How To Increase Longevity | Prof. Matt Kaeberlein

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Professor Matt Kaeberlein discusses the Dog Aging Project, longevity, Rapamycin, mTOR, and if we can 'solve aging'
Timestamps:
0:00 Dog Aging Project
4:18 Intermittent fasting
10:23 Best longevity lifestyle
16:25 Rapamycin & mTOR
23:27 Rapamycin human study
30:18 Protein restriction diets
39:46 Combination longevity therapies
45:38 SGLT2i therapies
47:23 Metformin & longevity
52:50 Navigating misinformation
55:28 Creatine
59:00 Best exercises for longevity
01:03:00 Can we solve aging?
01:09:45 Epigenetic reprogramming
1:16:50 Supplements Dr Kaeberlein takes
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Пікірлер: 222

@DrBradStanfield Жыл бұрын

• Look & Feel 5-Years Younger in 90-Days: drstanfield.com/5-years-younger/ • Join Patreon For Early Video Access & Discord Chat: www.patreon.com/bradstanfieldmd Timestamps: 0:00 Dog Aging Project 4:18 Intermittent fasting 10:23 Best longevity lifestyle 16:25 Rapamycin & mTOR 23:27 Rapamycin human study 30:18 Protein restriction diets 39:46 Combination longevity therapies 45:38 SGLT2i therapies 47:23 Metformin & longevity 52:50 Navigating misinformation 55:28 Creatine 59:00 Best exercises for longevity 01:03:00 Can we solve aging? 01:09:45 Epigenetic reprogramming 1:16:50 Supplements Dr Kaeberlein takes

@eugeniakyriakopoulou5212 Жыл бұрын

Totally agree about happiness being a factor! My grandma is 96, lives alone without any need for help and the only med she is on is blood- lowering medication and only every other day, because taking it every day makes her dizzy. She is the most optimistic and happy person I have ever met and I am pretty sure that goes a long way!

@drednac Жыл бұрын

I don't usually watch videos that are over an hour long (I am a busy person), but this really felt like time well spent.

@jhunt5578 Жыл бұрын

Watch on 2x speed

@amgis5218 Жыл бұрын

This is one of your best videos, because of your choice of interviewee. A quality researcher.

@FunMushizzle Жыл бұрын

Brilliant as usual, extremely educational inspiring discussion. Love your work Dr. Brad keep it up!

@amgis5218 Жыл бұрын

Here's my two cents' worth, being an extremely muscular, fit, and healthy guy in his late forties: 1) Exercise, especially add weight training four times a week. 2) Get your diet right, reduce simple carbs, increase protein and soluble fibre, add hemp seed oil (or hemp seeds) to at least one meal daily, since it contains the perfect balance of Omegas 3, 6, and 9. I add hemp seed oil and hemp seeds to my daily leafy salad or parsley salad. 3) Stay hungry. Don't ever overeat or feel excessively full. 4) Drink black coffee, with no sugar, during the day, and try to eat your first meal later in the day. 5) Sleep well. 6) Stay mentally and socially engaged, challenging your mind daily. 7) After all that, then you can add supplements like D3&K2, niacin, magnesium, zinc, creatine, hyrdolyzed collagen peptides, SAMe, NAC, turmeric, berberine etc. But the supplements are the final piece of the puzzle. Anyway, from my experience and my perfect health and extremely muscular body, this has worked wonders for me.

@bob-ss4wx Жыл бұрын

Matt always provides an excellent reality check!

@thisisfullspectrum Жыл бұрын

So refreshing to see a very smart humble human being giving a balanced view on the state of longevity interventions. Thanks for this talk!

@seregv Жыл бұрын

Really love the interviews. Quite informative. Well done!

@audreyhurley6248 Жыл бұрын

The best video you’ve posted! Will definitely be following Matt closely! Thank You both!

@VanOlove Жыл бұрын

So much info. Thanks for an excellent interview. I’ll be processing the talking points for the next few days.

