Ep:276 THE RANDLE CYCLE - EXPLAINED AND DEMYSTIFIED by Robert Cywes

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Ep:276 THE RANDLE CYCLE - EXPLAINED AND DEMYSTIFIED by Robert Cywes

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Dr. Robert Cywes the #CarbAddictionDoc

Күн бұрын

THE RANDLE CYCLE EXPLAINED AND THE MYTHS DEBUNKED. FAT AND OBESITY DO NOT CAUSE DIABETES. Dr Cywes discusses the physiology of the Randle cycle in detail and exposes new truths since 1963 that alter Phillip Randle’s postulations. This is a NERDOUT TECHNICAL DISCUSSION. The Randle Cycle has become a popular explanation that dietary fat controls metabolism and causes diabetes. THIS IS COMPLETELY FALSE. Anyone referring to the Randle Cycle to explain diabetes has no clue about human physiology. These insights are not beliefs or conjecture - they are facts as explained in this video. (error in video - at the 6:54 mark, Dr Cywes uses the word Glycolysis but meant to use the word GLYCOGENESIS). Ask and answer the right questions to optimize your health! Whether you agree or disagree with our content, if we’ve made you think and ask questions, we’ve done our job. Leave comments below.
Research Discussed...
RANDLE PJ, GARLAND PB, HALES CN, NEWSHOLME EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963 Apr 13;1(7285):785-9. doi: 10.1016/s0140-6736(63)91500-9. PMID: 13990765.
Hue L, Taegtmeyer H. The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E578-91. doi: 10.1152/ajpendo.00093.2009. Epub 2009 Jun 16. PMID: 19531645; PMCID: PMC2739696.
WHERE TO FIND DR. ROBERT CYWES and SHERYL FOX RD:
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ROBERT CYWES M.D., PhD and SHERYL FOX RD ARE clinically PRACTITIONERS in Florida and COVER THE ENTIRE USA AND WORLD VIA TELEHEALTH. The mission of our media content is educating the public about a CARBOHYDRATE ADDICTION approach to treating obesity, diabetes and metabolic syndrome. Understanding the importance of replacing carbs in your diet with REAL FOOD while simultaneously replacing carbs as a toxic, harmful response to emotional tension with a more effective diverse healthy set of emotion management tools for lifelong sustainability of mental and physical health, happiness and well-being. Converting people from toxic sugar burners to healthy fat (keto) burners while addressing the CAUSE of addiction to carbs from an emotion management perspective. Sometimes using obesity surgery and devices as tools along the way, and helping people who have had bariatric surgery stay healthy and not relapse
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**DISCLAIMER: Any information on diseases and treatments available at this channel is intended for general guidance only and must never be considered a substitute for advice provided by a doctor or qualified healthcare professional. Always seek the advice of your physician or qualified health care professional with questions you may have regarding your medical condition. This site and these videos exist to provide information and support about nutritional health and do not provide medical advice and should not be thought to provide medical advice. We can only give medical advice if you establish yourself as a registered patient and consult with us in our medical practice - JSAPA. We always recommend working with a team of knowledgeable and experienced practitioners, including a physician such as Dr Cywes and a Registered Dietician such as Sheryl Fox in our practice. Do not self-diagnose. Always seek medical guidance when you have a medical condition. -------- #randlecycle #diabetes #insulinresistance #physiology #glucose #fattyacids #anabolic #catabolic #insulin #glucagon
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Пікірлер: 366

@biancagadi786 Жыл бұрын

Dr. Cywes, your way of explaining complicated biological/medical/scientific terms and processes is so clear and to the point without fluff. I always wanted to study medicine witht the goal to become a brain surgeon. However I was not smart enough to enter medical school. Life has its way. Nevertheless, my interest in medical subjects has never waned. You, as an accomplished medical professional offering these free lectures, provides us lay people with invaluable access to knowledge. You spent years to acquire this knowledge, and all we have to do is listening for a short time to start grasping complicated concepts. I consider you a master teacher. thank you for your effort.

@Thefoodguidetofitness Ай бұрын

@biancagadi I echo your story and comments

@xmenotux 6 ай бұрын

I see a lot of people suggesting this video discredits Bart Kay's understanding of the Randle Cycle, but it doesn't seem to do that at all. Both Dr. Cywes and Bart Kay seem to be saying that cells prefer fat, and in the presence of fat it doesn't utilize glucose. The mitochondria, once satisfied, will block further energy absorption. As I understand it Dr. Cywes is merely pointing out some nuance about how Randle incorrectly assigned causality to the presence of fat blocking glucose pointing out that Glut4 would facilitate the transport of glucose into the cell. However ultimately the effect is still the same, that the cell prefers fat and once energy requirements are satisfied it will block the glucose even with the facilitation of GLUT4 which would then cause the glucose to enter adipose cells. They are both saying the same thing about the effect of the Randle Cycle, Dr. Cywes is just providing more scientific clarification that Randle's assumptions weren't entirely correct because he assigned causality to the presence of fat instead of to the satisfying of energy requirements.

@adriansrfr 3 ай бұрын

Beautifully stated

@aspiresk8boarding 2 ай бұрын

Cell arguably prefer burning glucose as they increase the nad to nadh ratio which speed metabolism of the cell, creating more atp and co2 production with less reductive stress and ROS. With a high metabolism from glucose burning that energy systems won’t be “satisfied” for long compared to fats. The brain, red blood cells, CNS, and kidneys for example need a constant supply of glucose

@bigglyguy8429 Ай бұрын

@@aspiresk8boarding which the body makes for itself, so that's irrelevant.

@alphacause Жыл бұрын

Dr. Cywes' explanation here, of a pretty complex topic - the Randal Cycle - is a great example of how to simplify something so as to make it comprehensible to a layperson. Dr. Cywes is not just teaching us about the Randal Cycle, but he is teaching a masterclass on how to distill the esoteric nuances of a scientific concept into something that is more accessible. Thank you Dr. Cywes! I am sure you are a busy man, but given how much attention the Randal Cycle has been getting, if time permits, maybe you can do a presentation on this with slides. Visual aids, especially when dealing with the such a intricate topic, helps describe things more clearly - especially for those who are more visual learners. Given how much the Randal Cycle is being used or misused to argue for a particular point, and just the sheer amount of misunderstanding there is around the concept, warrants taking the time and effort to do a deep dive into this topic.

@stealth48nurse 5 ай бұрын

Prof Bart Kay was on the Nutrition with Judy channel and showed charts of the Randal Cycle

@garyharvey3545 Жыл бұрын

Love the discussion. Will puzzle me for weeks until I can sort out the concepts and practical applications. Never ending challenge and never boring.

@lauriehaas7386 Жыл бұрын

Don't eat sugar. Eat fat. Sadly, that's all I understood, I'm not real sciency, but at least I understood that. And that's a start...

@davegriffin9083 6 ай бұрын

I wish someone would put this in layman's terms I'm no Einstein either.

