Explore our entire animation video library at: www.nonstopneuron.com/
All videos from autonomic Nervous system Pharmacology: www.nonstopneuron.com/post/ph...
Video Summary:
For pralidoxime to work the anionic site of the enzyme must be free. In organophosphate poisoning, it is free. So pralidoxime can bind to this site, and then take away the organophosphate molecule. So the benefit of reactivation of enzyme is present in organophosphate poisoning. But in the case of carbamate poisoning, the anionic site is occupied. And pralidoxime cannot work on such enzymes. So there is no reactivation of the carbamylated enzyme. Small loss due to weak anticholinesterase activity is present in both cases. The final answer is, pralidoxime is indicated in organophosphate poisoning because the benefit is much more than the loss. But it's contraindicated in carbamate poisoning because there is no benefit in form of reactivation of enzyme. There's only loss.
Find related videos on Autonomic Nervous system Pharmacology below:
Cholinergic Transmission: • Cholinergic Transmissi...
Acetylcholinesterase Enzyme: • Acetylcholinesterase E...
Anticholinesterase Agents: • Anticholinesterase Age...
Cholinesterase Reactivators (Oximes): • Cholinesterase Reactiv...
● Follow me at:
• Facebook: / nonstopneuron
• Instagram: / nonstopneuron
DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.