What is MTHFR? MTHFR Mutation Explained

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What is MTHFR? MTHFR Mutation Explained

Рет қаралды 34,725

Күн бұрын

1) Schedule your INITIAL APPOINTMENT (Now Accepting Insurance!): www.oswalddige...
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What is MTHFR?
MTHFR, also known as methylenetetrahydrofolate reductase, is an enzyme that plays a crucial role in the methylation cycle within many different processes in the body. This is actually one of the more common gene mutations in humans, and many people actually have a MTHFR gene mutation without even knowing it. One of the more common ones being MTHFR C677T. In this video, I will talk about what exactly this MTHFR gene is, more about the MTHFR enzyme, and dive into the components within the diet and body. One of the main topics being folate: why low folate levels may occur, foods high in folate, folate metabolism, and what methylated folate is. The other being related to neurotransmitters: what high homocysteine levels mean and methionine's benefits.
www.oswalddigestiveclinic.com
*This content is strictly the opinion of Oswald Digestive Clinic and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Oswald Digestive Clinic nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program. Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is in NO WAY obligated to use these links. Thank you for your support!
• What is MTHFR? MTHFR M...
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Пікірлер: 109

@Spartacus69 9 ай бұрын

I've been gluten free for 11 years due to gluten intolerance. I just heard about this MTHFR, decided to try Mythelfolate 1mg as an experiment. Within 3 weeks I'm completely regular and can enjoy a wheat treat randomly. amazing!

@OswaldDigestiveClinic 9 ай бұрын

Thanks for sharing!

@Mind69420 9 ай бұрын

Oh man don't get my hopes up!

@elkeschmitt9285 4 ай бұрын

Abdolutely awesome

@almandoi 3 ай бұрын

Does this really work? Can't wait to try it. My diet is so restricted due to this gene's mutation.

@IreneYoungFoto Жыл бұрын

For me, this is the best MTHFR video I have seen. Thank you!

@OswaldDigestiveClinic Жыл бұрын

Wonderful!!! Thank you for watching and commenting!

@ginamiller6259 2 жыл бұрын

Thank you for more information.my phycologist actually tested me for adhd and it came out I had mthfr and ask me if iv had miscarriage I was surprised how she new it it was not for my phycologist I would of never found out

@OswaldDigestiveClinic Жыл бұрын

Wow! I'm so glad you got connected to a great psychologist. If you ever want to explore the nutrition side to things - we are here for you. Thanks for sharing your experience!

@user-gs3fs5ny9d 8 ай бұрын

Thank you for the most succinct presentation I’ve heard yet on the MTHFR gene mutation.

@elkeschmitt9285 4 ай бұрын

Check Dr. BEN LYNCH

@sarahbarnier1819 2 жыл бұрын

This was a very clear and informative video. Thanks for posting!

@OswaldDigestiveClinic 2 жыл бұрын

This is music to our ears. Thanks for your support, Sarah!

@acsearchingfortruth 10 ай бұрын

Fruits and veg increase my inflammation and digestive issues.

@OswaldDigestiveClinic 9 ай бұрын

Thank you for commenting. There are many fruits and vegetables that can cause more digestive issues, likely due to a microbiome that is not diverse or other underlying causes. I recommend working with a practitioner to sort out root cause.

@mac-ju5ot 3 ай бұрын

Me@@OswaldDigestiveClinic

@Cinnamon349 Ай бұрын

The fodmap helped me find what fruit and veggies were bothering me. Try that❤

@naturalwitchery 16 күн бұрын

I recommend the fodmap as well

@MatthewWright001 2 жыл бұрын

Best video on this ever! So clear. 🙂

@OswaldDigestiveClinic 2 жыл бұрын

Thanks Matthew! We appreciate your support!

@GraceHarringtonMurdoch 11 ай бұрын

One thing to also address is finding out if you are over-methylating, which often does not favor methylated folates and methylated b vitamins from what I have learned.

@OswaldDigestiveClinic 11 ай бұрын

Thank you for sharing!

@chrismyers9951 11 ай бұрын

If I overdo it with TMG it changes my mood for the worse.