@xmenotux 6 ай бұрын

@@davegriffin9083 Cells prefer fat for energy, not sugar. Stop eating sugar. It causes hormonal dysfunction. Was that layman enough? 😅

@frodehokholt3944 21 күн бұрын

Great video! You are the first have seen that brings up the role of glucagon with relation to the Randle cycle! I have severe type 2 diabetes. Even after a full year of strict carnivore diet and cutting out all meds, including insulin, my average blood sugar was in the 270 range. I finally twisted my docs arm and got both a fasting insulin and fasting glucagon test. My insulin was 12, so high, as expected. But my gucagon was only at 18, so severely depressed. So then the depressed glucagon no longer restricts the insulin production, which again makes my liver produce as much glucose as possible, to get rid of the excess insulin. Then Ben Bikman explained the role of glucagon in detail and the fact that eating healthy saturated fat actually boosts glucagon production, thereby LOWERING the insulin production. So if you wanted to conspire to get as many people as possible to die from the effects of insulin resistance, the obvious first thing to do is to completely demonize or ban eating saturated fats... Something to think about... With all this information I have devised a strategy for curing my diabetes. I do periods of 9-10 days of waterfasting combined with daily exercise. This will after a few days completely normalize my blood sugar. Then when I start eating, I ONLY eat fat, as in lard, for the first few days. After completeing two such cycles, my avarage blood sugar is now reduced to around 130 when eating a normal carnivore diet. I believe that with a couple more of these cycles, my diabetes will be cured. So get tested for both blood glucose, A1C, fasting insulin and fasting glucagon. That gives you a complete picture of what is going on.

@uberneanderthal Күн бұрын

i've fasted several times, even dry fasting, and I have to say the health benefits are exaggerated. there's less stressful methods for achieving equal or greater results. it may be necessary in your case, idk. but I would attempt less severe protocols first. the rule should always be: if you're hungry, eat. the only exception is carbs, since our instincts are evolved for an environment where carbs are rare and seasonal, nothing like our current environment.

@terrencedrakeford6452 Жыл бұрын

CAN YOU PLEASE DO A VIDEO WITH BART KAY!!

@BarbaraJ1111 Жыл бұрын

I agree. Terrance. Although this video was a bit over my level of understanding.... I will do more research so that I understand. The little bit of digging that I've done today.... it appears that Bart Kay disagrees with what Dr. CYWES just discussed. A conversation between Bart Kay and the good doctor would be enlightening!

@terrencedrakeford6452 Жыл бұрын

@@BarbaraJ1111 These two guys know ALOT and are also huge advocates for the carnivore woe. So it would interesting to hear both sides.

@oyvind6838 8 ай бұрын

@@BarbaraJ1111 I do not see disagreement on the issues in this video

@nataliajimenez1870 8 ай бұрын

@@oyvind6838Dr Cywes is saying that the Randle paper was great for its time but Randle didn't know about a lot of mechanisms that have been discovered in the 50 years since, particularly the hormonal influence of glucagon in the process. Bart Kay is stuck in the past and has not kept up with new discoveries. Dr Cywes is definitely keeping up better with the new discoveries. I really recommend the lectures of Dr Richard Johnson on the metabolism of fructose to get the most recent discoveries from a biochemical and physiological perspective. If the Randle process was correct those children doing extreme ketogenic diets to treat epilepsy (fat making up more than 90% of their calories) would have developed diabetes and that is not the case

@xmenotux 6 ай бұрын

@@BarbaraJ1111 I don't see a disagreement fundamentally.

@wocket42 Жыл бұрын

Thanks, Dr.. You are the first one to explain the Randle cycle in a way I can easily understand it (and explain it to others).

@TheCuratorIsHere Жыл бұрын

Please debate Bart Kay on this as there seems to be disagreement here and we need an actual consensus to make a decision. Please. This would help a lot.

@emsea1658 7 ай бұрын

Whats his disagreement?

@xmenotux 6 ай бұрын

I don't think there is disagreement. They both seem to agree that cells don't use both fat and sugar at the same time. It's one or the other. Unless I'm misunderstanding this video.

@xmenotux 6 ай бұрын

Dr. Cywes literally says "The Randle Cycle is absolutely true".

@nevinkuser9892 5 ай бұрын

He said "true but..."@@xmenotux

@philippewinston2740 4 ай бұрын

Take away practicality : separate carbs from fats if not on carnivore diet and never exceed proteins if on carnivore diet . That's listening to your metabolic needs through taste buds Lions and cats just stop eating , when their saliva either stops or changes !

@deflo56 Жыл бұрын

Finally the pieces of the puzzle. To make a long story (2.5 years)short; fat, lost weight, lost bladder, found adenoma (flunked suppression test) and now I know why I can do a three day fast with high blood glucose and normal A1C. Thanks so much for the information.

@erharddinges8855 Жыл бұрын

Fasting and controlling overall healthy behaviour seems to leed to success.

@MvanderWel Жыл бұрын

Bravo. Very good and very respectfull (with regards to Randle) explanation of this complex subject. This is why enjoy watching your videos so much. Thanks for enlightening us by providing us with this valuable information!

@robertcywes2966 Жыл бұрын

Dankie.

@kateaye3506 Жыл бұрын

Has anyone updated the Randle Cycle with our current knowledge? I wish there would be more discussion at keto and carnivore events regarding this. Having the input of Ben Bikman, Eric Westman, Tim Noakes, Zoe Harcombe etc would enrich our understanding.

@ladislavtrojak4328 Жыл бұрын

Yes there is. doi: 10.1152/ajpendo.00093.2009 published Jun 16. 2009

@foxedrey622 Жыл бұрын

Bart Kay has addressed this topic many times.

@robertcywes2966 Жыл бұрын

Yes. See second reference in show notes. Great question

@kateaye3506 Жыл бұрын

@@robertcywes2966 Thank you!

@LTPottenger Жыл бұрын

bikman talking about brain preferring ketones to sugar by about 2.5 to 1 kzfaq.info/get/bejne/mJakf6hhx93Rk2g.html

@susanhayes6207 Жыл бұрын

I love the way you explain concepts. I put this talk on repeat and get more out of it every time I listen. Thank you.

@sherriedaubenmire3364 Жыл бұрын

If I am understanding correctly, we won't lose fat in our fat cells until the glucose and fats in our circulating blood is used up first? I have high triglycerides and cholesterol, prob genetic. Initially in 1995 had chest pain hypertensive episode and found a Chol >800 triglycerides >1600. Turned out I had esophogitis. I was a normal weight gal. A doctor once told me, abt 30 yrs ago that I was a hyperproducer of chol. Put me on 2 statins and fenobrate, vegan diet. Many diff diets later, and change in statin names gained upwards 70 lbs Im an overweight, diabetic nurse who.... Stopped taking fenofibrate and statin 18 mo ago. went low carb, then transition to carnivorish..a1c 5.5. Trigly 149. Ldl is 284. Hdl 58 vldl

@erharddinges8855 Жыл бұрын

You found your own way, and it never begins with statins,I think.

@suzannewhitaker3507 4 ай бұрын

Question: Does this mean "Don't eat carbs with your fat because the fat burning will be blocked and result in insulin resistance and cause metabolic syndrome."?

@arwenhardy1995 Жыл бұрын

Beautiful explanation of the Randle Cycle; presented without the arrogance and sarcasm of, say, a Bart Kay. Lol. Much love & respect.

@bonnieo8 Жыл бұрын

Yeah, Bart Kay may have the correct facts, but his contempt with which he expresses himself just hurts my soul. Don’t need that kind of negativity in my life.

@neechee1 Жыл бұрын

@@bonnieo8 disagree

@johnl3680 Жыл бұрын

Bart Kay seems completely nuts.

