I'm 42, have been prescribed benzos for insomnia since 14. my life was falling apart. Your first 3 episodes on sleep allowed me to fix a life long problem in days. No drugs, no benzos, its been 3 years. You saved me from the depths of insanity. I have recommended you to countless friends and will continue to do so. I owe you a debt of gratitude. Thank you.

Omg to see research on BPC-157 from my little ol med school from Croatia quoted on Huberman .... I'm having a moment lol

Dear Dr. Andrew I don't think you will read this comment, but I wanted to tell you that thanks to your videos, here in the Ukraine I am learning English and new interesting information. Thank you very much.

00:14 🧬 Peptides are gaining attention for therapeutic use, beyond GLP1 analogues, focusing on tissue healing, longevity, and vitality. 02:32 💊 Peptides are categorized into prescription, gray market, and black market, with safety concerns increasing outside prescription use. 07:50 🧪 Peptides are small proteins made of amino acid chains, often exhibiting pleiotropic effects, influencing various cellular processes. 11:07 🧠 Therapeutic peptides rarely have single-target effects, commonly affecting multiple pathways and cell types. 14:34 🚑 It's crucial to obtain therapeutic peptides through a board-certified physician to ensure safety and efficacy, avoiding risks associated with gray and black market sources. 15:02 ⚕ Therapeutic peptides can be utilized for tissue rejuvenation and repair, impacting muscle, connective tissue, and gut health. 21:38 💪 BPC-157, a therapeutic peptide, promotes tissue repair through stimulating angiogenesis, encouraging fibroblast migration and growth, aiding in injury recovery. 22:20 🩺 Gastric juices historically used for tissue preservation and repair, even in gruesome scenarios like preserving severed fingers. 23:44 🧪 BPC-157, a peptide compound found in gastric juices, shows promise in tissue preservation and rejuvenation, but its mechanism of action outside the gut remains somewhat mysterious. 26:17 ⚠ Limited human clinical studies on BPC-157 make its effectiveness and optimal delivery method uncertain, despite anecdotal evidence and animal studies suggesting potential benefits for tissue repair. 28:48 💊 BPC-157 has a high safety profile, but caution is advised due to potential tumor growth risks associated with its mechanism of action involving upregulation of growth hormone receptors. 32:16 🚫 BPC-157 may pose risks for individuals with tumors due to its promotion of angiogenesis and vascular growth, potentially accelerating tumor growth. 36:53 💉 Thymosin beta-4 (TB-500) and thymosin beta-4 (Tβ4) are peptides gaining attention for tissue rejuvenation and repair, particularly in conjunction with BPC-157, but their efficacy in humans remains uncertain without clinical trials. 41:04 💪 Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) play crucial roles in metabolism, muscle growth, fat loss, and overall vitality, with GH secretion decreasing with age. 44:02 💉 Growth hormone and IGF-1 have various effects related to youthfulness, vitality, and energy, but indiscriminate growth may pose risks like tumor growth. 47:07 🏥 Category one peptides, such as CJC-1295, tesamorelin, and sermorelin, are FDA-approved and more thoroughly tested in humans for stimulating growth hormone release. 49:13 💤 Side effects of peptides like tesamorelin may include altering sleep patterns, potentially reducing REM sleep. 53:54 💊 Type two peptides, like ipamorelin and hexarelin, increase growth hormone release by mimicking or stimulating ghrelin, which can also increase hunger and anxiety. 56:41 ⚠ Hexarelin, while potent at increasing growthhormone, can lead to receptor desensitization and other adverse effects like increased prolactin levels. 01:00:38 🤝 Combining different peptides in cocktails may offer benefits but requires careful dosing and supervision by experienced healthcare providers. 01:03:52 ⚠ Augmenting the growth hormone pathway, whether by synthetic growth hormone or peptides, increases the risk of tumor growth and cancer due to the indiscriminate nature of growth hormone and IGF-1. 01:04:21 💊 Peptides like growth hormone secretagogues have potential benefits like faster injury recovery, but there's a trade-off between benefits and risks. 01:05:02 ⚠ Considerations for taking growth hormone secretagogues include age, potential tumor risks, using minimal effective dose, and assessing clinical need. 01:06:01 🧬 Peptides for longevity like Epitalon mimic naturally occurring peptides and show potential benefits in animal studies for suppressing tumor growth and adjusting circadian rhythm. 01:09:21 🌞 Peptides stimulating the melanocortin system, like Melanotan, can darken skin and potentially improve mood and libido, mimicking the effects of sunlight exposure. 01:20:55 💡 Kisspeptin peptides stimulate hormone pathways related to vitality and libido, potentially impacting mood, energy, and reproductive function, but their effects are still being researched.

