She is my favorite Charmed one, love you Alyssa

Thank you for bringing up Ryan White. He has been a role model since both of my parents were diagnosed HIV positive. This was in 1988. I was 7 years old. This was my father was diagnosed. My mother was diagnosed in 1990. I was 9 years old, an day father had just passed away. After my mother was diagnosed in April of 1991, I was sent from NYC to my aunt and uncle (which I am so grateful) to Texas. In the 6th grade, my beautiful science teacher Mrs. Keel asked me to please explain to my peers how HIV was actually transmitted. The reason for this was that students would constantly me if I had HIV, which I didn't. So there I was, 12 years old, discussing how HIV was transmitted. This does not even remotely compare to what Ryan White and his family went through. Sending his family so much love 💘

R.I.P. Ryan White (1971-1990). I'm 37 and I remember him and the impact he had on the world. Such a tragic story but very inspiring.

Can we get Shannen Doherty on please?!?! And all the Charmed questions and all the questions of how she is an amazing, incredibly strong woman ❤️

I love seeing Drew with a talk show i worked for her on her first directorial debut Whip It in Detroit and seeing how she’s elevated since Whip It she keeps reinventing herself. Keep going Drew!

Drew is so ultra human. Such incredible positivity She extends to all. She wants everyone to feel appreciated and respected. Such a kind woman.

Drew always brings such humanity to all of her interviews. I grew up watching these two and I’m so happy for both of them.

Drew is doing some Iconic work with her show.

Awww Drew’s adoration of Alyssa is how women should treat each other always! Just to hear the praise and affirmation is beautiful!

These two were everything in the 90s and I was obsessed with both of them!

Love this show and Alyssa. I grew up on charmed. Every time I see Alyssa, I’m reminded of my childhood. I used to be a member of her website around 15 years ago and if I remember correctly, she would go live in the chatroom on her site every Thursday and let us ask her questions. She was such a light for me in a very dark time of my life.

I remember watching what Ryan and his family went through. It was incredibly heartbreaking (still is). These 2 ladies were icons to my 80s kid/90s teen self! They really turned out to be great women

I don't think any Gen X kid forgot about Ryan White. I remember seeing him on the news and in the Weekly Reader. That poor kid.

The Ryan White story is amazing, thank you for standing up for him!

I'm actually glad that both Alyssa Milano and Michael Jackson were there for that young boy Ryan White, and how they used their fame to help bring awareness for people especially children with HIV ❤️

I never thought about it, but these two really have had similar experiences in Hollywood, I'm shocked they've never worked together before.

I love how naturally Drew has aged.

I went from absolutely falling in love with Drew’s outfit, to sobbing. I will never forget Ryan White and the horrific battles he faced, all while smiling. He is still such an inspiration and so loved to this day. He always will be. Rest In Peace Ryan. 🙏🏻💜

Ryan White and his family stayed at the hotel I worked at in Santa Monica. I was happy the management agreed to host them. It was a lovely stay for them, thrust into the limelight for all the wrong reasons. It was sad when he passed away.

"It made my fame make sense to me". Thank you Alyssa Milano for what you did for Ryan White and educating millions of people around the world about HIV. ☆●☆●☆

Adore Drew so much and she is aging gracefully

I remember Ryan White!! I'll never forget him & what his story taught me! Im the same age as these women & absolutely ADORED them both growing up! (I honestly feel like Drew is def one of my Soul Sistas) but I'm so proud of both Alyssa & Drew!! Gorgeous women, BEAUTIFUL HUMANS!! 🙏🙏🙏

4:14 WOW, Winona Ryder beat out the both of them to win the role in Beetlejuice, that says a lot. I wonder who else she beat out.

Drews Poison Ivy hair was my 90s inspo, it was everything.

I was obsessed with learning about Ryan White. I mentioned him in my journals in 90s❤️🕊

I wish Rose McGowan could be on the show too. She's done so much for women and men in the industry ❤

Love Alyssa's personnality. She's so down to earth.

Alyssa has always been a beautiful person. What a lovely thing she did for her friends. And for the world really

I totally forgot that they both portrayed Amy Fisher! FLASHBACK!!!

I love these two women 💖I have grown up with them & admired them both & find them to be amazing examples of successful women.

Drew is a fantastic interviewer and does all her homework to give a level of respect, empathy, and unwavering amount of gratitude to everyone, I love it! Thank you Alyssa for being human with courage to show the world what's up about loving people with Aids! Yes!!