@robertcywes2966 Жыл бұрын

Thanks. No hyperbole necessary

@GoldenBlaisdale Жыл бұрын

I can’t listen to Bart .. his know it all delivery and dismissive attitude of others makes him a bad communicator. On top of that his assertion that everybody is wrong about the metabolic bio chemistry and only he is right re Randle’s Paper, seems likely to be wrong as Randal was unaware of other important mechanisms undiscovered at the time the paper was written.

@GoldenBlaisdale Жыл бұрын

Hey Dr Cywes As this video is three months old, I don’t know if you’ll see this post . The issue with some very loud influences regarding the Randle cycle is that they use it to deny insulin resistance. I think they read Randle’s paper as showing that once the cell is full of energy, the cell itself down regulates the insulin receptors to block more energy coming into the cell, because that would be deleterious for it. They say because trying to put too much energy into a cell is toxic for it, the cells actively down regulate and force the excess fats and sugars to remain in the blood where they are also dangerous, but it’s the lesser of two evils. So insulin resistance is wrong as a concept. Thoughts?

@xmenotux 6 ай бұрын

Most of what you said is true though, and Dr. Cywes's video does not debunk it. Also, who are these people saying insulin resistance is wrong? No one is disputing the existence of insulin resistance, but some are disputing it as a condition. And frankly from what I've seen of Dr. Cywes, he doesn't necessarily argue against that either. He himself is saying insulin resistance is a result of too much carbs and sugars. Even in this video he is suggesting too much glucose causes a disregulation of glucagon hormonal system. Why would you have too much sugar? Because your cells don't need energy either due to fat or having too much sugar to satisfy its needs.

@yann664 21 күн бұрын

There's something fundamental that's missing here and that is that glucose must be converted to glycogen because glucose is water soluble, and that means that when it gets released into the blood stream the blood gets viscous and sticky. Think of it like trying to push runny honey round the body. It makes it extremely difficult for the heart and the body won't allow this to happen. Therefore, it immediately releases insulin in order to turn glucose into gycogen which is insoluble meaning it floats around in insoluble lumps and the viscosity of the blood stays the same. (In fact, it's so important that even the taste of something sweet starts the insulin response which is why artificial sweeteners do too). We say glucose but starches are just glucose molecules linked together so when you break down your pasta, rice, potatoes, bread etc, it becomes glucose quite quickly. This is happening before the Randle cycle gets involved and irrespective of it. Now, if you are eating carbs all the time and snacking (which you probably will because that's what carbs make you do but that's a whole other story) then you will get used to constantly having high levels of insulin in your blood stream and the receptors which can't cope with that, will tend to die off. This is insulin resistance and it's nothing to do with the Randle cycle in fact.

@GoldenBlaisdale 21 күн бұрын

@@yann664 nice explanation my understanding is like yours but a particular professor influencer who is dismissively dogmatic say's insulin resistance through hyperinsulinaemia is wrong

@runemartinguldberg9056 Жыл бұрын

It’s not the fat causing. Is the combination of fat and carbs. They block each other. Fat comes naturally with protein. So what is the unnatural part here. Carbohydrates.

@runemartinguldberg9056 Жыл бұрын

Milk is exactly a prof. Milk does the same and they gain weight in a critical phase in their life when it is critical.

@Damudean Жыл бұрын

Have you tried to talk to Prof. Bart Kay it would be nice if you two had a conversation about this cycle

@GoldenBlaisdale Жыл бұрын

Why?

@hair2050 Жыл бұрын

The guy is extremely rude and arrogant, I wouldn’t want to see a rational person discussing anything with Kay.

@Damudean Жыл бұрын

Because they are both clever people that are trying to do what they do to help as many people as they can. If you can make a point that is correct he sees that point. Bart isn’t arrogant, he is just confident of what he knows

@GoldenBlaisdale Жыл бұрын

@@Damudean not arrogant .. I think we’re watching different videos. I would go as far as to say that he is rather narcissistic. He is always completely right and everybody else is wrong. I just went back to look at his list of videos, which rubbish literally everybody. And now it appears that he’s wrong about the Randle cycle, as the paper in question missed a lot of important but at the time undiscovered information.

@hair2050 Жыл бұрын

@@Damudean you’re right. More obnoxious than anything else

@my-yt-inputs2580 5 күн бұрын

Ben Bikman has done a few videos on the Randle cycle since this video was first published. He just very recently did one with Ken Berry which included a short discussion of the Randle cycle. Bikman made a very compelling condition on using an untreated Type 1 diabetic as a perfect example. The untreated T1D will have sky high glucose and will also have sky high fatty acids. Yet because NO(or very little) insulin is present the body will ALWAYS choose the fatty acids for energy even though there are tons of glucose available for use. As soon as you treat with insulin the body will shift to burning glucose. Which brings us back to the Hormone insulin. Which is where/how insulin resistance can effect things. "Construct" or not.

@uberneanderthal Күн бұрын

insulin's job is to shuttle glucose out of the blood and into cells. the Randle Cycle's job is to protect the cell from glycation and mitochondrial burnout. it is by design that the Randle Cycle overrides the role of insulin, because it is more important to protect organ and muscle cells from glycation than it is the more easily replaceable red blood cells.

@TheMJT515 Жыл бұрын

So how do we increase insulin sensitivity vs insulin suppression? Great video btw.

@arwenhardy1995 Жыл бұрын

I did it by lowering my carb intake to as close to zero as possible; eating two meals per day. Best regards.

@lucia_cossu_voiceteacher Жыл бұрын

For what I have understood it is a two phases process: by a ketogenic or fat adaptation process you get back to insulin sensitivity in most cases and when fat adapted you avoid the insulin suppression by reintroducing carbs one or two times a day (dairy for me is optimal and I do some days but have still cycles of pure ketogenic).

@CarbageMan Жыл бұрын

@@lucia_cossu_voiceteacher That's what I'm thinking. I've recently taken to having carbs after exercise, and I'm considering being more judicious about how much protein I eat in one meal, to limit gluconeogenesis.

@erharddinges8855 Жыл бұрын

is this the key?

@phinehaselohim7111 Ай бұрын

This is why I am not concerned when a carnivore's body produces more glucose on demand via gluconeogenesis and the individual may have a slightly higher fasting glucose reading of course it will be higher!!! the on-demand process in the liver is happening DURING fasting in the person who consumes no carbohydrates

@zuleikadobson Жыл бұрын

Love this, but barely hanging on. I want more of this, please. However ... can you please suggest a book/books to read and study about biology - especially of the cell - and and "Microbiology for Dummies"? I need to repair and rebuild a foundation begun long ago. Thanks!

@brookstorm9789 Жыл бұрын

You are a masterful teacher. So pleased to have a better understanding.

@tampajan1790 Жыл бұрын

A chart or diagram would have been very helpful. It was hard to follow you.

@michaelwaldmeier1601 Жыл бұрын

I would say, "essential" in order to make it easier to comprehend. In the British National Library, a book written by Leonardo Da Vinci had illustrations, captions, and explanatory paragraphs, it was a good example. In contrast in an adjacent room, a copy of the Magna Carta showed that the tremendously important content was made difficult to comprehend because of the poor writing style.

@alexakalennon Жыл бұрын

It's called pen and paper. It's used to take notes.

