Shock NAD results after 11-month NMN trial | What did it do for us and will we keep taking it?

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Күн бұрын

After taking the so-called longevity supplement NMN for 11 months, alongside my 80-year-old parents, in this video I reveal our surprising test results!
Plus I discuss the effects of NMN that we experienced, whether we intend to keep taking it long term and why.
#longevity #nmn #healthyaging
Subscribe to my channel here / thehonestchannel
What's the deal with the sale of NMN in the US? www.honest.scot/nutrition/wha...
WATCH more on NMN
Interview with Dr Elena re NMN benefits part 1: • Is NMN the 'longevity ...
Part 2, with our early-stage experience of using NMN: • 'Age-reversing' supple... [Safety is discussed at 12.12]
Dr Brad Stanfield interview: • What are the best long...
SUPPLEMENTS
I should have flagged in the video that I stopped taking berberine when I switched from using NMN Bio supplements to DoNotAge. Both makes of supplements worked well for us. Details follow.
DONOTAGE: You can get 10% off DoNotAge anti-aging supplements using code HONEST donotage.org/products/ I take NMN powder, TMG, vit D with magnesium and k2, hyaluronic acid, collagen powder and Omega 3.
You can also buy NMN in capsule form from NMN Bio with a 10% discount using code ClareJ nmnbio.co.uk/discount/ClareJ
Both are reputable UK-based companies who use third-party-certified ingredients.
I use affiliate links on this channel which means if you choose to buy a product using one of my links I receive a small commission - thank you! : )
MY SKINCARE ROUTINE shopmy.us/collections/243245 On this link you'll find most of the products I use in my routine with discount codes where available.
PLUS I use:
BLUELENE sunscreen • Scientist & Bluelene f... Get 10% off orders using code THEHONESTCHANNEL bluelene.com/?dt_id=329188
QURE MICROFUSION SYSTEM: 10% off using code HONESTCLARE10 www.qureskincare.com/pages/qu...
This video is not sponsored. You can find my commercial policy here / @thehonestchannel
TIMESTAMPS:
00:00 Intro
00:58 NMN and its longevity link
03:45 What the studies show
06:39 Our experience with NMN
09:20 Our baffling blood test results
11:59 An unexpected bonus
13:04 What will we do now?
I've written two fictional novels which you can check out here : )
From the Outside amzn.to/3ZaGYds
Polls Apart amzn.to/4637ibQ
Connect with me on social media:
/ honestclare
/ clares_j
/ honestclare
Edited by David at www.redfacilities.com
Disclaimer: This video and all content on this channel is for informational purposes only and is not intended as medical advice and should not be treated as a substitute for medical advice.

Пікірлер: 752

@marcjames3487 6 ай бұрын

I've been taking NMN for 6 months, starting at 250 gms then 500 gms. Added TMG about 2 months ago. I'm 70, still working 7 days a week, and still remember the early days of NMN where I'd have periods of buzzing round my shop feeling like I was in my 30s, though not with the same stamina. Now that's the new normal. When I took NMN at night I had a truly awful week of sleep because my brain just wouldn't switch off, so that was a negative proof if you like. Thanks for this honest review ~ I'll make my own experiment by splitting my dose into morning and afternoon - now I think about it, that seems an obvious thing to do ! I also eat in a 6 to 8 hour window each day, and started a carnivore diet more recently to fix some gut issues so it's hard now to isolate the benefits, but I do feel NMN has been a very positive influence.

@thehonestchannel 6 ай бұрын

Thank you for sharing this with us.

@Seeker_of_sense 6 ай бұрын

You have to take it in the morning, together with TMG.

@markmartin6436 6 ай бұрын

@@Seeker_of_senseI take my nmn in my coffee, tmg before bed...any harm this way?

@roba.8907 6 ай бұрын

@@markmartin6436They work best when taken together (in the morning) to help keep homocysteine levels from rising.

@Seeker_of_sense 6 ай бұрын

@@markmartin6436 No, that should be okay. Dr. D. Sinclair takes 1 gram in the morning with joghurt. I take it with water. Sinclair said that natural NAD levels in your body underly a circadian rythmn and spike in the morning which is why he takes it in the morning. Taking it in the evening might make it harder to sleep.

@RHYTHMgirlMo 4 ай бұрын

THANK YOU!!!! I greatly appreciate this perspective!

@digitaldonotage2605 6 ай бұрын

Thank you for such a detailed account of both your experience and that of your parents. Glad you have seen such great results so far with our pure ingredients.

@nian60 6 ай бұрын

Thank you to your parents for agreeing to be tested on. 🙂 Interesting subject.

@Cristina_Dhyan-S. 6 ай бұрын

Thank you Claire 🌷 very clear and detailed review and super helpful like all of your reviews and recommendations 👌

@thehonestchannel 6 ай бұрын

Thank you so much ❤️

@wildflower-web 4 ай бұрын

I've been taking NMN, TMG and berberine for over 12 months now. My waist size has dropped from 28 inches to 27 inches and my body tone has definitely improved. However, I don't feel any different. I've always has no health issue. I'm now 45yo. I have recently started taking Creatine and Taurine, and have always taken Cod Liver Oil. I weight train only about 10 minutes, but on a daily basis. Also, I have started being able to lift heavier weights since starting on Creatine.

@nsudatta-roy8154 2 ай бұрын

Good stuff! Consider adding intracellular glutathione therapy, and add an Activated B-complex to support methylation.

@leonleong9863 3 ай бұрын

Great to see superpowers coming together on one platform! Huat ah !!!!

@kwakaman555 Ай бұрын

Amazing clarity. Tks

@rsmith9094 3 ай бұрын

Invaluable video that captures all angles.

@thehonestchannel 3 ай бұрын

So pleased you found it helpful - thank you.

@jenxsj3902 3 ай бұрын

Hi Clare, I take Nmn for two years. I never checked my levels. I just have faith.

@G.G.8GG Ай бұрын

Thank for an excellent overview.

@MissKrisLoves 6 ай бұрын

Thank you! ☺️ ❤️ I think this very helpful!

@KatJaguar1122 4 ай бұрын

Thank you. This is the first video of yours I have watched and found it informative. I do dowsing and muscle testing. The first few min of the video I was questioning the use of NMN for myself and others and kept getting a No. I thought that was odd. Then after you mentioned it was suggested to take NMN with TMG, I questioned again about taking NMN but with TMG for myself and others and then got a Yes. So I found that interesting. I am taking many supplements and superfoods now however I will want to save this video and begin an NMN + TMG and possibly Berberine at some point when the budget allows.

