Thrombotic thrombocytopenic purpura (TTP) is a rare disorder characterized by the formation of small blood clots throughout the body, leading to a decrease in platelet count. These clots can disrupt blood flow to the organs and tissues, causing symptoms such as purplish bruising, hemolytic anemia, fever, renal failure, and neurological abnormalities. TTP is typically caused by a deficiency in the enzyme ADAMTS13, which is responsible for breaking down a specific protein in the blood known as von Willebrand factor. Treatment usually involves plasma exchange therapy to replace the deficient enzyme and remove antibodies that are attacking it.
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