Will Sernova's Clinical Trial Cure Type 1 Diabetes?

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Күн бұрын

Curing type 1 diabetes isn't as simple as we'd like it to be! Sernova Corporation is working on a functional cure with a cell pouch containing insulin-producing cells from organ donors.
Learn how to prevent lows during exercise 👉 amzn.to/3RQd1NK
Eventually, this pouch will contain manufactured insulin-producing cells from Evotech - starting potentially in 2025. The pouch protects the cells from the immune system of a person with type 1 diabetes. So far, 5 out of the 6 participants in the first phase of the trial are insulin independent - this means they are no longer taking daily injections of insulin to achieve normal blood sugar levels!
Learn more about their ongoing clinical trial at the University of Chicago Medical Center: tinyurl.com/357d3v8v
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DISCLAIMER: This video is not medical advice. Ginger Vieira is not a doctor. Please consult your healthcare team before making any changes to your healthcare regimen.
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Пікірлер: 127

@phantomx2003 3 ай бұрын

Man I hope it's soon. I've been type 1 for 22 years now and at the age of 45 I am so ready to rid myself of this disease. It has drastically changed my life for the worse in terms of I just don't do the things I want to do, or can't really. Not without the constant worry that I may have put myself in jeopardy of having a low or high blood sugar. Example, I tried scuba diving one summer about 2 years ago and really liked it. But being underwater for extended periods of time and not knowing what my numbers are gave me a bit of PTSD since the temperature of the water and how much I'm exerting to swim all play a part in having a low blood sugar under water. So I basically say it's not worth the risk of being wrong and dying so I just avoid it. Traveling scares me... working out scares me... being in a remote area scares me, basically type 1 diabetes has caused me to become an introvert who would rather stay at home where I know I'm safe than be out an about living life. Come on cure, I need you. :)

@DiabetesNerd 3 ай бұрын

Ah, you're not alone: T1D can lead to some pretty intense anxiety. I hope that cure comes for us some day, too. Hang in there! (I have a book that teaches you how to exercise with less worry! It might help you! "Exercise with Type 1 Diabetes" on Amazon, it's only 100 pages, very easy to read!). Thank you for watching!

@roms515 3 ай бұрын

When wil it come ...plz my son is just 3 n needed it more...plz

@Sriram-bi3hk 3 ай бұрын

@romyms515 my son age 7 type , 1 diabetes

@DiabetesNerd 3 ай бұрын

Ah, that's hard at such a young age. Give your son a hug and high-five from me! @@Sriram-bi3hk

@Sriram-bi3hk 3 ай бұрын

@@DiabetesNerd thanks sister

@waynezeigler3354 4 ай бұрын

Thank you for the update on some of the research that is going on! I’m thankful that I was introduced to you on diabedtech, Justin’s channel!

@DiabetesNerd 4 ай бұрын

Thank you! Justin is awesome.

@shahinmsh 4 ай бұрын

Just got diagnosed with noropati , eventho I was diagnosed with type 1, 8 months ago but have burning on my left leg all the way down. I'm trying very hard to keep my a1c below 5.5, and i have been, but still, I'm losing the battle. Your vidoe will keep me going and fighting.

@DiabetesNerd 4 ай бұрын

Ohhh, please don't give up! Keep going. You've gotta. I hope you have a good healthcare team helping with your neuropathy? And the burning? Sounds like you're working really hard to manage your blood sugars, too.

@melmatos4210 3 ай бұрын

This came by power full stress please be calming you not diabetes

@riannair7101 3 ай бұрын

Was thought for 10 years i on diabetes type 2 (trying hard to keep my BS low with low carb regime , fasting , and so on ) , only to find 4 month ago , in fact i have diabetes type 1,5 (LADA) and i am not insulin resist at all (fact are my pancreas do only 25% insulin from 100%). My BS was high all the time , was just because i have not the right necessary insulin amount need ,it for on day. Now...after i was try 2 weeks of treatment with Jardiance(1 month ago) , i finally understood the only solution is to go with Injection daily insulin (Tresiba one injection at day above 11 or 13/u ). Last 2 weeks my bs was under 100 mg/dl (in conditions in which now i can eat some chocolate , ice cream , some cake in reasonable amounts). Do not give up ! Always will be some solution at the end of the tunnel ... even when train come from that tunnel !👌

@sunshinesunshine2714 Ай бұрын

My 11 yr old daughter was just Diagnosed with type 1 , we are all devastated but positive and hopeful for a cure!!!

