Classical Pathway of Complement System

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Andrey K

Andrey K

Күн бұрын

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Пікірлер: 239
@SuperTalvar
@SuperTalvar 9 жыл бұрын
Should be called the complicated system
@suntrespasser9684
@suntrespasser9684 8 жыл бұрын
Definitely.
@arnobashtar6707
@arnobashtar6707 5 жыл бұрын
Exactly what crossed my mind as I was watching this
@Null257
@Null257 2 жыл бұрын
It's a homeostatic master mechanism too. The more we understand it, the more it becomes apparent that killing invaders is just what it does in its spare time.
@laiaplaiap1688
@laiaplaiap1688 2 жыл бұрын
B zabet 😂 5osousan eza kent 3am te5od hede l mede b jem3a lebneniye 💔😂
@stevencool9657
@stevencool9657 Жыл бұрын
🤣💀
@soojinlee3527
@soojinlee3527 2 жыл бұрын
I got through Pre Med because of you. Sometimes your lectures were too advanced for me and I thought "I will probably need these when I'm in medical school." 5 years later and I will get through medical school because of you. Thanks man. I hope someone is paying you very well out there.
@nooshinmirzaee7008
@nooshinmirzaee7008 7 жыл бұрын
i love the way you stress on words it helps me stay focused.. ;) you are born a teacher ,keep up the good work
@RaulGonzalez-oq5ei
@RaulGonzalez-oq5ei 2 жыл бұрын
Yup! He kept my attention the entire time and I understood everything !
@midnightsblaze27
@midnightsblaze27 8 жыл бұрын
In respect to the C4bC2b complex, for about 5 years or so in the recent past, immunology textbook writers wanted to make the process more uniform since C2a is the only large factor which remains associated with the cell surface and renamed it C2b to be more inline with C4b. So C4bC2b was published for a couple of years but it never really stuck as C4bC2a was already widely accepted and established.
@gggggggggg-uc3ss
@gggggggggg-uc3ss 8 жыл бұрын
Fragment b is always kept and Fragment a is thrown into the plasma, but there is one exception, it's for C2. So instead of keeping C2b , you keep C2a instead.
@LuciferMorningstar-dp7by
@LuciferMorningstar-dp7by 6 жыл бұрын
Correct bro I also think that C3 convertase is C4bC2a
@Srobvio85
@Srobvio85 6 жыл бұрын
If you known so much why are you here¿¿ Just watch the damn video and then go to a book. Damn whites ruining everything
@96butterfly95
@96butterfly95 6 жыл бұрын
I think that this correction help lot of students......my opinion....
@96butterfly95
@96butterfly95 6 жыл бұрын
I think it s only C4b2b
@lonelywanderer2467
@lonelywanderer2467 6 жыл бұрын
It's actually debatable, I observe, some of the older editions have it C4bC2b, even wikipedia says so. In my textbook it's C4bC2b.
@aslanr6
@aslanr6 8 жыл бұрын
clearest explanations on youtube. Much better than a certain "academy"
@neslihangroll7597
@neslihangroll7597 4 жыл бұрын
You helped me to pass the oral exam in Biochemistry in Step1. My professor asked me the questions you underlined in your videos and it would normally required me to read thick text books to understand. Now you are helping me to pass Immunology. I can't thank you enough.
@leonidas2930
@leonidas2930 Жыл бұрын
This was SO helpful - You are making such a difference for me. I am almost crying of hapiness
@Arthensolutions
@Arthensolutions 8 жыл бұрын
Hi! I'm from Brazil, I'm Pharmacy student, and I must say u r an incredible teacher! Your classes help me a lot! Thanks for Everything!
@beckybrown4405
@beckybrown4405 8 жыл бұрын
hi Luiza Aguiar . am also a pharmacy student. hope it does help
@fahimzubair3766
@fahimzubair3766 7 жыл бұрын
Amazing summarized lecture on the classical complement pathway and its significant immunological functions! Thank you so much for this, sir!
