THE MOST BEAUTIFUL EXPERIMENT IN BIOLOGY: Meselson & Stahl, The Semi-Conservative Replication of DNA

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10 жыл бұрын

yourekascience.org/portfolio/t...
In 1958, Matthew Meselson and Frank Stahl published the "most beautiful experiment", where they demonstrated that DNA undergoes semi-conservative replication. In this video, we describe the experiments that lead to this discovery and why understanding how DNA replicates is so important. This video is a complement to Matthew Meselson's iBiology Discovery talk, where Meselson recalls the events that led him to meet Frank Stahl and to plan and execute these experiments.
This video was produced in collaboration with iBiology.
iBiology (www.ibiology.org) is a growing collection of free open-access online videos by scientists about research and discoveries in fields including cell biology, neuroscience, molecular biology, microbiology, ecology, development, and biophysics, and also features short talks on topics such as professional development, careers, policy, and education. iBiology is funded by NSF, NIGMS, and HHMI, and is supported by the ASCB and UCSF.

Пікірлер: 257

@victoriarobinson3958 8 жыл бұрын

this was so satisfying to watch...your handwriting is GLORIOUS

@timmy18135 4 жыл бұрын

Kind of like Vihart

@scottelon2837 2 жыл бұрын

i know Im asking the wrong place but does anybody know a trick to log back into an instagram account..? I somehow forgot the login password. I would love any tips you can offer me

@scottelon2837 2 жыл бұрын

@Caleb Luis thanks so much for your reply. I got to the site through google and Im waiting for the hacking stuff atm. Seems to take a while so I will reply here later with my results.

@scottelon2837 2 жыл бұрын

@Caleb Luis it did the trick and I now got access to my account again. I am so happy:D Thank you so much, you really help me out :D

@calebluis2910 2 жыл бұрын

@Scott Elon glad I could help =)

@Skittlezs710 8 жыл бұрын

Actually, everyone gives Watson and Crick all the credit for discoverying DNA Structure buuuuuutttt, Rosalind Franklin was the one to discover this, for she spent so much time using X-Rays in order to figure out the DNA structure, which caused her Cancer. While she was sick battling cancer, two other students researching DNA Structure in the same University( WATSON AND CRICK) sneaked into her Dorm room and stole all her notes AND Published them taking all credit and A Nobel Prize for it But Rosalind Franklin died of cancer before she could take back all recognition of her Research.

@DanielLieu 8 жыл бұрын

+Adlin Hernandez I like how you talked about Rosalind Franklin! She was actually a huge part in the discovery of DNA because of the X-Ray diffraction she was able to obtain. It was critical in understanding that DNA spiraled in a double helix. Unfortunately, due to the reputation of women in science, her work wasn't really respected and neither was herself as a scientist in general. Unfortunate that her death occurred before the Nobel Prize because I believe she would have made a huge impact in the stigma that women scientists aren't as great as men -- which even exists today as women get paid less :) Hopefully that can change!

@rohanshetty5103 8 жыл бұрын

is it true ..? i mean i never heard of it before !

@DarwiiNs 7 жыл бұрын

yea she basically told them everything they wrote about

@teresataylor-whiteley823 7 жыл бұрын

This is not strictly true. Yes Rosalind Franklin was an X-Ray Crystallographer at Kings College London were work was undertaken to determine the crystal structure of DNA (along with the scientist Maurice Wilkins) , the data of which Watson and Crick used to describe the structure of DNA in their publication 'The Double Helix'. However, Watson and Crick were working at a laboratory at Cambridge, not Kings College London and neither of them were students, they were all research scientists working in different laboratory groups. In 1956, three years after Watson and Crick had published their model, Franklin was diagnosed with ovarian cancer, which exposure to x-rays has been suggested to be a possible factor in her illness although other members of her family had previously died of cancer.Nonetheless, Franklin's work was crucial to the development of Watson and Crick's model and she definitely should have received recognition.

@jemmaxoxo9229 6 жыл бұрын

TRUTH she died because of her research and work

@rachellyman468 8 жыл бұрын

this must have taken ages, but I am so grateful for it! it's difficult for me to pay attention to stuff like this, but the drawings made it very entertaining

@christaguevara7582 7 жыл бұрын

As a biology student I found this really helpful. Thank you for posting it!