@brucemckay6615 Жыл бұрын

Yeah… Bart Kay has a few videos about RC with charts…. Worth a look…

@janrios7516 Жыл бұрын

@@brucemckay6615 Yes, thx... much better 👍

@stealth48nurse 5 ай бұрын

Prof Bart Kay was on the Nutrition with Judy channel and showed charts explaining the Randal Cycle.

@dr.robertjohnson6953 Жыл бұрын

Very good. I love getting into the science of things. Now, consider this. Heart disease. Plaque build up. Calcium build up. The CAC score is a measurement of built up calcium, under the plaque. But what is causing the calcium build up? Is the calcium somehow attracted to the damage done to the arterial wall? But what about oxolates? Oxolates build up in the body. Oxolate crystals build up, get caught is these damaged areas. Oxolates love to bind with calcium. Could it be then, that the plaque build up is caused by oxolates? If so, there is a larger commonality in heart disease with Plants than with animal products? Many plants contain oxolates, so ergo... The root cause of heart disease is plants?

@troytmd Жыл бұрын

Interesting! In a review of coronary arteries from 80 patients, we found 4 cases in which there were prominent oxalate deposits within the atherosclerotic plaques in coronary arteries. Oxalate deposits were also present in the media of arteries, the thyroid gland, and other organs, but not the kidneys, and the patients surprisingly did not have renal failure. (Fishbein and Fishbein 2009, p. 1315)

@ryanray6215 Жыл бұрын

Yes ! Dr. Robert Kiltz explains that beautifully on KZfaq .

@arwenhardy1995 Жыл бұрын

I'd say oxalates could be a contributing factor but it's my understanding that heart disease is caused by excessive, inappropriate carbohydrate consumption.

@redhotz21 Жыл бұрын

Our bodies can make oxylates on its own

@mikewoodward8532 Жыл бұрын

And what would cause the body's inability to properly dispose of oxalates before they are deposited in arterial plaque?

@pattib1731 Жыл бұрын

Dr. Cywes, I understand some of this, but too fast and detailed for me to synthesize and retain. Would like a simpler more concise explanation. Also would love a video with recommendations for labs to check for insulin resistance, glucagon excess, etc. I try to eat a lot of fat with meals and limit protein, but am not satisfied with less protein. This is on pure carnivore with nothing plant based or sweetness of any kind. Could glucose produced from higher protein be driving overconsumption? I think I'm a fatty with no shortage of insulin, not diabetic. Thanks for your great videos.

@erharddinges8855 Жыл бұрын

At the end everyone needs practical advice what to eat and to do and what to avoid!

@Emadagban777 Жыл бұрын

There is a crucial point that needs to be highlighted here which is where all of the excessive free fatty acids come from in the first place. Dr Ben Bikman explained that adipocytes start leaking FFAs when they become hypertrophic, up to 4 times their normal size, as the fat droplet within the fat cells gets larger, perilipin can no longer protect the stored fat from the effect of lipases. Again, it is Insulin that activates lipogenesis and it is carbohydrates that spike insulin.

@chrisryder1073 Жыл бұрын

I wonder what it is about one's lifestyle that is influencing this hormonal imbalance, looking more holistically, is there a primary imbalance somewhere else?

@robertcywes2966 Жыл бұрын

Yes. Carbophilia and lipophobia

@JohnnyRay920 Жыл бұрын

@@robertcywes2966 But I love both!

@ryanray6215 Жыл бұрын

So true . I'm about 3 yers on a carnivore . I feel way better if I add lots of fat to my diet like pork shoulder , pork belly , butter , makrel etc .

@hohohomer8566 Жыл бұрын

@alba:you should stimulate your bile by eating bitter things 😉

@YeshuaKingMessiah Жыл бұрын

@@muchasalud2011 don’t tolerate how? GI upset? Scale back. Eat a little more every week. Take bitters as suggested above.

@ketontrack Жыл бұрын

He is not only saying eat fat. He is saying become insulin-insensitive but don't suppress insulin. So we need some sugar just not excessive

@gribbler1695 Жыл бұрын

@@ketontrack Any sugar you eat is excessive, toxic and not required. That's why the body wants to get rid of it first.

@erharddinges8855 Жыл бұрын

That´s an everyday question to make life and meals more comfortable. Meat and fat without any bread or potatoes is not funny.

@gaylerule6707 Жыл бұрын

A great explanation. Thank you for clarifying this.

@ConanFC Жыл бұрын

You're going to get a review from Bart kay

@TerriblePerfection Жыл бұрын

😂 I wish I had a euro for every time Bart's mentioned in KZfaq comments.

@ConanFC Жыл бұрын

@@TerriblePerfection I think that the Dr have made a good point, let's see what will come in the future

@TerriblePerfection Жыл бұрын

@@ConanFC I would bring the popcorn but...

@pirkkarannali Жыл бұрын

👍🏻👍🏻

@M-MMo Жыл бұрын

Super important video! Thank you for all your work, Dr. Cywes, we need to understand in order to do the right thing. Eat fat, not carbs!

@wilsont1010 6 ай бұрын

Which part if the Randel Cycle say this?

@LTPottenger Жыл бұрын

eating fats doesn't make fat in the blood (triglycerides) go up. Eating carbs do. This is 100% caused by carb overconsumption. You should always eat fat with each meal, whether it has carbs or not. And there is no natural healthy food that you would want to eat that has only carbs in it anyway. So the people who characterize this as saying not to eat carbs and fat together are wrong. This is a pathogenic state caused by eating too many carbs.

@gribbler1695 Жыл бұрын

Don't mix fats with carbs, since carbs shut down lipolysis leading to fat storage.

@daleval2182 6 ай бұрын

As the vegan dumps fatty dressing,seed and avocado to his salad

@maryannehill8821 4 күн бұрын

Love how you explain this, thank you Dr Cywes 🙏

@RenG24 Жыл бұрын

Dr. Cywes, you are 💯 brilliant man. Thank you so much for your blunt explanation‼👏🏻

@GoldenBlaisdale Жыл бұрын

Hi Doc great video. Question: Does the Randle cycle debunk the concept of insulin resistance? Others explain the Randle cycle thus: “When a cell is full of fat it will lock the door to both fat and carbohydrate because there is heaps of energy stored in that cell ready for use, we don't need it right now and actually sugar inside your cells is incredibly toxic. So to protect the inside workings of the important cells like muscle cells, organ cells etc the ‘door is locked’ no more fat can come in.… We don't need any more sugar so we are locking the door to that sugar too, so it then sits in the blood and starts to pool in the blood which is detectable as an increase in your fasting blood glucose level…. They then diagnose it as ‘insulin resistance’, no, it's nothing of the sort, it's a mechanism by which the body protects itself from damage. The sacrificial lamb in this case is the red blood cells which become damaged by the glucose in a high blood sugar situation.” Is the above what the Randle cycle describes?

@dr.robertjohnson6953 Жыл бұрын

Insulin resistance is not a thing in and of itself. It doesnt exist in the way that its there, and can be measured directly. The Bart Kay says it best. “Its a concept”. But its a valid concept, in that we can see results of it physiologically or pathologically.

