Gout: Glycine Lowers Uric Acid!

Рет қаралды 9,875

11 ай бұрын

In this video Dr. Pete discusses the uric acid lowering properties of the amino acid glycine. Most gout sufferers are hyperuricemic (high uric acid) and many of you take urate lowering drugs. Glycine may offer an alternative to drugs like allopurinol or can be coupled with a urate lowering drug to more effectively lower uric acid.
Dr. Pete proposes a comprehensive model of gout, obesity, diabetes and the best practices to put gout in remission and reverse obesity and diabetes. His ability to breakdown the science into understandable terms is unmatched and no one else in the low carb space can match his depth of knowledge concerning fructose/uric acid pathway and potential remedies for the number one inflammatory arthritis in the US and the worldwide epidemic of obesity and diabetes. If you suffer from gout, obesity, and/or diabetes makes sure and watch this presentation. It can change your life.
Find Dr. Pete at www.drpetesgoutintensive.com
Find Dr. Pete at www.drpeteandt.com
Email your questions to peterdelannoy@drpeteandt.com
Join his free private discord support group: / discord
Find tart cherry, quercetin, and meters here: drpeteandt.com/dr-pete-ts-pro...
Email Dr. Pete here: peterdelannoy@drpeteandt.com
Some References: 1) some references appear in the presentation 2) Click the link for general reference and crystallization papers here: docs.google.com/document/d/1k...

Пікірлер: 97

@sgtaneja 2 ай бұрын

Glycine is my favourite amino acid. I have 3gms -5 gms on regular basis. Its excellent for gut, liver, gall bladder, kidneys, brain & heart / vascular health.

@g33k37 9 ай бұрын

Hey, I just found your channel from the algorithm. We started giving my grandfather, who's 92 glynac in July. We did this to try and help his heart failure. Which seems to have worked fantasticly. He's also suffered from kidney infections as well as kidney stones for years. He had a large stone removed from his left kidney in April that was removed via surgery, it was too big for standard lithotripsy and they were going to go after the stones in his right kidney only when we did the CT SCAN two weeks ago to find all the stones were GONE! It's absolutely amazing, and his urologist is scratching his head. Because we know he didn't pass them. So something between Glycine and Cysteine has had a major effect on his kidneys. As his eGFR is going up as well.

@DrPetesKetoKlub 8 ай бұрын

Awesome news! Keep up the good work.

@v-22 8 ай бұрын

That is an amazing story given he's 92 and has had all those issues. Well done!

@feli931 6 ай бұрын

Hi my father who is 89 years old is going through similar situations what was the mg you him.

@questingspangle 2 ай бұрын

What dosage of glynac is he taking?

@g33k37 2 ай бұрын

@@questingspangle 3.0 -3.5g twice daily with 2.0 Taurine twice daily as well

@michaelberman3648 5 күн бұрын

I also take the magnesium-L-glycinate as a glycine contributor with additional supplementation of NAC to form glutathione with the assumption there is excess glutamine in our tissues.

@saxgirlhornboy6458 11 ай бұрын

Interesting info, thanks.

@blackbart5803 8 ай бұрын

A mix of rutin and quercetin lowered my UA from 7.5 to 5.1.

@doomsdaycompass3279 12 күн бұрын

Since 2020, I substituted glycine as a sweetener, and stopped sugar. I used it to make my own Whip Cream. Though I don't use a lot of heavy cream any more, I still use glycine to sweeten my hibiscus tea, to sweeten my Golden Milk, and to sweeten my morning Cacao, I don't sweeten my coffee, since I take it black for its bitter taste. During Holidays, we make a blueberry salad with heavy cream, sour cream, gelatin, and glycine for the base. Blueberries are in a gelatin, as well. I found glycine can lower post prandial spikes. And it can help sleep. I take at night -- Golden Milk -- with Ghee,Turmeric, Cardamon, Nutmeg, and Saffron, all sweetened with Glycine. Or I take 3 bags of Green Tea for L-Theanine, sweetened with Glycine before bed time. Now I will experiment with Glycine, and try to lower my Uric Acid levels, as I have been a carnivore for two years. Now, I eat my meats on the weekend, following a 5:2 PSMF schedule. During the week, I eat egg whites, some goat cheese, and whey. Lowering my saturated fats during the week to avoid palmitate. I followed a similar Gout diet in 2005 and I lost a lot of weight, and reversed my gout using yogurt, cheese, and eggs. It was a Keto diet based on Barry Sear's Diet books. Today, Quercetin, Coffee, Elderberry, Tart Cherry, Garlic along with Vitamin C is how I reduce Uric acid.

