Folate Deficiency, Causes (ex. medications), Pathogenesis, Symptoms, Diagnosis and Treatment

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Folate Deficiency, Causes (ex. medications), Pathogenesis, Symptoms, Diagnosis and Treatment

Рет қаралды 97,763

4 жыл бұрын

Lesson on Folate Deficiency: In-Depth Overview of the Causes, Pathogenesis, Signs and Symptoms, Diagnosis and Treatment. Folate (or Vitamin B9) is an essential water soluble vitamin that is necessary for red blood cell development and maintenance, due to it being required in nucleic acid synthesis. There are several categories of causes of folate deficiency including reduced dietary intake, malabsorption, impaired metabolism, and increased utilization. In this lesson, we discuss in detail the many causes within each of these categories. We also discuss the classic signs and symptoms of folate deficiency, the characteristic findings on laboratory investigations, how to diagnose and what we do to treat folate deficiency. We also discuss why folate is important during pregnancy, specifically with regards to neural tube development.
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Пікірлер: 136

@hollymurphy-jerrett1894 Жыл бұрын

I have chronic folate deficiency and one of the main symptoms I experience is low mood. When my folate levels are good I feel mentally very well, I don’t have depression or low mood or anything like that, but when my folate is low, my mood is low.

@rajeenarasvin9306 8 ай бұрын

florate and bl12are same

@nerychristian 6 ай бұрын

@@rajeenarasvin9306 No, they aren't the same.

@jbeauty4150 4 ай бұрын

How much folate do you take?

@Jimbo878 Ай бұрын

Folate is b9 @@rajeenarasvin9306

@emilywood6830 3 жыл бұрын

A medication I wish you included was the hormonal birth control pill which decreases many key vitamins, including B12 and B9

@stryk3r Жыл бұрын

100%

@Zetsuke4 4 жыл бұрын

Please post more videos! I love your teaching style so much. The most effective format I have seen on KZfaq honestly

@CreatingintheWaiting 2 жыл бұрын

Agree!

@24carrotgold8 2 жыл бұрын

MTHFR defect runs in my family. Unfortunately my niece got the defect from her father's side as well. A genetic savvy doctor prescribed Thorne Methyl Guard prior to pregnancy and she carried twins almost to full term. Mark was 5 lbs and Penny was 2.9 lbs. Autopsy on Penny's umbilical cord showed a missing artery. After 3 weeks in NICU she came home and overcame digestive issues and is now a thriving child. Her little sister born 2 years later had a normal development because my niece continued with the supplementation.

@astromob1 6 ай бұрын

Which genetic savvy Dr did she see?

@24carrotgold8 6 ай бұрын

@@astromob1 Kadlec Regional Medical Center, Richland Washington was doing the research. Her Dr. Is no longer there.

@farahsabz8468 17 күн бұрын

Hi, are the children all healthy, no learning needs? I have mthfr gene and my child gas autism ,,,so scared to plan another pregnancy

@Frommel2000 2 жыл бұрын

0:20 Folate does not come from fortified grains. Fortified grains contain folic-acid which can be harmful when taken long term.

@yellowiris123 Жыл бұрын

Fortified grains have folic acid, which is synthetic, man-made. I have the mutation of the MTHFR gene and my body does not use folic acid.

@nomadicexplorers Жыл бұрын

@@yellowiris123 you just need riboflavin to fix the MTHFR

@yellowiris123 Жыл бұрын

@@nomadicexplorers never heard that. I do take methylfolate

@nomadicexplorers Жыл бұрын

@@yellowiris123 Chris Masterjohn has a great article on it.

@NeitouSama 9 ай бұрын

@@nomadicexplorersnonsense, l methlyfolate is the only remedy, stop spreading misinformation.

@caroline61804 3 жыл бұрын

If you lack methylation correct it via supplementing with B2 first. Add B9 aka folate and B12 after like a week of supplementing with B2

@edimoelvis9904 Жыл бұрын

So the Methylation issue can fixed by B2? Like permanently fixed?

@edimoelvis9904 Жыл бұрын

But what is the best form of B2 to take?

@caroline61804 Жыл бұрын

@@edimoelvis9904 the cheapest most common one. Works for me

@FLgardener67 3 жыл бұрын

My Doctor has me on Folate, B- complex and B 12 supplements due to having MTHFR mutation. Can you update your video's highlighting this. Thank you

@susanfrail9564 2 жыл бұрын

Hi could you please give me more information on what you take please

@brianohamill7236 2 жыл бұрын

Kinda shocked that he didn’t mention the MTHFR problem

@MR.SKANDAL0121 2 жыл бұрын

What is MTHFR I've been suffering with folate deficiency for years & take vitamin b supplements I feel there is something causing this but I don't know know

@24carrotgold8 2 жыл бұрын

@@susanfrail9564 Thorne Methyl Guard about $50 at Amazon. Folate and B12.