@OswaldDigestiveClinic 10 ай бұрын

Self-awareness is good and certainly helps to keep you feeling your best!

@RealFakePhD 6 ай бұрын

I have the heterozygus mutation and seem to be the only one out here having a good time.

@Anna-yh5kb 11 ай бұрын

Thanks for this great information on MTHFR and explaining everything now i understand what that gene is.

@naughtydog9843 3 ай бұрын

Great video, thanks !

@anywherenutrition 2 жыл бұрын

Bravo, Katie!!!

@janebass4057 7 ай бұрын

Best explanation ever!!!!

@SuperSnarr 6 ай бұрын

This was an incredibly well done video. This is the best explanation I found, and I’ve tried to watched a lot of videos to understand it this. I’ve just started taking methylated folate and everything seem to be fine but I think I overdid it and it came down incredibly sick. Terrible nausea and just felt horrible for about three days. I’ve stopped taking it now and it must be a dosing issue. Have you found, any side effects from taking too much methylated folate? Thank you so much and I think I’m going to schedule an appointment.

@tanyawieczorek6603 9 күн бұрын

Did you try taking folate again and what happened?

@SuperSnarr 8 күн бұрын

@@tanyawieczorek6603 So my reaction to the methyl folate was extremely negative for me. I must have a serious problem with that form. That said I did some research and found a supplement on Amazon from a company called PINK STORK that uses a natural FOLATE that worked really well. It was started by a woman as she needed to find a good solution for her own personal situation.. and I am very impressed with it for me. It fits my system well. :) Thanks for asking.

@divergentmind2023 Жыл бұрын

omg i have insomnia since early on changes of humor allergies to food and everything adhd dyslexia memory loss digestive issues weight issues for the last few years strokes i will give it a try bloating 24x7 no one was ever able to help me in 30+ miscarriages

@OswaldDigestiveClinic Жыл бұрын

Thank you for watching! Sounds as though you have had many health issues over the years. It would be recommended to work with us to help you find health again. www.oswalddigestiveclinic.com/schedule

@samanthaketterer3064 24 күн бұрын

Hi, ive been taking LDN for 2 years, which reduces inflammation. So will my Homocystein levels be wrong? Meaning is LDN hiding the fact that i have high Homocystein?

@OswaldDigestiveClinic 14 күн бұрын

No. Homocysteine levels are connected to vitamin deficiencies.

@sallypettit7156 Жыл бұрын

Loved this

@OswaldDigestiveClinic Жыл бұрын

Wonderful! Happy it was helpful!

@cg1811 2 жыл бұрын

Does your clinic have experience working with Lyme and Mold patients who also carry the MTHFR?

@OswaldDigestiveClinic 2 жыл бұрын

Hi CG! Yes, Katie can help with this, and you can schedule with her here: secure.gethealthie.com/appointments/embed_appt?dietitian_id=1143185&provider_ids=%5B1143185%5D&appt_type_ids=%5B144062%5D

@GygaxGirl Жыл бұрын

Many of us also have slow COMT which makes the methyls problematic to us.

@OswaldDigestiveClinic Жыл бұрын

Good to point out there are other pathways that may inhibit methylation. Thank you for watching and commenting!

@AnnA-jd4xm Жыл бұрын

If theyre so common and can cause so many issues why do they not test for it as kids?! its insane to me that they dont. so much made sense once I found out I had it

@OswaldDigestiveClinic Жыл бұрын

Thank you for watching and taking time to comment! There is some conflicting data in mainstream medicine as to what this mutation may cause. You will find Functionally trained physicians will screen/test for this.

@LauraHickmanLauraHickman 10 ай бұрын

Also, MTHFR has only been known about since 2013 , so 10 years. Many doctors are woefully under informed

@AnnA-jd4xm 10 ай бұрын

@@LauraHickmanLauraHickman I hope that changes in the future!

