Review how SSRI Antidepressants work including Mechanism of Action, Side Effects, as well as types of SSRIs.
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Serotonin-selective reuptake inhibitors, abbreviated as SSRIs, are antidepressant drugs used to treat both depression and anxiety. Drug names of the SSRIs to know include citalopram, escitalopram, sertraline, paroxetine, and fluoxetine. Common side effects include sexual dysfunction and weight gain. Another important adverse effect is serotonin syndrome, which is a medical emergency resulting from an overload of serotonin in the body, manifesting as hypertension, tachycardia, muscle rigidity, and diarrhea. The risk for Serotonin syndrome can be reduced by teaching the patient to avoid other serotonin-altering substances like MAOIs, St. John’s Wort, as well as avoiding any and all grapefruit products.
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0:00 Introduction
1:27 Citalopram / Escitalopram
2:00 Sertraline (certificate)
2:24 Paroxetine
3:12 Treats Depression (crying)
4:39 Treats Anxiety (anxious)
5:15 Causes Sexual Dysfunction (rejecting kiss)
6:11 Causes Weight Gain (overweight fish)
6:46 Causes Serotonin Syndrome (happy face bag)
8:02 Avoid MAOIs (maul ticket)
9:05 Avoid St John's Wort (saints warthog)
10:40 Outro / Summary