Timestamps: 0:00 Intro 0:36 What Are Epigenetics 2:02 Reversing Age & Yamanaka Factors 5:11 Biological Age Clocks 12:40 Yamanaka Factors Part 2 17:30 When Will These Treatments Be Ready 19:00 Why Do We Age 20:40 Senescent Cells & Fisetin 24:30 Longevity & Supplements 28:48 NAD Precursors 32:25 Resveratrol 33:35 TMG (Trimethylglycine) 35:30 Stem Cells 37:40 Extending Lifespan 39:40 Rejuvenation Therapies 43:20 Diet & Exercise 47:50 COVID & Aging 53:30 The Future 55:00 What Biological Clock Is Best

Huge improvement since the early days of the channel: Brad looks so much more relaxed and less robotic, the background is good, much more slick overall. Well done Dr Stansfield.

Key takeaways for me were: 1. She is risk adverse, no matter the possible benefits. She avoided saying anything too positive about any supplement/diet/drug/rejuvenation technique except Rapa. 2. She validated the Truage clock for healthspan. CA-AKG needs more research but may provide a significant benefit as the big worry was the accuracy of TruAge in regards to healthspan. 3. DNA Methyl clocks have a long way to go before they can be used in a way that we all intend to use them for accurately measuring the progress of our interventions. 4. We are 10-20 years out from anything in the full clock reversal product/treatment Brad, you asked the right questions, good work!

For those of you who don't have an hour to waste, let me tell you that she doesn't tell you how to reverse aging. She simply tells you that we have a lot of stuff that we need to study. So save yourself an hour.

What a breath of fresh air this interview is. Great communication skills with a priority on truth and accuracy. Thank you Dr. Stanfield and Dr. Levine. Nailed it with the "selling the fountain of youth" statement. It is incredibly refreshing to have educated & ethical people that can be trusted on this topic.

Brad thank you so much for all the work you do and giving us so much information. I honestly can't think of any other professional who has poured so much time into presenting this information to people. I'm proud to be a patreon

Great video Brad - Really happy to see you doing well and your channel blowing up as you deserve it with all your hard work digging through scientific literature

Congrats to Dr. Brad Stanfield for reaching 100k subs! You are my absolute favorite youtuber for unbiased clinical trial updates regarding aging and NAD research. Keep up the great work!! :)

This is more content I was excited to see from the channel. Examining the essential proteins would be a great video as well

This was such an interesting and enlightening interview. Thank you!

Oh, I saw Dr. Levine on Wired the other day. As soon as she said, "epigenetics", something clicked, and I went back to check. Loved your "Aging Support" Q&A session.

What an excellent interview. You should live stream next time because KZfaq puts a priority to livestreams that generate revenue to the company.

Dr Morgan is smart. I like how she the future of health and clinical trials, I agree with her and I love what is doing someone like Kellis Manolis. I think clinical trials are way too slow, archaic and biased. IMO and I know lot will disagree, we need to share our data in a secure system where AI can make prediction and understand it. Anyway it was a very good interview, she was concise and realist. Good pick

I purchased 2 biological age tests from 2 separate companies. There was a ten year difference between the two results.

Congratulations for the 100k subscribers. Live long and prosper.

Wonderful, enlightening interview thank you both!

The only Doctor on the Web that I trust to give a no BS, and unbiased assessment on the subject of anti aging. Much appreciated Brad.

Glad to see an expert on your channel.

Great conversation! bravo!

I can always trust this channel to bring true evidence based information. Thank you! 🙏

Dr. Levine appears young and healthy. I am curious to know what she might do differently at this point in terms of available supplements/ therapeutic options if she was older and suffering from health issues such as chronic pain or disease.

I’m so happy about this video 😁

Awesome video. Morgan seems super nice and knowledgeable.

Discouraging this women prévisions! When you are young you could take your time!

Thanks for Askim about predictions:) I am always waiting for the predictions

This is certainly fascinating...but it doesn't exactly live up to the title. After listening I know more about what not to bother doing but not how to reverse aging. Very interesting conversation though and I appreciate the video.

I like her comment about the noise variance in clock measurements. For your trial, I *would* be interesting to pick what's considered the most reliable clock and do two tests per-subject at the beginning, and again at the end, to both check test noise levels and to see if there's a correlation. I mean, once you have your population and trial rolling, why not?