@yellowiris123 Жыл бұрын

@MR SKANDAL BEATS 0121 the MTHFR gene mutation. All humans have the MTHFR gene. About 50% of the population have a mutation of that gene. Those without the mutation it is expressed as CC. One C from each parent. So somebody with the mutation can be expressed as CT, TC or TT. I have the TT expression of the gene, so the mutation comes from both of my parents. So I have the more difficult version of the mutation. My body does not process vitamin b9 (folate) well. The folic acid which is fortifying much of the foods in the US, is fake, synthetic, man-made. My body does not use it much at all. I took medicine called Trileptal and I had mouth sore to the bone. Trileptal strips your body of folate and since my body doesn't process it well anyway, I had a major deficiency. The Dr office ran a DNA test and I have this mutation. I hope this explanation helps.

@dianarhyne Жыл бұрын

Folic acid form is in fortified foods, like grains and cereals. This form is harder for many people to use. It can actually do more harm. Folate form is best.

@justinhale5693 Жыл бұрын

My wife has the MTHFR gene and has always had nausea in the morning. It was worse when pregnant. We have three children. The first and last were supplemented with *folate* but for the second she used *folic acid*. The second was the only to have a tongue tie and after using methyl folate she no longer is nauseous in the morning. This is just FYI. Who knows if it is a coincidence.

@KBB-nf1dr 9 ай бұрын

MTHFR it’s not a gene, mutation genes, don’t mutate, it’s a hereditary Passover of a damaged liver, agent, orange glyphosate, DDT mercury, any number of people have tested positive to MTHFR , and then detox the liver and tested negative afterwards, medical research and training is funded and manipulated by the pharmaceutical industry they always put the blame back on the victim, by saying it’s genetic, it’s not.

@sajidkhanmahmood 3 жыл бұрын

very good presentation. I have just been diagnosed with severe folic acid deficiency. I have been on sodium valporate for epilepsy for the last 20 years and never did any Dr recommend any supplementation until the last week when i started to suffer from severe tiredness and feeling dizzy at which point a blood test showed the deficiency.

@yellowiris123 Жыл бұрын

Take methylfolate so your body can use the folate. Also, ask Dr for a DNA test for MTHFR gene mutation which around 50% of the population has. That could be causing the deficiency.

@sajidkhanmahmood Жыл бұрын

@@yellowiris123 interesting I would like to ask for this test but here in the UK we can't ask for specific tests. We can only get tests which the Dr feels appropriate.

@yellowiris123 Жыл бұрын

I would just mention you had heard that a folate deficiency could be caused by genetics. Could that be my problem? Maybe he'll order a test.

@edimoelvis9904 Жыл бұрын

@@sajidkhanmahmoodAre you saying that in the whole of UK there is a not a single private Lab for you to go do your own preferred Test? Hmmmm

@The_New_Abnormal_World_Order 8 ай бұрын

I'm also on valproate. It angers me that our Drs don't mention any of this. I also read that valproate depletes L-carnitine and inositol. I hope you're doing better now.

@cricket700612 2 жыл бұрын

Excellent video! Thank you! Precise and instructive.

@binathere2574 2 жыл бұрын

not comprehensive though.

@ZerHour Жыл бұрын

I believe there's a growing link with folate issues and the CV virus ,I got the virus and it wiped out my folate big time ,still undergoing treatments

@key2lyfe 11 ай бұрын

Can you elaborate, please? What symptoms did you have .

@astromob1 6 ай бұрын

How did symptoms indicate low folate?

@antipharma1615 3 жыл бұрын

should never use folic acid instead use the methylated ,5-mthf, variant as 60% got mutations of the methyl tetra hydro folate reductace enzyme and therefore cant in a good way convert folic acid to the active form

@tangomcphearson74 2 жыл бұрын

I agree completely

@prasadgaikwad7108 2 жыл бұрын

my b9 level is 1.2 and i took 2.5 mg foluc acid tablet for a week. it didnt help but gave me constipation. then i tried l methylfolate 1 mg .it gave me result the very next day.

@123private3 5 ай бұрын

@@prasadgaikwad7108my folate level is 0.47 how to recover it and how many days takes to improve symptoms plz share your experience.

@El.1355 3 жыл бұрын

I was losing vision, getting disorientated, headaches and motion sickness feeling and diareah Absolutely horrible.

@THEPLANETEARTH 2 жыл бұрын

How are you now?

@hiq4509 Жыл бұрын

Because of folate?

@stefstef434 Жыл бұрын

Omg same !!! I had low acid folic

@fnatic7629 5 ай бұрын

Same issue how did you fix it?

