On medical advice I have been taking NMN for a little over six months. It has changed my life for the better and I am so grateful. For me the fog over my brain has lifted. Now I wake up in the morning looking forward to my day because my mind is clear and I am physically more able. I shall happily and confidently continue to take NMN

Thank you Clare and Brad for such a great and informative discussion, I just didn't want it to end so soon! Brad is so naturally logical being a doctor that it really is good to listen to his advice as you say and not get carried away with taking so many supplements. I would love to know more about protecting bones as we age especially osteoporosis as so many videos are concerned with either muscle or skin aging although they are all linked of course and important.

A great one! Thank you.

I love that you continue to seek the truth and bring reality to this topic. My issue with the information provided today is that Dr. Stanfield is seeking to meet 'minimum' daily requirements. The minimum daily requirements were specified to be the very minimum dosage that is needed to keep someone alive but were not designed to keep you in optimal health. He should be looking to identify dosages that will lead to optimal levels to stave off illness not minimal. Vitamin D is a great example of this as was shown during that last plague that we won't name. People that had only minimal levels of Vitamin D did not fare very well when it came to staving off that illness.

Check out Dr. Darren Candow’s work on creatine supplementation. The info provided here is not quite up-to-date. The dose is 2.5g/100lb of weight, and you can slowly load 1-2g each day for the first 30 days, if it causes stomach issues. Also, don’t take creatine within an hour of caffeine intake, as caffeine can hinder the absorption of creatine.

SUPER INTERVIEW!!!!

Its nice that you reply to comments

Thanks I to got got up in hype. I tanks Dr Brad’s sound scientific backed channel

Same, my husband & I both stopped taking NMN recently. We really appreciate your sharing this interview Claire. We agree, the evidence just isn’t there yet.

i found it interesting, his comment on carbohydrates from fruits an veggies...thank you:)

Hey, you're a Kiwi Dr Brad. Gill here from Auckland. Love this Honest Channel. Great discussion.

really like this Doc - supplements look good - unsure about the glaze ? shellac in the ingredients tho?

Caloric Restriction, CR, is the only intervention shown to lengthen the life span in multiple species including mammals. Newer research into why CR increases lifespan has shown that it's the restriction of protein, specifically the amino acid methionine, that gives the benefit. The amount he recommends is double the RDA for protein. The amount that research has shown is restrictive enough to get the benefits of CR without restricting total calories, is equal to the RDA: .8mg / kg of body weight.

The difference in muscle NAD levels between aged persons who exercise and those who do not is linked to the differences in the numbers of mitochondria. Since those who do not exercise have fewer mitochondria their NAD levels are lower and supplementing will not help them as its primary role is in the electron transport mechanism of the mitochondrial ATP production. Coffee drinkers need to take care when taking creatine as the combination has been linked to the onset of Parkinson's disease. The major route for reducing homocysteine involves folate and B12. Trimethyl glycine turns homocysteine into methionine which is not a good idea since excess methionine can lead to over methylation and depression. The recommended daily intake for vitamin D3 was set for rickets and is far to low. The best guide is blood level which should be between 50 and 80 ng/ml. To achieve this without sun exposure requires loading with 10,000 IU per day and then 5000 IU daily for maintenance but it is important to take it with magnesium and fat for good absorption and vitamin K2 to prevent calcification of arteries. Vitamin D3 is necessary for over 1000 metabolic reactions and for immune response where it initiates naïve T cells. Magnesium is critical for over 200 metabolic reactions including the formation of ATP.

Thanks for taking on something that's somewhere between a minefield and a Halloween fun house (things popping out at one unexpectedly, etc, if you don't have them in the UK). You said in reply to an older post "That said, an optimum level for 1 person is different to another so it is easy to over and underdo it. As with all things it's finding the right balance for us. Not always easy!" I think you pegged it.