I actually found this podcast very pessimistic. - nothing really works in terms of supplements. Most do more harm than good - she's too diplomatic to admit resveratrol is useless but hints at it - no real rejuvenation techniques work either - good old fashioned diet and exercise is all we have to combat ageing - next 10-20 years look interesting at best. Human trials IF UNBIASED should validate/invalidate current molecules/drugs. Longevity science seems to be progressing so slow. It accounts for almost all diseases and this is the best we've been able to do 🤦‍♂️

I'd love to hear her views on the potential risks of various popular interventions since she sounds oriented toward caution about supplements. Overall we don't hear enough credible input on that topic. Brad always covers it when he does a video on a certain supplement but it would be good to have a video that focuses only on dangers. Like now I'm wondering if my fisetin is targeting cells it should not, lol.

Thank you for the interview. You both mentioned how biological marker tests are something you have to be careful with and mention specifically the alpha ketoglutarate test but didn't say whether or not that really is something trustworthy when there are a lot of not trustworthy ones out there. I would love to know but have a hard time finding out because I feel like scientists and physicians are afraid of offending other scientists and physicians. Could you do a video on various aging biomarker tests and their data back to credibility please?

My comment with respect to discussion at time 17.20. The OSK (OCT4, SOX2, KLF4) protocol, developed at the Sinclair laboratory at Harvard resets the epigenome but stops short of reaching pluropotency such that the cells retain their differentiation. If cMyc is introduced as well then the cells reset down to the pluripotency level and cancers such as Teratomas can likely occur. Sinclair's lab demonstrated good safety for the OSK protocol in mice.

Big fan of Morgan - Go Yale

Interesting comments on epigenetic clocks and the current effort to identify which ones or combination of clocks relate to which disease

Great video! Also 100k subs soon!

I’m hoping it takes 5 years :)) I’m hopeful

Brad what webcam have you bought recently ? Thanks for this interview! keep doing amazing work

What it shows about aging is that there is alot of conflicting points of views. I like the fact she isn't as optomistic then others in the longevity community. Aubrey De Grey when interviewed also said this would take longer then anticitpated. Sinclair states its more or less a done deal. The fact that Altos Labs is here is a very good indicator that aging will be controlled to some extent.

The answer that is always correct “ we don’t know” , so this is the answer for how to reverse aging

Informative discussion. I appreciate that Dr. Levine recognizes that there are purveyors of unsubstantiated longevity hype amongst fellow academicians, but chose to not throw anyone under the bus. As an aside, I noticed Dr. Levine said "verse" when she meant "versus". Verse for versus seems like a trending colloquialism.

Thank you. Very informative. Where do you find the time?

thanks

For me, looking on a wide array of biomarkers (30-40) gives you most of the data you need to see if your interventions work.

So, Professor Levine was a paid scientific advisor for Basis, but she stopped taking the supplement they were sending her because she felt it wasn’t beneficial? Could someone explain this?

This scientist seems to be very, very, very cautious and that's what you would expect from a good scientist. We're not sure that these clocks are actually measuring anything meaningful. We're not sure that taking an adult fibroblast back to a new born pluripotent stem cell is actually rejuvenating anything and we don't know who is funding our work. English is not my first language so I probably missed out something 😁 Thank you Dr Stanfield, you really did a fantastic job and asked very good questions during this interview.

Aging is our deadliest enemy - more people should be involved in a fight with it, a lot more.

lol thats so cool, I work for Yale University and I think ive seen her there

Marvelous interview! Two minds are better than one! That said... Epigenetics seems like the piano player and genetics like the piano. Why the hell does the piano-player perform worse and worse over time?! Seems like all these damn cells -- which easily replicate over and over for 70 years -- should be able to repair and replace themselves PERFECTLY. Evidently there's a major malfunction taking place when this doesn't happen. :-(

I have a good watch, where do I get that supplement PLEASE

So far the best we have that I've heard is growing your own organic whole food plant based diet, exercise, healthy lifestyle/environment, and dry fasting with prolonged water fasting. Living cleanly and using fasting to get rid of senescence. Use it or lose it! :) For me my favorite supplements have been shilajit, zeolites, functional mushrooms, adaptogenic herbs, Nyrture Natto.

Is Altos forthcoming with its research, will it publish? 🤔

She really looks fantastic for a 70 year old lady!

I look forward to seeing your ashwagandha review.

I can't quite hear or understand what supplement she is referring to, referring to the one that she took for a short time but stopped does anybody know the name of that?

By how much time does reverse aging treatment will given to people

I haven't heard the whole thing yet but the Prolon fasting-mimicking diet is the real deal as you know or should know.

