Raphe Nuclei | Serotonin System Anatomy

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Күн бұрын

The raphe nuclei (found in the brain stem) are the anatomical origin of the serotonin (also known as 5-hydroxytryptamine or 5-HT) system in the human brain. This video focuses on the subdivisions of the raphe nuclei, the patterns of connections within those subdivisions, and the localization of various serotonin receptors in the brain, and some of the psychological consequences of all of this.
What do you think of Sense of Mind’s new style (more visuals, shorter videos)? Let me know in the comments.
The neuroscience of serotonin is complex. That’s why I’ve created a playlist on the neurobiology of the serotonin system. Link to the rest of the serotonin videos: • Serotonin Receptors | ...
Chapters:
00:00 The serotonin system anatomy is found in all animals, plants, and fungi.
01:00 The raphe nuclei is the origin of the serotonin system in humans
01:20 This video is part of a serotonin playlist
01:42 Introduction to neuroscience playlist
02:03 Serotonin (5-hydroxytryptamine or 5-HT) is made in the gut and the raphe nuclei in the brain
02:45 “Nuclei” definition in neuroscience
03:20 Anatomical subdivisions of the raphe nuclei
04:40 Subdivisions of the rostral raphe nuclei
05:00 Effects of stimulating the median-rostral and dorsal-rostral raphe nuclei
05:55 Trajectories of the axons of raphe nuclei serotonergic neurons
06:38 Two patterns of serotonergic neuron connectivity in the brain: Movement and Emotion
07:25 Serotonin in the amygdala may be important for forming fear associations
08:05 Please sign up for the weekly video newsletter (and the podcast!). Thank you.
08:41 The many serotonin receptor subtypes (see my video on Serotonin Receptors)
09:41 Some distinct patterns of serotonin receptor localization in the brain
10:55 Cell-type specific expression of serotonin receptors
12:00 How do our brains produce serotonin? (topic of the next video)
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Sources Cited:
Sharp, T., & Barnes, N. M. (2020). Central 5-HT receptors and their function; present and future. Neuropharmacology, 177, 108155. pubmed.ncbi.nlm.nih.gov/32522...
Dingman M. Know Your Brain: Raphe Nuclei. Neuroscientifically Challenged. neuroscientificallychallenged.... Published October 27, 2017.
Di Giovanni, G., & De Deurwaerdère, P. (2020). Serotonin research: Crossing scales and boundaries. doi.org/10.1016/j.neuropharm....
Hoyer, D. (2020). Targeting the 5-HT system: Potential side effects. Neuropharmacology, 108233. pubmed.ncbi.nlm.nih.gov/32805...
Mosienko, V., Bader, M., & Alenina, N. (2020). The serotonin-free brain: behavioral consequences of Tph2 deficiency in animal models. In Handbook of Behavioral Neuroscience (Vol. 31, pp. 601-607). Elsevier. doi.org/10.1016/B978-0-444-64...
Carhart-Harris, R. L., & Nutt, D. J. (2017). Serotonin and brain function: a tale of two receptors. Journal of Psychopharmacology, 31(9), 1091-1120. pubmed.ncbi.nlm.nih.gov/28858...
Bacqué-Cazenave, J., Bharatiya, R., Barrière, G., Delbecque, J. P., Bouguiyoud, N., Di Giovanni, G., ... & De Deurwaerdère, P. (2020). Serotonin in animal cognition and behavior. International journal of molecular sciences, 21(5), 1649. pubmed.ncbi.nlm.nih.gov/32121...
Carvajal-Oliveros, A., & Campusano, J. M. (2021). Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?. Frontiers in Behavioral Neuroscience, 14, 262. www.frontiersin.org/articles/...
JJ Medicine. “Serotonin and Melatonin Synthesis | Tryptophan Metabolism” • Serotonin and Melatoni... .
#serotonin #raphenuclei #serotoninsystemanatomy

Пікірлер: 43

@senseofmindshow 10 ай бұрын

⚠ CORRECTION!!! In this video, I said "this video is brought to you by the Diamond Mind Foundation." Well, as of December 2022, that is no longer the case. Sense of Mind is now 100% dependent on viewers like you. So if you value this content, please go to www.patreon.com/senseofmind. For less than $5 a month, you'll get exclusive content and the satisfaction of knowing you're helping to keep Sense of Mind alive! 🧠

@rionachmisteilofionnagain9807 Жыл бұрын

This channel is one of the best things on KZfaq.

@bluesquirrel2472 2 жыл бұрын

Med student here for a revision:) Thank you for this beautiful video and for citing sources!!

@senseofmindshow 2 жыл бұрын

I’m glad it could be of help, and thank you so much for checking it out!