@DiabetesNerd Ай бұрын

Please know your daughter’s future is BRIGHT whether a cure comes along or not. The secret to thriving with T1D is to see every blood sugar as simply information (don’t panic, don’t blame), to keep learning, and to remember that everyone in life has challenges, this will be one of hers. ❤️❤️😬

@himanshukaushik5036 11 күн бұрын

My son has diagnosed in April this year .I am also praying to God that to cure soon

@sunshinesunshine2714 11 күн бұрын

@@himanshukaushik5036hugs and momma love your way !!! Our babies will get through this !!!❤️☀️

@sunshinesunshine2714 11 күн бұрын

@@DiabetesNerdthank you so kindly!!!❤️❤️☀️

@DiabetesNerd 11 күн бұрын

@@himanshukaushik5036 Do you live in the US?

@abulbashar4754 Ай бұрын

I love your helpful videos. I’m t1d since 39 years.

@DiabetesNerd Ай бұрын

Thank you!

@EarthlingsT-uh7jj 6 күн бұрын

I read the related article, and it didn't say that the recipient of the cell pouch will take immunosuppression drugs for only three weeks. Instead, it mentions that "The Sernova Cell Pouch is implanted against the abdominal musculature. A minimum of three weeks after Cell Pouch implantation, immunosuppression is initiated and optimized for another 3 weeks." It doesn't specify when the drugs will be eliminated or if they may never be eliminated.

@BTHDreamer 4 ай бұрын

I believe that in the not too distant future we'll be healing ALL diseases with different frequencies.

@BTHDreamer 4 ай бұрын

@@jackschitt6235 A lot of good books out there. Check out, Anatomy of an Illness by Norman Cousins, All of the Abraham Hicks Books, Heal Your Body by Louise Hay, Breaking The Habit of Being Yourself by Joe Dispenza, The Hidden Messages in Water by Masaru Emoto, and many many more.

@jeminaz5644 3 ай бұрын

I hope you are right ! There are millions of children and adults are waiting for a cure!🙏🙏🙏🥰

@DiabetesNerd 3 ай бұрын

YES! I'm one of them! ❤‍🩹

@axelbosson303 Ай бұрын

Good video.

@topofladder 4 ай бұрын

I hope this comes out I''m so sick of living with diabetes and the changes I had to change in my lifestyle but this is very awesome news

@DiabetesNerd 4 ай бұрын

It offers hope for sure! Still a long road before something like this would be available to the general public. Human studies must demonstrate it's safe long-term.

@Ary0247 4 ай бұрын

Diabetes for 20 years, im emotionally burned out, i just got a pump but adapting is being difficult, im doing some small progress before getting into the automatic insulin delivery system. God help us, the cure is almost there 🤞🏻 I would like to know if there’s any clinic trials in Germany or Europe Amazing channel, It is very updated, thanks for your job ❤

@DiabetesNerd 4 ай бұрын

No trials for this in Europe yet. Still lots to do establish in the US before they could reach Europe! Congrats on 20 years! Keep going! It's exhausting but we've gotta keep showing up. Thank you for watching!

@aubiergebikoi2124 14 күн бұрын

30 years type 1 and recently diagnosed with another auto immune. So definitely taking immuno suppressing.

@anakublashvili5892 Ай бұрын

Can you tell me if somehow i can help my 9 years old girl who just was diagnoSed?

@DiabetesNerd Ай бұрын

Some day this treatment or something like it will be available hopefully! But it’s not available today. For now, you and your daughter need to go learn learn about t1d! Look up @ChildrenWithDiabetes to find their parenting resources! ❤️ I also have two books for kids in the description details on the video.