@DavidMM255 Жыл бұрын

Great video, great discussion, lots of very interesting questions right to the point! Thank you for the content

@YANKTON1000 Жыл бұрын

Epic Interview ! Thanks for this Dr. Stanfield.

@arturocastelo Жыл бұрын

Great interview! One of the best , or maybe the best for Matt K on Rapamycin. Thank you so much Brad!

@susymay7831 Жыл бұрын

Great timestamps! 😊 Great interview!

@Alpha_fitz Жыл бұрын

The most sure way to increase longevity by 15% is to spell it with two t's and a capital L. Longevitty. Much longer.

@AnkushSharma-zv5hv Жыл бұрын

thanks for bringing in Matt

@clovismerovech6537 Жыл бұрын

Thank you for this solid and down-to-earth interview, Dr. Stanfield. However, the two main strategies suggested for healthspan/lifespan - exercise and calorie restriction - conflict each other, since regardless of whether we do cardio or resistance training, we will always need increased calorie intake, if we don’t want to start losing muscle. This being said, I think many of us would appreciate it if you find a way to give us your feedback on this issue. Thanks again!

@clarehazell2097 Жыл бұрын

This was great although not always what I wanted to hear!! Thanks Brad

@dijayventures Жыл бұрын

Great discussion, I’m very interested in such information, thanks!

@Mark_Trail Жыл бұрын

Awesome interview Brad! Loved the 4th recommendation for health and longevity being happiness. Couldn't agree more! If u love life you'll want to keep experiencing it for as long as possible ❤

@donnaryan71 Жыл бұрын

well my placebo reaction to NMN is far superior to any anti-depressant I've tried in the last 10 years and I'm keeping it. I can now get through a workout without crashing and after a month on it I now feel ready to live a normal life; I wasn't functioning before I started it. I did not expect such a response. Don't like the insomnia that goes with it but in terms of getting me to function daily, I now need it, don't want to be without it and if they make it unavailable, I'm going to be lost.

@SteveHazel Жыл бұрын

my 2 favorite people concerning rapamycin and health in general - yay !!

@TheSheekeyScienceShow Жыл бұрын

Really enjoyed this interview Brad!

@miloradmilutinovic7691 Жыл бұрын

And I enjoyed this comment 😁😂😂

@PsycheCharge Жыл бұрын

honest interview - excellent!

@spek2554 Жыл бұрын

Thanks for not interrupting your guest. So many interviewers do that....those that i don’t return to.

@adonm6998 Жыл бұрын

I love the way Prof Kaeberlein presented his views and ideas on all these supplements because this has been my view point as well. Very unbiased and calls out the error in the system with how supplements are branded without the need for any real substance behind them. My rule as a scientist is, if i cant understand the biological mechanisms of how a substance acts and the litterature data is conflicting, then take it with a huge grain of salt because we know labs will push for a certain outcome just to satisfy the people funding the research.

@genesmolko8113 Жыл бұрын

Prof Kaeberlein is the most skeptical scientist I've heard in this field, and that's a good thing. He's the exact opposite of Dr Sinclair, who was the elephant in the room during this conversation.

@patrickmchargue7122 Жыл бұрын

I'm glad that Prof. Kaeberlein i able to take rapamycin. What can people do who can not prescribe this for themselves?

@mikespector2 5 ай бұрын

Ask your doctor.

@molnar804 Жыл бұрын

Matt is one of the best. I would love to see richard miller and kevin bass on the podcast.

@juanfermin1841 Жыл бұрын

Excellent video, Thank you.

@garydinmore1598 Жыл бұрын

Thanks Brad. Great interview, although my dogs sleep through it. I agree with Matt’s foundational pillar of Happiness. I have also wondered why over the years that our pets lived so long … “one meal a day”

@zack_120 9 ай бұрын

55:10 - Appreciate this point by Prof. Kaeberlein that simply telling one 'you should take this or that for longevity' is irresponsible or simplistic for a highly complex subject. Actually, "the more uncertain (leaving more room) one's saying the more scientific/correct he is". Decisions one has to make at some point are a compromise of pro and con. 1:01:43- well, that is only practically speaking. Scientifically tho, being able to live long in unhappiness would be very interesting for understanding longevity. Actually there is no sci proof of 'happiness' benefits on longevity. People just say so - sci or fi ? If it does, then next happiness must be clearly defined for different kinds. 1:22:51- No, peptides are hydrolized to AAs then absorbed, in small intestine, well before large intestine.

