It's simply a crying shame that an episode like this that contains SO much accurate, critical information, gets so few views-when the much less accurate but more provocative interviews attract millions. 😔

Another great one. The quality of your guests, the questions, the duration, the pace, and the different directions these conversations are unmatched. I learn so much.

Many years ago, my dad took part in a clinical trial in a small Scottish town. Doctors were surprised that he had not developed type 2 diabetes despite having many of the characteristics associated with that disease. At the time, I thought it was great that he was helping scientists with their research but didn’t realise how important it would be in developing our understanding of obesity and metabolic disease. I am a retired Biology teacher and we were just touching on Leptin sensitivity in lessons before my retirement. I hadn’t fully grasped the implications of the research at that time but it’s such a game changer for those living with obesity. Thank you so much to both of you for helping to increase public understanding of this incredibly important area of research.

What great questions, Simon. This was an exceptional show today. Thank you Dr. Mantzoros, for coming and sharing your knowledge! 👏

Exceptionally informative podcast! Simon’s calm and thorough interview style combined with quality guests like Dr Mantzoros is invaluable!

Excellent episode! I just completed a master of science degree in nutrition & dietetics and believe this talk should be included in the curriculum. I have learned quite a bit about obesity and the newer medications over the last couple of years, from school, and also from episodes like this with thoughtful and probing questions and field leaders who present evidence-based / science backed information. Thank you both for the very interesting and enlightening conversation. Im ready for part two 🤓

EXCELLENT, podcast! LOVED listening to Dr. Mantzoros. Lots of information is provided clearly and very concisely. ❤ THANK YOU BOTH for a great, informational show

This is the most interesting and informative podcasts on the Science of health and nutrition that I have listened to in a long time. Thanks Simon and Dr Mantzoros!

What an AMAZING interview! I hope you will invite Dr Mantzoros back again!

I could listen to Dr. Mantzoros all day long❤

Excellent guest! I hope you give some thought to this interview and start a list of questions and follow ups to ask in a second interview. Fascinating stuff. 👏

This was an exceptional interview with so much relevant information we all need to hear.

Simon I couldn't DM you on Instagram cuz it won't allow me, but I just wanted to let you know that you're an amazing man. Your book has taught me so many things, I feel like acquiring this much knowledge so easily is illegal lol. I never understood the nuance and science behind nutrition and couldn't even decipher whether something is true or not (health claims online). It's only been 3 months since I bought your book btw, and now looking at health advice online I'm really able to identify accurate information and BS, Manipulation and misinterpretation of information too. I feel smart lol☠️☠️. I was one of those guys who were totally against veganism just because of the liberal movement, but reading through your empathetic book, my biased lenses have been cleared. Your Book is not one of my favourites, in Nutrition it IS MY FAVOURITE. I'm someone who rarely comments and leaves reviews, but you sir deserve it. Thankyou 🙏🏽

Great episode. Listened twice and will do a third. Thank you.

Wonderful episode packed full of so much information I will need to rewatch it!

Dear Simon and Dr Mantzoros, thank you so much! I was just waiting for an episode completely dedicated to this issue and Simon, what an exceptional speaker you selected. As an ED doctor, I report and discuss with my patient their US or CT scans results, including all incidental findings. I can tell you so many have radiological findings of "fatty liver" and I am talking about even my 18-30 years old pts ,not just the middle age one. Very ofter their first reply is " My liver is fat? But I do not even eat fat!".Yes, fat is a triggering word but gets to the core in a simple way. I am trying my best to explain to them they are going to be the " new cirrhosis " in 15-20 yrs if they do not change their lifestyle and that the solution is simple, although admittedly, not easy in this horrible food environment we are in.

This pulled so much seemingly unrelated information together. A great thing. Thank both of you for a great show.

Simon-kudos on two comments. Following the lead up to a new drug for weight loss-you mentioned odds of success if we do not change the hyper-palatable food environment. Second comment also on the tail of drug with weight loss/anti-sarcopenic properties-should be performing resistance exercise in addition. We keep spending more money for more grants new drugs and we achieve more illness with new acronyms. We have to first agree the current food environment is destructive and envision profits generated from planetary health. Thank you Simon.

Thank you for your work. Your passion for regular people to learn about their health so they can manage it better is greatly appreciated.

Excellent! This fine-tuned a lot of my understanding of these issues. Thank you.