@gskyle4822 3 ай бұрын

NMN only is not good. But NMN taken together with TMG is good. Skeptical about Berberine, not for long term at least.

@elizabethkennedy4423 6 ай бұрын

Loved this video- Consider me officially influenced to try the NMN and TMG supplements… fingers crossed that my results are as great as yours :)

@thehonestchannel 6 ай бұрын

I do hope you feel a benefit from using them. Let me know!

@X17PHL 2 ай бұрын

Really informative and honest thank you, and you've actually run your own trials, not just recycling others' viewpoints! I was talking to my brother (37) about NMN a few weeks ago and unbeknownst to me he'd been taking it for a while (500s) and does feel more alert from it. I'm 6 years older than my brother and about to place an order to try it myself. I'm hoping it will improve my sleep and boost my energy. Thanks for the great vid.

@thehonestchannel 2 ай бұрын

So glad you found this helpful! Hope the NMN works out well for you

@vadimfedenko 11 күн бұрын

so what's the result?

@animalover1963 5 ай бұрын

Great video. To hear it's actually working. Now I have to try it. Thank you

@thehonestchannel 5 ай бұрын

Thanks. There's definitely mixed reviews about NMN in the comments from other users. Hope you find a benefit if you decide to try it.

@user-he9kr3rf6w 5 ай бұрын

Thanks for the personal trial with MNM! For NAD boosting, I've been taking liposomal NMN at 500mg/day along with 50mg niacinamide with 500 mg DMG for over a year. I also lift weights 4 times a week and do treadmill HiIt twice a week. I've always exercised, so I know it produces many benefits including NAD. But now, I weight train at the end of my fasting window in a fasted state... which is hard but makes me feel AMAZING! I also do intermittent fasting (17/7) and do 48 hour fasts every 10 weeks. So what does all this mean? Well at 67, I am still squatting 450 lbs and plan to set a world record by age 70 as the record is only 365lbs for this age and my 198 weight range. My theory is simple. Keep the body at a state that still is in the "REPRODUCTION CAPABLE" state. This extends quality of life. "DON'T LET THE OLD MAN IN!"😊

@geoffbendel9467 5 ай бұрын

Wow amazing, do you have any other supplements to suggest in your protocol?

@user-he9kr3rf6w 5 ай бұрын

@geoffbendel9467 The body is a complex system and everybody is unique. So go to an integrative health professional and start with healthy oral hygiene. Consider Dr. Berg's protocol. .. Hydrogen peroxide mouth rinse. Next, work on healthy gut. Most people have LEAKY GUT . due to all the pesticides. Consider Gut Restore by Ion and organic bone broth. I also take 5 grams glutamine with grass fed colostrum and kefir. Take this all together prior to breaking your fast before the first meal. Once your gut is healthy, you can start looking at other supplements. To boost glutathione, I take 1000 mg NAC and 5000 mg collagen (contains 4400 mg glycine)

@Robbo_547 4 ай бұрын

Impressive. Did you notice an increase in lean muscle mass after starting the NMN? I have...

@user-he9kr3rf6w 4 ай бұрын

@geoffbendel9467 I've been doing Amino Acid therapy... taking 2 gm taurine, 2.8 gm beta alanine (different times) 3 gm HMB (post workout) and just added 2.8 gm creatine. However, I switched my NMN to NMNH... Doublewood brand due to the far greater NAD+ boosting for longer periods. I also am trying molecular Hydrogen by Dr Mercola. I feel 25 again!

@user-he9kr3rf6w 4 ай бұрын

@@Robbo_547 Started NMNH from Doublewood... AMAZING! Doing 60 lb dumbell curls l8ke they're 30s!

@primordialmeow7249 6 ай бұрын

I love your vids; you bring a journalistic quality to the research of products, devices and practices. BTW: Anecdotal observation of course, but your skin and hair have improved greatly since your early vids. You are looking vibrant and beautiful. ❤

@thehonestchannel 6 ай бұрын

Thank you. I appreciate every word!

@billkipper3264 5 ай бұрын

I'm 66 and have been taking NMN for about 16 months now. I immediately felt results on day one. My energy levels increased, I no longer felt drowsy in the afternoon after lunch and I just felt better overall. I also lost 40 pounds over a five month period but I'm not sure how much of a role NMN played as I changed my diet as well. Before starting NMN I had decided to get in better shape also and started doing one thing I really love, day hikes. I live at 7000 feet in the Rocky Mountains and the hikes ranged from that altitude up to over 11,000 feet. At first I could only walk about three miles without feeling exhausted with minimal improvement until I started taking NMN. Almost immediately, my range improved to over four miles with another leap to over six without feeling beat. Now, I can do over twelve miles while reaching the high altitudes I mentioned earlier and, while tired, I'm not just totally worked. I also believe my pace is on par with what I could do in my thirties. NMN has had a significant effect on my life despite what Brad Stanfield says. I've come to the conclusion that he will take the opposite stance on just about anything that Dr. Sinclair and others do just to feed his own ego. I stopped following his KZfaq channel months ago.

@tomg5405 5 ай бұрын

If you feel results day one already then it is a placebo.. Because it can't work so fast..

@cravarc 5 ай бұрын

I also take what Dr. Brad Stanfield says with a grain of salt. But it's good to have a devil's advocate in the longevity community. I like to consider the other side, too. That said, I'm also very grateful to NMN for boosting my own energy levels.

@ningunoag 5 ай бұрын

Your changes dont come from nmn but from your different lifestyle. Jesus open your eyes and save money

@elliottrubenstein1746 4 ай бұрын

So true. Same with me. Brad gives appearance of a health hustler b

@george6252 4 ай бұрын

Dr. Stanfield takes an opposite stance and flip flops. This might be to get more clicks on his channel. "Grain of salt" with this guy.

@sabinakrivenko4900 6 ай бұрын

Awesome report with clarity and genuine info❤ thank you

@thehonestchannel 6 ай бұрын

So glad you found it helpful!

@user-ky4dt2or3w 5 ай бұрын

claire, thank you for the great video, learned a lot. hope your family has a great holiday season.

@thehonestchannel 5 ай бұрын

Thank you! You too!