Posting through like nothing happened… nothing can stop this man

This man is giving us all a World Class education right over here!

I’ve been giving my dog bpc-157 and it’s helped her tremendously. She developed digestive issues in her old age making her nauseous, stomach bloated, sometimes throwing up after eating. Since giving her bcc-157, her condition has improved dramatically. Her stomach is no longer bloated, she’s not nauseous, and hasn’t thrown up. She also doesn’t moan anymore if I pick her up.

I fixed my insomnia because of your sleep protocol. Understanding why we need sunlight helped me go outside during different daytime and it definitely helped. I am not going to be budged by these so-called accusations targeting you. I understand so much about myself, my struggles, and my behaviors because of you, and can confidently say that you have changed my life in a significant way. I'm very interested in neuroscience now and if I decide to pursue my Ph.D. in NS, it will be because of you. Thank you, Mr. Huberman. I'm grateful to you.

Thank you for this video and all of your videos. There is a reason why you created this platform… It’s needed. KEEP GOING ❤

Dr Huberman, thank you so much for the contributions you have made to informing and educating the public. I am a full-time student suffering from ADHD and many of your episodes have helped me manage my condition: focusing my eye sight without blinking helps me immediately regain focus, taking phosphotidyl serine has helped me with working memory, hyperactivity and executive dysfunction. I have cut down my alcohol intake, I have read the book and followed the advice of Anna Lembke, I can handle anxiety better with your breathing protocol, and I could give so many more examples of how your podcast has helped me. So thank you so much for that and THANK YOU for your interest in science 😊😊

¡Hola Profe! Just wanted to express my deepest gratitude for educating us every single week.Thank You for Your hard work and care for all of us.

You can tell when you are "bigtime" when parasites try to attach themselves to you and benefit from your achievements. I read the comments on "Rising The Hill" and EVERYONE supports you and acknowledges your great contributions to education and science. You are a powerful MAN and force for the best we can be....Respect to you Dr. Huberman, Sir.

Can you do an episode on the healing power of LAUGHTER? I know laughter yoga is something that improves sleep, pain and even speeds up healing. Would be great to understand what is going on in the body when we laugh :) 🙏🏼

The real peptides were the friends we made along the way.

You helped me to overcome my bad habits and I learned how to focus gratefully to your videos. Thank you for your work! Keep going. Your loyal follower, Julia.

Dr. Andrew Huberman, thank you for another info-packed episode. You are one of the greats of our time...way out in front as a scientist and teacher. Your contribution is felt around the world and it’s enormous! My health has improved so much thanks to what I have learned here. ❤️

Thank you for what you do to improve people's lives! You've changed my life and countless others.

Dr. Huberman, My kids (6 and 8 year old) and I listen to you most mornings on the way to school and work! It’s incredible how you can dissect complex topics in a way that anyone can understand. My 8 year old often repeats concepts you explain and asks me for clarification, thank you for all you do!

Huberman pretty much saved my live as in giving me selfguidance and effectivness after bad injury. Pretty exicited for this one. Was planning to try Oxytocin with my wife, so as always perfect timing. Thanks my man

Just wanted to show my support. Thanks for everything dr. Huberman! Your work is priceless!