@laurasophiaparedes863 10 ай бұрын

Soy homocigota nunca gracias a Dios con mis 35 años he tenido ningún problema de salud, de niña era hiperactiva y me enteré tras la perdida de embarazo ahora tengo una nena y obviamente es si o si heterocigota la alimento muy BN es la mejor manera de cuidarnos

@sarabear7432 4 ай бұрын

Wait cleft pallet???? My son has a cleft in the soft part no one knows why. I have the double mutation my daughter only has the one mutation. Could this be to he also has the mutation or the mutation in me caused it maybe?? We are driving 4 hours tomorrow for his cleft team.

@OswaldDigestiveClinic 4 ай бұрын

It may be possible as research does suggest there is a connection.

@kingpetra6886 Жыл бұрын

If 50% of the popu;ation has this "mutation", then why is it a mutation to begin.

@kayjay-kreations Жыл бұрын

Because the mutation is passed on

@OswaldDigestiveClinic Жыл бұрын

Thank you for watching and taking time to comment. As the commenter below indicated the mutation is passed genetically. Having a parent or even a close relative with MTHFR may increase the likelihood of a person inheriting the same variant.

@brendan3081 Жыл бұрын

How does this gene mutation effect those seeking depression and anxiety treatment? is there data that shows how medications do or dont work well in treatment due to this mutation?

@OswaldDigestiveClinic Жыл бұрын

Research has shown that C677T mutation may contribute to reduced neurotransmitters due to low folate levels. With a reduction in neurotransmitters, anxiety and/or depression may present in an individual.

@jy7841 Жыл бұрын

@@OswaldDigestiveClinic what treatment do you recommend for those suffering from anxiety/ depression?

@OswaldDigestiveClinic 10 ай бұрын

There are many things that can contribute to anxiety/depression. Working with a dietician/nutritionist may help uncover things that are playing a role in your mental health.

@nehaan8323 2 ай бұрын

Hi! Thankyou for this video. One question- if i have this gene mutation but also have thalassemia minor, would methylfolate work/help or would it work against?

@OswaldDigestiveClinic 2 ай бұрын

It would be beneficial, but best to get labs tests to see where your folate levels and homocysteine levels are before beginning supplementation.

@nehaan8323 2 ай бұрын

@@OswaldDigestiveClinic thankyou :)

@vaniakazan1930 Жыл бұрын

What if my 3.5 years old have high b12 without even supplementing or having egg or fish in her diet ? Doe that that means she has the gene ? Plus she is low on b9 Her b12 is level is 1100

@OswaldDigestiveClinic Жыл бұрын

It is recommended to do MTHFR testing to rule it out and help you take the next right steps! labs.rupahealth.com/store/storefront_84by1nw?storefrontProduct=strprod_GxElPXO

@peterlanephotography Жыл бұрын

I know 2 people with MTHFR mutation and double dose of B6 in the blood. Does it mean that it can’t be turned into active form and the body is in deficit? Do they have to supplement with the activated form? How to get rid of this blood excess? They don’t supplement.

@OswaldDigestiveClinic Жыл бұрын

Thank you for watching and commenting. When taking supplementation for MTHFR is recommended to take the activated forms, because due to the SNP's individuals are unable to methylate them properly. If there is a high amount of B6 in the blood, the way to reduce is to eliminate supplementation until levels reduce. To find underlying causes of high B6, I recommend they work with a practitioner.

@SanFranMission415 2 жыл бұрын

Thank you so much!! I recent had a test done with Genomind due to depression and ADHD and why medications weren’t working. My MTHFR gene came with the following C677T: C/T A1298C: A/A They recommended that I take Deplin or L-Methylfolate and exercising instead of using SSRI’s. I noticed the following day after taking L-Methylfolate, I felt happy and sharp. I was able to hold a conversation without forgetting what I was talking about and just felt happy overall. But unfortunately that only lasted a week. What do you think went wrong and what can I do to feel normal again? I did buy a small bottle Niacin as I read an article it may help. Many articles say L-Methylfolate takes 2-3 weeks to kick in but for me it started working the next day. I have taken several medications in the past and never had results like that so I am sure it wasn’t a placebo effect, at least it felt real to me. I don’t drink alcohol or caffeine, workout 5-6 days a week and my diet can be better but I try. I can’t eat certain veggies as they make me sick but I do try to make up for that with vitamins. Any recommendations you can provide would be appreciated. I do have IBS, get migraines and headaches, have sleeping issues, high cholesterol and pre diabetic. I had these issue since I could remember. Cheers.