Good interview, Dr. Stanfield! Check out, on DailyMail, this article, "Is This the Key to Turning Back the Clock?" It details how the Yamanaka transcription factors rejuvenated mice. Brand new research published in the journal below Nature Aging Article Published: 07 March 2022 In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice

Getting into my third bottle of Tru Niagen NR. No changes noticed. Certainly nothing like the so called customer reviews. As a matter of fact, my physical strength has gone down in the last few weeks. My maximum bench press which I try for every two weeks has dropped from 105 kilograms to about 95 kilograms. Of course this may or may not be related to NR supplementation but it's pretty rare for me to lose strength. I will finish the course of 180 capsules but I'm pretty sure that it has been a huge waste of money.

refined sugar is known to suppress immune function around 70% for 6 hours after consumption

You mentioned that in your Rapomycin study you will take the physical improvement in muscles doing certain exercises. Have you considered that your results will be skewed due to the fact that our muscles improve even with little exercise?

Brad - on your stack page there’s a typo (FYI). “…conversion of Dihydrotestosterone to Testosterone” This is in the paragraph on finasteride.

Many people are obsessed about aging. Their life restricts to taking supplements, training, stressing, ... these interventions are not a goal or sense in life. each life must find what makes him joyful and not try to copy what other say and become a pseudo expert. I am a patent examiner and I see that humans are good at creating artificial objects using hard science but concerning human health we deal with soft science and real improvements do not happen. we forget that we are not machines and that the spirit triggers biological changes and without spirit giving real goals and joy in life the biology will age faster whatever intervention we apply. In soft science like biology and medicine results are bad conflicting and mainly the results of placebo.

Morgan Levine 😫

I once read of a study conducted on a single honeybee. The bee was marked so that it could be monitored. At the end of the first colony, the marked bee was extracted before dying and transplanted into a fresh nest just beginning. The subject bee rejuvenated, and worked normally on the second nest until that 2nd nest was done. The study honeybee was again extracted before it would have normally died with the second nest, and then transplanted into a third new nest. This was done a total of 7 times. Could this finding be associated in humans with the placebo effect ?

I had the omnicron version of covid from a hospital and also the vaccinations which were worse and made me very Ill. I walk everyday and dance … for sure this helps me the most and I don’t eat red meat

I am impressed, thank you Dr Stanfield. Hopefully you invite Aubrey de Grey next time.

Really informative interview. Kind of disheartening to hear supplementation is only like 1% of the formula

obesity is linked to 7x increase in covid severity risk. and telomere length is linked storngly to increased severity also around 8x for short telomeres

I saw her on some news yt channel before this

This rapamycin trial is really interesting. But the difficultiy in financing adds new challenges. I think that such a promising drug to anti-aging could be tested by a group of scientists. The trial Dr. Stanfield wants to carry may be used to answer questions that maybe won´t be in the project. And if financing one trial is hard. Imagine two or three...

The clocks are so expensive, I wish you had asked if they are working on lowering the cost itself.

any studies on the RNA vaccine effecting aging process. the exogenous spike created by ones own cells should most certainly be studied.

Whatever Levine is taking is too good...she was phasing in and out of existence during the interview. That aside, great interview, enjoyed the honest, evidence based conversation. Thanks!

In more than one interview the interviewee has told you they're not supplementing at all. Assuming they're being completely honest, how does this make you feel about your own supplementation? You emphasize the importance of diet, exercise, sleep, and stress, and also have a disclaimer about your supplementation, but I wonder how their answers affect what you're doing for yourself. Despite your disclaimers you must know that listing your affiliate links results in viewers making purchases of the supplements you list which benefits you financially. Is this an ethical practice? I realize that KZfaq is an income for you, and that affects everything from your video titles, content, questions asked, etc. I guess I wonder how incentivized you are to go from Google doc to website, to always be taking supplements, even if you list the ones you no longer take. Do you see yourself ever adding all of your supplements to the No Longer Taking list? I appreciate your content despite finding some of it a little misleading. I don't think you're looking for quick fixes for yourself, but we both know that some of your viewers are. Honestly you'd probably get a lot of hits from a video about accepting death and stepping back from the supplements for a second, because let's face it, despite all this hype all of your followers are probably going to die. We're not the rich and powerful, a lot of us struggle to be healthy in a world that seems to be going so wrong for all kinds of reasons. I know you're a medical doctor and not a therapist or philosopher, but this is clearly a complicated subject that I believe deserves some introspection.

Hello Dr. Brad: What about fasting? I believe that the criteria for taking a supplement for a young person and an old person may be different: An old person may not be able to wait 10 years for studies of a certain molecule to be completed. One criterion to use may be the following: If the molecule is safe and there is some kind of evidence that it has potential, it should be subject to further scrutiny to determine whether to take it or not....