TOP discussion, finally science for us!!!

Excited for this!! Thank you so much. I really appreciate how your podcast consists of talking with research career experts. In the coming months I plan to share it with some physicians I work with, I'm hoping this information gets spread out more. I also am really happy to see you got your dad on the podcast a couple weeks ago

That was brillant and I enjoyed it till the end. Thank you Professor, thank you Simon.

Absolutely fascinating episode! Thank you for this discussion and for all the insights! ❤

Invaluable information communicated extremely well. Thank you kindly!

Σάς ευχαριστούμε κ. Καθηγητά. Μας δώσατε αρκετά νέα στοιχεία, αλλά και ολοκληρωμένη προσέγγιση για τους φυσιολογικους μηχανισμούς τού σώματος, που σπάνια παρακολουθούμε τέτοιες προσεγγίσεις. Θα ήθελα να μάθω ποία είναι η άποψή σας για τον ρόλο της LDL σε σχέση με τα καρδιαγγειακα προβλήματα καθώς καί για την αποτελεσματικότητα των στατινών

We are all sympathetic to obesity problems. Somewhere it needs to be simply stated, if true, that everyone can lose weight without pharmaceuticals. If you cannot, there is no shame in trying drugs. Both methods will fail without lifetime dietary changes.

Wow, this is a great interview!

Thank you for sharing this discussion...definitely this will create a lot of more discussion in the future. Looking forward to hear from Dr Mantzoros soon.

Thanks. Very informative interview

The anorexia and high leptin story is fascinating. This is not one we often hear addressed in the WFPB movement. The closest I've heard is increasing consumption of nut butters and dried fruit.

That was an excellent episode. I really loved it! As a non-overweight person of European descent with non-alcoholic fatty liver disease Dr Mantzoro’s was an extremely interesting and helpful perspective.

Hugely informative conversation - thank you both. Have shared this with family members.

That was amazing! Hope to see more of Dr. Mantzoros!

Epic interview!

Fascinating! So much information packed in. Thanks

The caffeine comments might be relevant to the masses. But those like me carrying one or two copies of the slow metabolic allele of CYP1A2. Once I break 1-2 cups of caffeinated coffee per day, my risk of non fatal MI rises quickly. Pretty well established science. I push the decaf hoping it is the polyphenols that are beneficial. My BP is also very sensitive to greater than baseline caffeine, likely a proxy for my original comment.

Simon, what a great podcast! I've been searching for a rational podcaster, and I think you're my favorite so far. This might be speculative, but I believe the evolutionary reason for depositing visceral fat is tied to survival mechanisms. In times of starvation, the body prioritizes holding onto fat around vital organs. Once all other fat stores are depleted, this visceral fat acts as the final protective layer before organ failure. So, when it comes to the Dave Feldman Lean Mass Hyper responder (LMHR) phenomenon, it makes sense to me that in keto mode, the body starts producing high levels of LDL and ApoB to deliver fat to these critical areas. However, I think there's nothing inherently special about LMHRs, and their cardiovascular disease (CVD) risk might actually be accelerated. In environments where only lean game was available and fat was scarce, like with rabbit starvation, despite the protein intake, one could still starve, so absorbing fat was so important. Much like how now we have an abundance of refined carbohydrates, access to lots of fat sources will surely lead to bad health outcomes. But maybe a new marker of CVD might be needed for those following keto diet. Like LDL per ketones or something 😆

Love all your interviews ❤️ listening from WA

So clear, calm, and hugely informative. Love ya work Simon, inspiring health!!!

Thank you Professor. You gave us a lot of new information, but also a comprehensive approach to the physiological mechanisms of the body, which we rarely follow such approaches. I would like to know your opinion on the role of LDL in relation to cardiovascular problems as well as the effectiveness of statins

This dude is a G

Fascinating stuff, thank you for sharing!

I would really like to see an episode about both natural and artificial sweeteners, their characteristics, comparisons, safety considerations based on scientific research and also use in cooking. For example, what happens to them if they are heated, do their organoleptic characteristics change? Can they replace effectively sugar in both cooking and baking? And to also include some not so well known culture specific sweeteners to western audiences like for example carob honey or petimezi to name but a few. An episode with probably both a scientist and a chef invited. Dr. Mantzoros is amazing, i absolutely loved him. Knowledgeable yet so humble with a very open and humorous communication style as well. Simon, on the other hand, brilliant as always but he seemed so gloomy. On another level, the prices in the US for MRIs are crazy 🤯

Loved this one mate. 👌👌

Hey Simon! What did you say at around 58:30?