@GoldenBlaisdale Жыл бұрын

@@dr.robertjohnson6953 this isn’t my area of expertise, though I have been carnivore for five years mostly finding my own way. Only recently have very knowledgeable people got into the space. So in general, I’m not arguing the rights of wrongs but I’m finding the infighting confusing. For me, it doesn’t really matter whether the Randle cycle locks the door to more energy coming in as Bart says. Or if the cell becomes resistant to normal levels of insulin and needs more to push energy into it. In the end like most animals if we eat the diet we are supposed to we will be healthy. Understanding the biochemistry is just interesting. For example, another Bartism is that evolution just hasn’t bothered to turn off our digestive enzymes that digest starches. I think that is just wrong. I don’t think we are obligate carnivore and many people can eat a mixed diet including starchy veg my whole extended family have done so in the past and without those starchy vegetables would’ve starved to death. Most people during the Second World War in the UK would have starved without our ability to make use of plant starches. And although it is only my experience, my mum has just turned 90 and just about everyone in my family from poverty in the Welsh valleys have lived to their very late 80s and 90s none of them were on a carnivore diet. Yet they were all healthy and died of old age. And another example, I turned carnivore as I say about five years ago, I’m 58, so I until about the age of 52 I ate a western diet, though I didn’t indulge greatly in processed food. However, I have drunk copious amounts of alcohol and suffered hangovers, and yet when I had my CAC score measured, my coronary calcium was zero. That’s 52 years on a standard diet.

@robertcywes2966 Жыл бұрын

Randle cd not consider insulin resistance bc did not know about GLUT4 receptors

@heavychevy4616 Жыл бұрын

merry christmas, happy new years, & thank u sir for all uve done for us. god bless

@ItalianGoneCarnivore Жыл бұрын

Dr Cywes, I live to explore, explore explore. I continue doing the research And I so appreciate these types of videos. 2 weeks ago it dawned on me that my A1C went from 4.9 as a 10-month low carb eater to a 5.4 as a mostly omad carnivore (for just 6 months). This makes perfect sense to me. My question is, what if in my next A1C blood reading my numbers are higher? Is it problematic? I literally eat meat, eggs and occasionally cheese.

@robertcywes2966 Жыл бұрын

Yes. U need insulin release. Wd be a good idea to check ur bloodwork

@erharddinges8855 Жыл бұрын

Maybe a keto diet a la long is not the golden way?! Change to a low carb diet?

@ItalianGoneCarnivore Жыл бұрын

@@erharddinges8855 Thank you for the suggestion.. I found my way! kzfaq.info/get/bejne/a5qlepSk3ryZiYU.html

@YourLifeRedefined Жыл бұрын

No. A1C measures the life cycle of red blood cells and they live longer with a Carnivore diet which raises the A1C. If it raised under a SAD then you have worries. This is why a fasting insulin or HomaIR is a much better measure of metabolic health, especially for us carnivores. Under 5 is good. Dr. Paul Mason discusses this quite often.

@ItalianGoneCarnivore Жыл бұрын

@@YourLifeRedefined Thank you! I have since learned all of this and am doing great! A1C of 5.1 and thriving!!

@tubasteinar Жыл бұрын

Wow, what a beautiful rabbit-hole... Very interesting!

@thewellnessroom6574 Жыл бұрын

Wow, totally loved this breakdown! Made it so easy to follow and understand! Always questioned the theory of fat causing diabetes and now it is super clear.

@Davidkxf Жыл бұрын

Do you think it's this Randle Cycle what gave me two heart attacks on the carnivore diet?

@robertcywes2966 Жыл бұрын

Nope. Likely ur precarnivore lifestyle and sudden plaque rupture

@joelouis1667 Жыл бұрын

Thanks Dr. Cywes!!!!! Kind of complicated for me!!! To make it simple: Can we combine fat and carbs in the diet without being detrimental for health??? Have been doing that for all my life and am in my 70´s, proper weight, work out 3 p/week, strong all my bloodwork very good, HDL 59, Triglycerides 44, glucose 78 ??????? I feel so confuse????? thanks for all your help! Of course, never use seed oils nor processed foods or sugar by itself.

@erharddinges8855 Жыл бұрын

Your way seems to be the best! Trigl/HDL under 1!!

@joelouis1667 Жыл бұрын

@@erharddinges8855 Thanks Erhard!!

@paulwood5534 Жыл бұрын

Enjoyed this video. Can I suggest a video on lactate metabolism? Trying to comprehend Xiaolu Li et al Lactate metabolism in human health and disease and also George Brooks Role of the heart in lactate shuttling. You mentioned lactate at about time stamp 15:00. Lactate seems to be a potentially greater source as a fuel than previously given credit, but only if one is adapted to using it? I’m 61 and have been doing low carb for about 5 years. Been seriously exercising the last 3. Did a fitness test at UT in May and I have a pretty high VO2 max and and a really good ability to clear lactate (as measured by aerobic fit w/ lactate test). I’m wondering if the ability to clear lactate is a surrogate of metabolic health?

@erharddinges8855 Жыл бұрын

Isi t?

@robertbucsh8840 Жыл бұрын

I went to nerd heaven with this video! Thanks Dr. Cywes.

@whatta1501 Жыл бұрын

Thank you so much, i always wondered why my sugar levels were high even when i would fast.

@daleval2182 6 ай бұрын

It takes up to 96 hrs before we spend the livers glocogon,

@grahamhobbs5491 19 күн бұрын

Hoping the good doctor reads my question. My wife is on a Jak inhibitor , ruxolitinib, for myelofibrosis. She is on a strict low carb diet, attempt to keep daily carbs below 20g . For some reason she seldom if ever goes into ketosis. Could the drug be somehow interfering with this cycle?

@DaveIrish66 23 күн бұрын

What's your thought on being metobolically flexible while endurance trail running? I am animal based during my normal day, I mix in carbs /fruits for a little extra energy but only about 25-30g hr.

@christinashawgo6510 Жыл бұрын

You hav a brilliant way of explaining

@juliapace2845 Жыл бұрын

Good explanation. Thank you.

@ellie698 Ай бұрын

So, if following a carnivore diet, should i include a small amount of carbs with my fatty meat, or not? I'm so confused! Dr Bart Kay says to eat no carbs ever. But I've recently discovered that another role of insulin is to allow immune acids to ever a cell and stimulating protein synthesis. Which is good🎉, right! So that would suggest that *some* insulin production is a positive thing. Not excessive production, but some? I don't know what to do now. I'm so confused 😵‍💫😵‍💫😵‍💫😵‍💫😵‍💫

@uberneanderthal Күн бұрын

protein stimulates insulin production, while avoiding the nasty spikes carbs create. this is why most keto diets are low-protein, because protein will 'kick you out of ketosis'. but the benefit of low-carb isn't ketosis, it's alleviating the Randle Cycle.

@gigalyrics Жыл бұрын

very well explained! thank you

@Bepartofthepanacea Жыл бұрын

Wow this explanation is gold 👌 thanks

@user-fx4ds9re4z Ай бұрын

barts data is more updated. showing that the glucose is blocked at the glut 4. meaning not reaching pyruvate etc. also sliding scale

@VerySeriousUser Жыл бұрын

Very interesting video! Do we know the mechanism(s) how insulin resistance actually happens? E.g. how does the Randle Cycle (or inflammation?) cause GLUT4-receptors to stop working or perhaps the insulin receptors stop working? I keep hearing about how inflammation causes insulin resistance but to me it is a big, important puzzle piece to have a somewhat complete understanding, as a layman.