@wadestarr1926 5 ай бұрын

Hey Clare, another great video. I totally agree with the need for more informative investigations into the use and beneficial claims made about MNM , NR and other precursor only supplements. The discrepancies in your NAD+ blood test levels is no surprise. Accurate and reliable at home consumer NAD testing is still a long way off. The reason being - the NAD coenzyme is extremely unstable and it degrades really quickly. The only way you can accurately measure NAD is through a process call mass-spectrometry and is used after any samples of blood are immediately placed on ice to prevent degradation. I do agree precursor-only NAD boosters (like NMN and NR) do increase a person’s NAD levels but “lack of available precursor material” is not the reason for our declining levels of NAD These pre-cursor only NAD boosters do not address the root cause of NAD decline as we get older. There is also growing and concerning evidence over the use of NMN in isolation and the resulting short and long term impact of methyl donor depletion hence why one of the products you and your dad were using also needed TMG. An effective and efficient NAD supplement needs to have a whole-systems approach that is backed by real clinical evidence in the form of human trials and addresses the root cause of NAD decline. These products do exist. Keep up the awesome content.

@yoheurtel 4 ай бұрын

Are you referring to Nushido supplements ?

@alfonsoiovine377 3 ай бұрын

Why not take NAD+ in the first place ?

@mikenelson8351 2 ай бұрын

Thank you. The discussion was appreciated and helpful. (a 77year old Australian). I haven't measured my quantities precisely relying on a combination of diet and an exercise regime and in general I feel very well. This has been over an 18 to 24month time period. As well my supplement' s being D3 , K2, C , D, B12, Zinc and Magnesium along with an occasional dose of Ivermectin.

@thehonestchannel 2 ай бұрын

Great to hear you're doing well and thank you for sharing your regimen.

@user-ph1yd5gn8n 5 ай бұрын

Thank you for your studies on mnm and nad. I am doing my best with what i have to work with...😮😊

@southsun1149 2 ай бұрын

That is a very informative video. Hopefully after one more year, please provide another update. I have subscribed.

@thehonestchannel 2 ай бұрын

Pleased to hear you found it helpful and thanks for the sub!

@jefflittle8913 23 күн бұрын

Don't underestimate TMG - it is sold as helping with methylation, but it is also a good source of glycine and some people think that glycine supplementation can help you hit healthy glutathione and collagen levels. This is pure speculation, but I wonder if we need a good glycine + taurine to Methionine + BCAA ratio analogous to the Omega 3/Omega 6 ratio.

@thehonestchannel 22 күн бұрын

Interesting.

@annalinstrum8558 6 ай бұрын

Wow this is so comprehensive! I’ve just had some more delivered from Youth and Earth. Now I’m wondering if it’s worth my money from here on in, having watched all this…. I can’t say I’ve noticed a marked improvement in either energy/sleep or pain reduction, but maybe if I STOP taking it I’ll take a dive. If this happens I’ll let you know, cos then we’ll know it was working! X

@thehonestchannel 6 ай бұрын

Let me know how you go with it. NR is a cheaper alternative so I may try that out for a few months.

@MissKrisLoves 6 ай бұрын

1:48 hahaha 😂 did you decorate a pile of books for Christmas?? I love it! I have shelves and shelves of books and piles here there and everywhere lol

@beyond50skin 6 ай бұрын

Thanks for keeping us updated on your family's experience w/ NMN. I stopped taking it about 6-8 weeks ago and feel less fit and energized. I am planning to bring it back into my supplement routine.

@thehonestchannel 6 ай бұрын

I remember you saying when I interviewed Dr Brad that you'd stopped taking it. Really interesting that you've had an energy dip as a result. I might switch to NR after I finish my current batch of NMN to see how I feel with that, but the weight loss and increased energy mean I'm unlikely to walk away completely!

@jeanrobertplante 4 ай бұрын

You never mentioned the effects of berberine

@julissarivas6992 2 ай бұрын

@@thehonestchannelwas your weight loss as a result of having more energy to exercise?

@carolinekelly8481 Ай бұрын

Great honest talk , thank you

@thehonestchannel Ай бұрын

My pleasure!

@Siddhia1 6 ай бұрын

Thanks I have tried NMN and I wasn’t sure if I felt a difference but listening to your podcast has helped. I’m 75 years old walk 2 to 3 miles every day and lift weights 5‘,5“ and weigh 120. Sometimes I’m embarrassed to tell people my age because they don’t believe me and that’s a good thing!

@thehonestchannel 6 ай бұрын

So glad you found it helpful

@rudylopez692 3 ай бұрын

I have never heard of NMN until today. i have been looking for something to help damage cells in the prostrate, as I have BPH. Since you mentioned your father’s prostrate problem got better, i wonder if this would work for me. Loved all the information from this video. This could be a game changer for me. I am a male at 66 years old and looking out of the box.

@nsudatta-roy8154 2 ай бұрын

@@rudylopez692Take a look at the sulforaphane studies on prostate cancer. You can incorporate this, along with INTRACELLULAR glutathione therapy. These protocols reverse prostate issues, and promote apoptosis even in cancer stemcells.

@XeNos3131 2 ай бұрын

Same here but I am only... 74😂

@benji6825 6 ай бұрын

Dear Honest Channel, i have watched your first video also with Dr. Elena Seranova. Really in this video you look younger and more healthy. I think it works on you. I have started using NMN, TMG and Berberine also last month.

@thehonestchannel 6 ай бұрын

Thank you. It's such an interesting supplement and I'm sure there will be many more studies to come and more scientific debate but we all feel we've benefited from taking it.

@tyanite1 5 ай бұрын

Thank you. It's very helpful to get information on doses that put you into the optimal range. Please follow up, of course, if 250 mg keeps you optimal.

@marknasia5293 6 ай бұрын

i have been taking NMN and also same about losing weight with minimal effort, also back to weight of my 20’s and i am 51. i stopped taking it for about a week and noticed it immediately. I only get exercise from yard work, and i have reduced the amount of carbs in my diet while boosting protein intake. i take a liposomal version of; MNM, Berberine, TMG and for me the liposomal version showed a much more noticeable positive difference everywhere except my wallet as it is a little more costly. I don’t regret the money i have invested in the last 4 months, in fact taking supplements my entire life, this has been the most effective investment i have made over the years.

@scottbucc 6 ай бұрын

Would you mind sharing which brands you like?

@MrRESolutions 5 ай бұрын

I'm also interested in your liposomal brand please.