@beatrizsaraivadacostaearau7368 Жыл бұрын

I just wanna say THANK YOUUUU, your videos are really helping me in understanding this subjective. LOTS OF LOVE FROM BRAZIL. Actually if I may, you are really pretty that helps me to watch the videos too. ;)

@KyurinDiary Жыл бұрын

superb! studying for my neuroscience final exam here and helped a lot to revise

@senseofmindshow Жыл бұрын

Great to hear!

@judyju7416 2 ай бұрын

Thank you! Love the clear presentation and citations! Keep it up❤

@gabrielepealer8029 2 жыл бұрын

This is a great video- looking forward to your channel's future success!

@senseofmindshow 2 жыл бұрын

Thank you so much! On a side note, are you a neuroscience student or just a curious observer? Either way, I'm just interested in how people are using this video. Thanks again!

@gabrielepealer8029 2 жыл бұрын

@@senseofmindshow For sure, I am a Chemistry and Biology undergrad student taking an Intro to Neuro course. We haven't gotten too much into detail, but there are aspects that are overwhelming without additional help!

@senseofmindshow 2 жыл бұрын

@@gabrielepealer8029 Very cool! I was a molecular bio major in college. If you think of it, let me know if there are any video topics that would be helpful as you continue in your neuro class. And good luck!

@A_Psych_Nurse Жыл бұрын

damn. ok. I think i'm going to have to start bingewatching again. . .thanks Andrew

@senseofmindshow Жыл бұрын

Thanks so much for checking it out! You've got some great stuff on your channel too, by the way!

@zane003 12 күн бұрын

great content!

@thePSYCHcollective 2 жыл бұрын

Your videos are great. Thanks for the amazing output. Must takes ages to put them together

@senseofmindshow 2 жыл бұрын

Thank you! They can be time consuming but definitely a labor of love.

@eustab.anas-mann9510 Жыл бұрын

@@senseofmindshow Could you please do a video about what causes consciousness to arise? As in, why are we aware instead of being like robots or hypothetical philosophical zombies?

@senseofmindshow Жыл бұрын

@@eustab.anas-mann9510 Hi there, thanks for your comment! I recently did a livestream about consciousness and the brain which addresses (but admittedly does not fully answer) your question: kzfaq.infoy3u-GeEMPzs?feature=share ... I'll likely do more content on consciousness in the future!

@eustab.anas-mann9510 Жыл бұрын

@@senseofmindshow Thank you very much! May you be blessed by the algorithm so your channel blows up.

@MikeDacre Жыл бұрын

Excellent video. I would love one on wakefulness and the regulation of the sleep-wake cycle.

@makaylamoore8831 4 ай бұрын

excellent content😃

@smart4689 2 жыл бұрын

Very perfect indeed

@AMogus-jr6qk 2 жыл бұрын

Excellent video

@senseofmindshow 2 жыл бұрын

Much appreciated 🙌

@AdrianSUniversity 2 жыл бұрын

Thanks for this

@senseofmindshow 2 жыл бұрын

Thank you for checking it out!

@essex0926 Жыл бұрын

Informative video

@senseofmindshow Жыл бұрын

Thanks for checking it out!

@jimenezcruzado 2 жыл бұрын

Congratulations, very good and interesting video

@senseofmindshow 2 жыл бұрын

Thank you for watching!

@andreeamosulet 2 жыл бұрын

Very good explanation and well made video. I trully apprecciate your work💪💪💪 I'm very interested in the neuroscience topic! Keep up the good work!!! 🙏🙏🙏🙏

@senseofmindshow 2 жыл бұрын

Glad it was helpful! Thanks so much for watching and commenting. Also let me know if you ever have any video topic suggestions

@andreeamosulet 2 жыл бұрын

You' re very welcome🙏🙏🙏 I haven' t seen all your videos and I don' t know if you already covered this argument. I would really like a video, if possible, about the areas of the brain that are responsible for nostalgia. Thank you very much for your reply🙏

@Zed-cy8zj 3 ай бұрын

G.O.A.T

@boaudihernandez2704 Жыл бұрын

Wow

@friesart4516 Жыл бұрын

Sir who to make strong to make serotonin I have depression all the time do you know the way ?

@leewilliam3417 10 ай бұрын

Mmmmnn 😊

@acupunctureclinic 3 ай бұрын

I am not sure where I read it or saw on KZfaq but it said that the serotonin in the gut can go to the brain via the vagus nerve. Is this incorrect information? This video states that only in the brain the serotonin that is there will do its work.

@senseofmindshow 3 ай бұрын

From my reading of the literature, that does seem incorrect. The vagus nerve may be affected by serotonin in the gut, but it does not transport serotonin from the brain to the gut or vice versa. Serotonin's molecular structure makes it unable to cross the blood brain barrier, so the sertonin that's produced in the gut can't enter the central nervous system.

@acupunctureclinic 3 ай бұрын

@@senseofmindshow thanks for responding. There goes my idea of doing sit ups to affect my gut to get more serotonin into my brain and feel supercharged :-)