@juliaappleton17 11 ай бұрын

Thank you. You have been a beacon of wisdom for me. Appreciate your work is vital.

@reviewer5286 11 күн бұрын

Thank you Sir!

@dregbayonsaymay 2 ай бұрын

Doc thank you for this

@trevormarcray 6 ай бұрын

Your channel is great. Really helping a friend of mine who is trying keto but has gout issues on it. Thank you so much

@sugarandfoodaddiction9868 5 ай бұрын

Thanks for the comment! I work really hard to try and help with the gout.

@DrPetesKetoKlub 29 күн бұрын

Thank you!

@EarmuffHugger 4 ай бұрын

I'm on it !! SUBBED 👍

@SL-ml6fy 5 ай бұрын

Have followed your advice for several months and have not had a gout flareup but like you said my UA level is still quite high. Will be trying Glycine and will see if UA will come down. Thanks for sharing your knowledge !!!

@DrPetesKetoKlub 29 күн бұрын

Go slow and take your time. Sudden fluctuations in UA can set off a flare.

@tonir6532 7 ай бұрын

Blue berries in fresh or frozen form and sour cherries in frozen or canned form or frozen form work to reduce/ remove uric acid and pain and remove osteo arthritic pain in fingers and toes.

@michaelberman3648 5 күн бұрын

I am taking liberal amounts of Magnesium-L-glycinate. I take this compound for a variety of reasons including its ability to activate vitamin D3 to its physiological potential. Can this compound I am taking also act as a significant contributor as acting also as a glycine supplement?

@faisal-ca 7 ай бұрын

I have been gout-free for ages but have a slightly higher Uric acid. I have recently introduced Collagen and hopefully, it's going to give me enough Glycine.

@johnwick-mh9ry 4 ай бұрын

how did you manage it? thanks in advance.

@faisal-ca 4 ай бұрын

@@johnwick-mh9ry I don't know the underlying cause. I got gout when I went on a pure protein diet, eliminating everything else. After that, I kept on having toe discomfort or small flares. Then it went to remission. I took a more balanced approach to diet. My last blood work showed UA is within the permitted range.

@sgtaneja 2 ай бұрын

Collagen and Glycine are Not functionally equivalent. Besides, to breakdown collagen, you need to start with nano hydrolyzed collagen peptides, then have enough stomach acids and proteases to break down those collagen peptides, and you'll also need cofactors like vit B6 in active form to process the peptide aninos to finally get to Glycine ! Soln : Have free form Glycine directly !!

@paulyoung3504 10 ай бұрын

Hi Dr Pete. What's your opinion on creatine. I'm 60, in gout remission for just over a year and on a low carb diet but not keto. Thinking of trying out creatine, 5 grams per day, but noticed there's next to no KZfaq videos discussing gout and creatine. Thanks, Paul Y

@DrPetesKetoKlub 10 ай бұрын

Be aware that in the 60's biochemists showed that crystalline creatine could cause the same symptoms of gout as monosodium urate. Just FYI.

@paulyoung3504 10 ай бұрын

@@DrPetesKetoKlub ......Thanks Pete. I'm not on any anti-gout medication like Allopurinol because my gout attacks only occur maybe once a year to 18 months, but I have colchicine on standby if I need it. (Gout is the strangest problem I've ever had...no real pattern to it. ) Thankyou for all your advice.

@zaxtoy2431 3 ай бұрын

I take Trimethyl glycine. Would that lower Uric acid the same as regular glycine? If so, are the dosages the same? Does anyone know? Thanks

@DrPetesKetoKlub 29 күн бұрын

I don't know.

@Xanad00699 5 ай бұрын

Is magnesium glycinate helpful?

@sugarandfoodaddiction9868 5 ай бұрын

Maybe. Try it and see. Use UA testing to determine if UA is coming down.