Great summary for the layman… you mentioned CJC-1295 in that study with the 1 death. It’s because they used CJC-1295 with DAC to make it longer acting. Regular CJC without DAC does not have that effect. That difference should have been mentioned because many board certified physicians like myself use CJC-ipemorelin for patients with great success.

Thank you for the work you put in to these podcasts

As usual, thanks for spreading SCIENCE for free! You’re a GOAT!

Dr. Huberman I have been taking peptides and read a book by William Seeds, MD. Your information was more granular and detailed as I’ve been taking peptides for over 1 year. I am learning something new daily especially about Sermorelin. I learned to wear my Fitbit to explore that REM decrease. I can’t thank you enough. Heck, wish I had friends like you, ha-ha. Have a good rest of your evening sir.

In the past I damaged my lower spine permanently and a few years later my right knee permanently giving grief to my hips. All in all mostly ligaments and tendons/some cartilage. I decided to take Organic Collagen Hydrolyzed(peptides) classifies as Type 1, 2 and 3. After taking it(powdered) the first time I was near amazed that I had noticeable relief from pain and mobility. Yep, still using it. Not exactly what you are talking about, but noteworthy enough to mention

Just discovered this podcast. Wow what a wealth of information I feel blessed to be alive at a time when such high-quality information is so readily available. ❤

I'm a aesthetician. Before I only knew that Acetyl Hexapeptide-8 (Botox in a bottle) which is used widely in cosmetics and skincare products for its anti-aging properties. Now I learned more about peptides! Thank you for your insight. 🙏

which of the 6 peptides is your favorite?

Thank you so much. Very interesting topic!😊

Dr. Huberman, the information that you have shared over the last few years has improved my life in countless ways. What you do in your personal life doesn’t change that.

I love you doc, you changed my and many millions of other people's life. Keep your head up against those scammers 👊💯

Great podcast. Thank you for the information

Your awesome contribution to science and self development makes you bulletproof. Your message stands for itself and cant be hurt by mean people writing articles about your personal life.

Thank you for the information. I have a knee injury and reconstruction, this is very helpful.

You are an amazing teacher, do what you want in your personal life and enjoy it to the fullest!!

Thanks for adding so much value Andrew!

I've never heard of him till the controversy. Now I'm subscribed. Anybody that the media tries to smear I find out what they have to say. It's usually the truth or something beneficial to you. It's a good barometer for figuring out who you should listen to.

Here to say how life-changing your podcasts have been to me. I hope you continue to share your knowledge with us. Thank you

I am currently on week 5 of taking cjc-1295 + ipamorelin 5 days per week, and I absolutely love it. I did speak with my doctor about the concern with the FDA and I feel safe to continue using these peptides.

Thank you so much for the amazing work you. I've benefited much from your offerings.

Dr. Huberman, could you do an episode on the most efficient learning techniques, like mind maps, interleaving, spaced repetition, etc.

Never explain, never complain

Andrew, your breakdown of peptides is enlightening. Understanding both benefits and risks empowers us. Thanks for the clarity!

thank you for continuing to be the best resource for health and science!

tissue repair: 21:50 BPC-157 36:43 TB-500 40:49 IGF-1 type 1 GH secreting peptides: -GHRH peptides 45:25 (“category 1”) sermorelin 47:25 tesamorelin 49:50 CJC-1295 50:39 -GHR peptides (“category 2”) 54:00 ipamorelin 54:46 hexarelin 55:40 GHRP’s 57:00 1:06:12 longevity: TB-500 epitalon 1:07:00 vitality: PT-141 1:16:15 kisspeptin 1:17:21 1:21:46 summary

Andrew Huberman - the Stoic Scientist. Salute sir.🙏🙏🙏

I have been following your lectures for a long time dr Huberman and thank you so much for all that you do to enlighten others on healthy living I have very frequently referred your lectures to my patients for their well being as well

Andrew I want to show my gratitude towards your information you provide , I’m 25 years old and you help me understand things I would need to go to school for here on KZfaq and it’s awesome thank you SIR!

