Please answer>>>>I am a ex-soldier and have had some small CTE and I read some huge study that was not in America and it stated NMN worked on Dementia patients and even found some synapses/brain repair at a cellular level...I am not sure but I think I read 2 for mice and 1 for human with mild dementia, so that is why I have been taking NMN since they say it is a smaller chemical compound that creates NAD+ and I have seen results with short term memory. I also found out by my seller that the FDA is wanting to make a prescription out of it...guess who was named backing that, Dr. Sinclair. Can you explain this. Thanks and God Bless

Dr.Stanfield, is it even advised to take NMN with a diagnosis of meningioma.

I think we need research replicating Michael Lustgarten niacin research. It suggests that 60mg of niacin is about as effective as 1g of nmn, but less than that effectiveness drops at least for him personally. It may be that there's a minimum dose based on body size for effectiveness.

​@@lchordasI developed a benign tumor in my kidney after taking NAD booster which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed

Is any of those studies involving Andrea Maier?

Thanks for doing the good work 😂

Yeah, you want muscle improvement? Go lift.

I'd like to see the data on how they came up with the recommended daily B3 amount

Thank you for the shortcut. It saved a lot of time of mine

​@shumandaniele i use it and it works

Dr Scamclair

make sure you keep being open minded and form evidence based opinions. don't replace a reliance with one authoritative figure with another. that being said, yeah, Sinclair seems to be full of shit lol

Totally. And now trying to monetize NMN for his own benefit.

No need for an investigation, it's confirmed he's a charlatan.

David is a hack. I've never liked or believed that guy.

I'd like to challenge him to a math competition against me to see how smart he really is.

I’m sure he’s extremely smart but he’s been pushing hard on claims for supplements without sufficient science backing the claims. Revesterol, Metformin and NMN.

Beautifully said!

Well considered.

I had complete visual failure.. eyesight became kaleidoscope, would last for 10 seconds.. eventually realized it was the Astaxanthin ... never an issue since stopping, except once when I didn't know it was in my omega sup.

He did an episode on Astaxanthin. My recollection was that there was good evidence of benefits, however taking excessive antioxidants might have downsides so he recommended it for those 60 and over.

There’s no biological pathway for orally supplemented glucosamine to place itself into the tissues. It’s snake oil.

Very good you pointed this out as Stanfield superficially and carelessly trashes supplements doing a lot of harm to people who could otherwise benefit from them. He lacks critical indepth analysis needed to make an accurate judgement. I too have read that it makes the difference if it is the G-sulfate form since the cartilage is made up of glycoaminoglycans in sulfated forms, so if you lack the sulfate it seems to be an incomplete form for cartilage synthesis. Glucosamine sulfate stimulates the production of glycosaminoglycans (GAGs) in cartilage. GAGs are important building blocks of connective tissue, including cartilage, and are necessary for healthy joint structures. Glucosamine sulfate also inhibits the degradation of GAGs. Stanfield needs to go back to his biochemistry text books and look a little deeper.

I have always caught 3 to 4 colds every autumn/winter period, but since I started NMN, 0,5 go now 1 to 1,25 daily, I haven't had one in 4 years...

Anecdotal

@@slimturnpike All personal experience is "anecdotal". However, we happen to be living in unusual times. Sometime in the next 10 or 20 years, for the first time in human history, extending life-span will become possible. For an older person, the rational analysis is " do nothing, resulting in certain death" or "study the existing limited research and play the odds, as best one can read them" and try to survive until the first breakthrough happens. Waiting passively is not an appealing option.

Absolutely spot on. Brad, as usual, continues his hate campaign against Sinclair, albeit more cautiously and subtly nowadays. I’m amused how he selects mainly negative research studies for his ‘talks’. I find his campaign interesting in so far as I see a display of open antagonism from a relatively literate man ( whatever that may mean). Sinclair had to block him eventually and left Brad whining about his t. Let’s hope he eventually gets what he himself has become.

