Longevity Science 2024: New Insights on "The Hallmarks of Aging" & What They Mean

Longevity Science 2024: New Insights on "The Hallmarks of Aging" & What They Mean | 14 - LS #5

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The Optispan Podcast with Matt Kaeberlein

Күн бұрын

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Over a decade ago, five researchers published a paper proposing the Hallmarks of Aging paradigm: a set of cellular and molecular processes that underlie the aging process in different organisms. These hallmarks encompass a range of interconnected pathways, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient signaling, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Together, the hallmarks contribute to the gradual decline in physiological function and increased susceptibility to age-related diseases that occurs with age, and provide a framework for understanding how we age.
In this episode, Matt takes us through a quick download of each hallmark of aging, talks about some of the paradigm's shortcomings and limitations, and discusses the implications of the Hallmarks of Aging paradigm for the geroscience field.
0:00 Trailer
0:44 Introduction
2:30 Definition of the hallmarks of aging
4:40 Criteria 1: Age-associated manifestation
6:43 Criticisms of the hallmarks of aging
8:36 The current version of the hallmarks of aging
9:00 Genomic instability
10:27 Telomere attrition
12:40 Epigenetic alterations
15:32 Loss of proteostasis
17:40 Disabled macroautophagy
20:17 Deregulated nutrient signaling
21:57 Mitochondrial dysfunction
23:13 Cellular senescence
27:13 Stem cell exhaustion
29:50 Altered intercellular communication
30:47 Chronic inflammation + "inflammaging"
32:09 Dysbiosis
33:43 The interconnectedness of hallmarks
35:48 Our rudimentary understanding of biological aging
40:37 Advice for the field
40:48 Pillars of aging and their impact on the aging process
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.
On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!

Пікірлер: 19

@jamesgilmore8192 2 ай бұрын

The hallmarks are useful signposts with our current understanding. Eventually I'd expect a very long list of hallmarks. What we need however is a much larger network analysis of the changes in biology during aging and a rigorous assessment of the association and casual relationships between the nodes of the network.

@jozette-pierce 2 ай бұрын

Wow, we have alot to learn. Thanks for very informative lecture.✔💯

@szghasem 4 ай бұрын

Thank you Dr. Kaeberle for another great class! Looking forward to next episode. Can't wait to see where these courses will lead us.

@danos5181 3 ай бұрын

Amazing lecture. So clear. Thank you!

@PaulTozour 4 ай бұрын

Aubrey de Grey originally defined what are now known as the “hallmarks of aging” as the SENS model in his book Ending Aging, published in September 2007, a full 6 years before the 2013 paper. Let’s give credit where credit is due. As someone who’s spoken out about academic integrity, I’m sure you can respect the need to tell the true story of the origins of this model.

@mkaeberlein 4 ай бұрын

Why do you believe that? Aubrey's seven types of damage are partially overlapping with the Hallmarks but are obviously not identical. I have no idea whether the authors of the Hallmarks paper were influenced by SENS or not. Despite what you may hear, the idea that damage causes aging or cataloging the types of damage associated with aging was going on far before Aubrey came along and many, many people contributed to that literature. SENS made the bold claim that fixing a small number of types of damage would essentially cure aging, which I disagreed with at the time and still disagree with. I'm not trying to minimize the role Aubrey played, but the Hallmarks paper has been much more influential within the field - both good and bad - than SENS. - MK

@PaulTozour 3 ай бұрын

@@mkaeberlein I appreciate your candid response. The hallmarks do seem to me very much like a slightly modified and repackaged version of SENS, and almost no one outside of Aubrey was discussing this sort of model before 2013. Having said that, I obviously can't prove that SENS inspired the 2013 paper. It just seems to me that the SENS model gets far too little attention, and credit.

@IAMMANIFEST 3 ай бұрын

It's so good to see you with your own podcast! I've actually been referring to you on my Tik Tok. Hopefully you'll start posting your content over there as your grounded information is so needed to reach the masses. Funnily enough I was getting reported for misinformation especially re resveratrol and your views on this. I'd actually really love to hear what constitutes healthy/balanced nutrition and your thoughts on the extreme diets out there. I started extended water fasting and keto green as an extremely healthy person based on seeing 'experts' refer to this. I've been sick ever since but rarely see anyone warning extremely healthy people about these extremes. I now feel they're perhaps better suited for those who are obese or have type 2 diabetes and that it may be detrimental for extremely healthy people. For me, it at least contributed to my severe burnout. I literally love all of what you share! Thank you.

@user-xw1ve1pw9c 4 ай бұрын

I like this concept that includes "connect" - simply because central nervous system involvement is seminal (and central) to biological processes. Furthermore, connection implies this interaction with the most critical aspect of the environment - the self and others.

@alexandrejuve1305 3 ай бұрын

In 500BCE they already know that the earth is a sphere. And a in 1500BCE too and fore sure before.

@SilverFan21k 3 ай бұрын

Wow you rocketing fast to 3k subscriber

@autisticautumn7379 4 ай бұрын

The hallmarks of ageing are fascinating.I read the paper by Lopez truly eye opening.

@mdavid1955 4 ай бұрын

So do we have any idea what instigates aging yet? What do these very long live species do different? Better genes? More copies of certain genes? Better epigentic regulation? 🤔

@HvdHaghen 4 ай бұрын

Many have searched for ways to stay healthy and live longer. The results have been disappointing. What does work is don't do things that are bad for health. Avoid nutritional deficiencies. Stay active. Most medicines for healthy people to live longer did not really work. Many centenarians tell about their way to success, but it does not result in many people becoming centenarians with those methods. Maybe there are some exceptions: In Acciaroli there are a lot of centenarians who use rosemary. The Hunzas use apricot kernel oil (cyanide, senolytic?). In China Gynostemma pentaphyllum is used in an area where many centenarians live. Any thoughts about this?

@askingwhy123 3 ай бұрын

Pragmatic and logical.

@captainremington 3 ай бұрын

Limitations are wellcome, but being simple can make us to overlook details. On the contrary, simplicity may be the best tool leading truth (Feynmann inspiration😉)

@livingsmart 4 ай бұрын

Sounds like we are "looking for the keys under the light just because it's more convenient" with hallmarks. Similar problem is with mice studies vs humans, mice are more convenient, but good luck with translating. P.S. I prefer 12 pillars of the healthspan, because imo granularity adds clarity.

@user-xw1ve1pw9c 4 ай бұрын

Wouldn't eating overlap dysregulated nutrient sensing?