Resting membrane potential physiology | Nerve muscle physiology mbbs 1st year
Рет қаралды 13,780
Күн бұрынPhysiology lecture details generation of resting membrane potential (RMP), Nernst equation with equilibrium potential, and Goldmann Hodgkin Katz Equation. Also, understand why different cells have different resting membrane potential and how RMP is affected if intracellular or extracellular potassium concentration is changed.
Buy concept based physiology notes here:
Download
Android app for Physiology notes here: play.google.com/store/apps/de...
IOS app: apps.apple.com/in/app/myinsti... (use org code:ezlep)
Website: www.physiologyopen.com/
Link for Gibbs Donnan Equilibrium: • Gibbs Donnan Equilibri...
Other popular playlists and videos:
Sensory physiology playlist: • Sensory system
Special senses Physiology: • Special senses Physiology
CNS physiology: • Central nervous system...
Cardiovascular physiology: • Cardiovascular physiol...
Respiratory physiology: • Respiratory system phy...
General Physiology: • General physiology mbb...
Blood physiology: • Blood physiology, path...
Renal Physiology: • Renal system physiolog...
Endocrine physiology: • Endocrine system | Phy...
Gastric secretion: • Gastric secretion | Ga...
Buy our Practical Physiology book here:
Amazon: www.amazon.in/Practical-Physi...
Flipkart: www.flipkart.com/practical-ph...
#physiology
#1styearMBBS
#MBBS1styear
#physiologyopen
#physiologylectures
#generalphysiology
#nervemusclephysiology
@vedasamhitmatta8261 3 жыл бұрын
Fantastic Mind-blowing Unbelievable
@PhysiologyOpen 3 жыл бұрын
Thankyou, thankyou, thankyou 🤗
@subianbu8398 Жыл бұрын
U r the best i ever seen❤
@PhysiologyOpen Жыл бұрын
Thank you ❤️
@madhurabedekar7799 3 жыл бұрын
where can I get Effect of Kc l& Cacl2 on cardiac muscle ?
@dryash866 11 ай бұрын
Loved it mam keepup the great work😊
@PhysiologyOpen 11 ай бұрын
Thank you 😊
@garimajoshi6547 Жыл бұрын
Thanku mam ,you explained it very well
@PhysiologyOpen Жыл бұрын
Glad you liked it 😊
@DrJyotirmaySS 3 жыл бұрын
increasing extracellular k+ concentration will cause depolarisation. reason : normally the RMP is close to equilibrium potential of k+ as it has maximum permeability. also the equilibrium potential depends on ratio of K+ inside to K+ outside {from Nernst eqn} so, if the outside concentration increases , the ratio will tend to 1. from nernst eqn now it's evident that the value of emf( equilibrium potential of k+) will lie somewhere between -61 to 0 depending upon how much outside concentration is inceased. ie the RMP will increase towards 0 mV
@PhysiologyOpen 3 жыл бұрын
Absolutely correct answer with a very nice to the point explanation. Thank you
@tomcruise9317 Жыл бұрын
So in hypokalemia is hyperpolarisation seen........ Also mam in sympathetic situvation artrioles constrict by alpha 1 so TPR increase ..if TPR increase heart will find difficult to pump blood as diastolic bp will be high around 90 ...how this kind of action is usefull in emergency situvation flight fright.....i.e why do we want to maintain diastolic bp and its importance...
@Drraeeskhan3487 2 жыл бұрын
Mam you are the best
@PhysiologyOpen 2 жыл бұрын
Thank you 😊😊😊
@coronaman365 2 жыл бұрын
Dhanyabad
@PhysiologyOpen 2 жыл бұрын
Welcome
@sharanubb4837 2 жыл бұрын
Mam extraordinary
@PhysiologyOpen 2 жыл бұрын
Thanks. Glad it helped 😊
@nithinkrishna9861 3 жыл бұрын
Since there is increased extracellular concentration of potassium, there is a decrease in the concentration gradient of potassium from inside to outside, so the duration of the repolarization will be increased, altogether increase in the duration of action potential, thereby increasing the chance of arrhythmias due to early afterdepolarization.
@PhysiologyOpen 3 жыл бұрын
True...there is increased duration of repolarization in action potential , hence increased durationof action potential. Thank you for explanation
@nithinkrishna9861 3 жыл бұрын
@@PhysiologyOpen thank you physiology open. Hope this kinds of questions at the end of a video lecture is useful ,this make us think ,and even if we are wrong. .we will wait patiently for the next video to get the correct explanation
@PhysiologyOpen 3 жыл бұрын
Yeah will try to include questions at the end of each video
@dka3608 2 жыл бұрын
🙏
@PhysiologyOpen 2 жыл бұрын
😊
@madhurabedekar7799 3 жыл бұрын
where can I get videos on nerve muscle physiology ?