@@jimroth7927 I agree, not an option. I choose the option to read and evaluate empirical evidence such as what is presented in this video, and act accordingly, rather than follow KZfaq commenter tales and other anecdotal material. YMMV

That's why he is conservative with the dosing, compared to other supplements (hence "micro" vitamin). Ideally you want to set up your own stack based on your needs, and determining these precisely can be difficult. If you eat well and have no deficits, then maybe you don't need any supplements at all.

I did the same with another high quality NMN and felt nothing.

​@@mattc3510I felt good usually, however I developed a benign tumor in my kidney after taking NAD booster which was not there before , so I'm afraid of them now . Sinclair once said avoid if such concerns exist

What’s your age? I feel like NMN will probably only have effects for people over a certain age. Like say growth hormone, where it’s so high when you’re younger, no need to boost it

@@kevinsutube1p528 like with many supplements, if you feel a difference then it's probably because you had a deficit in something. Personally I don't feel a difference with a lot of supplements that supposedly help people (and I'm close to 50), which I interpret as a good sign :)

Resveratrol did nothing for me while NMN provides visible results, both in terms of stamina and immunity. I'm 67 and play racket sports 3 to 4 times a week, Donotage NMN is my provider. Sinclair is trying to get NMN stricken off the list of food supplements by the FDA and classify it as a drug.

Good question. Fisetin and spermidine should be on the list as well.

I’m 47 yrs old and started hot flushes early summer. I started doing my research on longevity. I started consuming soil milk and started taking Nmn last summer. My hot flushes disappeared in 1 less than a month of taking nmn and soy milk. My periods are so regular and my fogginess improved and my energy level increased. I’m a Nurse I work 12 hrs 4 days a week. My stamina improved and I still have thick dark long hair. I think NMn helped me a lot. I’m already almost taking 1 year of NMn from do not age. I also added taurine, speemidine and sirt 6 this January

I've read studies on all of those. The most promising appear to be glycine and taurine. I've tried supplementing with taurine (I'm past 60 so my level should be low) but my body doesn't accept it well. It made me quite dizzy. I tried lowering the dose (don't remember what it was but about 1/3 that recommended). It left me feeling chilled to point that although I felt ok, I lost motivation to do anything. In my case, it may be that I already have plenty of taurine as since COVID I've had mild fibromyalgia symptoms and that can mess up amino levels so I'm probably not typical. Glycine is a very promising supplement. It too declines with age and supplementation seems to provide a number of benefits. The main one for health being a significant increase in the production of glutathione, the body's most potent anti-oxidant. Glutathione also decreases with age and is critical for maintaining mitochondrial health. Glycine is also well tolerated in very high doses - much higher than you need to gain from its benefits. It can also increase creatine. I've been taking it for a while. I just add it to drinks, it tastes like sugar. I've seen the studies on NAC but the only good studies that seem to show benefits are those that combined it with glycine. Then studies using glycine alone seemed to give similar results to the combination. Also, as I understand it cysteine is not something that declines with age. I heard one explanation that it may help as a sulfur donor in the production of glutathione. In that case, if you eat cruciferous veg or eggs while taking glycine, that should have the same effect as well as being cheaper and safer. I eat plenty of both. Interesting to see how cause and effect have been misinterpreted in the case of age-related NAD+ decline. Rather than NAD+ decline leading to less energy expenditure, it's just the opposite!

Taurine and Glycine cancel each other out in liver uptake when taken together. Taurine can be sedating due to its effect on GABA, very noticable when taking 1 gram on empty stomach with glass of water.​@@antonystringfellow5152

I forgot to mentioned, I also take GlyNac, omega, vit k2, D3, mag and other micro vitamins like collagen hyuloruc acid including vitamins for bones.

I developed a benign tumor in my kidney after taking NAD booster which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed

Don't tell stories like that. As the father of a type 1 diabetic who intentionally keeps himself low and often overshoots the mark, I can tell you that the need for glucose is absolutely real, the effects are almost immediate and no amount of placebo effect can bring a low diabetic back to normal.