@marknasia5293 5 ай бұрын

@@scottbucc renue by science lipo nmn, the berberine code age, and apigenin code age. you have to take apigenin as is suppressed the cd38 protein that will consume any excess created nad from the nmn uptake. if you don’t take apigenin you will not see the benefits. my guess is the cd38 exist to consume any perceived “excess or extra energy that might be used by a cancer cell or zombie cells” So to prevent from feeding bad cells since i am 51, i did three months of liposomal fisetin benign a brand, 1200 mg for three days, every 28 days. basically mimicking a woman’s menstrual cycle to in an attempt purge the bad cells senescent or precancerous as i didn’t want to boost their nad levels. you will experience brains fog, at-least i did by day two of the fisetin uptake. but you only take it for three days then stop wait 28 days and start again. i also increased my uptake liposomal resveratrol during those three days, and liposomal curcumin code age. that was to encourage the zombie cells and precancerous cells into atophagy. i started to hit a plateau two weeks ago, so started full carnivore. i thought my energy levels couldn’t get better. Wow. a steak, 6 eggs and water, little butter and avocado oil one meal a day. i can’t believe the improvement. i also take NAC Glycine milkthistle 1000 mg each. i have a chest cold currently and worked 9 hours straight cleaning a rural lot, woke up this morning 6 hours of sleep feeling great.

@marknasia5293 5 ай бұрын

@@MrRESolutions sorry for the late reply i am not so good at social media and checking replies etc. i hope the information i posted helps. i got my start reading dr laura kaufmann two books, the kaufmann protocol aging solutions, the kaufmann protocol why we age and how to stop it. i thank God everyday i saw an interview with her on modern lifespan channel. it has changed my life, inwas debilitated by gout in my hands knees feet now all gone after 3 months. i also read nathan s bryan phd, functional nitric oxide nutrition and take his N1O1 nitric oxide lozenges. i focus in less mouth breathing whenever i can. i take the seed synbiotic, after reading william davis md, book, super gut. i did take one bottle of restor flora pd about month two for 20 days. i stopped using fluoride products and switched to tooth paste that uses xylitol. it works my gums never bleed, almost no plaque build up and i had bad dental habits because i never liked the fluoride toothpaste. i quit using mouth wash that kills bacteria because it was killing the good bacteria in my mouth. i share this because i did all of these th8ngs at the same time, 90 days after starting i have seen a complete turn around, lost 30 lbs, never felt hungry, thanks to the liposomal berberine really killed my sugar cravings. allowed me to ween off that sugar addiction. now going full carnivore i have no hunger, i have an appetite same time each day before i eat my steak and eggs but no cravings for snacks which i cut out completely by month 2. i lost 4 inches in my waist and had to buy new shorts. and because i am older i take nattokinase by wright life. i no longer need the blood pressure meds i have been taking for 8 years.(losartan). libido is also like a 20 year old. it did cost money, but you can either pay the health stores now, the doctor twice as much later or the mortician. the books were important for me to understand why this concept of supplementation would work. i had to have the details, i am not as good at regurgitating them, but these doctors and people posting videos about increasing lifespan have completely changed my life for the better. Happy New Year btw. i hope you find what you are looking for on your health journey this 2024.

@loracle540 6 ай бұрын

I am 76+ have been taking NMN for the same period of time as yourselves. I did not find an initial increase in energy as many in the U.S. reported. What I did find was that pains in my feet, particularly big toes, that had been there nearly 10 years and were affecting my ability to walk with no medical explantion, had dissapeared and after a month that the 'liver spots' on my hands were fading. Now though I do feel better, I stand more upright and I do not fall asleep all the time. I also take resveratrol and keep up my input of flavinoids though red/dark fruit and veg.

@raybod1775 6 ай бұрын

It took my almost a year to feel really good.

@the.parks.of.no.return 5 ай бұрын

Same here, within weeks sore feet for a year disappeared

@user-nv8ix3rm9r 4 ай бұрын

Since it's very expensive is it okay to take nmn 500 mg for a diebetic person 66 years old or should I have to take resveratrol as well

@the.parks.of.no.return 4 ай бұрын

@@user-nv8ix3rm9r make sure it's actually real NMN. Buy from renue by science, DO NOT AGE or life extension.

@Mike-du1dc 6 ай бұрын

I have to agree my own experience with NMN at age 66 is quite good. I have always been athletic cycling 8000 miles a year with 500,000' climbing but I was feeling more & more my age the last 3 years. Since taking NMN a gram a day for three months I am really happy with it & the results. As an aside I would like to say you yourself look very much better than your earlier video...Not that there was anything wrong with those videos which you showed clips of in this video but now in this video you clearly look healthier/younger more vibrant...It Shows! Thanks you for the video it was interesting & as I said echo's my own findings

@thehonestchannel 6 ай бұрын

Great to hear - and thank you for noticing my own positive changes!

@frankparoutoflovefci571 6 ай бұрын

I love your attitude. Many would go the route of “ it’s doing so much good, I need more of that”, yours is completely different.

@thehonestchannel 6 ай бұрын

Thank you. I always feel that when we don't have a huge amount of evidence for so many of the emerging 'longevity supplements' and products we need to be cautious.

@pattersonellen 6 ай бұрын

If you generate ATP, you will also generate free radicals and speed yp aging . You need SOD to put out the free radicals. Google Catherine Arnston.

@wyattfamily8997 6 ай бұрын

As a 74 y.o. male with COPD I decided to try NAC + Glycine ( 1 Gram of each) around 5 months ago. Within 2 weeks of starting I found I had better oxygen levels which permitted faster walking and longer duration. As a byproduct to the improved oxygen circulation levels my cold feet are no longer cold, and my hair apprears to be getting darker. Tyhe only word of warning is to ensure you get good quality NAC from areputable company as there are many fakes around this unregulated industry. From Australia.

@mdk2901 5 ай бұрын

Thank you for sharing your experience ❣️ this was inspirational

@thehonestchannel 5 ай бұрын

Thanks so much for this - I was actually just reading about NAC. It looks really interesting.

@ravindersingh1609 5 ай бұрын

Hi Can you share the brand of NMN you use please

@RicardoBravo 4 ай бұрын

What a beautiful presentation so clear and honest. Personally, I take 500mg NMN, TMG, and resveratrol, sincerely I have never clearly understood the effects of these supplements, but I try to follow the results of research in this area, and I believe that we will evolve towards more conclusive results. I think research should focus more on why NAD levels decrease with age, rather than looking for strategies to increase them.

