Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion, Sushil K Jain 1, David Micinski

Contact Dr Gordon Crozier with the Crozier Clinic in Lake Mary Florida and ask him to explain HydraStat Molecular Encapsulated Glutathione. Tell him Keith Chaisson sent ya!

whats the 1 Pill you took?

@@abukarabdirahman7846 It's in the title of the video and what the video is about.

Oh wow - I did not know that. I just started taking DAO and it’s helping me so much. I have NAC in my cabinet. I’ll look into this further.

Just add molybdenum

I'm 2008 I took nac and completely recovered from chronic fatigue while I was in it. Then became histamine intolerant. I wonder if this is why.

OP, can you please provide a reference (re: NAC dropping DAO 30%)? I'd love to read more about that and validate that claim. Keep in mind that GSH boosts TH1 activity, which in turn suppresses TH2 activity, and thus, mast cell activity. So, depending on the context of the individual, it can still have a net anti-histamine effect.

She is right i have the same info. I double the DAO intake while taking NAC

I'll be starting a full on cleanse next week Can I ask why you've decided to go carnivore rather than Keto or vegan etc ?

@@user-tl2ii7sr7t SIBO gets worse with fiber, starch and carbs.

Welcome aboard! I'm glad you're here, too :)

🥰🥰🥰🥰🥰🥰🥰 I'm so glad to hear that! Thanks for commenting!

I haven't used it much, so I can't really speak to it!

NOW brand is good. I buy a lot of their supplements.

Pure Encapsulations Liposmal Gluthione absorbs well.

@@emiliegray6737 I have been taking nac and it helped in the beginning should I just supplement with glutathione

@@lisagardner4814 glutathione supplements don't work as well because they're not as stable. Better to get into amino acids by food or supplements. I got glycine powder. Gonna look more into glutamic acid and cysteine

I wouldn't use supplements with flow agents...magnesium stearate, stearic acid, titanium dioxide or silicon dioxide! Beware!!!

🥰🥰 You're welcome!

Thanks Jackie!

I cannot take L-Glutamine at all as it gives me terrible stomach aches. Look into something else to heal your gut like Zinc carnosine (just be mindful that it can inhibit iron absorption).

Hmm hard to say without more context. For example, if you do more cardio than me (it wouldn't take much to beat me there these days 😂😂) you'll need more starch than I do. If you're gut is doing well on 52g of fiber, I wouldn't sweat it. However, sometimes excess fiber consumption can plug ya up and cause constipation, so if that is a chief complaint for you, it may be worth playing with. Hope that helps!

@@gutmicrobiomequeen You've given me the perfect answer, couldn't ask for a better one, you helped me big time by providing reasons why I would want to keep it up and also reasons to watch for why I would want to reduce! :) - being thin and very underweight is what guides me to push the starches, especially since I don't experience much of the negatives by drinking over 2L of water daily :)

What were your results? if you dont mind me asking.

I also have a citrobacter problem, did you friend manage to heal theirs ?

ALA is capable of regenerating glutathione and several other antioxidants

Sulfur intolerance is most likely a molybdenum deficiency.

@@gnosisdespirit I've been taking 2 mg of molybdenum for past week or so. I think though because I present with constipation that I'm dealing with methane and h2s. Just got atrantil in the mail.

Another major thing you need to check into is your vit d levels (make sure to take vit k2 and magnesium if you bump your vit d3 up). Also look into thiamine deficiency - EONutrition has some GREAT info on this - also his latest interviews are priceless.

I'm not convinced of this, actually. I have the +/+ CBS SNP (confirmed with two different companies) and I tolerate Sulfur (including high dose GSH and high dose NAC) like a champion.

I have IMO and I can’t tolerate sulphur, I quit all sulfur foods Including eggs, meat,and onions,gives severe constipation,any suggestions?

​@AL l maybe you're deficient in molybdenum, which can cause sensitivity to sulfites and can be cured by taking a little molybdenum

Can we talk about Thiamine? Elliot Overton has a theory that many people are deficient. This is connected to glutathione, and has been used to treat parkinson's...

@@brainwithani5693 Mr. Overton's personal recommendations to me did not work. I needed riboflavin not thiamine.

Yeah, they say oral GSH isn't absorbed well. Or, rather, that it breaks down into its 3 amino acids prior to absorption. So, you might as well just supplement with the amino acids you need and call it a day. One paper I read said that oral GSH supplements are just really, really expensive cysteine supplements 😂😂😂

@@gutmicrobiomequeen Facts💯🎯🎯

@@gutmicrobiomequeen so nac glycine and what else should we supplement

Glycine can act as an inhibitory neurotransmitter. That is totally separate from it's other roles (glutathione production, detoxification, etc). SAMe is a methyl donor that can boost Serotonin and dopamine, but I'm not aware of it affecting glycine in the brain. My guess is that you tolerate the addition of excitatory neurotransmitters better than you do the addition of inhibitory neurotransmitters.

It does! Probably because of that TH1 promotion/TH2 inhibition thing I talked about.