@shahirahsofea6261 4 жыл бұрын

i've never ever written a comment on a youtube's video before. but this video totally helped me and it deserves all the recognition it can get. this video was so amazingly clear, fun to watch, understandable and just life saving. thank you so so much, love from Malaysia !

@dreamstar18 9 жыл бұрын

Wow I'm German and hadn't unterstand the Meselson and Stahl experiment til yet. I watched 10 german videos about Meselson and Stahl, but only THIS video has show me how it works! I thank you so much!! :)

@barracudacsgovideos9056 9 жыл бұрын

Indeed... :D

@Antonia-pj1jf 7 жыл бұрын

Salmmor haha Same 😂

@mohammedsaqhibbilal1203 2 жыл бұрын

How is being German related to better understanding of a molecular biology topic? Science is universal..nationality should hardly matter!

@susukiii4836 Жыл бұрын

Omg ja einmal auf Englisch angeschaut und alles verstanden

@marinaromanova3475 9 жыл бұрын

The only Meselson and Stahl video on KZfaq that actually helped me. Two thumbs up!

@lillylindner8067 5 жыл бұрын

This was amazing because you gave it so much context. My Biology teacher wasn‘t able to explain it in a logical way. 🙆🏻‍♀️ Now I‘m feeling well-prepared for my pre-exams. 👍🏼

@Ibra4Soso 8 жыл бұрын

simple, well explained, easy and clear sound , may Allah bless you for that !

@timmy18135 4 жыл бұрын

🕸🕷and may your good angel 👼 support you

@feedmewifi_477 4 жыл бұрын

Ibrahim Aldhoon inshallah

@Get2KnowJesus1 3 жыл бұрын

false god and idol. Jesus is the ONE true living God.

@rubydirks147 3 жыл бұрын

@@Get2KnowJesus1 this might be a shocker but there is more than one religion in the world!

@burrito7317 3 жыл бұрын

@@Get2KnowJesus1 stop shoving your religious beliefs into others, let people believe what they want to believe geez.

@lyzabethhadynedwards2482 6 жыл бұрын

This video was so so SO well done. Please continue on!!

@ryanandida8618 3 жыл бұрын

I have never studied anything bio related before my first bio class in college. I was crazy nervous but these videos have helped me understand much better! Thank you so much !! :)

@diraaa99 6 жыл бұрын

Brilliant! Was having a hard time understanding my Biology paper but this makes everything so clear! Thank you very much!

@nadinetaylor2449 6 жыл бұрын

OMG I finally understand what my teachers were talking about! Thank U so much ☺

@Myron19 7 жыл бұрын

This is the best video on the internet for learning this. Thank you guys for the amazing video :)

@gabriellewilliams1048 8 жыл бұрын

this video is super good! definitely helped me understand this experiment A LOT more than i had before.

@orangesandlemons40 6 жыл бұрын

Thank you so much! It was hard to understand in class and in my textbook, but you explained it very well and now I understand it!

@navimumbaisatark 6 жыл бұрын

It's awesome how it describes the process in such a interesting way and also the drawings are Soo good

@danicading1362 5 жыл бұрын

This literally gonna help me on the bio test tomorrow. Thanks

@perfecteducationhub5019 7 жыл бұрын

Fantastic!!! Your videos keep getting better and better... Thanks for this videos...

@NirmalKumar-xw3ko 5 жыл бұрын

Yours is one of the most beautiful videos on this topic .

@jasmineyeh6693 6 жыл бұрын

Thanks for this amazing video!! It makes it much more easy to understand

@lakshya8390 4 жыл бұрын

Super, wonderful, fantastic, amazing, mind-blowing, such a good creativity , explaining using diagrams makes students understand the concept easily and remembering quickly , tq so much, for this type of videos

@sarazafar3734 4 жыл бұрын

This really helped clear my concepts. Thanks a lot

@tammamzouihed3371 5 жыл бұрын

Whoever disliked the video has a mental problem ...seriously who In the damn world would dislike this amazing creation, it's perfect from the colours to the voice to the explanation .. everything in this video is perfect.. thank you soooo much ❤❤

@anupamagoswami 9 жыл бұрын

Very educative, thank you very much. My semester just got saved!

@timothyso9781 8 жыл бұрын

+Anant Goswami I feel your pain. School is tough.