@OswaldDigestiveClinic Жыл бұрын

Hi Calirican! I'm so sorry for not seeing your comment here sooner, but I hope this reaches you. You are on the right path, with looking for root causes to your symptoms instead of settling for medications that don't give you full results. With mental health, there can be many possible root causes, and often multiple at the same time. I'm guessing this is happening with you. With IBS, there is a gut - brain connection, so I would suggest exploring this further. At our clinic, we have helped clients get rid of IBS (and I got rid of my own IBS many years ago, too, prior to starting our clinic). Migraines and headaches can have their own root causes, which could be what's going on with your gut, or it could be a nutrient deficiency like magnesium is very common (and low magnesium can cause some of the other symptoms you're experiencing either directly or indirectly such as causing sleep issues), pre-diabetes could be contributing to hormone imbalances, contributing to mental health challenges, and more. Do you have insurance? I really feel our clinic could help you - you are so similar to other clients we have and we'd be thrilled to get to work with you on the journey of feeling better! You can schedule here if this sounds aligned: www.oswalddigestiveclinic.com/schedule

@ditchy5512 6 ай бұрын

Check out a low carb or carnivore diet, Dr Ken Berry has heaps of info on here

@sisterfrennn Ай бұрын

Try eating beef liver! It’s been helping me!

@elementsofbeing8203 10 ай бұрын

I’m Taking SamE how long taking it til I notice a difference

@OswaldDigestiveClinic 10 ай бұрын

It can take up to 6 weeks to feel a difference when taking SamE. Always advised to take a supplement for 3 months to see full benefits.

@ezzovonachalm9815 6 ай бұрын

Why should I take a grain of salt before I take folate to be methylated ? If I forgot to take that bloody grain of salt, can I take it after folate ?

@OswaldDigestiveClinic 6 ай бұрын

Folate is best absorbed when taken with vitamin c containing foods or supplementation. Salt has been shown to help folic acid to be absorbed better, however, it is best to stay away from folic acid supplements and consume a methylated form of folate if needed.

@ezzovonachalm9815 6 ай бұрын

@@OswaldDigestiveClinic Thank You for Your precise response.I 'l keep these precious and hard to find engramms - even on Google !

@ezzovonachalm9815 6 ай бұрын

@@OswaldDigestiveClinic Thank You for Your clear answer.

@debmom978 6 ай бұрын

Do you have any info about the COMT gene mutation?

@OswaldDigestiveClinic 6 ай бұрын

The book Dirty Genes by Ben Lynch is a good resource.

@Amanda-cl6lh Ай бұрын

Can this cause elhers danlos

@OswaldDigestiveClinic Ай бұрын

Due to the low folate bc of the MTHFR mutation, it may be a factor in Ehlers Danlos.

@MsBuffalopoo Жыл бұрын

Hey, wait a minute! Hold up. Am I seeing things? Aren't you the same woman who gives homesteading tips on Instagram? Do I usually see you talking about chickens and stuff?

@OswaldDigestiveClinic Жыл бұрын

Yes! You are right! Thank you for watching and commenting!

@MegBHikes 2 ай бұрын

I don't understand why you said eat beans then you said eat anti-inflammatory a minute later... legumes are totally inflammatory! Kinda confusing honestly

@OswaldDigestiveClinic 2 ай бұрын

Legumes may be inflammatory for some individuals but not apart of the top most inflammatory foods.

@tifffteal 6 ай бұрын

My mthfr1298 is GG. What does that mean?

@OswaldDigestiveClinic 6 ай бұрын

Common variant of a homozygous copy. This means it increases the relative risk of many chronic diseases, but this does not mean it will cause you to have that disease.

@williamhenry3337 6 ай бұрын

I am also a mutant. A1298C G/T and C677T G/G. For whatever reason I do not show any of the symptoms. I'm also Apoe2 so maybe that helps.