Their glutathione have so many artifical ingredients

That's why I advocated focusing on nutrition (especially getting enough cysteine) rather than supplementing with GSH directly. It's pretty common to get funky symptoms from glutathione but tolerate cysteine containing foods just fine.

Thank you for commenting! I appreciate the help in my quest to conquer the algorithm 😉 I've been taking 500 mg 2-3 times per day. Occasionally I would take more (when sick), and occasionally I would forget to take it for a few weeks though 🤦‍♀️ I've played with glycine here and there, but I've never been diligent with it. I have been more diligent about using collagen peptide protein powder, though, and that has glycine in it. Again, I'm very inconsistent, but I'd day I average using that about 3 or 4 times a week.

@@gutmicrobiomequeen Thank you for this great info. I wondered 2 things. When do you stop taking supplements before your testing so that the results are not effected? Also, I understand that cysteine can also effect hormonal levels by effecting DHEA levels? What does that mean for post menopausal women?

@@salleone6387 I think I discontinued all of my supplements for 3-4 days prior to testing. For me personally, I knew that my GSH and some B vitamins were low when I wasn't supplementing and I don't intend to stop my multi or my NAC... So, in a way, I wanted to test how effective those were for me rather than simply testing my levels. I hope that helps! Also, I'm not savvy enough with the DHEA thing to really weigh in on it... but, I'll share this. If you were supplementing way above and beyond your nutritional needs (ex. cysteine), then I could see it potentially mucking with other systems. But, I find that many people are under-consuming Cysteine to begin with, as was the case for me. So, most of us are not supplementing above and beyond our physiological need- we are simply filling in the holes from an inadequate diet. When that is the case, I'm inclined to think that it's quite safe.

@@gutmicrobiomequeen Thanks!

Milk thistle works quite a bit differently. It protects the liver cells from damage as opposed to supporting detoxification. If you can't eat eggs, then I'd focus on other Sulfur-rich foods (red meat, brassica veggies, onion, garlic), B vitamins (many are needed by those detox enzymes), and protein (in general). Hope that helps!

take Alpha Lipoic Acid (ALA). It regenerates Glutathion and other antioxidants.

Theoretically? In several doses throughout the day taken away from food. Practical take: I personally hate taking pills between meals (I never remember them which means I take fewer doses per day AND pills tend to feel stuck in my throat if I don't chase them with food 😑) sooooooooo I just don't. I'm willing to live with theoretically slightly worse absorption.

@@gutmicrobiomequeen Awesome, thank you!

@@gutmicrobiomequeen thank you for the great context I a on nac and it’s only 900 a day I think I’ve plateaued and I need to add another capsule. I’m going to do one in the morning and one at night. Does that make sense or should I do the other one mid day or afternoon?

I am no dr but that certainly makes sense if you are dealing with sibo you should address that as well before using any sulfur products ,

It complicated organic chemistry stuff that many of us have chosen to block out of our memory LOL 🤣🤣🤣 But seriously, there is a D and an L form (isomer) of most molecules. In this case, we're using the L isomer.

Try watching Dr Brad Stanfield’s U Tube video on glutathione. He says you should not take glutathione because it bypasses the bodies regulatory system and can deliver dangerous amounts of glutathione where it’s not wanted. Best use NAC and glycine it allows the body to manufacture and regulate its own glutathione and deliver the correct amount to the cells.

Cronometer :)

@@gutmicrobiomequeen Thanks for the reply. Sure but you use a good scale to measure the weight of your food to enter it correctly. I wanted to know what food scale you use. I'm tired of buying crappy ones. 😝

@@littlebear853 OHHHH, gotchat. I honestly don't know. We just have one we got on Amazon 10+ years ago! I didn't get super exact, though. I'd say I weighed or measured my food about 50% of the time, and I just eyeballed it about 50% of the time (particularly later on when I was getting better at eye-balling).

Oh I see! Thanks for the reply. No worries. :)

Hard to say without knowing more about the person who has the condition. Here's a good bit of info to get you started, though: www.lifeextension.com/protocols/infections/hepatitis-b

@@gutmicrobiomequeen big thanks 🙏

That's what I advocated in the last section of the video 🙂 I mean.... I CAUGHT YOU. YOU DIDN'T WATCH MY FULL 40-MINUTE VIDEO!? HOW DARE YOU! 🤣 Just kidding, of course. I know this was a looooooooooooooooooooooooooong one, even for me!

@@gutmicrobiomequeen True, I have ADD or ADHD so I have a hard time watching longer videos.

I suck liposomal glutathione (200mg is enough). It boosts REM sleep which is really helpful for people with ADHD. Sorry to interrupt your conversation but that’s what people with ADHD do 😮😮😮

I mentioned toward the end of the video that you might as well take NAC. They are different molecules, but NAC gets made into GSH anyway and is much cheaper :)

@@gutmicrobiomequeen great- i'm currently taking NAC now for candida/dysbiosis

Is it working for you?

1. Since the growth of "bad guys" is highly dependant on the presence or absence of "good guys," it depends on the architecture of the microbiome overall. I hardly ever treat one marker in isolation. 2. I cannot give medical advice via KZfaq or social media. I hope you understand!