұрын

They both make me feel weird. Doesn't make sense.

@Dang3rMouSe 7 ай бұрын

The initial Metformin study is a great example why no one should take a single scientific study at face value.

@ericmaclaurin8525 7 ай бұрын

Being clear on the actions of a substance is only half of it. The other half is being clear on the other things it does that are unrelated to your goal. Not using as much sugar is good. Not being able to make sugar when you need it? Who knows.

@MrBinalter 7 ай бұрын

Does fasting produce similar effects?

@miaya3898 7 ай бұрын

yeah. why would you take rapamycin when you can induce autophagy on your own. it's free

@brandonleesanders 7 ай бұрын

If I didn’t know any better… I’d say you been puffing the ole magic dragon 🐉

@Physionic 7 ай бұрын

Nah, not my thing.

@HateDietPepsi 7 ай бұрын

If Sinclair pushes it I don't believe it.

@ichbinderroboter 7 ай бұрын

Why?

@vickyverma6852 7 ай бұрын

@@ichbinderroboter Just personal dislike stemming from internet hearsay.

@HateDietPepsi 7 ай бұрын

@@vickyverma6852 Wrong

@HateDietPepsi 7 ай бұрын

@@ichbinderroboter He's a propaganda scientists using poorly designed preliminary study data to push a narrative that something works.

@EduardQualls 7 ай бұрын

So ... in so many of these studies, it looks like we really just need to avoid _placebo_ - right? Why would they allow something so bad, or so inconsistent on the market? _Damn! And I just received my_ placebo _shipment from Amazon!_ _Interestingly, all the_ placebo _you can get is _*_vegan!_* 😃

@MrDjhealth 3 ай бұрын

Study highlights impact of aldehydes on DNA damage and aging Story by Science X staff

@ET.... 7 ай бұрын

why dont think about & try Berberine 😅

@ALDUIINN 5 ай бұрын

Bro you microfone , has a sound at 17khz that is really annoing. could you fix it?

@terrygrimes3332 7 ай бұрын

Astragalus..🤔

@zeuso.1947 7 ай бұрын

Active mTOR is needed to maintain muscle mass.

@netional5154 2 ай бұрын

This is a conundrum. In other videos on this channel mtor is portrayed more positively. So the goal is to maintain muscle mass without activating mtor. As far as I understand the best way to do that is not eat a lot of protein and focus on plant protein since that activates mtor less. And exercise of course to stimulate muscle growth.

@larsnystrom6698 7 ай бұрын

The second research article compensated for the selection of diabetics only on metformin over those with more medication, and thus presumely more severe diabetes. How do one do that? I can't see any way of doing that! The original research seems to have compared mild diabeticsi on only Metformin with non-diabetics. I see no problem with that. No need for any compensation at all. What am I missing? Although, that minor difference between the curves has to be compleatly insignificant. So it would be false to say that the diabetics survived longer. I would simply say that the research couldn't detect any difference! It's likely that someone with a mild diabetes has a tendency to try to take care of themselves. That's probably enough to compensate for the diabetes. The result is therefore not really surprising!

@jplkid14 7 ай бұрын

Random correction, you say LKB but the slide shows LBK. Cheers

@Physionic 7 ай бұрын

Pinned comment :)

@jplkid14 7 ай бұрын

@@PhysionicGod damnit, I swear I checked for that before I commented and didn't see it. My bad man!

@Physionic 7 ай бұрын

No worries at all :)

@maarten7 7 ай бұрын

♥

@maxiomburrows2099 7 ай бұрын

a bit disappointed no mention of berberine when addressing metformin, not that they are the same of course but... good vid otherwise Thanks

@codgerfiasco 7 ай бұрын

It always makes me sad when I hear you need mtor and inflammation for muscle growth but you need to reduce those things for longevity. I really wish there was a way to have your cake and eat it. Especially because putting on muscle later on in life is so difficult.

@arihaviv8510 4 ай бұрын

The key is balance. You mess up that balance when you try to hack your growth with steroids and overtraining (make sure to have good stimulus to fatigue ratios)

@wachtwoord5796 7 ай бұрын

You missed Metformin's little brother with no known side effects and a much longer history: Berberine Thanks for the correction of me thinking Metfornin extending life expectancy of diabetics on it over those of the general public not on it. Perhaps I should reconsider whether my continued (6+ year) use of berberine is still a net benefit (also considering cost) now it's not such an enormous no-brainer as my previous belief would imply.

@AnotherJoe 7 ай бұрын

I would be interested on hearing Nicolas’ @Physionic verdict on Berberine also 👍🏻

@ericmaclaurin8525 7 ай бұрын

You can't be malicious on a premeditated basis?

@jayaybe1 7 ай бұрын

Go subcellular!

@swenic 7 ай бұрын

Great stuff! Love your show. Writing this is distracting to me so just take my pants already. Panties? Good thing you're the content creator and not me. :) Really trulu great stuff though, thx

@jedwards1792 7 ай бұрын

I come for the hair, stay for the science.

@omkarpatwardhan3070 7 ай бұрын

Hey Nic, I would Appreciate if it would be possible for you to read the books and literature by Dr. Michael Greger. He has 3 books related to Diet, and Ageing of which the Ageing one is the latest in which he claims to back his claims with thousands of reference studies. It would be great if you you enlighten us about their validity. Thanks!

@Physionic 7 ай бұрын

You want me to read 3 books and dissect 1400+ studies? Is that all? 😉 I do plan on covering his work, but I probably can't devote a year of my life on the topic. 😆

@richardbreeze7898 7 ай бұрын

@Physionic his advice will consist of eating plant food only and no meat, fish eggs. That's about it. Oh and he talk about nuts and teas, herbs.

@oolala53 7 ай бұрын

Greger definitely has plant bias. It’s amazing how he never cites any positive results from studies of low carb. But the low carb people are the same. Almost everyone is susceptible to confirmation bias. No guarantees.

@timh-c7186 7 ай бұрын

@@richardbreeze7898and be a great example of that human frailty, "confirmation bias"

@miaya3898 7 ай бұрын

@@richardbreeze7898he already lost credibility by advocating vegan