@GianlucaDAngelo-fj9mi Ай бұрын

Hello my 7-year-old diabetic daughter since 2023 I follow all the trials I believe in it 7/10 years it matters that we get to the end, Sernova seems to me was supposed to start the Human Trials with evotec cells in 2024 but the new manager Cynthia Pussinen announced the postponement to the second half of 2025, Vertex with vx 264 is also in the clinic in Italy where we live. If the results are good, it may be that the time is shortened

@margaretrivercrackerco.4542 4 ай бұрын

Can you show me the reference for the 3 day immune suppressant. I can only see full time immune suppressant drugs required at this stage.

@DiabetesNerd 4 ай бұрын

The trial details describe that the participant only needs 3 weeks of immunosuppression therapy.

@user-bn6rj8yz1b 4 ай бұрын

What is the average price of tose new treatment. Thankyou four your informations

@DiabetesNerd 4 ай бұрын

This treatment is still in clinical trials. There is no pricing established at this time.

@Kalebent 3 күн бұрын

I wish...

@larschr5dk 3 ай бұрын

Type 1 diabetic for 36 years (48 year old) and while this is potentially exciting it’s still gonna be at least 10-15 years away from clearing clinical trials, FDA approval. And then it’s availability will be limited because of the price. Have lost hope. I”ll die with this diasease.

@DiabetesNerd 3 ай бұрын

Maybe. Indeed, it's still quite a ways from being at our door step, but it's tremendous progress. If it doesn't cure me, I'm grateful it could cure my children or grandchildren if they were to develop T1D. We've gotta appreciate progress, regardless.

@atulgupta7262 3 ай бұрын

How much time will it take to finish 2nd part of the trial

@DiabetesNerd 3 ай бұрын

Oh time will tell! I have no way to predict this. There will be many phases to testing the efficacy and safety of this therapy.

@alterrille5863 3 ай бұрын

Do you know if anyone has looked into the benefits of fasting on a newly diagnosed type one diabetic?

@DiabetesNerd 3 ай бұрын

Hi there, fasting will not change the immune system's attack on your pancreas. Before daily injections of insulin were available, you'll find in history that "Starvation diets" were used to treat type 1 diabetes and try to prolong children's lives. The result was simply that they were starving while also dying from T1D.

@abdullahalzaben8200 3 ай бұрын

I am an Arab and I follow your channel through experience. Can you provide a translation feature into Arabic so that we can benefit from your channel on an ongoing basis?❤

@DiabetesNerd 3 ай бұрын

Hi there, I'm not sure I'm capable of doing that!

@Katy-sh3ru 3 ай бұрын

Hi! My 15 year old was diagnosed in mid December 2022. All along, she's had fluctuating need for insulin treatment. I guess her pancreas hasn't quite packed up yet. We're in the UK- does anyone know of trials over here? Is she still recently diagnosed enough?

@DiabetesNerd 3 ай бұрын

Hi there, I'm afraid she's definitely past the typical trial window for the research on delaying newly diagnosed T1D. Sounds like her honeymoon phase is probably winding down? Remember, the most important thing is that she learns that T1D doesn't stop her from living a full life! I know it's scary and challenging every single day, but the more you can teach her to face this with resilience and a positive outlook (life is challenging for EVERYONE), the more she will thrive. She can do this.

@theresameade6633 2 ай бұрын

How can the pancrease stop working and then start then stop? This honeymoon phase makes no sense. I believe in reasoning things out. The insulin is what stops the pancrease from working over time. It messes the feedback mechanism system. Pure BS

@sanjeevtiwari621 14 күн бұрын

A lot years 😢😢😢

@lmikeydagoatl Ай бұрын

My brother was diagnosed yesterday at the age of 13 and I’m kinda of scared about of him dealing with it bc it’s runs in the family I’m surprised there still isn’t a cure for it.

@atulgupta7262 3 ай бұрын

Is this POUCH or ENCAPSULATION got successful in any other transplantation therapy

@TimothyJones-mm9tb 16 күн бұрын

I have been type 1 for 37 years. I looked into Vertex and I was accepted but they said you would get the implants and you need to be on the anti rejection drugs for the entire study and then they remove the implants even if they are working. So that was the killer for me. It made it not worth doing. If this new study only requires 3 weeks of drugs and if I can keep the implants as long as they are working, then I would do it. I mean yes after they fail you can have them

@DiabetesNerd 16 күн бұрын

Ohhhh interesting!!! Thank you for sharing your experience!