@bertlindsay 4 ай бұрын

Being from Australia myself, what do you recommend for NAC brand? Ta

@organicgardenproject 6 ай бұрын

Thanks Clare, for this great follow-up to your NMN testing. It would be very interesting to see blood test results from an independent lab with no involvement from donotage, as a comparison.

@thehonestchannel 6 ай бұрын

The labs they use aren't owned by donotage so in that sense are independent, but it would definitely be interesting to do another test with an unrelated lab.

@russmartin6781 6 ай бұрын

Thank you for your update. If you're waiting for the US's FDA to approve anything they can't patient don't hold your breath.

@hanniehoekstra8511 6 ай бұрын

Hi Claire thanks for the update. I have been taking NR and TMG (250 mgr) for a year now and have experienced the same benefits as you describe . The difference being the much lower price tag. But then again you probably get your NMN for free.

@thehonestchannel 6 ай бұрын

That's really good to hear. I got the initial batch free but am buying my own now. I may well switch to NR for a while to see how I go. Did you experience the weightloss too?

@hanniehoekstra8511 6 ай бұрын

@@thehonestchannel thankfully no weightloss as I’m superskinny as is.

@jlg3315 2 ай бұрын

great video!

@Sylvie_X 6 ай бұрын

A few months ago, I start taking GlyNAC, NMN, and TMG. I only did NMN for a couple months and then swapped it out for Niacin because NMN was too expensive. I've been feeling the best I've felt in a while, and quickly somehow lost 15 pounds barely trying. I don't get tired half as easy when doing any kind of exercise anymore. Just a word of warning to others, if you decide to use Niacin: in the large doses you need to take to affect NAD levels, it causes an intense flushing effect on your skin. It's really itchy, and your skin can feel really hot. It lasts 10-15 minutes, and it's not in any way dangerous, but the first time it can be a little scary if you're not expecting it. Some say that flushing effect also has a benefit to our skin by circulating blood through it.

@thehonestchannel 6 ай бұрын

Really interesting to hear your experience, thank you.

@kathleen9456 6 ай бұрын

Interesting you commented on NAC cost when NMN is far more expensive.

@jdxx59 6 ай бұрын

You can purchase non flushing niacin.

@Sylvie_X 6 ай бұрын

@@jdxx59 If it's the slow release stuff you're talking about, you can get liver damage. I personally don't mind the flush. I feel like it's good for the skin.

@lawnmower11 6 ай бұрын

Flushing niacin (nicotinic acid) lowers Triglycerides and increases good HDL

@KerrieMeyer 6 ай бұрын

Question Claire. Did you continue to take the TMG and berberine when you switched to the powder instead of capsules? Thanks!

@thehonestchannel 6 ай бұрын

I just continued with the TMG, though I was less consistent with it than NMN.

@dianekoziol6990 Ай бұрын

Great information

@davidruiz18 2 ай бұрын

Great video. Have you any information of taking NMN+resveratrol. Thanks

@andybowen5814 6 ай бұрын

Interesting information i haven't tested but over the last year I've lost weight and have had drastically improvement in prostate health and mental clarity

@thehonestchannel 6 ай бұрын

That’s great to hear and so interesting that you’ve had a similar experience to my dad.

@johnrwilliamson 5 ай бұрын

I'm 58 and have recently started taking nmn and resveratrol as new supplements to a few vitamins I take. I also have been eating a strict keto diet and incorporate OMAD and 48 and 72 hour fasting. I have to say I feel great but it is very hard to quantify how much good the diet, fasting or supplements are doing but I do not see myself changing anything until I get do to my desired weight.

@MarsX69 6 ай бұрын

Thanks you Claire for this video. Using NMN as well for almost a year. Noticed the results very quickly in terms of the weight lifting at the gym and feel more energised (even though it didn’t solve some other challenges). How about interviewing Marcel from the KZfaq channel The Pulse? He’s sharing his NMN journey for quite some time with amazing results (in combination with other supplements and exercising, mainly playing tennis. You will love his story. Thumbs up and keep up the great work!

@HigherThinkersClub 6 ай бұрын

Hello Claire I feel the Berbrine is a key for the weight response

@thehonestchannel 6 ай бұрын

Hello! We stopped taking the berberine after a couple of months when we moved to the donotage powder and TMG capsules. Should have made that clearer. The weightloss became most obvious around 3 months in.

@thehonestchannel 6 ай бұрын

Great suggestion, thank you!

@helenareich9938 5 ай бұрын

@@thehonestchannelI’m a new subscriber and really enjoyed your series on NMN. I’ve been sitting on the fence about NMN because of that controversial article on NR and its effect on cancerous tumors. I was happy to hear you and Dr. Elena addressed this issue! Question: So when you switched to Do Not Age’s NMN powder, did you discontinue taking TMG & Berberine? I’ve taken Berberine before with no discernible difference.

@thehonestchannel 5 ай бұрын

@@helenareich9938 Great to have you as a subscriber! When I switched brands I stopped taking berberine but continued with TMG.

@andrewrivera4029 6 ай бұрын

I take TMG, Berberine, Niacin and Hyaluronic acid and high doses fish oil at 58 years young. Working on the ranch I do experience the flush from the Niacin but now that my wife and I are traveling for the winter and have started working out at the local gym, hot yoga and mtn biking I do not get the flush anymore.

@seppimweb5925 4 ай бұрын

NMN and Homocysteine: NMN may theoretically increase homocysteine levels because it increases the consumption of S-Adenosylmethionine (SAMe), which is needed for homocysteine methylation. This could raise the risk of cardiovascular diseases. To counteract this, the intake of TMG (Trimethylglycine) is often recommended to balance homocysteine levels. TMG and TMAO: However, TMG intake can increase the production of Trimethylamine-N-oxide (TMAO) in some individuals, which is also linked to an increased risk of cardiovascular diseases. These interactions between NMN, TMG, and TMAO are complex and require further research. It's important to use supplements like NMN and TMG under expert supervision and after careful consideration of potential risks. Regular blood tests can help monitor for any adverse effects.

@ClimbAClassic 3 ай бұрын

Would taking SAMe directly mitigate this instead of taking TMG?