@leighmegan13 4 ай бұрын

@@fnatic7629speak to a doctor to get your blood checked, you will usually be prescribed a 4 month course of folic acid to help you.

@linfu-sheng9066 3 жыл бұрын

I went to see a psychiatrist for depression a couple years ago, took a swab test and found out (if I remember correctly) that my problem isn't the typical brain receptors being too small to allow serotonin in, but instead my body has a hard time absorbing folic acid, and just doesn't make enough serotonin. I think I was told to try out a B vitamin? Does this sound familiar to anyone? And if so what supplements should I be taking? Thanks

@binathere2574 2 жыл бұрын

watch NOOTROPICSEXPERT on youtube for the information you seek.

@binathere2574 2 жыл бұрын

@Ed I've been drinking green smoothies for at least 25 years. Greens are the best way to get folate. I At one point I was not looking after myself. My folate was low. Yes methyl folate is good. I used it when my folate was low. Normal levels now.

@samsonslmpson1986 Жыл бұрын

I take sublingual b12 5000mcg and sublingual methyl folate 1000mcg every 2 days. You can get both from sprouts. Try it out. Hopefully it helps.

@cindywhittaker3003 9 ай бұрын

Do you have MTHFR? You need methylated B vitamins.

@jiayouchinese Жыл бұрын

Genetic conditions also cause issues with low folate, and resveratrol intake reduces folate.

@bugpray Жыл бұрын

i have a folate deficiency from a blood test and i really don’t know why, i’ve never been told i just take folic acid

@user-zk8ed4kd2b 2 жыл бұрын

Would you include plaque psoriasis as one of the exfoliative skin conditions?

@sportspharmacists 4 жыл бұрын

Can you update this video series for folic acid and furin in covid?

@tonyacampbell4903 3 жыл бұрын

Another reason is MTHFR.

@saragiddings1984 Жыл бұрын

What is that?

@astromob1 6 ай бұрын

Is that the genetic cause that he barely mentioned but does not cover?

@ruthjohnson4380 2 жыл бұрын

Also scleroderma can cause malabsorption.

@user-zk8ed4kd2b 2 жыл бұрын

What could account for an RBC of 5.42 and a hematocrit of 46.6 with a serum folate of 5.0 in a 65 year old female with psoriasis? Wouldn't the RBC and hematocrit be lower?

@garrettsmelosky5008 5 ай бұрын

Folic not folate acid is added to foods in the US. Folic is the synthetic version that people struggle to use.

@vaishnavkadam6909 Жыл бұрын

How folates are useful for increasing haemoglobin

@urfavegemini4231 2 жыл бұрын

Drs just TEXT me saying I have this. I have a history if autoimmune disease, ITP. I got HYSTERICAL at first, I didn't understand what they where telling me... few hours dabbing on Internet, I'm calm, I will get better with the meds, I will not panic... I am OK!!! I am mad they text me tho, with my history and also autistic... I need then to call and explain to me !!

@CreatingintheWaiting 2 жыл бұрын

Excellent! I wonder if this is why I have hyperuricemia

@User-to7nb 4 жыл бұрын

This is my lesson today. HOW DID YOU KNOW?!

@sugarwalker89 2 жыл бұрын

Great job young man!

@jbeauty4150 3 ай бұрын

I'm having a hard time treating my folate deficiency. Getting severe side effects. Have you heard of this?

@ldjt6184 3 жыл бұрын

What about methylfolate supplements as opposed to the fake folic acid?

@pelletey 3 жыл бұрын

its not fake, synthetic is different to fake. It is still processable by the body's enzymes

@ldjt6184 3 жыл бұрын

@@pelletey folate is better than folic acid as I've learned.

@ldjt6184 3 жыл бұрын

@@pelletey Don't even bother with folic acid supplements.

@pelletey 3 жыл бұрын

@@ldjt6184 it depends on your genes, some people have the enzymes to break down folic acid fine.

@ldjt6184 3 жыл бұрын

@@pelletey But for those who accumulate a lot of unmetabolized folic acid there can be health problems. Best not to take it.

@Meisterling 2 ай бұрын

Great video!

@K4katwc 2 жыл бұрын

I had pretty severe anemia with low hemoglobin. It was macrocytic megaloblastic anemia in 2012. I've been on Folic Acid 4mg per day every day since. But you only recommended 1mg. Should I question my dose? I've never been told the cause of my deficiency either. I've scheduled an appointment with a GI doc to investigate. Maybe ill find out.

@freeminded7790 2 жыл бұрын

Folic acid is synthetic and should be avoided. Avoid all fortified iron-folic acid produce, there’s been studies done and it’s shown to be horrible for our health!!!!

@K4katwc 2 жыл бұрын

@@freeminded7790 ok. What should I take instead? & how much?