Im so slow it took me a minute to realize they BOTH starred in the first and second Poison Ivy films! Loved that they went down a trip of memory lane❤❤❤😁

I love Drews style!!

This was a totally WILD interview. Talk about 90’s throwback. Milano is hilarious. Her work in Charmed was so well done.

How did I not know this about Alyssa and Ryan White?! Even more respect as a fan for her. 🤘💪🔥🥰👊💥

Pleas tell me that SNL does a skit about this show. This is Drew Barrymore being so Drew Barrymore and I love it. How can you not like this woman? She amazing

We watched The Ryan White Story in elementary school in the late 80’s and it was traumatizing, I remember it like it was yesterday!

Easily the best interview with Alyssa Milano I have ever seen. Just an amazing clip, thank you for the video.

Drew is refreshingly genuine and warm. there isn't a hint of ingenuity, I hadn't realized until watching a few clips.

I have always loved this woman. So much depth and compassion. Very moving! Like attracts like; Drew rocks, too.

For make up users that read this that haven't tried Drew's make up line 'Flower' you NEED to!! I absolutely love it!! It is actually better than most Charlotte Tilbury products in my opinion. I don't know why I haven't heard more hype about the brand ( I love and so does my make up artist neice, we pick up the Flower products to use instead of our expensive version all the time )

Oh my I watched both of them as Amy Fisher & both poison ivy movies. I love them both. Charmed is still my favorite show.

LOVED this interview connection!

Wow, I'm so proud of u & being so kind to Ryan 🤍

is it just me or do they not seem to be looking at each other like this isn't even a catfight thing it's like they did this separately and split screen them but they had different eyelines

So Talented and likeable. Big Fan of Alyssa Milano!!

I'm the same age and grew up in the model industry. I too have been extremely protective of my child! I get it.

Love love love these 2 strong women and to see them on stage at the same time is special.

This is my whole childhood coming full circle. These two were my idols and plastered all over my walls. Love you both sooo much!!

WOW! Now that Alyssa is a lot older.. I noticed that she looks *SO MUCH* like her mom.

Have been battered, abused and they have moved thru this and not let the anger eat them up, like Rose has done. I feel for Rose, because I was stuck in that hatred for many years. Now, I have moved thru it and beyond the hatred and anger and into the helping survivors.

I am genuinely glad I stumbled on this video.

I wish you would have brought on Rose McGowan she is such a strong woman with wise words and so much life experiences she is so brave

Ladies I love you both so much!! I am 44 and have admired you both for so long!!

Wow. I never knew she did that for Ryan White. How amazing. I was a small child then, but I remember reading old magazine articles about his tragic life.

I love Alyssa Milano, she's beautiful and timeless.

I actually met Alyssa Milano when we were kids. I think we were both 12 or 13 at the time. not so sure. but it was right after the movie Commando, which she was in, came out. Who's the boss? I think had just started early that year. But she was doing these mall tours, going around the country signing autographs, meeting fans. I didn't know she was going to be at the mall, my family and I were there shopping and we come across this open area where they had set up a stage. there was a black curtain behind it. so we couldn't see what was going on as we approached the stage. they had a table set up on the stage and stairs on both sides to allow fans to go up to the table and meet Alyssa. when we got close enough, there was a sign that said "come meet Alyssa Milano star of Who's the Boss and Commando. the event was already over. the fans were gone, a few were still lingering. And there she was sitting behind the table looking bored as hell. she was tapping her fingers on the table. she was waiting until it was time to leave. I remember telling my dad "look, it's the girl from the movie we saw". She must have heard me but she looked up and she had this huge smile on her face. She then started to wave me and my little brother to come over. My brother must have been around 4 at the time. She never stopped smiling. she tried finding more of the 8 x 10 photos but they had run out. there was nothing to sign with as well. no cameras. ugh. But she started asking us questions. where we were from? how old we were? what grades we were in? she was surprised that we were the same age. she asked if I saw Commando and I told her yes and she asked if I like it and I said yes again. then she go up and went around the table and started hugging my brother and pinching his cheeks. she called him "chubby cheeks". which we continued to call him for several more years. anyway, she just stood there talking to us and apologizing for not having anything to sign and then one of the "handlers" started to practically order her around. they needed to leave. they were waiting for her. she looked annoyed by them. she then said she had to leave that it was fun talking. she pinched my brothers cheeks again and then out of nowhere she just hugged me and gave me a little peck on the cheek and said bye. she was still waving bye at us as she disappeared through a maintenance door nearby. to this day I still wish we had at least gotten an autograph from her. it was just our luck. same thing happened several months later at the same mall. Alfonso Ribeiro showed up there, but this time the event was still going, only the lines were huge. he was there mainly because of Silver Spoons and some Pepsi think promotion thing. who would have known that one day he would become Carlton Banks.