@mreudeco 3 ай бұрын

Yes definitely

@kenshey3912 8 ай бұрын

I found many of these glycine studies… all referenced taking with tryptophan (a sleep assistance supp). Do you take the tryptophan? This current flare has been happening for a month now… not sure if I should drop out of keto or not. Lots of proteins but ratio is 80% fat Would love to see a new video on your glycine potassium citrate doses

@sugarandfoodaddiction9868 8 ай бұрын

I use the tryptophan off and on. I just didn't see the enhanced drop suggested by the papers. I use 1 gram Kcitrate with 3 grams glycine per one drink. I shoot for ~9-12 grams total glycine per day.

@kenshey3912 8 ай бұрын

@@sugarandfoodaddiction9868 thanks Pete,.. I’ve got some numbers to start working with. PS UA was travelling along 9ng since I got the meter. Much tighter on protein to fat ratio especially if I have any chicken. I suddenly dropped into the high/mid 7s but goal is 5s I have allopurinol but I’d like to see where I level off N=1 Data is power … n=many is even better

@DS-mr7gr 4 ай бұрын

When I started keto about six weeks ago, I had a 4 to 5 day mild gout, attack myself. I’ve had a few attacks of the last 3 to 5 years, and when I diagnosed for probably the first 3 to 4 years of that. Hopefully, yours will improve soon. I’ve read that infrared sauna can help excrete excess your acid, as well as foods that remove toxins from the body. But a lot of those are not keto.

@adamshand 3 ай бұрын

keto adaptation is known to cause gout flares. as you adapt the gout should settle down. it took me two months ...

@DS-mr7gr 3 ай бұрын

@@adamshand I came off Keto about a week ago, having been on two months and my trick acid levels were high. I’ve decided on my own to switch to something else. Although I like keto for certain reasons, I’ve come off and eating more nutrient focused.

@id9139 Ай бұрын

Can you eat red meat if you have high Uric acid????

@RoiPourpre 8 ай бұрын

Hello, no risk of uric acid stone in the kidneys by doing that ? I don't have gout but my Uric acid level is at 6.9, not good for cardiavascular health :( Ty.

@DrPetesKetoKlub 8 ай бұрын

Yes. Maybe. 2 things; 1st any urate lowering strategy like this that works on excretion or on production (like allopurinol) can bring on a flare. 2nd; with glycine I also take potassium citrate to increase alkalinity of the urine, raise solubility of urate, and decrease chances of a stone.

@RoiPourpre 8 ай бұрын

Thanks for your answer ! Have you tried quercetin ? Just find that this work nicely , im going to try this for the next 3 month and see if it reduce a lot my uric acid. Never got a flare but, i really hope im not going to have one... @@DrPetesKetoKlub

@RoiPourpre 8 ай бұрын

Do you still use Quercetin ?@@DrPetesKetoKlub

@v-22 8 ай бұрын

My kidney functions are of a healthy 20 y/o. I am lean, athletic, I have perfect blood pressure, great cholesterol and glucose levels. I have no other issues except for gout while my UA levels are under 6, so, explain me that because no doctor has been able to thus far.

@jonathankuhn2180 8 ай бұрын

I know, if you really research gout, seems people have hyperurcemia with no gout, people have monosodium urate crystals in joins with no gout, people have gout without crystals in joints, people have gout without high uric acid levels. It seems like there is a strong correlation with the crystals and uric acid, but I am not convinced it ends there, the medical establishment doesn't seem to care about us and getting to the bottom of different diseases, they have their treatments, and thats about it. It does seem a few people are an exception to this rule, I pray more and more people continue to contribute and help humanity toward health through their research and efforts. We need to be our own advocate and research as much as possible. Dr Pete has a good point, it could be a form of pseudo gout.Oxalates can do this too.

@DrPetesKetoKlub 8 ай бұрын

You may have the inflammatory condition that promotes formation of the seed crystals which can persist for years without the shift to the painful flare. There is also the possibility of other crystals like calcium phosphate and oxalates. If you are supplementing creating, calcium salts in protein powders, these can be potential contributors to seed crystal formation.

@v-22 8 ай бұрын

@@DrPetesKetoKlub My CRP is super low and the only supplements I take I just started taking, I've had gout for 9 years. I'm telling you, I even heard it could be a B5 deficiency- it's not. I have not idea, doctors have no idea.