@@bill9989 That person likely wasn't diabetic, though. He never said they were diabetic. They likely just recovered and stood back up and the person above is the only one who concluded that the ill person needed sugar from mints. Maybe she just felt better just because of the short rest and attention/aid from another person.

@anna-xz9yj Of course. That person was clearly not diabetic. You know that, and I know that. But I don't want people to think that the person was diabetic (obvious conclusion from the story) and that severely low blood glucose isn't real. Having to recently revive my son from severe low glucose, I can tell you it was a harrowing experience. No amount of fake glucose could produce a placebo recovery.

@@anna-xz9yj This exactly.

@@bill9989 It's never occurred to me that someone might interpret this as a diabetes reference so I've added this line for clarity: "In my experience people sometimes get lightheaded when they're out in the heat too long and haven't eaten enough so"

I feel no difference

I always feel good Not one supplement boosts my energy

I felt ZERO difference. Absolutely nothing. In fact I stopped and improved my sleep a bit and feel fantastic off it. Million other things to do first before wasting money on this. Sleep exercise will do 10x more than NMN

​@@mattc3510I developed a benign tumor in my kidney after taking NAD booster which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed

I took it for 3 months and felt no difference, but also took blood tests before and after those 3 months. No difference there as well.

Ditto on that, I took it for a couple years, no noticeable difference also. Stopped altogether unless there's new evidence. My antiaging choice is Carbon 60 and recently Urolithin A (juries out on that one).

Same here. I seem pretty immune to placebo effects, and it's hard to find anything that makes a difference for me. So I'll stick with sensible eating, exercise and sleep.

Same here.

I also took it for a year from a reliable source, DoNotAge. I never noticed any effects. I am 62 and in pretty good shape. There is always a risk of negative side effects, so I stopped taking it.

Same

If you do adequate cardio exercise weekly and eat a good diet and get enough sleep, you're in a nad+ levels will be adequate, there won't be any benefit. People under 30 years of age have good NAD+ levels even if they don't do lots of cardioI NMn is a lifeline for me as I recover from a major health issue at age 48. Makes a huge difference in my energy, the health of my gums, and many other things I noticed from taking it. I just don't get the same performance from niacin. The other trick that I've found is that much higher doses are effective taken in small doses throughout the day. I take at least three to four grams a day and sometimes up to 6 if I don't get enough sleep. But there's only works if I divide it in small doses that I take every few hours. I think taking large doses at once ends up being eliminated from the body before these doses can be utilized.

It makes difference for me. Effect starts around 30 days after first day

I developed a benign tumor in my kidney after taking NAD booster which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed

I included that study in my analysis. Please see the video description for all studies that I included

@@DrBradStanfield you may have included in your analysis but I don't see it included in your video presentation, specifically in relation to the effects of NMN on muscle/exercise which would have been very pertinent to talk about

​@@DrBradStanfieldyes Dr please include that study in question in your video next time as it is a crucial study for this topic

​@@nicklam66I developed a benign tumor in my kidney after taking NAD booster which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed and we need longer term studies on this before widely recommending which I agree with Dr Brad

I developed a benign tumor in my kidney after taking NAD booster which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed

Can I ask what benefit your friends with lupus had? I use NAC to control lupus but would like to try nmn too

See my above question...I was taking NMN for brain health.

I think the point of NMN is to increase capacity for cell repair and activation of good genes. That does not imply that it cures arterial diseases or reverses glucose etc. I think it is proven that NMN activated sirt genes which relates to longevity, but I may be wrong. I recommend to take TMG as well if you take NMN to make sure that you have enough methyl groups, it can be important.

Niacin and nicotinamide were also found to increase NAD, they are part of my poor man's longevity supplements

@@melkor321and life extension’s homocysteine resist: for example…for necessary methyl groups…

Instead of exercising, you chose a shortcut spewed by hacks who wanna make money from that shortcut. Nothing is as anti-aging as exercise! Nothing!!!

It worked wonders on our dog and she has no idea what 'placebo effect' means.