YES I WANT MORE OF HER(also lets interview Holly Marie Combs and Rose McGowan and or Shannen Doherty?)

Wish you both the best 🙏. Grew up watching both of you ...

I love that you have a talk show!!!!

Its so trippy to watch this show and and see them sitting there like a hologram out of Star Wars

Love Alyssa, I grew up watching charmed and now as an adult, I sometimes watch re-runs of Whos the boss, she’s a great actress Anna great activist.

Waaw so inspiring 🙏🏽🌙

Another great outfit Drew!!

Man!….. 😢 thank you Alyssa Milano for being such an amazing human. I myself am someone who benefits from the Ryan White foundation. You don’t know how much it means to me that you were brave and didn’t let what others thought to dictate your View. Unfortunately people’s perception of what it means to be hiv+ and even undetectable hasn’t changed much and the stigma is still very much so there in my experience living with HIV. Nonetheless again I want to thank you for being on Ryan’s side back when others wouldn’t, it’s hard as an adult I can’t imagine what it would be like as kid or teenager. But you were there when he needed an ally. Thank you 🤍💜🧡

I love the green screen trick and I wish everybody did it; but Drew's eyeline is off...can we move the monitor a smidge?

Omf. I love Drew's style 😍

Thank you for remembering Ryan White, he was on all the shows back in the day!! I believed he travelled with a quilt that was made for the HIV/AIDS cause!! I have thought of him a few times during this Pandemic for some reason!! RIP Ryan

Somewhere… in some place… rose McGowan is watching this and screaming at the tv

I have a soft spot for these child stars. They have been through a lot. Survivors.

I've always loved Alyssa!!

I remember them both doing poison ivy & feeling a little like I wanted to be them & didn't. It was a little weird at that age. I was such a huge fan. I'm not sure of their exact ages but it was close. I was born in 76. I've followed both since childhood & feel like I know them. I admire them both & want to be like them more fiercely than I did as a kid. I have always felt comfortable in my own skin, sure of who I am, but I can still be inspired & feel connected. I love them more than I did at 12 watching them.

Look at these amazing women becoming the adults they needed when they were kids 🙌

I still love that she’s the inspiration looks wise for the little mermaid back in the day 😍

I have VERY fond memories of charmed as a 14 year old boy, and especially poison ivy

WOW! Both of my lifelong ( ET and Firestarter... Who's The Boss and Commando celebrity crushes on the screen at the same time. Be still my beating heart.

They talk about their Hollywood glory days so much. Talk about today. Your greatness today. Your career today.

Drew’s memory. Omg!

Underrated actress. Who's the boss was great I'd love to see a reunion or reboot

Alyssa and drew were two of my absolute favourites growing up and I believe they both dated Corey haim 😍 I love both their poison ivy movies

Love to you BOTH! Happy Halloween 🎃🦹🏻‍♀️🧟‍♀️👻🤣

I love how Drew stated that roles like Poison Ivy were her choice; she could’ve played the victim in retrospect. I respect how authentic Drew is.

Such a good interview wow

Both worked in Poison Ivy series movies 🎥 and they were beautiful!!

What a great perspective about what Britney is going through on her IG. It makes sense. At 18-25 we take lots of pics of ourselves lol.

Alyssa has worked under many directors. 😂😂😂😂😂👌👌👌👌👌

Drew i love you always have keep going.

Omg I love this outfit on drew!

Her HIV story showed courage back when we really didn't know much about the virus. Over time, we have learned so much more about AIDS. I wonder how a similar gesture early on in the COVID crisis would have played.

Wow, they were both the leads on the the first two Poison Ivy films. That is really cool.

Awesomely genuine interview 👑👑💐💐

I remember that Phil D. interview with her and Ryan White. Beautiful soul.

Is that the title of Naya Rivera's book a few years ago???!!! *ps: no criticism! Great interview, Drew!

Now that they revealed the green screen technology for guests I can’t Unsee it! Lolol

Love both these actresses they take me back to my childhood with their work in poison ivy 1 and 2.

HI DREW BARRYMORE ❤ ANOTHER AWESOME EPISODE

Drew is so very pretty with her minimal make up.

Alyssa milano looks exactly the same

They both look amazing in this video.

Drew did Hollywood! Hollywood did do her! Amazing!