Linus Pauling, as i recall, Nobel prize recipient for his research on vitamin c recommended at least 2,000 mgs per day since it correlates to what animals produce

Great interview Clare - 😀 I love his balanced approach and you asked all the questions we needed to know. I take - a food based multi, vit D, gelatin, nettle leaf, bee pollen, magnesium malate, plus zinc twice a week. I've also started marine collagen. I like to take a break every now and then but keep it going during the winter. Be careful with things like berbeine long term - I've heard from a medical person that it can raise BP and lower potassium. Safer options to lower blood sugar are gymemna sylvestre or 200 mgs chromium polynicotinate as well as magnesium malate.

Yes, thanks for a great discussion. You asked great questions ! I am definitely guilty. I have a giant box of supplements that I take every day but the funny thing is I exercise every day of my life I lift weights I do aerobic and I feel great sometimes I’m like … “really do I need all of this crap!?” I will tell you that I was taking creatine because of everything that I read and then my stomach got huge and I was in pain. I actually had to stop it so be careful with that one maybe it was the brand I was using I’m thinking about trying again because like he said, there is so much evidence that it is good for us, especially as I get older, I am 62 I have been taking NMN and TMG. quercetin niacin for three months and I’m feeling good so I’m going to stick with it for now

I trust your judgement so love to listen to you. It's very confusing when experts never agree on things. Keep looking for that much needed magic formula for the rest of us. Thanks Clare ❤️

Great video. Regarding NAD boosting, there is a longevity research scientist (Nichola Conlon) who promotes a supplement she claims is much better for boosting NAD at the cellular level (rather than just blood levels) compared to NMN and NR. Would love to get an expert third-party's opinion about it.

I'm always leary of docs who have their own supplements on the market. Fact is, you could've interviewed a doc that swears NMN is the everything! It's just a free-for-all...ppl just have to do their own deep dive.

Good morning Clare. Listening while I count my vitamins. TY for keeping it real. I too jumped on NMN and then dropped it due to not feeling differently and not enough science yet. Curious. I added Berberine because of you and Huberman. Do you still take it?

Clare have you ever done an oxygen treatment facial? And if so which one is the best? I was looking it up online and found out there are all kinds.

he is honest and look young that's a base for his popularity

Hi Claire, I’ve watched Dr Stanfield s Chanel and been on marine collagen peptides powder for about a year and I feel in my skin definite results. I’ve now started on oral liposomal hyaluronic acid on my first bottle but my goodness my skin feels plumper , softer and more hydrated. I’ve signed up for a monthly delivery. It’s early days and I did have dryer skin to start with. So far so good.

For the low down on nitric oxide, heart disease (what causes it, how to prevent it), statins... Please interview our very own, totally brilliant, Dr Malcolm Kendrick, author of a numerous scientific publications and a number of books. Many interviews on YT. Love the channel Clare, excellent stuff...

Certainly, one should be cautious with high Vit D, but always check your vitamin D and calcium blood levels. My elderly family member, despite taking 5,000 Vit D is still at 18 ng/mL, not where we need at at least 25-->35 ng/mL.

The group that discovered nitric oxide in 1992 were awarded the Nobel prize for molecule of the year. Maybe he should look a little deeper into that?

This hair pony tail suits you - makes u look very youthful!