@matthewdethlefson586 3 ай бұрын

One of my fears is that research will figure out how to prevent type 1 or reverse it in newly diagnosed type 1s. And adter that generation nobody will be type 1 again but the rest of the types 1s just have to live out the last generation.

@DiabetesNerd 3 ай бұрын

Ah, that's interesting. And that would certainly be frustrating to watch. There is SO MUCH research happening for both newly diagnosed AND those with longstanding T1D. If you look at the investments behind Sernova and Vertex, you can see they are dedicated to finding a cure for those of us with longstanding T1D.

@matthewofarrell2970 3 ай бұрын

Yeah I had exactly the same worry a few weeks back, it's a horrible thought isn't it

@Draco-mb5zm 4 ай бұрын

I was diagnosed last month and my endo said i had diabetes for like 5 months. If you dont mind answering, if i was newly diagnosed why didn't she tell me about this drug which allows me to continue producing insuline? And is this sernova company done or still thinking in a way for making the medicine?

@DiabetesNerd 4 ай бұрын

Hi there! Many doctors still don't know about those newer drugs, unfortunately, or the ongoing clinical trials. You could still qualify for a trial at Diamyd! Look up Diagnode-3.com to learn more about that study and reach out to them! Sernova and Vertex have many years ahead of them to test their technology and hopefully get FDA approval. I'm sure you're feeling very overwhelmed and wishing for a cure -- but I want to tell you that your future is still bright, regardless of a cure. Take this disease one day at a time and just keep learning!

@lochy213 4 ай бұрын

My daughter was diagnosed 1 month ago where I can get information for that new therapy please.Im so sad, I need your help

@DiabetesNerd 4 ай бұрын

@@lochy213 Hi there! How old is she? There are several ongoing clinical trials for newly diagnosed children to test new therapies that could delay the full onset of the disease. Diagnode-3.com requires 12 and up. I'd reach out to the JDRF and see what clinical trials are available! Or go to clinicaltrial.gov and search for new onset type 1 diabetes, etc. But also please know: your daughter's future is BRIGHT regardless of a cure. Thriving with this disease starts with embracing it as a daily challenge that you are facing every day. No self-pity. No victim mentality. Teach her to be proud of what she has to face and how much courage that takes. And keep learning!

@Poopsie4-sb7kd 3 ай бұрын

I think you are really after views, sadly.

@DiabetesNerd 3 ай бұрын

Thanks for sharing your opinion, dear! And thanks for watching.@@Poopsie4-sb7kd Have a wonderful rest of your day.

@user-pi7df3ef7m 3 ай бұрын

Hi, i just found your channel. Thanks for the great info on cures. My daughter is 5 and was diagnosed with type 1 in January. Can you talk about the therapies for people that have just been diagnosed? She is currently using an inpen to get her doses of insulin. Not sure how much insulin she is producing, but if their is a therapy that we can talk to her doctors about that would be great. Thank you and ill keep watching your channel for information and for hope of a cure soon.

@DiabetesNerd 3 ай бұрын

Hi there! There might be clinical trials she can participate in -- you'd want to ask her doctor -- but many might require kids to be 7 or older, or 12 and older. DIamyd, for example, is looking for people 12 to 25 diagnosed in the last 6 months. You might also look for trials using Tepluzimab -- visit CLinicalTrials.gov to search and see what she qualifies for. Until then, yes, daily insulin therapy is her future! But please know your daughter's future is BRIGHT! I know it's overwhelming and scary. Learning how to manage insulin takes time. Definitely visit ChildrenwithDiabetes.org to get support from other parents. COnnecting with other families is so important for you and her!

@AdamAdam-gx6pt 4 ай бұрын

Hello do you know the name of the therapy that tells ur immune system to calm down..?