@sandybayes 3 ай бұрын

I'm an 82 year old and have been taking 300 mg of NMN for the past 30 days. I am having less trouble keeping my weight at 110-115 .and have a good energy level . My exercise routine at the gym is 2 days of hour long resistance training and 2 days of 1 hour stretching exercises. I also take Spermadine 20mg daily in wheat germ plus 1000mg of liquid B12 daily. I feel well and energetic plus I sleep 7-8 hours every night. I'm planning on continuing my whole plant based diet as it seems to be working for me. Thank you for your video and I will stay in touch. Also, my doctor is fully aware of my lifestyle and supplements and continues to encourage me.

@DebbieTDP 2 ай бұрын

Sorry about the plant based choice. 😢 Not healthy at all, it's the agenda for depopulation.

@sandybayes 2 ай бұрын

@@DebbieTDP Sorry you have succumbed to a false conspiracy theory narrative. All you need to do is read the science. I take no medicine at 82 except for a stroke before I went plant based. Follow the science my dear not the conspiracy theorists. Also I must add that if you search the scientific literature there is plenty of complete protein in plants. in case you were not aware.and there are many olympians on a plant based diet.

@monabommarito7126 6 ай бұрын

Thank you. Love your channel. You and your family are adorable.

@thehonestchannel 6 ай бұрын

Thank you so much!

@kristinek7436 6 ай бұрын

My husband and I have been taking NMN with TMG for over 2 years now and feel great with similar results to you. We are both in our early 70s and feel so fortunate to be able to take it.

@thehonestchannel 6 ай бұрын

Fantastic to hear this!

@brendabrenner2891 5 ай бұрын

What is the link 4nmn..+ did u start low + increase.. good info here , tu

@vetsai8199 6 ай бұрын

I’ve been taking NMN for six months, though it was hard to find and I had to have it shipped in from Canada. I started taking GlyNAC about four months ago, but it started causing diarrhea after about a month, so I have had to cut the dose in half, then half again! I started taking TMG two months ago, along with Creatine. So far the only positive effect has been that I have stopped losing muscle strength, and have been able to increase my weight workouts back up to five days per week (I had dropped down to three workouts per week, on my doctor’s advice). Other than that, I haven’t noticed any improvements in my appearance or health. I did start suffering from cold sweats at night beginning about one month into taking NMN. The only thing that has help my arthritis (both osteoarthritis and ankylosing spondylitis, which is in the rheumatoid spectrum) has been a large dose of MSM twice a day. I am no longer able to take the biologic drugs that had previously worked so well, due to the detrimental effects on my immune system.

@thehonestchannel 6 ай бұрын

Thanks for sharing this with us. It's good to hear that you're managing to work out five days a week again.

@rajanganger5942 6 ай бұрын

Take L-Citrulline for Nitric Oxide.

@TikToktemptress 3 ай бұрын

Great video

@sansabh 6 ай бұрын

You're looking much leaner, better, and happier, Clare 👍 I think you're actually looking younger than at the beginning of the year!

@Linh-rv5dg 5 ай бұрын

Yes I agree. I haven't checked the channel for a year, and Clare looks much younger. Her skin is smooth and glowy, she also seems happy

@ningunoag 5 ай бұрын

Its filters

@ninilozano9233 3 ай бұрын

Is it filters? I think we should know because we use her as a barometer and piece of anecdotal evidence on how nmn might work for women our age. I would sincerely hope that she would say, 'thanks, may also be the filter I am using', otherwise it it very disingenuous.

@annie-cy4tc 6 ай бұрын

Very well researched impressive video. I am curious regarding your weight loss. DId you only take berberine for one month or the entire time? Berberine is associated with weight loss so I am curious if you only stayed with theNMN or also took berberine...Thanks!

@thehonestchannel 6 ай бұрын

We only took berberine for the first six weeks or so until we ran out of capsules. I should have been clearer about that in the video. There was so much to pack in!

@wendymccleary1465 4 ай бұрын

I take berberine daily and have for at least a year. I have gained post menopausal weight around my midsection since starting bioidentical hormones. The berberine isn't helping me in this area.

@lindarobinson8110 5 ай бұрын

Thank you 🙏 very interesting

@markmcgrath4853 6 ай бұрын

good work again claire !

@rajanganger5942 6 ай бұрын

8:17 For arthritis you can try MSM powder, its very cheap too.

@danieledwards1483 6 ай бұрын

Great video and insights, top channel!

@thehonestchannel 6 ай бұрын

Thanks Daniel.

@user-gg2rt7kw9w 6 ай бұрын

Interesting anecdote. However, NMN has been taken with Bergerine which is a Metformin analogue, which is a blood sugar-reducing medication and is associated with weight loss.

@waltercunningham3246 5 ай бұрын

Hi Clare, thank you for the great video and by the way you are looking very trim, my question for you is how is your father's prostate doing after the 11 months? was the initial improvement continued. Kind regards Walter

@thehonestchannel 5 ай бұрын

Thanks Walter. My dad's prostate improved within the first month or so of using NMN and then he felt that improvement was maintained over the 11 months but the gains didn't increase over that time.

@Sunny-oc6ed Ай бұрын

This is excellent! So helpful…thank you💕 in the case of your mom, has she tried just taking Niacin or Nicotinamide and testing her NAD levels? She might not need NMN or NR since she is taking regular b12 shots. Did you feel the two NMN supplements were equally as effective?

@thehonestchannel Ай бұрын

My dad prefers the capsules from NMN Bio but I didn't feel there was a lot in it tbh. My mum has tried NR, not niacin, but feels the NMN has helped with the osteoarthritis pain in her back. Like me, she's not taking large quantities of it though. The B12 shots she gets very 8 weeks have by far made the biggest difference to her overall health.

@Sunny-oc6ed Ай бұрын

👍

@StancyInTheCity 3 ай бұрын

November 2022 I put my van 83-year-old mother on 500 mg of NMM per day. At that time she was 85 pounds, very frail. She had to hold onto furniture and counters to walk around the house and used a cane and the assistance of my father when walking outside. 15 months later, she is up to 95 pounds. She does not require a cane, she said she can taste food again, and didn’t realize that she had lost her sense of taste over the years. She often goes without her hearing aids, forgets to put them in because she can hear without them now. It’s turned back the clock for her.

@thehonestchannel 3 ай бұрын

That's amazing. I'm so pleased to hear she's doing so well.

@Borntosing12345 6 ай бұрын

I’m taking it when I remember! 200 to 400 per day. I’m hoping for that weight loss!