@binathere2574 2 жыл бұрын

@@K4katwc watch NOOTROPICS EXPERT on youtube for the information you seek

@K4katwc 2 жыл бұрын

@@binathere2574 thanks!

@kp5659 Жыл бұрын

Does folic acid deficiencies cause hairliss

@MyNguyen-hz1gn 2 жыл бұрын

Great thank you. it helps me a lot.

@victorgopio3119 3 жыл бұрын

Theres more ads than any other video i have seen damn... hahahaha useful informtion...

@hasanshokor3255 4 жыл бұрын

Thank you very much love your videos, hope more terms 🌾☘🌱💐

@missbeaussie 2 жыл бұрын

Just started ozempic two weeks ago and did blood yesterday which came back for low folate

@astromob1 6 ай бұрын

It created low folate? Ozempic lowers folate?

@ljmcdonald2703 17 күн бұрын

Ozempic can cause low B12 levels in the long term so can Semaglutide which can also do the same thing

@lakdasadassanayake9127 Жыл бұрын

Folate is said to be good for nerves.

@susanfrail9564 2 жыл бұрын

Hi somatic healer can you please give me more information on what you take

@justwatchingvids1560 10 ай бұрын

Is 3.2 low or is that normal (above 3)

@Liakoss 10 ай бұрын

Never give folic acid... Always supplement with active folate. Many people for many reasons cannot convert folic acid to 5 mthfr. The reasons are many. This guide is wrong.

@joesphbegley3088 Жыл бұрын

I developed folate deficiency due to malabsorption caused by daily use of Gaviscon antacid

@yellowiris123 Жыл бұрын

The medication Trileptal strips your body of folate as well.

@ljmcdonald2703 17 күн бұрын

Ozempic can do that

@abdelraouflaouisset7957 9 ай бұрын

thank you!

@00DaNnY000 Жыл бұрын

I’m on PPI’s and apparently they effect the absorption of B9/folate. and my bloods have come back low in B9 and folate now I’m on 5MG a day for 4 months I drink zero alcohol

@jbeauty4150 4 ай бұрын

How are you doing now? Are you still taking 5 mg?

@binathere2574 2 жыл бұрын

watch NOORTROPICS EXPERT on youtube. He has a much more comprehensive information.

@banzobeans Жыл бұрын

2:37 is this theoretical or evidence-based?

@TheSophiejadeable 2 жыл бұрын

I have reoccurring folate deficiency and have been prescribed folic acid 3 times by my gp. My gp is adamant its my diet but I just don't think it is.

@binathere2574 2 жыл бұрын

Folic acid in available from green leafy vegetables. Maybe also consider green barley powder.

@marijkevandeneijnden8971 2 жыл бұрын

Get a test if you have a 5-mthfr mutation. Maybe that's the cause why you can't absorb it

@ldjt6184 Жыл бұрын

You are an expert on some things, but folic acid isn't one of them.

@donbay1220 3 күн бұрын

Chicken liver/beef liver the best source

@Texas903G Жыл бұрын

Horrible brain fog

@eclipsekcb9201 Жыл бұрын

Stay away from folic acid or any synthetic vitamins. It's worth the studying.

@joshnajosheru 3 жыл бұрын

Does taking folate reduce ur b12 levels?

@maheshtanay 3 жыл бұрын

You have to take both to work better function. Methylfolate and methylcobalamin these two forms can cross blood brain barrier.

@edimoelvis9904 Жыл бұрын

Yes folate helps the body utilize B12 better . So use both together.

@jessicablackmore8447 8 ай бұрын

Synthetic folate is not good for ys.

@irienerd8178 8 ай бұрын

You need METHYLfolate so the "fortified" stuff is crap.

@moonbunny7380 2 жыл бұрын

Can someone tell me why my docter said i have low folic acid but not anemia

@daisiesandpandas1218 2 жыл бұрын

You can have low folic acid but not low haemoglobin - low haemoglobin is anaemia.

@moonbunny7380 2 жыл бұрын

@@daisiesandpandas1218 I am now diagnosed with folate anemia and haemacromotosis

@milks0ap002 Жыл бұрын

I have low folate but not anemia. But i do feel dizzy and tired/ weak. did you have those symptoms as well? ive been taking supplements for a week now but i gotta wait longer i think bv i still feel miserable

@moonbunny7380 Жыл бұрын

@@milks0ap002 low folate IS folate anemia, im tired alot but that's mostly due to haemacromotosis but a side effect in both I'm sure

@123private3 5 ай бұрын

@@milks0ap002same here I also have folate deficiency but normal hemoglobin and same symptoms weakness, fatigue, dizziness, low vision, tired. My folate level is 0.47. How many days takes to recover from symptoms plz share your thoughts.