@zack_120 9 ай бұрын

Collagen is not meant to be absorbed in whole. It can't. Rather, It is its AA profile that matches that of the target tissues, skin, tendon,... so that the absorbed AAs originated from the collagen supplement are utilized to synthesize these tissue's proteins at high efficiency due to the matching AA profile. Its effects can be literally seen of faster fingernail growth when one takes the supplement.

@ashafir20 Жыл бұрын

Matt Kaeberlein is my hero, I want a Cat aging project as well :)

@molnar804 Жыл бұрын

Take a lisen to Kevin bass on yt. I think it s science based and you will love him

@autisticautumn7379 4 ай бұрын

I want a cat ageing project after all cats are my main companions I just wished they lived a bit longer.

@TheBroSplit Жыл бұрын

I'm glad you presented the info for collagen peptides Dr. Brad. I do hope they work. I do the hyaluronic, collagen peptide powder and a proretinol cream. Spf in the morning or before sunlight. I do think it helps. Thank you for following the research closely.

@whiteninja9481 Жыл бұрын

I am glad my neighbor's dog can now live longer. I am also glad I don't have to smell as much poop from my neighbor's yard. Bless that Snoopy. Thank you researchers!

@Montie-Adkins Жыл бұрын

I would liked to have heard his view on plasma dilution and E5.

@claytonbrom8030 Жыл бұрын

Aww,Dr Brad you are adorable and look amazing 😍 thank you for your work

@rui-9-cs315 Жыл бұрын

wow, what a treat!

@RobertNaik Жыл бұрын

This was a great podcast. Matt is giving a very realistic view of where science is with longevity. Not like dr Sinclair… only think I’d say is I do think zone 2 is important from personal experience. It’s not very hard to do or figure out how to do it and the injury risk is very low.

@santanacaipirinha9536 Жыл бұрын

For me, it's not just been all the money dished out for these supplements, but the time spent researching them. You start taking a supplement, then find more information on it where people are saying "well, if you take supplement A, you must also take B to counteract C that might be caused by A". Before you know it you're taking 3 extra supplements because they supposedly work synergistically or fix each other's side effects. Then all those supplements in turn seem to have riders; a particular supplement has to be the kind that's excreted by polar bears and filtered through a platinum strainer or it won't be effective. You want to take a fish oil supplement? Better research all the brands' oxidation reports. Hyaluronic acid? Some say get high molecular weight because the low one causes inflammation, others say to get the low molecular weight because the high one won't penetrate. Now I read I'm supposed to look for mid-molecular weight, and good luck finding out from the manufacturers how many kilodaltons their product is. Then once you pick one and spend all that money, someone will come out with a video or blog on why that supplement isn't effective at all or why they stopped taking it (no offense meant, Dr.) and why this new study shows it. For people who love to dive deep into this subject and love the science and experimenting I'm sure that's not a big problem, but for some there just comes a point where they go: "F*ck it, I'll just eat my veggies and hope for the best."

@lukeoldfield7940 Жыл бұрын

Haha - this is all a very relatable experience, sadly. I have a growing stash of supplements that I only take intermittently now and have to remind myself why I bought them, and then why I stopped taking them!

@santanacaipirinha9536 Жыл бұрын

@@lukeoldfield7940 Just don't remind yourself how much you paid for them, then you should be fine.

@vibhaspalding6457 Жыл бұрын

How can we get rapamycin in UK? As far as i understand it is not available.