@raybod1775 6 ай бұрын

I bought a five year supply of NMN before FDA banned it in U.S. It’s vacuum sealed with dryer packs kept in a deep freezer so it doesn’t deteriorate. I’m 65 and take it daily. NMN seems to help my general health.

@thehonestchannel 6 ай бұрын

Smart thinking!

@ningunoag 5 ай бұрын

Placebo. U waste a lot of money

@ProjectMatthew-me3mo 2 ай бұрын

Interesting experience. Thanks for sharing. I've heard there are studies suggesting TMG potentially helps reduce white fat, increase brown fat, and may even maintain muscle mass while losing weight. Since you took both NMN and TMG together, I wonder if the TMG was more responsible for your body composition changes than the NMN. I'd be curious to see someone just try TMG and see what happens. There's a logical reason to take both together, but I wonder if it's obscuring which one is actually doing certain things.

@gsterw3818 6 ай бұрын

Very interesting video, thanks for bringing us your results. Being a bit of a geek, I did a very deep dive into NMN myself and this lead me to Dr Nicola Conlon's research on NMN and her company Nuchido. She's a British scientist who has created a next generation NMN supplement which is I believe one of the very few supplements to have undergone a rigorous double blind placebo clinical trial with published results. Her product aims to address the root causes of why our NAD levels decrease with age and I learnt a lot more about NAD from watching some of her presentations. I've been taking her companies supplement myself for 3 months now with very positive results so far, and in order to verify my subjective observations, I've also done a glycan age test prior to starting the supplement and will follow up with a repeat test in 6 months to see whether it has indeed lowered my biological age in any meaningful way. Anyway, I just wanted to bring this to your attention as I really think this will add a lot of clarity to the whole NMN debate.

@thehonestchannel 6 ай бұрын

Really interesting. Thanks for sharing this.

@gsterw3818 6 ай бұрын

Definitely worth watching some of her presentations on NAD cellular biology on KZfaq. Also, in my research I found that researchers don't put much stock in the postal NAD blood testing kits as the active NAD degrades so quickly outside the body. That's why it's better to do a test like the Glycan age test and use this as a proxy rather than testing for NAD itself as this needs to be done in a laboratory. Although I stand to be corrected if I'm wrong as I'm not a scientist, just a guy doing some research online!

@wendymccleary1465 4 ай бұрын

How do you get a Glycan Age Test please?

@daveoatway6126 2 ай бұрын

Stansfield is a junior doctor who confuses clinical studies with personal effects and apparent personal animosity to Dr. Sinclair. I am 80 and have been taking NMN (~1gm) with TMG (2 gm) for 6 years. I walk 3-10 miles a day, and do some weight baring exercises. I have reduced carbohydrates and increased protein. I am convinced the NMN has been effective in supporting my activity. I still do very complex consulting in data analysis. I prefer to look out the window to see if it is raining than listen to a expert weatherperson! I agree with your approach and applaud your openness in discussing your experience.

@thehonestchannel 2 ай бұрын

Thank you. Really appreciate you sharing your experience too and glad to hear you're doing so well!

@tamuman93 6 ай бұрын

I can’t get my NMN anymore. Renue By sci nice stopped selling it. Where can I buy quality NMN?

@dancarlson8449 Күн бұрын

Those placebo effects are remarkable

@larrysiders1 6 ай бұрын

If your Mother's B12 Injections were in the form of Methyl Cobalamin (likely)... that would significantly boost her system's Methylation efficiency. Low levels of AVAILABLE Methyl Groups is well known to limit lots of processes that require Methylation of precursor compounds...as is the case with NAD.

@thehonestchannel 6 ай бұрын

Thanks for flagging this.

@sharonkahan1079 5 ай бұрын

What is the best time to take it? Mornings? After a meal or with empty or semi empty stomach?? Thanks!

@cravarc 5 ай бұрын

Thank you for a truly balanced video and your honest personal experience. I was going to work my way up to 1.5 g of NMN but I find my own sweet spot is 750 mg with the same amount of TMG, split over two or three daily sublingual doses. In my 50s. Energy levels are up. I feel less creaky. And my greys are going away. I use Renue by Science. I plan to increase thedose in my 60s or 70s or when my body hints at it. On the other hand, I may taper down in the future if I exercise more.

@henvest3491 3 ай бұрын

46 years old and 1.5g nmn for years now. No bad side effects. I sleep better than i used to. Still strong in gym and seem to heal faster from cuts etc. I have been blood tested for nad i am smack in the middle of optimal so i am sticking to 1.5g with an open mind to going to 2g later in life.....

@comptytom 5 ай бұрын

Regarding B12 my DNA readout found that I was less able to absorb it from beef and should instead eat lamb. There may be other factors limiting B12 absorption. It would be interesting to know whether there are differences in these three peoples' uptake.

@lisanmc4536 4 ай бұрын

What kind of test did you take for these DNA results? Lab or company test?

@bowser2005 4 ай бұрын

I don't know if you are comfortable sharing this but I am curious about the dosage and type of B12 your mother gets to get that high NAD score. There are many different versions of B12 shots and I'm looking to get some B12 for my grandmother.

@waynewells2862 5 ай бұрын

Is testing for NAD in blood equal to NAD in tissue like muscle?

@angryoldcanadian3905 5 ай бұрын

I use to take NR (for just over 1 year) and felt absolutely no different. I quit taking it and my pocketbook feels much better.

@oceanwonders 4 ай бұрын

FYI there's a huge quality difference in brand and manufacturer. Tony Robbins talked about it; they bought several off the shelf and tested them. Some contained no active ingredient whatsoever! Assuming not every company was trying to scam, NMN degrades quite fast. It's not super shelf-stable (not sure about NR). But that could be what happened with the stuff you bought.

@ewen1140 2 ай бұрын

@TheHonestChannel Did your dads prostate symptoms continue to improve? This is interesting as if it does it perhaps a good selling point for the supplememt. Will checkout eh earlier video you linked above

@thehonestchannel 2 ай бұрын

He thought it was helping but he had a hernia operation in his groin recently which unfortunately aggravated his prostate so it makes it hard to tell. It seems to be an improving picture again though🤞

@gravityalchemist6599 3 ай бұрын

I'd like to know if you had your Horvath clock measured or did I miss that in the video?