@sugarandfoodaddiction9868 8 ай бұрын

Unfortunately you are correct. We don't know the cause of gout. We know that UA is required for the flare but UA is not sufficient. There are other factors--at least one protein--involved in the flare. Additionally, soluble UA is also involved in addition to the crystal. We do know that average UA doesn't drive flares. Large swings up or down in UA in a short time frame drives the flare. The best thing that you can do is make sure that you eat a whole, real food diet. Eliminate the drivers of Fructose/UA metabolism: hyperglycemic food (grains, potatoes, rice, etc.), any/all added sugar, alcohol, and Unami ( any packaged, processed foods including processed meat.) Eliminating the drivers of UA reduces the probability of large swings in the concentration of UA. One last thing: Sleep apnea is a known driver of gout. Get tested if you have not done so. Even if you think you sleep great, get tested. The reason is because sleep apnea causes regular hypoxic events through the night which activates Fructose/UA metabolism and can cause frequent large swings in UA and subsequently the flare. Hope this helps.

@v-22 8 ай бұрын

@@sugarandfoodaddiction9868 it's not sleep since, after I sleep, my gout always improve which is why I force myself to sleep as much as possible. It has happened in many different circumstances, when I was eating well and lean, when I was not, which is why it makes it impossible to pinpoint the cause, but thank you!

@evelynsimmons7602 10 ай бұрын

*Promo SM*

@keylanoslokj1806 7 ай бұрын

Sir how do we avoid high uric acid? Do we avoid tomatoes and spinach? What other lifestyle factors contribute?

@mreudeco 3 ай бұрын

That’s for oxalates

@Nero_1069 2 ай бұрын

the problem with alternatives to allapurinol is if it doesn't work you have to suffer yet another excruciating kidney stone.

@DrPetesKetoKlub 2 ай бұрын

Maybe. This remains unknown. One thing you can do is take potassium citrate in the appropriate dose to elevate the pH of the urine and lower the probablity of a stone. The best use of allopurinol is the lowest possible dose to get you to your target with elimination of the drivers of UA production and maintenance of a low inflammation environment.

@Nero_1069 2 ай бұрын

@@DrPetesKetoKlub Cheers.

@2tennhills Ай бұрын

QQQ DOES GLYCINE exacerbate cancer

@peterdelannoy Ай бұрын

I don't know.

@doomsdaycompass3279 12 күн бұрын

No. Serine is an amino acid implicated with cancer. Protein restriction, in general, is recommended for Cancer, particularly restricting Methionine. Glycine N-A-C Taurine are recommended for longevity since they boost glutathione. Prolonged fasting with Vitamin C is a protocol being developed by Dr. Valter Longo

@privatesuzie4071 9 ай бұрын

Pete, are you still taking allopurinol? Suzie

@DrPetesKetoKlub 8 ай бұрын

Yes. But I am experimenting with 12 grams glycine per day and reducing the dose of allopurinol. Also, maintaining potassium citrate.

@kenshey3912 8 ай бұрын

Pete… how long before you saw potassium citrate affects

@DrPetesKetoKlub 8 ай бұрын

I take kcitrate with glycine to increase pH of urine. You can monitor pH with pee strips. Glycine lowers UA by excretion so using Kcitrate lowers risk of stones. Glycine allows me to lower allopurinol.

@healthyselffirst6845 8 ай бұрын

@DrPetesKetoKlub how much K-Citrate do you take per day? And how do you take it?

@sugarandfoodaddiction9868 8 ай бұрын

@@healthyselffirst6845 3-6 grams usually mixed as a drink with 3 grams glycine. 1 gram Kcitrate, 3 grams glycine.

@wocket42 9 ай бұрын

Bone broth is mostly glycine. No supplements needed

@NickCager 2 ай бұрын

Really? Wow... I just had a large glass of bone broth before reading this...problem solved!

@copie77 Ай бұрын

Problem with bone broth is it’s super high in purines

@NickCager Ай бұрын

@@copie77 I didn't know that, thanks!

@doomsdaycompass3279 12 күн бұрын

Bone broth is umami

@Unsensitive 2 ай бұрын

Interesting. glycine also improves metabolic function. I've heard metabolically healthy individuals with elevated fasting blood sugar using glycine to lower their fasting blood sugar from the low 100's to 80's. Makes me wonder if it's the metabolic improvement helping the kidneys lower uric acid, or lower uric acid helping metabolic function.

@DrPetesKetoKlub 2 ай бұрын

No doubt that UA is required for optimum metabolic health. However, how much is too much remains to be determined.