@DS-eu2ww Жыл бұрын

this video shows longevity research is going at a SNAIL's pace. Very very sllllloooooowwww. Cant even tell if RAP will cause loss of muscle mass. maybe 3-5 yrs from now Just barely learning how to test more than one compound at a time. Good Lord, we should be able to test several at a time. That might come in 300 years from now.

@thenaughto1056 Жыл бұрын

Great interview Dr. Brad. Very informative and educational! Would love to see you interview Dr. Peter Attia if at all possible. His medical practice is about extending life and like Professor Mattt he is skeptical about the supplement industry but big on diet, exercise and sleep.

@kirktatum1051 Жыл бұрын

Dr. Stanfield- can you do a video on microdosing lithium and also calcium AKG? THANK YOU

@StaffanOlsson-sw6tx Жыл бұрын

The muscular system is a highly metabolic and adaptable system that secrete a wide a array of substances. Avoiding/reducing sarcopenia might be helpful in many more ways than just to keep people’s strength at a level that make them functionally independent and make their daily life manageable. (Conflict of interest - I take CreatineAKg and creatinemonohydrate)

@rnametaanalysis2583 6 ай бұрын

Push back a little when he says things that are wrong. The collagen peptide meta analysis was on clinical trials, not epidemiological studies. Would have also been nice to ask about a few of the following issues: 1. Evidence that Rapamycin can increase amyloid beta in a particular AD model (he generally dismisses this unfavorable data on Rapa AFAIK - exactly an issue that he criticized other scientist of) 2. Rapa generally causes weight loss in mice. I would presume it does so by reducing caloric intake. This seems to confound the Rapamycin data in general (is it partially just a drug that induces CR). Great interview! Love your content

@mikespector2 5 ай бұрын

Very interesting. Question for Dr. K. Why do you cycle rapamycin, instead of regularly once per week as most do? What is the cycle like?

@neilquinn Жыл бұрын

Any concerns for using rapamycin for men for reproductive health? (recent findings for metformin had some birth defect issues!). Agree with skepticism on supplements. Only thing I take if EPA/DHA since it seems to have the most evidence compared to all other supplements.

@rn5697 Жыл бұрын

I don't get it how can we change/repair epigenetics?

@d3877 Жыл бұрын

What about everolimus (a rapamycin analog)?

@larsbars7875 Жыл бұрын

Off topic but any reason you removed protein powder from you supplement stack?

@nonfictionone Жыл бұрын

Low protein intake seems to be associated with longer life.

@daviddavies2467 Жыл бұрын

Love the content as usual Dr. Brad this one was truly an eye opener for me. As I've always suspected, nobody really knows how different humans respond to supplementation. I've also wondered about multiple supplementation it could be highly detrimental to health and we just don't have the data to prove otherwise. On this basis I may cut my supplement stack considerably. FYI no mention of Ca-AKG is this because of lack of data??

@DrBradStanfield Жыл бұрын

Correct

@AB-zv6dz Жыл бұрын

He kept saying caloric restriction is the best intervention but what does that mean? Caloric restriction of 1 calorie below BMR? 10% of BMR? What is an effective calorie restriction? Would appreciate an answer or a steer

@JenLMcCarty Жыл бұрын

This is one of the best videos you've done, great, informative, clearly expressed content delivered by a very competent knowledgeable guest.

@swimbait1 Жыл бұрын

Really bright guy and quite conservative concerning supplements. We have all known for years that some of the data on supplements is questionable at best. Nevertheless, we also know for sure what happens if we take no supplements at all, we get old, feeble, etc and often live for many years in this condition. So to me the downside being the cost of the supplement is worth the it even if it improves my life just a little bit. I still take vit d, creatine, a multi, circumin, and focus heavily on a plant based diet and regular exercise.

@georgedres7914 10 ай бұрын

Hey tried to donate- am starting rapa and want to contribute but paypal wouldn’t accept

@abritrn Жыл бұрын

Regarding collagen studies, I’m confused about his (Prof Kaberlein) use of the word epidemiological when Dr. Brad was referring to placebo controlled clinical trials. Those are not epidemiological studies. I originally had the same questions that Professor Kaberlein did regarding the breakdown of collagen protein in the gut into individual amino acids. But there is evidence to show they get absorbed as di and tripeptides.