@nupur_mehr 3 ай бұрын

Thanks for the really honest review! Do you know if a female in her early 60s, not regular with exercise and only moderately active, can take NMN? Is it only good for people who are active in their lifestyle? TIA x

@thehonestchannel 3 ай бұрын

Hi. It's not intended to be only helpful to those who are more active though obviously being more active would be the priority over taking a dietary supplement.

@ghostindamachine 4 ай бұрын

Excellent journalism :)

@marthahicks8569 6 ай бұрын

Very informative video! Is it better to take NMN with or without food?

@anitav7090 4 ай бұрын

Love the science thanks. I find glycine really helps with muscle and joint stiffness and tiredness. As I added it after starting the NMN at 250 Mg day it seems important.

@thehonestchannel 4 ай бұрын

Thanks for sharing this.

@marsery 5 ай бұрын

Hi, i think you should look into NADH which is the "reduced form of this co enzyme as opposed to NAD+ which is the oxydised form ..when it comes to supplementation (10mg !! per,pill so 250mg is huge ) the first one ( reduced form) is considered a better choice . Exercising is best it boost anti oxudant levels.. and so many other bio markers so i would agree with the scientist who prefer exercise to supplementation..like i prefer a pristine clean diet to pills to address deficiencies etc .. for many reasons but super interesting testimony and i thank you for it :-) and would like if you could share which lab in Europe,isable to test those kind of NAD levels and other stuff probably

@mikrosurgeon 5 ай бұрын

NMN boosts all cells, including senescent cells. I initially underwent 4 cycles of senolytic therapy with Dasatinib and Quercetin, and now I am substituting with NMN. I'm curious to see what effects I can observe.

@wk9378 3 ай бұрын

The holy grail is NAD+ so is it better to go for regular NAD+ infusion?

@ShahidKhan-qw8yk Ай бұрын

Very interesting

@Kuttanwarrior 4 ай бұрын

EXCELLENT, AND BRILLIANT PRESENTATION OF ART.(aGE reversing technology).

@nian60 6 ай бұрын

I have recently started with intermittent fasting. I'm mostly following Mindy Pelz' IF advice. Still early stages with that so not much to report yet. (If IF gives you headaches then take a little salt with the water, is all I have so far). In general I think it's way too late to try and affect my life span. (I'm not sure I would want to anyway since I have very poor quality of life). But I take mineral and vitamin supplements, no tobacco/nicotine (ever) and very little alcohol, and I try to eat more veggies and fruit. I'm not particularly strict with my diet though, I eat sugar and less healthy foods sometimes.

@dianacoulson4724 5 ай бұрын

I Just read your comment, it's sad you feel you don't have a great quality of life... I think the best we can do for ourselves is try to live a better life rather than a longer life, as a result we may get a few extra years... The reason I replies to your comment was to ask you if you heard of Red Light Therapy, if you're watching this kind of content on KZfaq then, i'm sure you have... Personally I believe that along with a sensible and healthy lifestyle it's probable one of the best things you can do for your body along with practising yoga and everything else in moderacion... It's very easy to get caught in the mindfield of suplements and the trouble is, a lot of them do absolutely nothing other than make those manufacturers and suppliers rich... and in most cases you need to be taking something else to make something else work... We are what we are, some people eat shite all their life, smoke a packets a Day and out live someone who had a healthier lifestyle, it is what it is... If you haven't already then get yourself a Red light device, I believe it's a game changer... If you need any help with that then let me know Regards Oh and IF, another game changer, definitely believe in the benefits of that...

@margaritorendonortiz8628 3 ай бұрын

Never is to late, just don't give you keep adding some supplements exercise

@dewdew34 6 ай бұрын

I didn’t know about this , just showed in my feed. However I recently started taking niacin and tmg as well as b1that I’ve been on for awhile.I have to say I have noticed an increase in my activity level and desire to get stuff done. I get tired earlier though and I get up earlier as well. The niacin seems to make me a bit stimulated as I want to stay in motion and keep working longer. Anyways I have heard of NMN before but now I’m curious.

@carlakenyon6073 2 ай бұрын

I’ve been taking it for 3 months. I had such a crappy sleep schedule. Now I’m sleeping like a baby. Better energy during the day.

@lewynld 6 ай бұрын

Very interesting. However it would be super useful if you had a better timeline of the dietary changes you made, since, strict or not, the information is somewhat confounding. What part the nmn played, what part diet and exercise? Impossible to know based on what you told us. The b12 theory is interesting also.

@thehonestchannel 6 ай бұрын

I was worried about going into too much detail because there was so much information to pack into this video, but to clarify, both my dad and I did make improvements to our diet at the start of the year. I mention in the video we aren't strict and in the past, making healthier changes like these would have helped us lose a few pounds. The weightloss after taking NMN for several months goes beyond anything either of us have experienced since our youth.

@KOz1caa 5 ай бұрын

Awesome!!!!

@BarryGee-pm6rv 5 ай бұрын

It's amazing what a bit of placebo effect can do...:)

@rajeeb3500 5 ай бұрын

Really silly comment

@ningunoag 5 ай бұрын

@@rajeeb3500why? He is absolutely right. On a biochemistry view nmn can not work. Pretty simple

@annavieste7208 6 ай бұрын

You look amazing and younger than previous vids ❤ something is working

@thehonestchannel 6 ай бұрын

Thank you Anna!

@marinafoglietti9351 5 ай бұрын

May be because I never had arthrities and diabetic problems, but I did not see any improuvement to my aged ongles or my white hairs, so after 2 years I stopped taking nmn. I found best improvement with NAC and Taurine.

@thehonestchannel 5 ай бұрын

Thanks for sharing this Marina. I think NAC and Taurine are both very interesting supplements so good to hear you've noticed a difference with them.

@vanessaabbott3057 6 ай бұрын

Hi Claire, tryptophan can also increase NAD and is much cheaper. I've just started so I have not noticed any changes in energy but I take it before bed and I have noticed it helps me sleep. 🙂

@thehonestchannel 6 ай бұрын

I'd love to hear how you get on with it longer term.

@pietercastelein2568 6 ай бұрын

Tryptophan reduces lifespan

@vanessaabbott3057 6 ай бұрын

I'll keep you posted!@@thehonestchannel

@rudieye6666 5 ай бұрын

How so?@@pietercastelein2568

@user-hd4jc1ct8q 5 ай бұрын

but tryptophan is inefficient, and any reasonable amount of it would be needed to increase NAD as high as NR