She should provide some evidence about how she knows that epigenetic ageing as exhibited by DNA methylation is multi-factorial, and caused by many different upstream causes.

Interesting stuff one side we have people believing it around the corner then like this person who really doesn’t see any change really happening anytime soon sucks really and such a bi polar field

Quite surprised neither of you have banked the placenta for your children. This is something I would definitely do. Although I'm not sure of the cost.

To wrap it up: We don't know a lot about this issue.

I thought that Yamanaka was a herb to take LOL

that lady really nods a lot

I don't like biomarkers being referred to as "clocks" at all. Clocks implies some kind of a time (in relation to what we would expect from chronological age). But the whole point is to accurately measure the state of an organism's senescence, i.e. the current state of the body. This has nothing to do with time at all. Is this person sick? Is this person unacceptably senescent? Is this person susceptible to disease? Is this person in need of aging reversal? These are the sort of questions which, ideally, biomarkers should answer once they become accurate enough.

Not a single word about the vaccine for Covid19. Why?

Safe to say I almost learned nothing watching this video, so safe yourself an hour guys.

If scientists/ inventors of the past were this conservative and risk-averse we'd still be trying to figure out the wheel. Disappointing to see that this is apparently the mindset of a top university.

soft sciences like biology genetics and medicine make people confusing and stressful which make them age faster. the spirit controls the material and if the spirit goes down the material follows.

Is it possible to like reverse the age of 50 back to 25 or something like that ? Tbh i don't think that it's possible...

Dr Morgan Levine - such achomplishment and only 58 years old

I'm on a typical British diet: Fast food, booze and cigarettes. What about my biological clock?

I have aged 3 minutes after watching 3 minutes of this pretty lady.

Keto is a solution. Advanced glycation end products are caused by a high carb diet. IGF-1 is also proaging. Higher levels are found in people who eat too much carbs and dairy

I'm 73, well I be able to turn into my 20s?

Good job choosing a hot professor, I'll listen to every word. 💥

WTF...Title shameless clickbait... you tried to get her to say things multiple times but she would not... Hats off to her credibility!!

Watching through, did you go over the questions/topics with her at all before you started the conversation? Looks like you're really nailing her to the wall w/regard to hot-button questions. While you're a clinician and focused purely on data, she's a researcher of some renown and influence. That puts her in a very political position when answering hot-button questions. She has a lot to lose if she answers those questions bluntly, and she's at risk answering them at all. - We want to support the best researchers in advancing science; they can't do that if they lie, and they can't do that if they piss other powerful people off (too much) I recommend coming up with an interview outline, highlight what you think could be hot-button questions and warning your subjects in advance of them so they can let you know if it's something you'd be better off not asking. You'll get a better reputation as an interviewer if you do that.... and that means more access, and more information for the rest of us. Keep up the good work!

Tried, but couldn't follow.

So ageing clocks are inaccurate and not dependable at all. She should tell Steve Horvath that his clocks are no good, and any experiment using them is pretty much useless. +_9 years of noise. She should be generous and share this knowledge with Steve Horvath and David Sinclair. Also Greg Fahy.

What I find peculiar, is 20 years old like Brad and Morgan talking about what they take or not. Truth be said they should be taking nothing! Now let us just see what say Morgan is taking on or plastering at their face at age 50. Just the fact that at 20 you guys are taking something should tell us at 50 we should be taking all!

You are what you eat. Your diet impacts your health. Lower stress, reduce obesity and more exercise are key to a healthy life. Obesity in children and adults is rising across the world. Fast food and sugary drinks are contributing to the problem of poor health and obesity. Eat a healthy plant based diet and exercise regularly. Reduce or ELIMINATE cows milk, eggs, cheese and meat. Eat more salad greens, beans, fruit and vegetables. Eliminate fast food, snacks like cookies, cakes, chips, and sugary drinks and juices. Every adult and child should own a bicycle and ride it regularly. Regular exercise will help you sleep better. Yoga is a great stress reducer. Obesity is all too common today. Get off the couch. Get off the phone, ipad or video game. A variety of stretching and other exercises help with increased mobility. Ride to work, ride to school, ride for fun. Every city should be a bicycle city. Speak up for bicycles in your community

Immortal jellyfish.

Wow, I just spent over an hour of my life, listening to a woman say that she can’t commit to any answers and has no theory whatsoever on any of the subject matter other than she’s not sure! lol