@betzib8021 Жыл бұрын

So why didn't the title say how to increase longevity in dogs...and I don't ever hear you talking about using protein restriction to inhibit mtor. Did I miss that one?

@generic_cat Жыл бұрын

You look great in this video brad.

@SilhSe Жыл бұрын

Hell yeah ! 💯👍👍

@ramprabath7352 Жыл бұрын

Effect of collagen peptide and hyaluronic acid lol 😂

@mirellamatotek4294 11 ай бұрын

I am diabetic and metformin has caused extreme muscle weakness. If muscles are a sink for glucose disposal, how does metformin make sense when just walking becomes an insurmountable challenge? I have taken myself off metformin and the difference in my muscle strength is like night and day. Walking, exercise even running is doable. So what is more dangerous not taking metformin or not maintaining lean muscle & strength? I fear staying on metformin will result in being wheelchair bound then agecare. Metformin makes me miserable so what is the solution? I am happier being off meds because I can be active and strong.

@zhao11214 Жыл бұрын

why rapamycin over the other mtor inhibitors? also rapamycin also inhibits mtorc2, causes a lot of side effects like lung toxicity and diabetes symptoms, and increased risk of certain cancers... who will take this knowing these side effects?!

@lawnmower11 10 ай бұрын

100% agree. Suppresses your innate immune system and side effects evident quickly even at low weekly anti-aging dosing. Who want lower lymphocytes and compromised natural immune system?

@diamond_s Жыл бұрын

iirc Sinclair said that massive induction of DNA breaks without causing mutations leads to accelerated epigenetic aging in models and consequent display of aging phenotype. That does seem highly suggestive that epigenetic aging is behind the aging phenotype.

@Dan-uf2vh Жыл бұрын

The most complicated way to manage aging entirely ? Manipulate matter cell by cell, molecule by molecule. The simpler / easier ones are epigenetic manipulations for which current research is just looking into, let alone providing a medical application at this moment in time. A lot will be learned and modeled, many of these interventions will leave imperfections as they address some bigger factors. Overall we should be able to reach more thorough procedures to effectively deal with aging entirely within 30-50 years given the progress of computational technology and the current renewed interest in biotech and aging. Then perhaps 70 year in the future (30 years later) we can use all that data and understanding as well as forms of nanotechnology to provide "perfect" age controlling interventions.

@PM-dz9fe Жыл бұрын

At 55:45 you mentioned creatine and you've talked about it on other videos. Well, it may work for some people, but I've tried it for an extended trial twice because you've been enthusiastic about it. For me, I've noticed no effect whatsoever either good or bad. I do exercise with moderate intensity some days and high intensity on alternate days, but I am over age 70. So, maybe that has something to do with it. The tests I used are the total number of pullups I can do (8 sets of 10) and the 100 yard dash (4 sets). I noticed no improvements with these two tests. Any thoughts?

@vibhaspalding6457 Жыл бұрын

P M After my hip operation, I started creatine. I believe it got me fit and healthy very quickly with use of weights and kettlebells etc. When I ran out, the urge to do weights had gone. After further research, I understand you have to load creatine, 20grams for each of 7 days, after that about 5gram each day. So I started yesterday, around 20gms and will continue for full 7 days, so until next Monday, after that I shall take 3 to 6 grams each day. So within 3 weeks, I should see an improvement. I understand it is very quick result after loading is done.

@vibhaspalding6457 Жыл бұрын

By the way I have just started pull ups again in the last week or so and not getting very far. I am hoping to see vast difference in my pull ups and the time to increase to 5 minutes of practice instead of 30secs.

@donnaryan71 Жыл бұрын

some people are non responders, I heard that about 20 years ago

@TheCatseyepub Жыл бұрын

Nothing about Glynac? There was really definitive studies about this recently.