@ronettechojnacki232
@ronettechojnacki232 3 жыл бұрын
Thank you. You saved my life today!! I needed to teach the Complement System to my students and this explained it so well. THANK YOU!!!!
@codyrussell5885
@codyrussell5885 4 жыл бұрын
I just want to say ive watched this guys videos since grad school immunology. I am now in medical school, and still use his videos on all go his topics. 10/10 would reccomend AK Lectures!!
@user-ms4sx6iy2f
@user-ms4sx6iy2f 8 жыл бұрын
you made me understand in less than 15 minutes what my professor couldn't make me understand in more than 2 hours. thanks a lot :)
@marinapapuashvili1393
@marinapapuashvili1393 2 жыл бұрын
Everything is simplified and understandable. I am so thankful for your style and form of lectures.
@kelvinbrown6795
@kelvinbrown6795 8 жыл бұрын
Excellent Video! Clarity is second to none. Brilliant
@ameeralbaghdadi9798
@ameeralbaghdadi9798 Жыл бұрын
You are the best and i guess the only one on youtube who really deeply understand the scientific material and introduce it with no side talk and in a very simple and informative method Best regards to your efforts
@buixuanbaodanh5203
@buixuanbaodanh5203 8 жыл бұрын
Your lectures are amazingly easy to understand. I'm so grateful for your effort.
@halaalabboud480
@halaalabboud480 5 жыл бұрын
Love how you make everything easy, you’re the best 👌🏻keep up the good work.
@lujainaa6086
@lujainaa6086 5 жыл бұрын
He’s so good at explaining. I can’t do this even if I have perfect understanding of something.
@Sunny0894336431
@Sunny0894336431 9 жыл бұрын
"Clocked" couldn't figure this shit out for months!
@abulfazalwashim5117
@abulfazalwashim5117 4 жыл бұрын
Master of all, i almost use half of time before exam watching your so organized precise articulately presented lectures. Love and pray for you from bangladesh.
@elliegarcia4706
@elliegarcia4706 2 жыл бұрын
this was honestly so helpful! thank you for being so clear in you explanation
@kayamanesh3294
@kayamanesh3294 3 жыл бұрын
I love this man so much right now
@sonamraghav5830
@sonamraghav5830 7 жыл бұрын
love your accent 😍😍😍 ,the way you speak 😘😘 understandable
@hilarykayeocaba4898
@hilarykayeocaba4898 6 жыл бұрын
Thank you so much! This video really helped me understand the classical pathway of the complement system.
@annes5279
@annes5279 8 жыл бұрын
You're helping me so much in my Immunology and Clinical Chemistry subjects. Thanks a lot! :)
@samyavellani6111
@samyavellani6111 7 жыл бұрын
Thank you so much for making this video, I found your explanations really clear and helpful!
@NURSEKARMA
@NURSEKARMA 8 жыл бұрын
Thank you for this video! You explained this way better than my patho book.
@arvanaseer7699
@arvanaseer7699 4 жыл бұрын
your youtube channel is the 1st one that helps me a lot in my studies....solute you
@edessatanafranca1380
@edessatanafranca1380 8 жыл бұрын
Hi I noticed that the C3 convertase should be C4bC2a ☺️ I looked it up in Immunology 7th Ed David Male page 90 fig. 4.4 ☺️
@alnahi999
@alnahi999 3 жыл бұрын
I think he did great explanation for classical but he missed to explain more how C3 convertase formed instead to explain formation of C4bC2b complex
@harrishussain8926
@harrishussain8926 3 жыл бұрын
Yes me too
@melisengin9268
@melisengin9268 3 жыл бұрын
Actually, it was historically called C4bC2a. These days, scientists call it C4bC2b for the sake of uniformity. AK lectures is right.
