0:00 Overview of Rifaximin
0:26 Why Gastrointestinal selective
1:20 Why so safe ( no side effects)
2:32 Bactericidal activity
3:26 Molecular mechanism of action ( DNA-dependent RNA polymerase)
6:15 Indications ( Travellers diarrhea. SIBO. Cirrhosis. IBS)
8:12 Clinical mechanism of action
9:34 Why can’t kill invasive bacteria (contraindications)
Article review.
DuPont, H. L. (2011). Biologic properties and clinical uses of rifaximin. Expert opinion on pharmacotherapy, 12(2), 293-302.
DuPont, H. L. (2015, August). Therapeutic effects and mechanisms of action of rifaximin in gastrointestinal diseases. In Mayo Clinic Proceedings (Vol. 90, No. 8, pp. 1116-1124). Elsevier.
Koo HL, DuPont HL. Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases. Curr Opin Gastroenterol. 2010;26(1):17-25. doi:10.1097/MOG.0b013e328333dc8d
Shayto RH, Abou Mrad R, Sharara AI. Use of rifaximin in gastrointestinal and liver diseases. World J Gastroenterol. 2016 Aug 07;22(29):6638-51.
Bruzzese E, Pesce M, Sarnelli G, Guarino A. Pharmacokinetic drug evaluation of rifaximin for treatment of diarrhea-predominant irritable bowel syndrome.
Scarpignato C, Pelosini I. Rifaximin, a poorly absorbed antibiotic: pharmacology and clinical potential. Chemotherapy. 2005;51 Suppl 1:36-66.
Gatta L, Scarpignato C. Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther. 2017 Mar;45(5):604-616.
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