@DiabetesNerd 4 ай бұрын

Immunosuppresion therapy? There are a wide range of immunossuppression drugs. You cannot take them unless you've received a transplant, and they wouldn't help you as a T1D unless you also receive an islet cell transplant. Tzield is a new FDA-approved therapy for people recently diagnosed with T1D.

@AdamAdam-gx6pt 4 ай бұрын

@@DiabetesNerd interesting…yep newly diagnosed..wasn’t offered that unless its coz I’m in the UK..

@DiabetesNerd 4 ай бұрын

Ah, yes, it's probably still only in the USA! I'd look at clinical trials happening in the UK for newly diagnosed T1D@@AdamAdam-gx6pt

@tiblends5423 3 ай бұрын

hey@@AdamAdam-gx6pt i don't know but i have seen some video on some one who claims to be cured from T1D and he is in the UK, i have read some comments and i think he was misdiagnosed because the doctors in the UK said there was no need to see if his body is really not producing insulin or not, just check everything to be sure cuz if that is what they are doing in the UK then that is very bad , making type two people think they are type one is crazy, any ways it gives people false hope that they can cure T1D by exercising which is a lie, you can control it alot better with exercise tho

@AnkitKumar-nh4vf 4 ай бұрын

Which year will come to cure type 1 diabetes when FDA give approval to come in the markit for this therapy

@DiabetesNerd 4 ай бұрын

Time will tell! These human clinical trials need to run their course to determine efficacy and long-term safety! We must continue to be patient.

@AnkitKumar-nh4vf 4 ай бұрын

How many patients has been rid from insulin in the trial can you tell me

@DiabetesNerd 4 ай бұрын

Hi there, if you watch the video, so far the first 5 participants are insulin independent which means they no longer need to take daily insulin injections@@AnkitKumar-nh4vf

@AnkitKumar-nh4vf 4 ай бұрын

How many participant are there in this trial total

@DiabetesNerd 4 ай бұрын

6 in the first cohort, 7 in the second@@AnkitKumar-nh4vf

@MrWez420 2 ай бұрын

i was diagnosed 9 months ago .. since then ive dropped from 22ml of the 24hr insulin to just 6ml and only 4 to 6ml of the one i take before meals depending on the food.. thats down alot too .. just had a1c done and im 4.9, i eat 80% meat and try for less than 150grams of carbs a day but i take lots of stuff thats suppose to be good for the immune system .. and drink about 2litre of water a day .. alot of vit d .. mushroom extract .. too much to mention but im still hoping my pancreas recovers.. im confused still about it tho.. so if say 30% of my pancreas might still be working .. how is that exactly .. so that part produces b cells and they work and the other 70% produces them and my immune system kills them or the 70% doesnt produce anything .. wondering does it mean like 100% of my pancreas produces b cells but 70% of them are killed off by my immune system.. or just 70% of pancreas is basically dead? im not sure if im living in denial or just hopeful :/

@DiabetesNerd 2 ай бұрын

Hi there! The attack on your pancreas is gradual. Most people still produce some insulin for several years after their diagnosis -- it's just not enough insulin to manage safe blood sugar levels. Your pancreas isn't dead. Your immune system is attacking a very specific cell within your pancreas! You'll find more about this in my other videos on cure research

@MrWez420 2 ай бұрын

@@DiabetesNerd i think if i eat bit more clever i can go insulin free for now and exercise high sugars down, i might give it a go tomorrow but i will miss my desserts, im in the uk and insulin is provided free however id still rather not take it if i can help it

@jorgecarrejo7562 7 күн бұрын

@@MrWez420are you insulin free?

@MrWez420 7 күн бұрын

@@jorgecarrejo7562 no im currently using 8ml of the 24hr one and depending on what i eat a little of the fast acting , try not eat carbs tho .. less than 100gram a day .. take loads of stuff thats good for immune system or suppose to be

@jorgecarrejo7562 7 күн бұрын

Why not use embryonic stem cells

@DiabetesNerd 7 күн бұрын

BecauS there’s an extremely limited supply of those. Vertex started there but then developed their own way of manufacturing more cells. Think of how many people will need these cells.

@brendaparker6766 4 ай бұрын

🙏🏻🙏🏻🙏🏻

@GDNM502 4 ай бұрын

This trial requires staying on immunosuppressive drugs beyond the three weeks.