@gigglefeather
@gigglefeather 8 жыл бұрын
Amazing, very easy to follow. Thank you for sharing
@nkosinomusazulu9414
@nkosinomusazulu9414 7 жыл бұрын
classical pathway made simple and sweet..... great video
@Sunshine-zi7oy
@Sunshine-zi7oy 3 жыл бұрын
i hope you know that till this time while im in training for speciality i still return to your videos to remember things 🙏 may God bless you wherever you are 🙏
@jungshrimp998
@jungshrimp998 2 жыл бұрын
you're absolutely great and talented, thank you for these insightful videos, really help me to understand the materials in my college :) may God bless and keep you
@apricotpomegranate
@apricotpomegranate 6 жыл бұрын
I like how you started with the big picture first and then went into the nitty gritty details. My immunology prof doesn't do that enough, hence why I'm here. She will drill the process steps, but doesn't really get at the purpose of why these things happen. Thanks for this. :)
@user-bk5jr5kw8u
@user-bk5jr5kw8u 7 жыл бұрын
I love u man u are the best lecturer i have seen ❤️❤️❤️❤️❤️
@MA-dd9dd
@MA-dd9dd 4 жыл бұрын
Somehow you can make me understand those topics so easily. Thank you
@ethelswale259
@ethelswale259 Жыл бұрын
Your lectures are worth to be acknowledged on my final dessertation
@ivailopavlov5138
@ivailopavlov5138 6 жыл бұрын
Great teacher, great explanations!
@cincrlatko
@cincrlatko 8 жыл бұрын
quality of this video cured my cancer via my innate immunity boost
@Quztuk
@Quztuk 8 жыл бұрын
10:03 shows just the info. Fairly simple to follow what he's written. Much better explanation than my books.
@romainkamba969
@romainkamba969 5 жыл бұрын
Really, I appreciate these courses
@carmelokm
@carmelokm 2 жыл бұрын
What a Man,Good stuff..Life saver
@enoacres9592
@enoacres9592 2 жыл бұрын
i love this man makes every make sense
@zainababdulkareem7746
@zainababdulkareem7746 8 жыл бұрын
I had difficulty in understanding complement system but with this video I will teach complement system to my friends. thanks as much as sea :-)
@israelojo6875
@israelojo6875 Жыл бұрын
Hats off sir, you are better than my lecturer. Remain blessed.
@htetlin2449
@htetlin2449 5 жыл бұрын
Hello AK lecture, according to my professor, C4bC2a is the C3 convertase that cleaves C3 to C3a and C3b. And also C4bC2aC3b is the C5 convertase and C3 convertase cannot cleave C5. Please keep on making video. thank you very much.
@kayodetolulopeadeyemi2286
@kayodetolulopeadeyemi2286 5 жыл бұрын
Hi, This is amazing! Great Job! I use this to teach my students and it is really really really good!
@eugeniomtz5484
@eugeniomtz5484 7 жыл бұрын
You helped me a lot. Inmunology final tomorrow. Wish me luck.
@AKLECTURES
@AKLECTURES 7 жыл бұрын
Good luck!
@ashleywarren8181
@ashleywarren8181 2 жыл бұрын
AMAZING!!!!! You are the best explainer
@nurulbalqis2348
@nurulbalqis2348 7 жыл бұрын
glad that many realise whats in c3. overall, this video is helpful in my Immunology subject. worth the subscription.
@AdesanoyeOluwafemiibukun-yl5ku
@AdesanoyeOluwafemiibukun-yl5ku Жыл бұрын
Thanks so much for this... You are appreciated.
@gladmahlare2067
@gladmahlare2067 8 жыл бұрын
thank you for the helpful videos much appreciated.
@sallyyan3198
@sallyyan3198 8 жыл бұрын
Amazing. Thank you!
@drsiddharthsaxena
@drsiddharthsaxena 9 жыл бұрын
Shouldn't the C3 Convertase be C4b2a, instead of C4b2b?
@AKLECTURES
@AKLECTURES 9 жыл бұрын
Siddharth Saxena Look it up and link me to your source. Ill take a look and let you know.