The problem with some of what this guy says is that when you are looking for official human trials and basing all your advice on the results of those, you need to remember that the pharmaceutical industry has been quietly working for many years to dissuade people taking natural supplements (they cannot be patented) and as most science goes where the money is, most major funding does not go to any vitamin studies. It's a very complex situation with many moving parts where the public has been consistently pushed away from vitamins (being made to think they're a waste of money or even dangerous) and you will see regular anti-supplement propaganda show up on morning TV shows etc, no research is done or is discouraged, anything not synthetic drug related doesn't attract any funding, so the studies just aren't being done or are tiny and sporadic. This is intentional. So when this or that vitamin or supplement is suggested as a possible cure or help for this or that condition, or proves anecdotally promising in a given area, they publish articles stating "more studies are needed, we do not know at this time". How many times have you read that? I would imagine all the time. This is by design and is to promote pharmaceuticals over and above anything already in existence because that's where the money is, development of man-made drugs which can be patented and profited off. So when a guy like this, as well-meaning as he may be, says he is basing his opinions only off existing human peer-reviewed published studies, we all know there just aren't the studies around to prove what people usually have found out in their own lives anyway. The same goes for RDI's, they have historically been set at extremely low levels which are the minimum to support life, but not relevant for therapeutic benefit which is often much higher. So just be wary of someone when they refer to what studies are around and basing all their advice on that because it is not what it seems and the studies just aren't there and that is intentional. At the end of the day, if humans have been using something for generations (or sometimes thousands of years) with success and it hasn't been killing anyone, go for it and don't wait for the 'studies' because they won't ever happen while pharma is in charge.

Many of the studies he cites are quite small and they are not double blind studies using placebos, take most of these studies with a grain of salt and find out what works for you 😀

I communicated with the lead author on the exercise study which showed maintaining NAD+, and he said is wasn't just as simple as walking 13,000 steps a day, but that some of it had to be moderate or vigorous - can't just stroll. Study by Prof. Janet Lord also showed that elements if the immune function (thymus related) was maintained by longer term moderate exercise in older people (cycling in her study). Beyond this there are probably many other benefits to longer term moderate exercise. At 69 yo haven't tested my NAD+ but have walked 5 to 7 miles daily for last 11 years and also do a routine with light weights for 15 minutes a day. My normal gate speed is on the faster side which is a good sign. I'm pescatarian in terms of diet (also last 11 years) My Levine PhenoAge (based on normal blood panel) is consistently in low 50s if that means anything. On protein, quantity I disagree with Brad, studies show that exercise is much better at maintaining muscle mass than extra protein but do agree with his other dietary recommendations.

Oh wonderful. I’m so confused about MNM?

But isn’t it plausible that many of those levels being higher in many of the most popular multivitamins is because of the poor delivery systems.

Not sure about Dr Brad's multivits at £40 per month supplements (90÷3 a day).. expensive for most Brits...😮

Hi Clare, Just a heads up for all your viewers; I placed an order for Dr. Brad's Micronutrients & was billed for $53.10 back on 10/9, & I immediately canceled them the same day because I received notification that the supplements were out of stock but would be shipped when they had a shipment. I never received my refund nor the supplements, & am beginning to wonder if he is scamming people. (I hope not). I canceled my future subscription & again requested a refund, but have not heard from him as yet, & I trusted the guy.

Nitrites are a new thing?? Lol! 😂

What full body exercise can a 70 do?

Nobody is checking to see that fish isn't farmed when they say wild caught, also, overfishing is rampant. Chicken is now a high fat meal after decades of selective breeding and has the worst medical outcomes of all protein sources. Meat in general will erase years off our lives. I just take vegan protein powder, but the artificial sweeteners are not healthy either. There just doesn't seem to be a truly healthy source of protein besides legumes and you'd have to eat those for every meal to even get close to the optimal level of protein. Maybe they make a protein powder that doesn't have artificial sweeteners, just not in my supermarkets.

I’m starting carnivore after doing keto for a year and loosing stubborn menopause weight and bloated belly. I’ve just reintroduced meat ! .Go meat support USA Ranchers !

What a shame that you spent the entire time with this genius Doc talking about mostly weird supplements. Supplements are pushed because of their money making ability but not necessary for most of us if we live eat a healthy diet. We need to think about the real damage to our livers from these supplements which are mostly completely unregulated.

Vit D is toxic

Oh Laaaaaaaawd...we now don't need cleanser, just splash dirt off w water😂😂😂...c'mooooooon maaaaaaan! Moisturize if you "neeeeeed to...it's just not necessary". Absolute nonsense!

Is he just grifting, or does he really not know that green tomatoes do the same thing as rapamycin?

I like you, but I don’t trust and don’t like these doctor.