Many people were waiting for this one. Thanks :)

Thank you for your commitment to education through science 🎉you’re a treasure

Thank you dr andrew ,you have changed my life

I'm glad your still here Andrew, all you've done is try to help people and for people to try and cancel you says more about them then it ever will of you, keep going brother ❤

Couldn't come at a better time, just ordered some of these a few days ago!

Keep going Andrew ❤

Thanks for your guidance on improving my health Andrew!

I've used BP-157 in the past for helping with tissue repair with very good results. It's quite helpful in combination with other treatments.

Ive used oral BPC-157 for over 6 months now. Has made my bloating issues much better and has lowered inflammation a ton.

I really admire your ability to remain resilient and professional despite recent events. I would love to hear which mechanisms you find most helpful during challenging situations (broadly).

So! I knew nothing about peptides and have been hearing them being talked about in the health podcaster field. Thought I would try to educate myself on what they were … blah .. blah…blah. So glad I decided to watch this episode! I’ve learned a lot! And now know to listen with a cautious ear. Thank you for the in depth science review.

Just subscribed bc ive listened to a few and find the information extremely beneficial but also want the hit-piece on Huberman to backfire! Congrats on all that you do and more power to you!

Dear dr. Huberman I was diagnosed with acute anxiety 6 months ago to the extent that I had a constant tension type headache for 2 years. I took cbt and followed your protocols of health, mind, dopamine, exercise etc… Now I am in a generative drive I have never experienced before, I lost weight, put on muscle and have built an insane routine geared towards growth. It literally feels like I have control over my life now. It extremely saddens me to see the lengths the shit media would go to bring you down by attacking personally. Please note even Gandhi had personal flaws and we only look towards what he gave to people. You sir are a gem, a 1 in a million person! I feel extremely grateful for your contributions. Keep shining!

God Bless you for sharing all this knowledge with us! 🙏🏻 This was much needed for all of us who experiment with peptides.

I’m so glad you addressed this subject. Almost every collagen supplement I buy has peptides on the label.

Gracias Andrew!!! In order to get collagen, what are best foods, or best brand to ingest. Is insufficiency of collagen, cause of pain or sensation, inside the bones, specially when ovulating?

Thank you for sharing Dr Huberman ❤

Thank you so much for sharing all your knowledge🙏🏽

Dr Huberman, thank you for all you do. I have battled back pain due to musculoskeletal injuries from an accident. I have tried any and all remedies with nothing working but watching this episodes helps me stay motivated that there could be an option for me to heal. I’ve tried yoga, meditation, vitamins and mineral supplements, out patient physical therapy, etc. speaking with physicians is underwhelming as they don’t believe a 30yr male that is otherwise healthy is suffering from this pain but dismiss it as self inflicted anxieties and depressions. Don’t believe you’ll read this but thank you. I’d love to learn more how I can get my hands on this BPC 157.

Keep that head down and keep working hard. The haters will be gone as soon as they find their next target to brigade and moral grand stand. Much appreciated content.

Ive never heard of peptides. Lets get into this!

Great new episode. Can't wait for the other 5

The best way to prevent cancellation is to not acknowledge you have done anything wrong, especially if you haven't, and especially if it doesnt concern the general public or your public work. Huberman is a champion of lowering the spotlight on himself in order to brighten the light on the information he is providing and compiling.

Thank you Andrew!

Hi Andrew. Don't know if this message will ever reach you personally, but I just wanted to say that you're in my prayers, and I'm so grateful for the man you are in the world, with you wanting to educate and help as many people as you can. It's a beautiful thing. I also wanted to encourage you to keep going with your spiritual journey. Hearing you claim belief in God was so encouraging, and when anyone is "leveling up" in the kingdom of light, the kingdom of darkness will always attack and try to thwart those efforts. Hence, the recent, and fabricated allegations against you. All this to say, keep going. This is evidence that you're headed in the right direction. Thanks again for what you're doing for the education of all who follow you. God bless.