@OswaldDigestiveClinic 6 ай бұрын

What symptoms are you watching for? Low B12 or folate? It may be showing up as high homocysteine levels, hypothyroidism, conditions such as diabetes, high cholesterol, and high blood pressure or obesity

@williamhenry3337 6 ай бұрын

@@OswaldDigestiveClinic Just about longevity. I'm 75 years old and I have never had a blood test. Other than 1 colonoscopy my last doctors office visit and physical was in 1969. I have only had one prescription in my adult life (antibiotic for a root canal). I am Apoe2 so that might help my longevity. I have kept a 19.5 BMI my entire adult life. Really good video.

@samanthaketterer3064 24 күн бұрын

I am compound. My only B vitamin affected is high B6. But I also have high Renin and Aldosterone. Do you know much about how MTHFR mutation affects those hormones?

@katelynnvifquain9629 2 ай бұрын

Important correction: you mention ~3:00 mark that we get folic acid from food … this is NOT true, as it is NOT naturally occurring! As you explain later in the video, folic acid is the synthetic man-made version of folate, which IS naturally occurring in food. This is a very important distinction, as our bodies CANNOT use folic acid until converting it to folate via the dihydrofolate reductase (DHFR) enzyme. Many people - estimated to be a good 40% of the population - have genetic variations that result in limited DHFR activity … thus, these individuals are especially prone to the health consequences of over-consuming folic acid (because so much of our processed foods are supplemented with it) and over-accumulating metabolically inactive folic acid in their bodies. So, please share that in fact our bodies DO NOT get folic acid from food, and that MTHFR uses FOLATE - NOT folic acid! One great resource if you or your viewers want to learn more on this clinically significant distinction is to do a Google search on the topic and Dr. Ben Lynch.

@OswaldDigestiveClinic 2 ай бұрын

Thank you for the correction. Folic Acid is not naturally occuring.

@ArthurShelby-PB 3 ай бұрын

I'd like to get tested for this gene mutation to see if I have it or not. I live in the UK and don't know how to go about getting tested

@OttoNommik 3 ай бұрын

You have the internet, doofus

@OswaldDigestiveClinic 3 ай бұрын

You may want to speak with a naturopath or DO physician, there are online labs that may send internationally...

@GinoGraziano8 Жыл бұрын

I wonder how easy it is to get a test for the mutation in MTHFR genes.

@OswaldDigestiveClinic Жыл бұрын

It is very easy. Here is a link to test for MTHFR. Thanks for stopping by! labs.rupahealth.com/store/storefront_84by1nw?storefrontProduct=strprod_GxElPXO

@psalm23s Жыл бұрын

You can also get it tested through 23 and Me which will give you a lot more information regarding many other genes. You take the raw data from your 23 and Me and run a report through a gene database. It's about the same price and gives you so much info!

@jy7841 Жыл бұрын

@@psalm23s just curious if it will tell you what parent you got the mutated gene from... Of if that is too specific? I got a genesite test that is actually performed for prescribing psychiatric medicine and it showed I had the gene mutation.

@grace683 5 ай бұрын

I got it done by doing a blood test .

@luciouspyro9524 10 ай бұрын

She had to be working in a kindergarden before as she kind of joyfully addressing the childrens some sort of events and activities and not to nearly cripples suffering of poor methylation . Sounds like fun not to breath normally after a minimum of actinty and suffer panic attacks for no reason at any time but functional medicin its a money making business its suppose to be like this

@OswaldDigestiveClinic 10 ай бұрын

Thank you for sharing your thoughts.

@luciouspyro9524 10 ай бұрын

@@OswaldDigestiveClinic you are welcome

@OswaldDigestiveClinic 2 жыл бұрын

1) Schedule your INITIAL APPOINTMENT (Now Accepting Insurance!): www.oswalddigestiveclinic.com/scheduling Schedule with Katie: secure.gethealthie.com/appointments/embed_appt?dietitian_id=1143185&provider_ids=%5B1143185%5D&appt_type_ids=%5B144062%5D

@OswaldDigestiveClinic 2 жыл бұрын

2) DOWNLOAD YOUR FREE GUIDE: 5 Ways To Improve Gut Health And End Food Intolerances For Good: odc.mykajabi.com/FreeGuide