Gibbs Donnan Equilibrium | General Physiology mbbs 1st year lecture

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3 жыл бұрын

Physiology lecture on general physiology explains Gibbs Donnan equilibrium and its role in the generation of potential across membrane. Gibbs Donnan Equilibrium explains how charged particles distribute themselves across a semipermeable membrane in the presence of another charged particle to which the membrane is not permeable. By understanding Gibbs Donnan equilibrium we get to know why concentration of ions is different inside the cells as opposed to its outside environment and why this leads to generation of a potential across the membrane.
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Пікірлер: 61

@siddhant9213 Жыл бұрын

❤❤❤🎉🎉🎉 One of best explanation ever

@PhysiologyOpen Жыл бұрын

Thank you so much 😀

@subhamrathi2191 Жыл бұрын

I had a seminar competition to present on this topic @ AIIMS MANGALAGIRI and I stood first just because of your amazing explanation... Thank You Ma'am!

@PhysiologyOpen Жыл бұрын

Wow...really happy. I never imagined many ways in which the content may help students. Thankful to almighty and to all my students

@sangramjitroy6799 Жыл бұрын

Thanks for making us understand this topic in a short time frame.

@PhysiologyOpen Жыл бұрын

My pleasure

@MahaMaha-nv2eq 3 жыл бұрын

Thank you so much mam🙏 One of the best video for donnan effect👌🏻

@PhysiologyOpen 3 жыл бұрын

Really glad. Thanks

@krantikumar9345 3 жыл бұрын

Very well explained and crisp to the point

@PhysiologyOpen 3 жыл бұрын

Thanks😊

@fantasywarrior4541 2 жыл бұрын

Thank you so much ma'am for crystal clear explanation 🙏

@PhysiologyOpen 2 жыл бұрын

My pleasure as always

@madhurabedekar7799 3 жыл бұрын

excellent explaination, thank you so much

@PhysiologyOpen 3 жыл бұрын

Thankyou...glad you found it good

@aditipandey3244 3 жыл бұрын

Understood well❤️

@PhysiologyOpen 3 жыл бұрын

Glad 😊

@Touristmonk 3 жыл бұрын

When saw equation term in equilibrium, I shocked But u explain it in v simple and in magnified way Thank you mam 🙏☺️

@PhysiologyOpen 3 жыл бұрын

So glad. Thanks and welcome...keep learning

@chaimaasalhi9646 2 жыл бұрын

Thank you very much 😍 A question please : in case of capillaries , the difference of ions distribution will generate an osmotic pressure , is that what we call oncotic pressure ??

@PhysiologyOpen 2 жыл бұрын

No oncotic pressure is due to difference in protein concentration...interstitial space..almost no proteins since capillaries are not permeable to them. Iconic concentration almost equal on either side of capillaries except minor difference due to Gibbs Donnan effect

@aaqil8344 3 жыл бұрын

Ma’am in this case how is it that the sodium and chloride ion flow is stopped at the same potential, given that both of these ions have different nearnst potentials (i.e. the point at which elelctrical and concentration gradients are in equilibrium and ion flow is stopped)? Not just for these too ions but for any set of ions with different nearnst potentials

@PhysiologyOpen 3 жыл бұрын

Very true...if only single ion is involved then Nernst equation gives the potential at which flow stops...if many ions are involved , we use Goldman Hodgkin Katz equation for calculation of the potential...this equation also takes into account the permeability if the membrane to the ions...

@aaqil8344 3 жыл бұрын

@@PhysiologyOpen thank you ma’am

@waelfadlallah8939 8 ай бұрын

It was great, thank you 🙏

@PhysiologyOpen 8 ай бұрын

😊❤️

@Scale_69 8 ай бұрын

this is what I was looking for thanks mam !!! ❤

@PhysiologyOpen 8 ай бұрын

Always😊

@madhurabedekar7799 3 жыл бұрын

can you explain change in electrical gradient for potassium ? how it becomes 4, so many times i have seen video still not understand.

@PhysiologyOpen 3 жыл бұрын

See the change in net charge on both sides...substract the new net charge on each side...to get net charge responsible for electrical gradient

@abhinashsharma3456 2 жыл бұрын

ma'am the question that's confusing me since soo long is that on the one hand we say , the condition for Donnan eqlbm is electroneutrality on both sides and on other hand we are talking abt development of potential across membrane in the state of Donnan eqlbm ... how's this Even possible?

@PhysiologyOpen 2 жыл бұрын

The difference in ions is very very minute and just besides the cell wall (membrane acts as a capacitor).

@abhinashsharma3456 2 жыл бұрын

@@PhysiologyOpen sorry ma'am but can you please give me an intuition ...like a bit elaborative . I didn't get what you mean by capacitor thing

@PhysiologyOpen 2 жыл бұрын

Also within one compartment there is electroneutrality : the sum of positive and negative charges in each compartment has to be the same. In between compartments there is very very little potential difference, with the opposite charges accumulating near the membrane

@abhinashsharma3456 2 жыл бұрын

@@PhysiologyOpen ohh now it's clear . Thankyou so much ma'am

@ddas7974 2 жыл бұрын

Nice explanation

@PhysiologyOpen 2 жыл бұрын

Glad it helped

@madhurabedekar7799 3 жыл бұрын

Can you pl. make video on propogation of action potential in nerve ?

@PhysiologyOpen 3 жыл бұрын

Will do that...currently started work on vision physiology...

@muhammadjumar8628 Жыл бұрын

You are very perfect but I get confuse on how you made the calculation. How do protein electric back to 6 meanwhile it reduce to5 as a result of patssium move in to cell

@PhysiologyOpen Жыл бұрын

Positive ion will reduce negativity