@jozefwoo8079 Жыл бұрын

Will you review the research on collagen peptides again now that Matt has expressed his scepticism?

@roblake602 3 ай бұрын

Extra collagen peptides can INCREASE aging in humans...

@kevingilhooley2064 Жыл бұрын

I like this guy.....and the subtle dig at the snake oil salesmen such as Sinclair et al...thanks to Brad for the vid...even if Matt partly shit down his collagen and creatine theories.

@diamond_s Жыл бұрын

Certain long lived species of bats experience substantial epigenetic rejuvenation each hibernation cycle, this may or may not be influential towards their great longevity. I tend to suspect it might be highly influential but I could be wrong. We definitely need to see epigenetic reprogramming tests in mice.

@jozefwoo8079 Жыл бұрын

So does calorie restriction work for humans?

@fredcruegger9734 Жыл бұрын

also, if any of you struggle with migraines or frequent head aches. the primary cause is the shortage of vitamin b1, b2 due to its short half life in the body and magnesium, but magnesium has a long half life and doesn't need a frequent supplementation. the best form is the bio-coenzymated forms of the b1 and 2 as these are fat soluble and easily cross the brain blood barrier. also, if you are physically active, supplementation of collagen will prevent any excess joint wear, which is common among elderly due to the poor production and athletes due to excess consumption leading to rapid premature wear. in women soy based Phosphatidylcholine (PC) along with a mild use of vitamin k2 will prevent any formation of diseases associated with blood vessel plaque. such as a stroke, dementia, alzheimers and many neuro-degenerative diseases. also the occasional use of methyl folate (not folic acid) a vitamin b9, vitamin b12 and b6 will further stabilize the cns and the brain function in the long term. as well as promote faster healing/detoxification associated with strong methylation. with this formula you can easily make it up to 110 with nearly zero visits to any doctors whatsoever, which be annoying/costly/unnecessary. what more can you possibly want.

@khanbbarrhail3550 Жыл бұрын

Thanks for a great job, Dr. Standfield and Prof. Kaeberlein!

@richardjaffe9972 Жыл бұрын

Interesting study on mice by Satchin Panda with evidence of circadian eating being a relevant factor not due to diet restriction. Both mice feed same caloric western diet only changing feeding time and those with restrictive feeding time lost weight. Not sure if this has been done on humans😢

@SlamminGraham Жыл бұрын

The key here is that not all protein is the same. Proteins are very, very different depending on what types you're talking about. Fish is best, and legumes. Then shellfish (a little bad due to cholesterol), followed by turkey. The chicken, and eggs (keep it to egg whites only whenever possible). Then game, venison, etc. Finally, there is red meat: pork and beef, both of which you should never, ever have.

@hansnielsen6280 Жыл бұрын

I wonder what Prof. Kaeberlein and Brad would think of longevity “extremists” like Bryan Johnson?

@homesignup Жыл бұрын

Fabulous intervew and interesting longevity trial in dogs. Hope it translate well to humans

@ramprabath7352 Жыл бұрын

Sleep like a dog 🐕

@jonhylow1239 Жыл бұрын

Im not an official medical professional, but I know, that if we want to increase longevity, we need to be able to change our perspective and therefore our cultural programming, which will give us lots of new data. Atmospheres, contamination and surfaces are extremely important, but still most doctors dont take those things into account. Also Kundalini will help us to understand our body much better, which also will give us more data. Also we can have objects in our eyes, which will make our whole body sick and those are extremely hard to remove again, bc they are deep inside and bc the eye is so soft. I think no doctor really understands it, right now. If we remove those, we def will live longer and better imv.

@creativesource3514 Жыл бұрын

Back it up with research ....good research!

@sterlingrooke4712 Жыл бұрын

Kaeberlein's assortations are backed by facts which is so refreshing. Sinclair has just been a massive disappointment; he continues to push things that are counterfactual... I think he's still on the Resveratrol fraud?