@robertcywes2966 Жыл бұрын

Yes we know some but not all regarding IR

@erharddinges8855 Жыл бұрын

May be it is only a question of quantity in ovarall intake

@jberts3141 10 ай бұрын

My understanding of IR is the more insulin you produce the more resistant you'll become over time. I think more importantly than that simple concept is what we eat and the consequences of that. Take seed oils as an example, they cause a compound called 4HNE which damages the cells ability to respond to insulin it causes fat cells to grow instead of divide until they can't grow anymore and cause disease. A good book for this is "why we get sick" by Dr. Ben Bikman PhD. And zero acre farms has good info on their website under "white papers"

@markfox3083 Жыл бұрын

This is supposed to demystify but I think I couldn’t follow this at all. Need some graphics or something.

@brookstorm9789 Жыл бұрын

How do we modify the carnivore diet to control sugar from glucagon?

@adriansrfr 3 ай бұрын

What do you mean?

@brookstorm9789 3 ай бұрын

@@adriansrfr It's been a while since I heard this Adrian. I no longer remember the context.

@carlosvangrinder3754 8 күн бұрын

Excellent video, thank you.

@richardjohnston4682 Жыл бұрын

Dr Cywes, should we be careful of eating too much protein? Thank you!

@robertcywes2966 Жыл бұрын

No, but seldom lean

@marcjames3487 3 ай бұрын

Many thanks Dr. Cywes - it took me a cup of tea, notes and replays but at last I feel I understand what's going on. I've been carnivore for a while but looking at Ketovore. My take away is - add a few carbs to give my insulin a work out but continue with intermittent fasting.

@adrianamil3 Жыл бұрын

Very interesting video! I am curious: why in case of insulin resistance, the cell does not just switch to fat use, since not enough glucose enters them, instead of causing diabetes and other metabolic ilnesses? Another video about this would be very welcomed! Much love for your work, doc!

@oyvind6838 8 ай бұрын

Why poison the cells further with carbs? Fat adaption takes time and excess sugar damages the circulatory system. One must accept lower energy while the mitochondria translates into fat burning mode.

@patriceferguson7340 3 ай бұрын

As a type2 listening on these fascinating topics and also having for decades experience with ADA explaining it. And you and Bart K my own anecdotal experience doesn’t see fault with either gentleman. Rather that there are levels to this disease that disrupts chemical physiology. In my case it Non alcoholic stetoses or NASH. The communication between liver and pancreas were muted due to excessive fat on the liver and pancreas making them hard of hearing towards each other if you will. The insulin resistance is a body’s way of protecting the muscles and mitochondria from the excess supply of energy regardless of where it is coming from. Be ketones from fats that the liver also supply in and exogenous glucose from carbohydrates. And that glcogenous hit job called dawn. effect. The latter will be using the stored fat already turned into glucose that is trapped on the liver’s surface and glycated red blood cells. Even fasting 24 hours for a Gastrointestinal exam didn’t bring my blood sugar down 5 points. As my levels were 684 the start of the fast and by the time I was checked again it had only dropped 679. It was years to clear the liver issue up and get those enzymes under control before even insulin would bring my levels below 400. Insulin resistance was doing double duty damage control but the odd thing about that was my insulin levels in fasting was .08 and after a OTT they only gotten to 1.26. My triglycerides. 90. . Figured I was not a type 2 but a late adult type1 running out grace. But 3 years later I am satisfied that with limited insulin reserves I do eat strict carnivore and limit my bolus to 800 calories in a single meal per day. Now my A1c is 4.6. And I am still producing some insulin. I just don’t eat out of my production limit because I don’t want to start insulin and have that thing quit on me. Is it more to find a balance what amounts the body absolutely needs to restore balance. It will do the rest.

@postwarmage2839 2 ай бұрын

I knew it, the skeletal muscle and the muscles of the heart prefer non-Esterfied fatty acids over glucose!! I told this to people and they think I am crazy of course

@davenockels5028 Жыл бұрын

What a great educator……. !

@slowbaker Жыл бұрын

The only thing I understood was, "Don't eat sugar, eat fat." That, I can do!

@adriansrfr 3 ай бұрын

You would have to be able to eat an absurd amount of protein to create a state of high blood sugar. For carnivores, some blood sugar is necessary in order to create some insulin spikes which helps with retaining electrolytes. Cramps is an indication of too little protein.

@Philipk65 Жыл бұрын

Really interesting but it certainly went over my 😕

@missygee6155 2 ай бұрын

So in plain terms, what does that mean? Keto and carnivore are the way to go? According to the study, Bart Kay says that we should never ever ever ever eat carbs. At all. None. No vegetables, no fruit.

@AdamRK78 Жыл бұрын

Dr Cywes, What's your response to the myth that high fat intake is the cause of heart/cardiac disease, especially in light of the recent discovery that high blood pressure in diabetes may be linked to the effect of GLP-1 on the carotid body? Thanks!

@robertcywes2966 Жыл бұрын

We blamed fat for what nicotine did. Now they blame fat for what carbophilia is doing

@ekondigg6751 Жыл бұрын

I think the word "cycle" is a bit of a misnomer which tends to lead people to a wrong understanding. It's not like, say, the Krebs cycle where we see a circular chain of reactions. It's more to be thought of as explaining an either/or function where cells will either (almost) exclusively use fat for energy or (almost) exclusively glucose, but not both at the same time, except in exceptional circumstances.

@bahkbahksa8339 5 ай бұрын

I heard muscle also has insulin independent glucose receptor which is recently 🤔 verified. This is very complicated..... If you read Dr. Jorge Watson 's Nutrition and your Mind book which is written 1970's maybe he verified carb and fat should be simultaneously existed by every meal consumption because they work coordinatedly for normal ATP production. Otherwise they became mad because oxalo-acetate from glucose pathway and acetate from fat are not combining enough each other. What is the conclusion between Dr. Randle and Dr. Watson ?

@SueWoledge Жыл бұрын

So how do we increase insulin sensitivity?

@daleval2182 6 ай бұрын

Eat meat and fats ,which in return we become fat adapted , and our body will reduce fatty heart and liver, after we get the fats back to optimum, we begin to repair damaged insulin sensitivity

@lindachase1474 Жыл бұрын

Thank you for this information. However, how does one fix the problem of not being able to lose weight or bring their glucose down and stop being insulin resistant? I'm not a scientist (or a doctor) so I am at a loss of what to do and I cannot find anyone in my area to help me. Where do I go to find the information I need to fix myself?

@erharddinges8855 Жыл бұрын

e.g. go to doctor Robert Lustig on you tube! Reduce carbohydrates strictly!

@mohammedrehman8306 Жыл бұрын

Dr cywes can you please make a video and clear up what a fella called Georgi Dinkov is claiming about how excessive lipolysis from fasting and keto diets can cause inflammation in our bodies because the stored fat is mostly PUFA fats. He has scared the shit out of me about keto.

@erinmariebaker712 Жыл бұрын

Bart Kay has some videos on this that you may find helpful.

@josk5673 Жыл бұрын

I would like yo see that video from Dr Cywes as well.

@josk5673 Жыл бұрын

@@erinmariebaker712 What is the name of that Bart Kay video? I tried to see if Bart responded specifically to Georgi, but did not find one.