@DiabetesNerd 4 ай бұрын

Hi there, no it's just three weeks to protect the cells and the pouch as it gets established.

@GDNM502 4 ай бұрын

That’s not correct. I called Dr Witkowski’s lab to confirm.

@waynewollam5232 4 ай бұрын

coformal coating will solve this and they are close

@nwc3270 24 күн бұрын

Who cares, I would sooner be on immunosuppressive drugs than loosing my sight, limbs,kidney function or life

@GDNM502 24 күн бұрын

@@nwc3270 Have you tried to get into any of the trials? There is Sernova's trial, Vertex's VX-880, and CRISPR's CTX211 in Canada. Or you can get an islet transplant in a clinical trial. Contact Dr. Witkowski's lab if you are in the USA.

@atulgupta7262 3 ай бұрын

Has any autoimmune disease other than T1D found a cure upto now

@DiabetesNerd 3 ай бұрын

OOH! That's a great question! Google says no. These endeavors in T1D are "functional cures" though, which means they aren't changing the immune system, but they are introducing a therapy that provides insulin production despite that immune attack.

@abdullahalzaben8200 3 ай бұрын

I am an Arab and I follow your channel through experience. Can you provide a translation feature into Arabic so that we can benefit from your channel on an ongoing basis?😊

@munen343 3 ай бұрын

@DiabetesNerd Hopefully, that changes with Crispr 2.0. Casgevy is the first Crispr based therapeutic that is used to cure sickle cell anemia. I'm hoping one for T1D comes out (and isn't a gazillion dollars).

@DiabetesNerd 3 ай бұрын

YES!@@munen343 Crispr is doing some pretty cool things and I think Vertex is working with them to apply their work to T1D.

@anshudhiman8539 3 ай бұрын

What about type2 Diabetes patients with a big numbers in all over the world 🥺😔😔🥺🥺

@DiabetesNerd 3 ай бұрын

There is so much research and treatments being researched for type 2 diabetes. You cannot develop one cure that would treat both type of diabetes because they are fundamentally very different and caused by different underlying issues.

@anshudhiman8539 3 ай бұрын

@@DiabetesNerd😒😒😔😔🥺🥺

@rebekazidan49 2 ай бұрын

I'm type one diabetic since 2022 april, can I be cured???

@DiabetesNerd 2 ай бұрын

There’s no cure yet. Lots of cure research happening right now. But no cure yet. ❤️

@rebekazidan49 2 ай бұрын

@@DiabetesNerd I knw mam.. my eyes on internet all the tym to know abt the updates abt T1d.. But u said in the video,that the cure likely to b working on newly diagnosed diabetic not to the ppl having it for years... That's why i asked... Btw I think I will gone till it will have a permanent cure 💔

@DiabetesNerd 2 ай бұрын

@@rebekazidan49 Just THIS cure research. There are a variety of companies working on different types of cures! Some are focused on newly diagnosed. Some are focused on those who've lived with it for along time!

@rebekazidan49 2 ай бұрын

@@DiabetesNerd even reading this comment making my heart happy that there is research for cure going on ... 😭😭😭 I wish there will be a permanent cure before I turn 27 😭... i want to bcm a cabin crew but im my country tyoe 1 Diabetic r not unofficially allowed for this role 😭😭😭

@DiabetesNerd 2 ай бұрын

@@rebekazidan49 Are you sure it's not allowed??

@garyilgenfritz1827 Ай бұрын

Plain and simple no!!

@vincentwiese8414 2 ай бұрын

You don't understand all the corruption. Involved I been to all theses places all over. You don't understand half the story. To much to explain in a text mam. Sorry I don't know your name.

@DiabetesNerd 2 ай бұрын

I appreciate your theories and concerns. I've actually had the opportunity to meet and interview the people behind these companies. While there is certainly corruption in the healthcare industry, the people behind companies like Semma Therapeutics, Vertex, Sernova, and Diamyd are personally affected by type 1 diabetes -- with children diagnosed at very young ages. Their motives are clear: they want to develop a functional cure for this disease.