@anupamagoswami 8 жыл бұрын

I'm in college bru!

@timothyso9781 8 жыл бұрын

Anant Goswami oh boy

@kazkumail 8 жыл бұрын

Beautifully done, really helped!

@ayathassan123 9 жыл бұрын

Just the video I was looking for!!!! Awesome!

@deepjyotidas9163 2 жыл бұрын

Your voice makes the video more understandable ❤️

@wasanthikaathukorala6812 7 ай бұрын

This is such a logical explanation. Easy to understand. Thanks a bunch ❤

@freshlycleanedhands Жыл бұрын

This is truly an amazing video. Thank you so much!

@ditamayo7095 6 жыл бұрын

Great explanation!! LOVED IT

@SteadfastWorshipper577 6 жыл бұрын

Thank you for this thorough and clear explanation of Meselson's and Stahl's experiment.

@zainabalalshaikh3249 8 жыл бұрын

this was awesome plz don't stop making such type ved and thank you so much!

@isaacppailay8332 6 жыл бұрын

This lesson is quite amazing, am glad that I finally understand DNA replication

@dimamilli7516 3 жыл бұрын

So useful😍 simple and clear thank you❤️

@70RISHIKESHAVANS 4 жыл бұрын

The best video in KZfaq Hats off for you sir.

@ghinaraji 8 ай бұрын

Beautifully explained!

@philippammer5671 3 жыл бұрын

Thank you so much! Very informative and understandable!

@kimiazare1884 5 жыл бұрын

I loved it even for the international student was so easy to understand

@harish834 2 жыл бұрын

Thank you So much. It is Simple,Intresting to understand the concept.

@Godinus. 2 жыл бұрын

This is the most beautiful way to explain,the most beautiful experiment in the history of biology.

@YourekaScience 2 жыл бұрын

Thank you! So glad you like it :)

@vineelavudata421 5 жыл бұрын

Thank u for d video.. It was so simple and clear.

@aishwaryasinghal6374 7 жыл бұрын

Thanks a lot for such informative content!

@knithinmohan4293 5 жыл бұрын

Thank you, it helped me so much!

@madelynlewis3842 3 жыл бұрын

this video is sooo good thank you!!

@ilyassalmon9513 2 жыл бұрын

Thank you for posting it!

@iriscardoso1044 9 ай бұрын

OMGG!!!! THANK YOU SO MUCH!!! This was so helpful!!

@Chelsea-cd5lf 4 жыл бұрын

thank you so much this was so easy to understand!! 😭😭👍👍

@theinsomniac8792 3 жыл бұрын

wheenever i watch ur videos your writing is so satisyying

@KnockoutEcho Жыл бұрын

thank you! this video helped a lot

@gregoryyang8988 3 жыл бұрын

Very nice explanation.

@mrinavaition 3 жыл бұрын

Easy to understand and fun to watch too

@valentinaescalona8914 7 жыл бұрын

Muchas gracias ♥

@lynngedankenwelt9947 6 жыл бұрын

Thankssssss. The german yt videos were as complicated as my biology book, but this Video was easy to understand You saved my life xD

@Ta3allamOnline 6 жыл бұрын

Amazing video.

@ayano_sensei 2 жыл бұрын

Thanks now the concept is crystal clear😊😊😊

@rockycreation2342 3 жыл бұрын

Wow .....‼️‼️‼️‼️ excellent explanation

@malaikatanveer1406 3 жыл бұрын

Beautiful video

@libs8709 7 жыл бұрын

This video is so so helpful, I'm definitely a visual learner

@Eerisey17 7 жыл бұрын

same!

@ARedVelvetBunnie 7 жыл бұрын

English Rose me too

@aparnatalukdardas584 2 жыл бұрын

Really thanks a lot! It was explained so nicely that after watching many videos I finally understood because of this!!!!

@alishashashasha6909 2 жыл бұрын

Tysm for this video 💜

@ajinkyakarade8068 8 жыл бұрын

woww wowww woowwww... this video is superb as u gave us the information from the beginning :D

@rojapa2402 4 жыл бұрын

Nice clarification information 👍

@DiegoT888 8 жыл бұрын

GATTACA reference 5:27

@lyzabethhadynedwards2482 6 жыл бұрын

Death Metal?