@drsiddharthsaxena
@drsiddharthsaxena 9 жыл бұрын
Hi AK. Could you please check out this source: www.complement-genetics.uni-mainz.de/cp.htm I was reading Kuby's Immunology 6th edition (internation).. And the lecture notes supplied by university in UK also say it should be C4b2a.. really confused now..
@AKLECTURES
@AKLECTURES 9 жыл бұрын
en.wikipedia.org/wiki/C3-convertase#/media/File:Complement-pathways.png users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html Here are two separate sources that describe the C3 convertase as having C4b-C2b structure.Your lecture notes are probably based on the book you're using. Perhaps its an error in the book. Double check with your professor and let me know what he or she tells you.
@QueNhuPhamThi
@QueNhuPhamThi 9 жыл бұрын
Siddharth Saxena Yep. My teacher also said "C3 convertase is C4b2a too"
@AKLECTURES
@AKLECTURES 9 жыл бұрын
Phạm Thị Quế Như thanks for the feedback! I will look into it.
@serratumer7805
@serratumer7805 8 жыл бұрын
Sir, great explanation, I'm grateful 👏
@77daud45
@77daud45 3 жыл бұрын
This guy helped me pass my doctoral exams 🤲🤲
@kakinda1984
@kakinda1984 3 жыл бұрын
More thanks again for your help sir keep it up ,by abel kakinda from Tanzania at CUHAS.
@heysselg.3993
@heysselg.3993 4 жыл бұрын
There is Super man, there is Batman, there are the X man, there are all kind of super heroes and then there is you... the one who saves me every single time since I started Biomedical sciences.
@carmelokm
@carmelokm 2 жыл бұрын
Many Thanks from the UK🎖️🎖️🎖️
@sophiapauling6677
@sophiapauling6677 3 жыл бұрын
best video ive ever seen on this
@Andr295
@Andr295 8 жыл бұрын
I love your recaps at the end of your videos. Great video!
@AKLECTURES
@AKLECTURES 8 жыл бұрын
+Andres De Avila Thanks Andres!
@HussainBlogs19
@HussainBlogs19 8 жыл бұрын
I'm so thankful for your efforts ☺️☺️☺️
@simransharma1967
@simransharma1967 3 жыл бұрын
Thanks a lot for this lecture sir..... Your notes and explaining is legendary..... Keep up the good work sir
@vascaino946
@vascaino946 8 жыл бұрын
Thanks for the video....greetings from Brazil
@isisrateb
@isisrateb 3 жыл бұрын
Thanks a lot for your explanation
@ashri234
@ashri234 6 жыл бұрын
Woowoo.. you make it so easy and helped me with my exam..thank you alot.
@kelvinmagava444
@kelvinmagava444 4 жыл бұрын
these notes are wonderful
@Roseenmarie
@Roseenmarie 3 жыл бұрын
Very well explained! thank you very much 😊
@competitiveminds1264
@competitiveminds1264 3 жыл бұрын
Love from Indian occupied kashmir..... awesome way of reaching
@ktsi4884
@ktsi4884 7 жыл бұрын
Awesome! Thank you!
@mjeed4205
@mjeed4205 7 жыл бұрын
I am really grateful for these lessons that you are lecturing, but I've got a small note which I hope you will consider, you're speaking with such loud tone and keep speaking without any pause to take a breath. anyway your lectures are very useful for me, thanks
@malikbasharat7119
@malikbasharat7119 8 жыл бұрын
What a way of teaching.. Superb #AK
@Micro-life
@Micro-life 6 жыл бұрын
Great one👌👌👌...n thanks to A K Lecturers fo adding new stuff in C3 convertase part(c2b c4b)...it is nt at all mentiond in books till now, thnks again...😊😊😊
@arriettae8291
@arriettae8291 2 жыл бұрын
C4b2b is correct and it's the new form of formerly known C4b2a complex aka C3 convertase. Anyways, the name changed cause of some wrong nomenclature of complement proteins. The 'b' in these complexes stand for binding and 'a' stands for anaphylotoxins, so that should be it.
