The fact that a grounded guy like him still thinks we can crack this means a lot more than whatever Aubrey de Grey spews out for the 1,000 time. As if he has any idea which exact year we have a 50/50 chance of hitting LEV etc.

❤️

If we make it that far, then a lot of us are hitting 2100 AD. If they haven't cracked aging, period, by then, well...then civilization must have crashed and burned, in which case, we won't be around or want to be around to see that year anyway.

Japan IS doing them. Because it has to. It is where the USA will be in 20 years, and the USA should take note.

The speaker, Matt Kaeberlein, is a leading figure in the field of aging research. He focuses on understanding the biological mechanisms of aging to improve health span. Kaeberlein has published over 250 papers on aging biology and serves as the chief scientific officer at Optuspan Geroscience. Kaeberlein begins by emphasizing that modern medicine has primarily been reactive, focusing on treating diseases after they occur. He advocates for a shift towards proactive health care by targeting the biological aging process, which underlies most age-related diseases. This approach, he argues, could significantly improve health span, the period of life spent in good health. He discusses the concept of "geroscience," the study of the biology connecting aging to functional decline and disease. Understanding these biological mechanisms can lead to interventions that slow aging and thereby delay the onset of age-related diseases. Kaeberlein mentions rapamycin, an FDA-approved drug with substantial effects on lifespan extension in animal models. He notes that rapamycin works even when started in middle age in animals, suggesting its potential applicability for middle-aged humans. Clinical trials are underway to test its efficacy in humans. Despite these advances, Kaeberlein cautions against hype in the field. He is skeptical about the effectiveness of anti-aging supplements, the accuracy of biological aging clocks, and the current state of epigenetic reprogramming. He stresses the need for more research to discover interventions with substantial effects on aging. Looking forward, Kaeberlein believes that while curing aging entirely is unlikely in the near future, we can significantly extend health span using current knowledge. He urges individuals to invest in their health, utilize preventative diagnostics, find knowledgeable doctors, maintain a healthy lifestyle, and educate themselves from credible sources. Finally, he encourages a reevaluation of the risk-reward balance in aging interventions, suggesting that some level of risk might be acceptable for the potential reward of extended health span. Kaeberlein concludes by emphasizing the importance of considering personal risk tolerance in the pursuit of healthier, longer lives.

We do - and the only proven intervention so far is rapamycin. (I would say intravenous NAD+ too, but Kaeberlein doesn't talk about it, for some reason.) He's just saying what we can PROVE right now, not what we can guess. That's all.

Why?

A strange reaction. If you knew who he was, you knew what he would say. If you didn't know, you've now heard a concise summary of the the state of aging science by one of the best in the field.

@@NickWestgate Not just one of the best but one of the most honest and grounded as well.

Exactly - he is giving us lifestyle tips to lengthen life. Waste of 35 minutes viewing.

@@BR-hi6yt No, he is giving us the advice for us to remain grounded and measure our expectations in the shorter run.

Tf you mean no ???!

@@antoine.- That's what I'm saying.

Lots of things that were once impossible eventually became possible.

No u

Of course its possible to reduce aging at the cellular level, but when are these guys going to get there (never)