Can someone with an APOE4 genotype follow a ketogenic diet?

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Can someone with an APOE4 genotype follow a ketogenic diet? | Dominic D'Agostino

Рет қаралды 6,987

2 жыл бұрын

The ketogenic diet is contraindicated in people with pancreatitis, fat metabolism disorders, and other rare metabolic conditions. Some people carry a version of the apolipoprotein E gene called APOE4 - a risk factor for late-onset Alzheimer's disease. This gene variant affects fat metabolism and distribution to the brain. Dr. D'Agostino questions whether a high-fat ketogenic diet is suitable for people carrying an APOE4 gene variant. He suggests it may be prudent to select a more liberalized version of the diet and gradually restrict carbohydrates and monitor biomarkers for adverse reactions. Other thoughts include incorporating fiber-rich vegetables and choosing unsaturated rather than saturated fats. In this clip, Dr. Dominic D'Agostino discusses the applicability of a ketogenic diet for people with an APOE4 gene variant.
Interview published on April 28, 2022
Watch the full interview:
• Dr. Dominic D'Agostino...
#Ketogenic #Diet #Metabolism

Пікірлер: 20

@ken3marcus 2 жыл бұрын

What is the study reference or mechanistic evidence regarding saturated fat and APOe4 ?

@jacobfrank9556 6 ай бұрын

www.ncbi.nlm.nih.gov/pmc/articles/PMC8073598/

@TheJaYSolo Жыл бұрын

To Dr. Patrick & Dr Agostino, I desperately request your input on this question. Can a person with APOE 3/3 have familial high triglycerides? I ask because everything I find about 3/3 shows that it's the most common and it's the genotype that has normal lipid metabolism. So does abnormally high triglycerides in patients with 3/3 not hereditary? Is this conclusive that it's not familial and by default must be lifestyle or other factors since apoe 3/3 is a genetic test? I really need this information for my own case and I hope any of you amazing Doctors gets this message and gives any input as it will help me tremendously!!! I literally BEG of you both

@OttoNommik 11 ай бұрын

Lol

@grahamedwards6824 9 ай бұрын

If my triglycerides are sky high, I’m likely well on the way to Type 2 DM. I was Pre diabetic and since doing low carb and high healthy fats (EVOO) my triglycerides are low now, and HDL high. Intermittent fasting is also extremely beneficial in allowing the raised insulin levels to return to normal. But it takes a while. Try Dr Jason Fung, and Dr David Unwin. A test for visceral fat might be in order. Perhaps a DEXA scan…

@rongqut7576 7 ай бұрын

What is "high in fat and super restrictive" mean? High in what fat? "Super restrictive" refer to what food? Meat? Or fibre? Or Carbs?

@TheTibo13 2 жыл бұрын

It would be much more interesting if someone who has these familial Alzheimer's genes (Psen1 etc.) can follow a ketogenic diet

@zanetahulist Жыл бұрын

My genetics says that ketogenic diet give me inflammation I gave 2 copies What to do ;(

@bettywhill Жыл бұрын

Try it out and see if it indeed cause inflammation?

@zanetahulist Жыл бұрын

@@bettywhill thanks :)

@abioseht6284 Жыл бұрын

Try it out but avoid red meats. Eat lots of vegetable and fish. Think of yourself as a person who lives off the ocean or beach. That way you’re avoiding all Saturated fats and only eating the healthy ones

@zanetahulist Жыл бұрын

@@abioseht6284 hi. Thanks :)

@SuspensionTruth Жыл бұрын

@@zanetahulistDo you know your genetic profile? Is that what you meant by '2 copies' of the APOE4? It's a bit of misinformation to say 'only eating the healthy ones' by avoiding saturated fats. There are benefits to saturated fats, especially if you do not have the APOE4 marker AND are NOT insulin resistant (see 4:19). I have one of the APOE4 alleles but am NOT insulin resistant (although there are tendencies that run in my family). I exercise, meditate, focus on lowering my stress and increasing satisfaction. I use a lot of olive oil, avocados, flax, seafood and other high-MUFA sources in my diet. I do not eliminate red meat, however, simply moderate it to once or perhaps twice a week. I'm also male, type O and my genetics is more 'carnivore' based. Self-experimentation has shown me I am happier and healthier with some red meat vs. none. I'm glad to understand the modification related to the APOE4 allele which makes a Mediterranean diet beneficial. I suggest you find a good nutritionist to work with and get blood testing to track the changes you make in your diet. Good luck! P.S. I would also look into heat therapy (sauna) and ways to improve your overall 'healthspan' as Rhonda Patrick says. A 30 min walk every day and a 20 min sauna sit (4x a week) at 165 to 190 deg F show incredible benefits to health and wellness, plus overall mood. It may take some time to get used to being in the sauna that long, but now it's nearly a daily ritual for me. Bring water with minerals (lemon or lime plus stevia in filtered water, some magnesium) take your time and enjoy. kzfaq.info/get/bejne/e7djes2hrNeZiWw.html P.P.S. Just watched this talk by Dr. Andrew Huberman on dopamine - it's very insightful, perhaps can be useful for you as well: kzfaq.info/get/bejne/h9N_eZOU18rdgok.html

@philw9120 7 ай бұрын

So the most ancient genotype APOE4 which developed when we were eating exclusively meat (which is 50% monounsaturated BTW) and we thrived enough on it to pass the gene on to 25% of today's population is somehow now bad for APOE4 types? Oh and keto is scary say's the trillion dollar statin industry, even though we are born in ketosis, our natural state. And somehow we can't get enough selenium if we don't eat carbohydrates. This guy surely got his nutritional education from a comic book, or the AMA which is comparable.

@DoggieFosters 2 ай бұрын

Evolution doesn't give a damn about health & longevity past prime reproductive years. APOE4 seems to be protective against infection as it is proinflammatory. An advantage when young. A distinct disadvantage to the aging brain & vasculature.