In the bit about supplementing to support liver health, vitamin E and D were mentioned, but not choline. I thought choline had been shown in a study to reverse FLD.

Wow, this was important!

Thanks for all the amazing work!

Coffee I have 8, instant, coffee beans & organic decaf coffee . I do have a joint supp with Vitamin E. On HRT as I thought protective for cc’d?! Can’t remember what Prof Susan Davis said!!! Also I have EVOO Avocado almond spread. Being over fed is so easy when I love food though healthy Mediterranean style. Thanks enjoyed. Please episode 2.

This was so good!🔥🔥🔥🔥🔥

Amazing interview Simon🎉

In my country the MRI of abdomen area costs 150-200 USD.

I couldn’t stop listening and my dog walk got far extended. I wonder what has happened with leptin for bone health in athletes and anorexic women. Are there recent studies going on?

Dr. Mike Israetel, with Renaissance Periodization, is by far my favorite PhD sports scientist on KZfaq, and appears to be versed with the literature on nutrition as well. He has a really fantastic series called, "Nutrition for Fat Loss" - an 8 part lecture series, around 30 minutes each video, on how to lose weight. In it, he introduces a concept called periodization, where you basically are at 8 weeks of a caloric deficit, as most diets recommend, but after 8-12ish weeks, you HOLD that weight and maintain for at least 6 weeks. This is to normalize satiety signals, and probably other mechanisms I'm not aware of. And then you continue a caloric deficit as planned. I would really love to hear your thoughts on that approach. There's much more nuance in the playlist series. I have all of its episodes in a public playlist on my KZfaq channel if you're interested. But I'd love to hear if it is evidence based, if so, what are the mechanisms? I just haven't heard the periodization approach before, and one obesity physician I shadowed hadn't either.

Very interesting.

Hey Simon

@simonhill, please, my curiosity is killing me, what did you say at 58:50 (you edited out the audio) that made Dr. Mantzoros laugh??

90 minutes, just getting started.

Algorithm support

What causes the Obesity in the first place is most likely to be Sugar & Starchy Carbohydrates. 12:10

Surprised Fibroscan was not mentioned

Everywhere on my body is skinny except my chest and belly plus love handles. I think I have fatty liver

I may have understood but if obese people fail with weight loss in approx 5 yrs are we just doomed to failure and we are trapped!

What the deal with C15? More noise or actually interesting?

We do know that there are genetic differences in caffeine metabolism.

So how can i...a bone thin person...get leptin to get my hormones back on track...because I cannot gain weight and I have osteoporosis.

I was eating this up...until his interpretation of what the WHI supposedly showed about HRT for women. Gave me pause.

BigPharma loves this fellow. Just drugs, drugs & megadrugs. No personal responsibility for food & activity choices. Keep those big bucks rolling into Harvard!$!

Missed choline

Drugs are not the answer to weight loss. People have to change their diet or they will put all the weight back on. 58:07

👍👍

How many Cancers are related to Pharmaceutical Drugs. I cannot agree with many on this video. I didn’t enjoy it & it is much too technical & I don’t agree with the ‘Doctor’.

The only problem with dietary fat is the oxidative stress and inflammation from most highly processed seed oils. Otherwise the problem is eating too much food too often with a high glucose content, raising blood sugar levels which then breaks down to fat, leading to diseases like diabetes.

Fat doesn’t make you fat if you don’t eat too many Carbohydrates. 1:01:48

In this gentleman’s take being over fat in the wrong areas is causing harm. Yet the focus keeps being pointed to lowering LDL. The people who can become 600 or 700 lbs last longer because there is more available storage in the proper places. Once the storage runs out the downfall begins for all. We all see people who eat lots of carbs gain lots of weight. People who eat lots of meat and fat lose lots of weight. That observation alone in my opinion points to the likely cause to the world’s poor health problem. To paraphrase Joel Kahn being keto allows you to be a thin corpse because of the imminent heart attack coming.

That guy does not really know what he's talking about and fixing lepting fixes fractures makes no sense 😂

Dr. Greger shaved.