I would always choose C60 over nmn any day. And not just from any company out there. After what I seen in solid research and what it was actually doing for the first time ever in the body I will continue to take it and find it superior to anything else out there!

I developed a benign tumor in my kidney after taking NAD booster which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed

Same here , took NMN for more than 12 months from different sellers with good reputation. Stopped taking it , no effect(I’m over 50 years old) ! It seems to be a placebo effect and/ or I read there might be people age over 50/60 who could benefit .

12-18 grams of Glycine a day is insane!

1g nmn daily should be taken with 500mg TMG.

@@Fearzero already tried, no change

Creatine is proven, magnesium works great for better sleep.

NMN doesn't taste bitter. It's rather degraded or you have bought a fake product. Pure NMN tastes sour because it's an acid.

@@nanohatakamachi1066 I got it from Donotage, one of the most popular suppliers. I wouldn't really describe the taste as sour either. Do you react like you're eating a sour lemon? I'd say bitter would be a closer comparison? Guess neither really describe it.

Where do you get it? Oh never mind I looked it up I’m already good on that 🤍 it’s in fish and mostly dairy too but I’m off all dairy. Why do these things have like ten different names for the same freaking component 🤣

@@treesoul00 Tru Niagen

​@@treesoul00bugger all in fish. It's nicotinic riboside

​@@treesoul00I developed a benign tumor in my kidney after taking NR , which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed. They may give some benefits and cause other problems

Was there something about metformin?

@@user-do6dl5gh1z Only for those who were taking it for longevity..search for Brad's video on it.. So not relevant to those who take it for diabetes. Essential treatment.

I developed a benign tumor in my kidney after taking NAD booster which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed

anything that increases skeletal muscle - that usually means weight training. We lose muscle as we age, aerobic activities are beneficial but don't build or maintain enough muscle to offset the effect of sarcopenia. Substitute some of your 50 chins (overkill) for lower body weight bearing (lunges, squats, deadlifts) and add in some overhead presses. You need to challenge your muscles, and at 50 chins, your muscles are not challenged. Add weight. Lots of it. Your reps will go down but your strength go up, which is apparently the predictor of health/longevity.

@@donnaryan71 you can keep swimming for the cardio benefits and add streghth training for increased muscle mass and bone density. Start it with a trainer so you avoid injury

Walking

Seems like you can’t pinpoint where the energy comes from with all the other stuff you’re taking as well.

have that checked out to be on the safe side

I developed a benign tumor in my kidney after taking NAD booster which was not there before in scans a year before, so I'm afraid of them now . Such concerns always existed

I have the same problem with NR (300mg/day). Aging markers on a withings scale are worse for 30 days. I just stopped

@@Chris-rk6yp I actually had NR for a while and didn’t see any changes with it or with NAD+

Well... just because NMN is decreased doesn't necessarily mean increasing it would improve health outcomes. For example, cholesterol drops as you get older, due to reduced consumption of food, yet we KNOW reducing blood APOB (part blood cholesterol) is a good idea.

@@Colin-yu7pc I'm talking about NAD, not NMN. There is little doubt that having more NAD+ is generally good for health, as the production of ATP depends on it. It is not in the same category of cholesterol.

Tretinoin I believe

He does take finasteride which is known to cause dry eye disease.

@@adamc2320 Incidence of dry eyes with finasteride is incredibly low. And Dr Stanfield himself stated that it’s related to tretinoin in the past.

Big Pharma boy smokes something illegal

I’ve heard they’re mostly rancid so I switched to straight up cod liver oil. I do Nordic naturals too just as a bonus but keep it in the freezer. I’d never use the ancient grody ones from cheap sources after watching that report a few years ago about rancid pills.

Just take algae oil. That's where the fish get the omegas from.

Eat sardines

That's only a small problem for people with A-fib and taking very high doses of fish oil in the 3-4g+ EPA/DHA. They're fine at 1g EPA/DHA

​@@larryc1616Not long ago they were attacking apples saying they cause disease, yet big pharma is untouchable