Hey Dr. Huberman, Thanks for consistent and high quality content. I am a soon to be father and fitness enthusiast. I think it would be pretty useful if you had an episode about optimizing health and fitness during the first year of parenthood given the erratic sleep schedules and stress associated with early parenthood. It would be great to have strategies/protocols to optimize things like sleep, workouts, cognitive function, and general health. This isn't a topic I've seen explored by anyone in the fitness space or adjacent, and it would be very valuable to many in my age group who are becoming parents and want to avoid the "dad bod", and maintain high quality health and fitness. Thanks!

Fantastic, I have a 130 mile drive to work and back. I appreciate the content and length of the podcasts, it makes my drive easier and my brain swell with information. Thank you, for the variety of engaging guests.

Its incredible how you can go in-depth in a topic that would seem complex to me, and make it perfectly understandable. 😁Thank you so much!

God bless you and your work 🙏

It's a real pleasure going through all the comments , seeing the support for you and what you do and the lives you have changed or made a great impact on (mine included) Thank You Sir

Thank you so much for this podcast!

Would you consider doing an episode on personality disorders such as histrionic, paranoid, etc., and how to create and maintain boundaries? Thank you 🙏

The turning point, which made the industry fight back at Huberman, was the episode with dr Robert Lusting, where Andrew said that he is thinking to act in a political way to fight the big food and pharma industries, like pressuring the officials or the legal authorities. This is a worldwide hundreds of billion business and they will never surrender without a fight! So Andrew have just one option to clear those BS, and win the hearts of the World - just go and do it! People will support you! Power to the people!!!

Phenomenal video. Thanks!

Thank you so much for everything !!!!

I pray that no one ever gets to stop you from teaching us and giving us valuable information, information that is vital for good health. I thank you for continuing to bringing us great content always.

Great podcast as always. Thank you Dr Huberman, please keep doing what you do, your work is so important.

I can say with my personal experience. I suffered from chronic back pain where my disc would bulge and I Would not be able to walk for two weeks. When my back would go out I would inject bpc157 directly to where I feel the spasm occur and instantaneously my spasm and pain would subside and instead of being down for two weeks I would take it easy for 4 days. This was a game changer for me and allowed me to decompress and get strong. Now I haven’t had a spasm for about 8 months versus having one every 2 months. This stuff is a miracle for me.

This is very helpful at this time. Thanks.

I wasn’t familiar with how peptides work. As usual I learned a ton which is why I return to this channel again and again. Thanks so much, Andrew and your team (I am assuming you have a team). Your dedication & commitment to bringing easy-to-comprehend science education to the masses does not go unnoticed! 🙏

Huberman the people’s champion. A chad helping us mortals.

thnks you for your useful and amazing podcasts

Thank you Dr. Huberman!

Thank you for all you do to bring this information to us!

Thank you for another great video, Andrew. A suggestion for an upcoming topic: There are so many guys around the world suffering from p**n addiction, so it would be great if you could make a full episode on that. Millions of men around the world would be forever grateful. Guests could be, for example, MD Donald Hilton or perhaps Anna Lembke....

I've been thinking about my pancreas a lot and insulin and hormone and gut health, and how that relates to energy etc. I look forward to listening to this later.

hey andrew: i love watching you! i support you. keep up the excellent health videos. stay 🔥!

Very well done!You have cemented yourself as a real role model for everyone who is watching.

I'm here to support this man and to say I really really don't care about his personal life. I'm here for good and medically proven advice. The fact that people who never ever watch any of his podcasts are trying to deter his audience for issues that are unrelated and not their or our business is infuriating.

Thanks for the hard work!

Ta 1 has been a miracle in my life! I was hoping to hear you talk on this!

Dr Huberman - thank you for more excellent content!