@jksinorbit Жыл бұрын

Gotta burn through those Pufas anyway… no other choice.

@robertcywes2966 Жыл бұрын

Ignore the noise. It will always buzz in the background

@rajeevarora190 3 ай бұрын

Reference charts to understand this better would have helped.

@TomSmith-cv8hk 6 ай бұрын

I didn't know that Randle blamed fat for Diabetes, I thought he blamed carbs. If you mean he thought being fat caused obesity I think all the skinny diabetics would have showed him otherwise. I've always been thin but can easily shift my blood glucose, cholesterol and triglycerides with diet changes, have to swap one for another though, can't get them all low simultaneously.

@mrrpgswe8931 Жыл бұрын

This was just beutiful. Please, do not hesitate to do more ninja nerd hardcore stuff. I Just loved this one. As a layman I have wondered how the heck researchers could empirically identify the electron transport chain, the compartments and all that jazz. If someone could explain how thing like thas was identified it would be a real treat.

@9kat53 Жыл бұрын

Can you consider please doing a supplement to this video that explains it all in even more layman-language? I know you have significantly dumbed it down here, but if it cld be on the level of "insulin knocks on the cell's door" etc but for each of these chemical actions? It cld be both fascinating and motivating to think about the entire chain/sequence of events that happens both when we eat right and especially when we don't. Thank you for this video!

@marcoseggi7274 3 ай бұрын

Great great video and point of view, you show Always beautiful thinking on fisiology. I love It, ehat do you think about this? Your thinks lead me to think our ancestor, they moved a lot so their muscles had GLUT 4 spiking more trough cells membrane (insuline sensitivity) could Just fisical Activity the last puzzle in the low carb, carnivore or keto ? Just mimic ancestors fisical Activity and nutrition, at least we are Just their gene heritage.

@CarbageMan Жыл бұрын

So, when you hear people say fat causes insulin resistance, they're referring to Randle's incorrect assertion, and thus, they're wrong. Additionally, excess protein may not seem to be problematic, but it does indeed cause high blood sugar in someone who already has chronically high insulin. This tells me that it's very important to consume an appropriate amount of protein, of an optimal (animal) type, and even more important to make that protein source fatty or accompany it with fat, to avoid overproducing glucose. What I find interesting about this is that many carnivore advocates claim that gluconeogenesis is on-demand. This seems to indicate that is not true. I started my diabetes-reversal journey by extended fasting and eating a moderate-protein ketogenic diet, which many would say is appropriate, in context. However, I believe I did not get enough protein (I developed a hip issue) and went the other direction-to a "ketovore" diet, with (truly) intermittent 36-72 hour fasting on some weekends. I believe I've corrected protein issues, but my blood sugar isn't ideal (it's still below "pre-diabetic.") Now I'm trying to figure out how to best adjust. I'm doing more weight training now, so I presume that will help. I suppose I should be eating 3MAD with more level amounts of animal protein, and including fiber, to throttle gluconeogenesis. My preferred way to do that would be to accompany meat with cruciferous vegetables (which is more or less what I do, but I don't alway eat the veg.)

@CoachStephen 6 ай бұрын

I cant believe how long winded this is to explain a very well known aspect of type 1 diabetes called 'glucagon dominance' many things are examined once you simply learn that phrase. People on keto or carnivore have low levels of insulin and when eating protein you see a small bump in blood glucose due to glucagon (not the protein) and seems Robert does not know this either. It is common knowledge but he presents it like he has discovered something

@rheasarma1486 10 ай бұрын

Is it pkf or hexokinase? Because hexokinase converts glucose to G6P which can't leave the cell

@Damudean Жыл бұрын

I didn’t think the Randle cycle said fat causes I thought it explained too much sugar causes the problem when we have fat as well

@GoldenBlaisdale Жыл бұрын

Because most people in this space heard about the R. Cycle via Bart Kay. And Bart in his very ‘know all’ way rubbishes the idea of insulin resistance as a concept and uses this paper mistakenly to assert ‘the science is settled’ when Randal was unaware of other key components like glucagon. In other words Kay has muddied the waters and given us wrong conclusions.

@runemartinguldberg9056 Жыл бұрын

Would Cywes read Randall’s paper if Bart Kay didn’t bring them.

@robertcywes2966 Жыл бұрын

Nope. He blamed fat

@GoldenBlaisdale Жыл бұрын

@@southern842 What you said in my opinion fits with reality. Our bodies have complex enzymatic machinery to break plant starch into glucose. Kay says this is an evolutionary over site. There in you see his biased reasoning, denying reality to ‘prove’ we are obligate carnivore. Our ancestors if they had had a successful animal, kill and plenty of fatty meat and by coincidence came across starchy tubers, or sugary fruits. They would most certainly have eaten them together. One of the missing keys that I used to heal myself was fasting. Fortunately, Jason Fung was one of the first in the low-carb space, but focused on fasting. And fasting is ancestrally relevant because there would not have been an absolute guaranteed access to food at all times. I think one of the big mistakes, when thinking about the best diet for human beings, is not taking into account the not eating part of the process and it’s benefits e.g autophagy.

@xmenotux 6 ай бұрын

@@GoldenBlaisdaleI disagree. Both Dr. Cywes and Bart Kay agree the Randle Cycle is true. They may or may not agree on some of the nuance of why, but ultimately that's less important.

@jdawginu2668 Жыл бұрын

So what do I do on the carnivore diet to apply everything correctly

@robertcywes2966 Жыл бұрын

Check ur bloodwork

@redhotz21 Жыл бұрын

Nope, still not clear. Too much technical talk in the beginning to understand and agree with later summations

@robertcywes2966 Жыл бұрын

Warned ya!🙂

@aspiresk8boarding 2 ай бұрын

Separating carbs and fats in a meal is the wrong take away from the randle cycle. If u eat a meal with carbs and no fat you’ll be hungry in an hour. If u eat a meal with high fat no carb there will be enough insulin resistance to allocate glucose the cell that need a constant supply of glucose. Fat simply slows absorption of glucose. Eat the amount that helps u last 3-5 hours between meals if ur eating a balanced diet. If you’re eating low carb or keto… good luck

@darlafitzpatrick8770 Жыл бұрын

So interesting. You don't even need to understand the Randle cycle to recognize that competitive athletes (and their coaches and trainers) don't actually need to replace every calorie they burn during a competitive event. Yet they continue to force sugary gels and other crap into their systems at a rate of 100-200 calories per hour, often puking and bonking in the effort. It's hilarious to me. I spent the last dozen years as a recreational (not competitive) endurance runner who learned this from a book written by Phil Maffetone (a pioneer in this area) years ago, and I even had my fat-burning capacity measured in a sports medicine lab at a university. If a weekend warrior like myself can burn fat at very high levels during hard efforts, imagine what a highly trained, professional runner or cyclist could do if their coaches understood what you're describing. (A small number of them do know this, but they are considered a bit kooky in that world.) In my less-trained state, a marathon or a long trail race is very hard for me, and it takes me much longer to finish than a competitive athlete -- and yet, I can do it without ingesting a single calorie for hours. No gastric distress, no bonking. But competitive athletes are brainwashed into thinking it is not possible to generate your own energy during hard efforts. Their coaches calculate how many calories they're going to burn at a certain power output and make their athletes set timers to guzzle down an equivalent amount of sugar every twenty minutes to prevent... sudden death? (ha). Sure, some supplemental fuel might be needed or helpful at times for top-level performance, but the belief that you have to replace every calorie burned in real time is nonsense. This is why some marathoners and triathletes can have visible fat around their midsection despite training for 30 or 40 hours per week.