@PhysiologyOpen 3 жыл бұрын
kzfaq.info/sun/PLnt1wzLU3qo0DxK16gZnY2pbLnFLK3AB8
@PhysiologyOpen 3 жыл бұрын
Let me know any videos you need in particular..
@madhurabedekar7799 3 жыл бұрын
@@PhysiologyOpen excitation contraction coupling and exercise physiology
@PhysiologyOpen 3 жыл бұрын
Ok will make
@PhysiologyOpen 3 жыл бұрын
Exercise physiology will probably need a series
@chaimaasalhi9646 2 жыл бұрын
How can we define a difference in potential ? Is it simply the difference in charge ??
@PhysiologyOpen 2 жыл бұрын
Yes its charge difference, though in case of RMP it’s just near the membrane and extremely small
@chaimaasalhi9646 2 жыл бұрын
@@PhysiologyOpen Thank you So much 😊
@user-hz9es4eu8v 9 ай бұрын
Mam 140 meq. Is outside cell or inside?
@PhysiologyOpen 9 ай бұрын
This is regarding which ion?
@coronaman365 2 жыл бұрын
Depolarization As Depolarization indicates influx of Na+ions And hyperpolarization means extra efflux of K+ ions from cell but here the conc. Of K+ is more in ECF so hyperpolarization will not be suitable answer Am I right mam?🙂
@PhysiologyOpen 2 жыл бұрын
Bingo...
@PhysiologyOpen 2 жыл бұрын
You may calculate it as well by just changing the values in Nernst equation
@coronaman365 2 жыл бұрын
@@PhysiologyOpen OK mam
@bio366geethasankar7 6 ай бұрын
🙏🙏🙏🙏🙏
@PhysiologyOpen 5 ай бұрын
😊❤️
@rajshreemeena9316 3 жыл бұрын
Ma'am please make video on lambert Eaton syndrome and myasthenia gravis too(◠‿◕)
@PhysiologyOpen 3 жыл бұрын
Sure
@drkartikeytripathi8118 3 жыл бұрын
Hyperpolarized
@PhysiologyOpen 3 жыл бұрын
Kindly read explanation above in comments. It’s depolarised...a follow up question is welcome
@user-zf3uq5uj3r 3 жыл бұрын
Hyperpolarization. Hyperpolarization=increase membrane negative potential, which makes it harder to depolarize.
@PhysiologyOpen 3 жыл бұрын
Yeah most common answer...but unfortunately not correct..can you explain the reasoning how you got this answer
@user-zf3uq5uj3r 3 жыл бұрын
@@PhysiologyOpen Ha Ha. I was half asleep when I answered your question. I just read your question. what happened if increased extracelluar K+?... Increased K+ concentration extracelluar, which will work against the "leaking out" K+ from intracelluar to extracelluar, therefore, the membrance potential becomes less negative, it will make the membrane easier to depolarize. Here is the POINT. The "positive" change of membrane potential has to reach the "threshold" before it can depolarize/discharge. so, your answer "depolarization" is not an acurate one either. I can give you a clinical example, slightly elevating blood k+ will not make heart "Jittery" . the blood K+ level has to reach the neighborhood of "6.5mEq/L", which, then, will cause a widened QRS wave on ECG because the phase 0 of action potential decreases, leading to a longer action potential -- widened QRS. the nomal K+ level 3.6-5.2 mmol/L. Hyperkalemia can be life threatening, I will treat it way before it reaches level of 6.5 .. Thanks for your lecture. It is by far very detailed and informing.
@PhysiologyOpen 3 жыл бұрын
Absolutely correct. Thank you for giving a detailed explanation. I think this will be beneficial for other people too. Only one think I will like to add...depolarization is any change in potential towards positive. It may or may not reach threshold. So increased extracellular potassium will cause depolarization i.e resting membrane potential which is less negative. This makes the tissues more excitable. And in case of effect on action potential, it will increase the duration of action potential. Then this effect of K+ on RMP can be easily understood by putting the changed vaues in Nernst Equation. Thanks again
@user-zf3uq5uj3r 3 жыл бұрын
@@PhysiologyOpen thank you for clarification! Can you explain the effects of increased extra cellular Calcium level on action potentials? 😊
@PhysiologyOpen 3 жыл бұрын
@@user-zf3uq5uj3r Calcium will not have any effect on nerve and skeletal muscle action potential directly. However, decrease in extracellular calcium levels increases the probability of opening of sodium channels and hence making the membrane more excitable. In nodal cardiac tissue, there will be some increase in amplitude of action potential. However the main effect of increased extracellular calcium is on mechanical activity i.e contraction of heart rather than on action potential
Physiology Open
Рет қаралды 9 М.
Edu Club
Рет қаралды 57 М.
Physiology Open
Рет қаралды 13 М.
Byte Size Med
Рет қаралды 55 М.
Physiology Open
Рет қаралды 12 М.
Physiology Open
Рет қаралды 42 М.
Physiology Open
Рет қаралды 4,7 М.