@TheAhmedvienna
@TheAhmedvienna 7 жыл бұрын
Very useful!! Thank you :)
@Rebecca-op7id
@Rebecca-op7id 5 жыл бұрын
Very helpful!
@annika6282
@annika6282 3 ай бұрын
hello, in the classical pathway in my powerpoint lecture it says that c2a binds with c4b but in your lecture it is c2b and c4b, is my book wrong?
@MsLevi178
@MsLevi178 8 жыл бұрын
Wow, this was amazing! Thank you so much! #thumbsup
@katherineRAWAR
@katherineRAWAR 8 жыл бұрын
Great video! Very clear, thank you so much for posting. I do have one question though. When mentioning the C3 convertase you said that it is formed by a C4b and C2b molecule. However, in my text, as well as from my professor, I have been told that it is composed of a C4b and C2a, instead of C2b, molecule. I was wondering if there are any discrepancies in naming of the subpart of complement molecules after they are cleaved, or if this was just a small mistake? I apologize for the specificity and detail of my question, I just want to ensure I am understanding this process correctly. Thank you kindly, Kat
@niiinjaaa3241
@niiinjaaa3241 8 жыл бұрын
+Katherine Williams I confirm, it's a small mistake that I didn't even notice before I read your question ^^ It's indeed C4b and C2a, well spotted ;)
@AKLECTURES
@AKLECTURES 8 жыл бұрын
+Niiinjaaa Its not a mistake. As I said in a comment below this one, its currently known as C4bC2a but for a while people were pushing to change it to the C4bC2b to make it more logical. But people were simply not using it enough so I guess were stuck with C4bC2a for now.
@abinoffee
@abinoffee 8 жыл бұрын
Thank you. This helped a lot :)
@mehrdadfr8645
@mehrdadfr8645 7 жыл бұрын
thank U man thank U that was so efficient for me
@amangartia8415
@amangartia8415 Жыл бұрын
Thank you sir it was very helpful.
@ahmadkamal8693
@ahmadkamal8693 9 жыл бұрын
great video, definitely worth the subscription :)
@AKLECTURES
@AKLECTURES 9 жыл бұрын
Ahmed Kamal thank you Ahmed! :)
@lindseymartin-krikorian5204
@lindseymartin-krikorian5204 6 жыл бұрын
Are you going to do or have previously done a lecture on the lectin pathway?
@guerchr1993
@guerchr1993 3 жыл бұрын
Amazing... ty!!
@SaraAhmed-se9xj
@SaraAhmed-se9xj 5 жыл бұрын
Thank you doctor 💙💙
@lilfefeop5856
@lilfefeop5856 3 жыл бұрын
Thank you so much
@lauraritacco2443
@lauraritacco2443 8 жыл бұрын
Thank you!!
@sakshisharma8812
@sakshisharma8812 7 жыл бұрын
really well explained
@tamerawado4933
@tamerawado4933 2 жыл бұрын
beautifully explained 👌
@user-fg3gc2lo2b
@user-fg3gc2lo2b 3 жыл бұрын
thank you so much
@topalaluiza9647
@topalaluiza9647 Жыл бұрын
Thank you so much 🙏🙏🙏
@isaiahchitlay2175
@isaiahchitlay2175 6 жыл бұрын
Thank you so much.
@hanadyhanadosha4890
@hanadyhanadosha4890 7 жыл бұрын
This is just great
@mariabernadettedevera7856
@mariabernadettedevera7856 6 жыл бұрын
you got me confused there for a moment. But thanks, you helped me out a lot;)
@hadeeladel1625
@hadeeladel1625 8 жыл бұрын
(Amazing Video !!! THANK U SO MUCH , the best explanation (Y
@newworldorderordis-order6803
@newworldorderordis-order6803 4 жыл бұрын
thank you for teaching online
@caesar1752
@caesar1752 6 жыл бұрын
Much thanks man
@Hollandobloom91
@Hollandobloom91 6 жыл бұрын
Hi, do you also cover the Lectin pathway?
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