@mikafoxx2717 Жыл бұрын

This kind of training makes me think of the stories I've heard of ancient message deliverers that could run for up to days on end without stopping. Maybe a little overblown, but an interesting connection.

@patora13 Жыл бұрын

It was very clear. But the question is, how to restore and increase insulin sensitivity. A ketogenic diet seems to be one answer, fasting another, excercise (aerobic, anaerobic), combinations, etc. But as useful that it is as a lifestyle intervention, it seems a very simple approach to me. There are many situations, many hormones, women and men, pre- and postmenopausal women. With or without T2 diabetes, more or less insulin sensitivity, more and less excercise, etc. It's a puzzle that seems very difficult to access for a lay person, but of uttermost importance for our lives. How we get out of this situation is the question. How we can accelerate the metabolic changes needed to get healthy again. What are the different intermediate stages. How to identify them. I am fascinated by the science and knowledge available, but still incomplete.

@robertcywes2966 Жыл бұрын

This is what we do clinically w our pts. Figure out where they are and guide them onward. Bloodwork is key

@erharddinges8855 Жыл бұрын

Yes, this is the question, and many ways will contribute to come to success. Nevertheless all will have an end.

@FrannyBeepsAttic Жыл бұрын

I was keto for 2 years now I've turned Carnivore and I am experiencing still elevated BS. I am insulin resistant. How do I become insulin sensitive?

@hanshans7491 Жыл бұрын

Try with fasting

@craigzdyb390 Жыл бұрын

Extended fasting with only water. Work up to three, four and five day fasting once a month. Look at Butter Bob Briggs' video on the 50% insulin problem.

@Theoriginalgreenring Жыл бұрын

So how does all this play into lipidema and fat disorders? And can carnivore eventually reverse lipidema? I did carnivore for 19 months with little effect on my waist down lipidema fat. Even with exercise. Lipedema feels hopeless..the mobility limitations are the worst part.

@ivermec-tin666 Жыл бұрын

Have you looked into your hormonal levels and thyroid function? Keto will burn dietary fat first, and interstitial fat next, then fat around the core, and fat at the extremities last. Did you try daily intermittent fasting with a feeding window of 4 hours?

@ansebbianslip Жыл бұрын

I’ve heard on more than one occasion that for lipedema patients Doing keto, especially carnivore that adding fat is an absolute necessity when eating protein as i believe part of that is it will reduce the effect of turning proteins into sugar

@ivermec-tin666 Жыл бұрын

@@ansebbianslip Absolutely correct. The fat to protein ratio needs to be dialed in, neither Jack Sprat nor his wife managed this appropriately.

@robertcywes2966 Жыл бұрын

Set up a visit

@hair2050 Жыл бұрын

@@ivermec-tin666 😂

@cubeamspro1003 11 ай бұрын

What then breaks the Insulin/Glucagon negative feedback mechanism? What causes insulin resistance? This is an incomplete explanation and does not refute the assumption that excess fat causes IR. Secondly, if fat is the preferred cell fuel, then how come the carbohydrate loaded athlete can smoke any day of the week the ketogenic one?

@jaym9846 8 ай бұрын

For the same total calories, is there a certain combination of carbs and fats the maximizes the storage as fat?

@onestep1646 2 ай бұрын

no it is the fat that causes the insulin resistance but thats not the bad thing it is an adaptation of the body to spare glucose for cells that only can use glucose like blood cells or some parts of the brain It is a problem however if you continue to consume large amounts of carbohydrates (glucose) in a high fat diet then muscle insulin resistance becomes a problem and we see that in so many studies feeding a high fat high carb diet is the problem so yes it is the fat that causes the insulin resistance but thats only bad if you keep eating carbs while eating high fat

@alan2112drums Жыл бұрын

If a zero carb carnivore adequately produces insulin, is the Glucogon simply permitting Glycogenesis (where a carnivore gets the necessary glucose for cellular function without eating sugar)? Inversely, is a type 2 diabetic, who injects insulin and takes a statin, hyperglycemic due to normal Glucogon and low insulin (or insulin resistance)? Thanks for these informative and very important videos.

@mjoh090 Жыл бұрын

Fantastic insight! The takeaway message for me here is that we don’t want our blood sugar level to get so low that the body begins to continuously rely on glucagon to maintain a normal blood sugar level. This is because persistent excessive glucose production from constantly elevated glucagon levels can cause insulin resistance. The solution to this potential problem would therefore be to consume enough cabs with each meal that would support a normal blood glucose level while minimising the impact on insulin levels. This in practise would mean consuming low to medium glycemic index fruits as part of a keto/carnivore diet that have a low glycemic load - e.g. blueberries, strawberries, rock melon etc. This approach would essentially turn a carnivore diet into a meat based diet.

@erharddinges8855 Жыл бұрын

What kind of insulin resistance could this be? a secondary, due to keto diet? I have enough with my primary resistance!

@mjoh090 Жыл бұрын

@@erharddinges8855 I think it is more a concern associated with the carnivore diet where there is virtually no carbs ingested. probably not so much a concern with the keto diet where there are some carbs incorporated into the diet.

@adriansrfr 3 ай бұрын

You've got it completely backwards. You're body makes all of the glucose it needs. Glucagon activation is the preferred method and insulin activation needs to be kept at bare minimum. It sounds like you are saying glucagon resistance is a big problem and the solution is to tax the pancreas more with sugar to stimulate more insulin progression because diabetes is not a thing.

@mjoh090 3 ай бұрын

@@adriansrfr Glucagon and insulin work in balanced opposition and are regulated in a negative feedback loop. It is indicated in the video that type 2 diabetes can develop when this negative feedback loop is broken by persistently elevated glucagon levels. Did you watch the full video? If not see video at time 26:45.

@adriansrfr 3 ай бұрын

@mjoh090 , yes, that is why sugar and fat taken together are contraindicated. It confuses the cell's, and they reject both. The result is visceral fat. The confusion doesn't last for a few hours, it can last days. This explains why vegetarians can be lean (low fat). Keto can be lean (low carb). But those who choose to confuse the Randle cycle will end up overweight if not obese.

@Guccituccixo Жыл бұрын

Exercising muscles prefer glucose. Be careful misleading when mentioning athletes

@jobrown8146 Жыл бұрын

Thank you. I think I understood most of it.

@hair2050 Жыл бұрын

Ha, wish I could say the same 😊. Nar, more or less. But I would have appreciated a more succinct summary

@desmomotodesmomoto2033 Жыл бұрын

Makes sense.

@smacker360 Жыл бұрын

So, how does a carnivore protect against insulin suppression??? How many carbs should a carnivore eat daily? It appears to me that cutting out sugar 100% and eating fat combined with a limited diet of natural carbs may be the answer. ???? I'm not a doctor but I believe this was the message???

@robertcywes2966 Жыл бұрын

Nope. Depends on ur stage of change. That's why bloodwork and a knowledgeable dr matter

@smacker360 Жыл бұрын

@@robertcywes2966 thanks