@timmy18135 4 жыл бұрын

This is basically rewriting we

@timmy18135 4 жыл бұрын

No, battlestar gattaca

@tyneciadavis408 3 жыл бұрын

wow i have a bio final for college tommorrrow and you helped so muc

@YourekaScience 3 жыл бұрын

You're very welcome!

@jueedhar5449 4 жыл бұрын

Beautiful .

@lydilein346 6 жыл бұрын

You explaind it soo well that I can unterstand it even if I am german

@janlauterbach4696 5 жыл бұрын

It is indeed a very elegant experiment

@SBShuTingTeo 4 жыл бұрын

Very useful to me,thank you!

@biology_com 3 жыл бұрын

Very well explained

@randomname5118 5 ай бұрын

Even if english isn't my first languaje you managed to explain it better than other videos in spanish (first languaje) congrats

@pandeydivyjyoti 6 жыл бұрын

Very helpful 😊

@smorgi 9 жыл бұрын

Thank you... I understand!!

@hollowghost2 9 жыл бұрын

Perfect video.

@divyanshu6519 Жыл бұрын

Ceasium chloride density gradient was used to separate.

@subrat2021 10 жыл бұрын

Amazing. Very very damn helpful.

@aminakm3503 6 жыл бұрын

excellent presentation👍👍

@surajdewalkar9127 7 жыл бұрын

so nicely explaned...thnks

@ahmedmadhy842 3 жыл бұрын

Very clear

@Ash-zb7bu 4 жыл бұрын

thank you so much! this saved me.

@afifaamjed2294 6 жыл бұрын

AMAZING EXPLANATION!!! I finally understand this yayayaya :D one question though: what if the bacteria were allowed to replicate a third time in N-14?

@charlieshin9868 6 жыл бұрын

Afifa Amjed it would depend on which strand was getting replicated i think. So if it was the light strand it would just come out as 2 light strands. But if it was the hald half strand it would come up with 1 strand that is light and 1 strand that is half half

@afifaamjed2294 6 жыл бұрын

www.thestudentroom.co.uk/attachment.php?attachmentid=698336&stc=1&d=1508899096 This is the picture in my textbook. I don't get the results of the 3rd generation with N-14 (test tube 4).

@user-tf9zh2jh6w 9 ай бұрын

This is really good

@theperplexchild2078 3 жыл бұрын

thank you for this really helped me

@iraqi3612 2 жыл бұрын

Thank you very much doctor

@masud4491 2 жыл бұрын

You should add time stamps it will be more convenient for us 😉 . 👏 Amazing video

@YourekaScience 2 жыл бұрын

Thanks for the tip!

@DeepakKumar-dg9wn 4 жыл бұрын

Niche wali line ki vajhe se nhi dikh reha hai

@k2chloe91 5 жыл бұрын

why does the 1st to 2nd replication support semi conservative? i know you said it doesn't support conservative but it does support semi and dispersive, but why?

@mirzaahmadsaeedbaig5798 7 жыл бұрын

can u explain beadle and tautum experiment

@Ma3h1d1 Жыл бұрын

Ayo this confused me while i wasnt even confused so no mention of hybrid of daughter cells that were found in their studies?

@jcn268 2 жыл бұрын

so is n15 old and n14 new?

@captainp1623 3 жыл бұрын

That was absolutely helpful Thank You guys great job :)

@ukaszsurzycki845 5 жыл бұрын

really beautifull idea....

@yellowbelliedslider6719 7 жыл бұрын

Well done! ^.^

@dangthatscool1 9 жыл бұрын

Good work, here!

@theinsomniac8792 3 жыл бұрын

i need those markers

@fatimarafiq1043 5 жыл бұрын

Ahhh thank God for KZfaq!

@zafariqbal2183 7 жыл бұрын

superb!

@shashaantil2690 5 жыл бұрын

Nicely explained ,but still have to listen twice....

@priyal5873 3 жыл бұрын

THANK YOU

@manassingha5705 4 жыл бұрын

Owing to the semi conservative method of replication, the hybrid DNA must've been produced when normal DNA was cultivated in 15N medium. I don't totally understand.

@kebrongurara4417 2 жыл бұрын

Very old comment but still, the cells were grown in 15N for many generations until almost all the DNA found in them was 15N, then medium was changed. So, all 14N DNA made after this point would have been new DNA.