@andrewchoi5808 Жыл бұрын

Build strong ageless sustainable solarpunk immortal utopian resilient future without aging, diseases, old age and death

@ichkaodko7020 Жыл бұрын

we're more interested in increasing the health and youth span than longevity.

@edouarddebonneuil149 8 ай бұрын

Do does fed once per day still do better than those fed more WHEN considering non-obese dogs, based on a weight-race proxy?

@molnar804 Жыл бұрын

In next episodes please ask him how much will be an increase of 30% in mices to humans?

@danceprometheus Жыл бұрын

What about consciousness uploading? That may be the ultimate game changer

@SilhSe Жыл бұрын

When my Cat was sick she stopped eating for 3 days and it seems there is an instinct to restrict food for autophagy/ longevity. Anyway on day 3 I gave oral anti biotics because she has a flu, shes doing well now and has a good appetite.

@jimdandy8996 Жыл бұрын

Antibiotics don't treat viruses. She improved coincidentally.

@SilhSe Жыл бұрын

@@jimdandy8996 😂🤣 yeah I know, I didn't have time to go to the vet for tests for FLC, shes got other stuff; breath that smells like a rafflesia. I have to choose to whom I shall give my time and attention; a sick Cat 🐱 or a WW2 Veteran 🥇.

@elensayista8988 Жыл бұрын

Ill die defending that cinnamon tea + chamonille is metformin without the the toxicity. Or maybe I wont die because that tea makes me live longer :)

@kevinhuxley9252 2 ай бұрын

❤

@gryphonschnitzel7140 Жыл бұрын

Im 22 what would happen if i were to start taking rapamycin now?

@jimdandy8996 Жыл бұрын

You'd grow hair on the palms of your hands.

@Fearzero Жыл бұрын

You can't so why think about it?

@jimdandy8996 Жыл бұрын

@@Fearzero Yes they could. It can be purchased.

@Fearzero Жыл бұрын

@@jimdandy8996 Under what pretense, organ transplant lol? I don't see rapamycin for sale on any supplement sites. By prescription only.

@mrmikeeu Жыл бұрын

It seems to work best in older mice. Also, it lowers the immune system, and can cause diabetes. Not a drug that is ready for prime time...

@susymay7831 Жыл бұрын

Do you think a low protein diet should be generally moved to a medium protein diet after the age of 65?

@mrmikeeu Жыл бұрын

Yes, this is known and should be put into practise. Older people need more protein. I'd start at age 50.

@barbarafairbanks4578 Жыл бұрын

susy may - imo (based on what I've heard/read) forget low/med protein intake unless you are

@xmonikerhotmailcom Жыл бұрын

Plant based protein doesn't have the same negative effect on the body as animal derived. There is a lot of science showing this. Go to pubmed and look.

@alans177 Жыл бұрын

👍

@jimbob4456 Жыл бұрын

There was a new study that just came out that indicated intermittent fasting led to shorter life. I’m not kidding

@justingirard7476 Жыл бұрын

just fast for 36 hours and get that GH flowing. You don't need a lot of protein if you have the right eating / activity .

@computerhelpcc 2 ай бұрын

Data re Interventions on already healthy middle-age people are the only ones that matter to 90% of your audience. Sleep, eat well, exercise, socialize in person THEN let’s see what these add-ons can do. Eye health, agility, ability to solve problems one has the skills to solve….

@mutanthorrorshow Жыл бұрын

In my experience metformin definitely blocked muscle gain.

@definty Жыл бұрын

It would ,its an AMPK antagonist so all exercise will be muted. Not completely but you will notice gains aren't as much as before. AMPK activates when we exercise so if your already taking Metformin and exercising your AMPK won't react when you exercise, at least as intensely as it does without the Metformin and your gains won't be as much.

@xmonikerhotmailcom Жыл бұрын

It made my feet feel like they were on fire lol!

@Pixel-junkies Жыл бұрын

Oh this is interesting thanks for that!

@betzib8021 Жыл бұрын

So I can't afford rapamycin for myself...and now I'd have to buy it for my dog?