Ibuprofin, youbuprofin, we all..bu... I'll see myself out.

Ibuprofen or Acetaminophen? Hah, please - I'll take an IV drip of morphine, thanks.

Acetaminophen is the to-go medicine in my country; you got a headache? 1-2 acetaminophens each 6-8hrs and you're good to go; injured your knee? same thing; got an arm chopped off? SAME FUCKING THING.

I enjoy my liver functioning, so I'll stick with ibuprofen for most of the time

so it's basically is a cox blocker - i hate cox blockers...

Ibuprofen for regular pain, Excederin for migraines and headaches. Nothing is better

Death - best painkiller of them all.

please never stop making videos they are so intresting!

Thank you for being well researched.

Why not address each drugs down sides at all? Ibuprofen can be very damaging to the digestive tract causing bleeding while Tylenol is associated with Liver damage. I'd have loved to have this aspect of these drugs explored as well.

(psst, acetaminowhatsit is american for paracetamol)

Good job DNews, well reported.

She didn’t answer my question 😂😂😂

thank you for the knowledge

I'm allergic to ibuprofen, so I'll stick with Acetaminophen.

I've used both. Ibuprofen is actually my favorite NSAID (over aspirin and naproxen), but since it's still hard on the GI, I was switched to celecoxib (Celebrex). Currently off it since doc is worried about liver damage.

The image for prostaglandins is wrong, but good info allround.

Great video!

Good film!

Julia, Great job on this, and all your videos. You present the material very well, and you come across as an intelligent, good-natured person who is fun to be around. Keep up the good work!

Another fascinating video from DNews. I just wish I had a better understanding of the sciences behind this. Ah well maybe I'll be able figure it all out later.

I think I'm allergic to ibuprofen and plus it causes gut damage so I don't use it. I never take pain pills unless I feel like I'm dying, and when I use them I only use acetaminophen and it works like a charm. There's pros and cons to everything.

Some good info, but I was hoping for a clearer delineation of indications for using one or the other ( i.e. when suffering from this sort of pain, use this med, etc.)

My question would be: can you build up a tolerance to ibuprofen? It used to work great for me but over the years the effectiveness has dropped to near zero. For migraines, the over the counter pill that combines aspirin, acetaminophen and caffeine works wonders.

Hello, which one do you recommend for swollen and injured knees? Damaged ACL to be particular. Since I can't get my hands on the big stuff like Morphine and Vicodin!

Ibuprofen works better for me than acetaminophen, but I've had several doctors tell me taking up to 1000 mg of acetaminophen with up to 800 mg of ibuprofen is always best, and it works wonders for me, ALMOST as much as a 7.5 mg hydrocodone.

Both. If I want to reduce swelling or reduce pain from physical trauma, I use Ibuprofen. If I want to relieve a migraine, be more wakeful, or help with a hangover (assuming I lack either Midol or Gatorade), I take Excedrin Migraine. If I am sick, I abuse Ibuprofen while consuming a lot of water, and either sinus/sleeping meds or Excedrin, based on what I am doing at the time. I use Ibuprofen additionally for things like toothache and new piercings.

Good thing every on KZfaq is a doctor or other medical provider with at least 10 years of post-high school education...

Acetaminophen used to be my go to, but now I'm all about Ibuprof.

Ibuprofen/NSAIDs is my favorite, but to be fair, I hardly ever use pain medicine. More research is needed! It does suck though that NSAIDs increase your risk of ulcers :(

I use Ibuprofen and/or Naproxen rather than Acetaminophen because I like to drink a few times a week, and acetaminophen can cause liver damage in people who use alcohol regularly.

Ibuprofen is easier on the Liver! In fact, the leading cause of Liver failure in America, is Acetaminophen poisoning. (Overdose of Tylenol). You would think it would be Alcoholism, but it is not. Alcoholism is sometimes a contributing factor. Tylenol for a hangover headache. It is actually the Tylenol that causes the most damage. Take Ibuprofen!

All I know at this point is after my kidneys failed and had a transplant I'm not allowed to take ibuprofen, only acetaminophen. But the fact that I now know more about ibuprofen and not acetaminophen is kind of worrisome.

In Australia it is ibuprofen versus paracetamol. I always find ibuprofens works a lot better than paracetamol especially on period pain

DNews Make a video about natural supplements compared to drugs. Like 5-HTP vs. Prozac for depression.

Ibuprofen has always worked better for me, and I use it for any kind of pain, mild or severe. Prescription pain meds often make me feel sick to my stomach, so even when I had them available after I had my wisdom teeth out, I took ibuprofen instead.

ibuprofen is the go-to for me. tylenol has always made my head really foggy and it's really uncomfortable, so i don't like taking it. i wish i could just pop an ibuprofen when i get a migraine and feel better though like you said, it would be nice if life really worked that way.

This show was very interesting to more like this.

Pain medication has only worked for me sometimes. In fact, most of the time, it doesn't work be it acetaminophen, naproxen, or ibuprofen. Oxycodone works for pain but it is an opiate and opiates can be addictive. For menstrual cramps, Midol is the only pain medicine that is not an opiate and that works. I am not sure why but I seem to have developed a tolerance to acetaminophen and NSAIDS unless it is midol. I don't know what is in midol other than acetaminophen that makes it work so well but I don't want to take opiates simply because NSAIDS don't work. I guess I will have to endure every pain and just not take pain meds. But here's the thing. My pain medication levels are usually 1 dose per month and at most 1 week's worth of pain medication per month(but it only reaches these levels when I am close to having a seizure despite taking anti-seizure meds or after surgery(of which I have had only 1, an appendectomy)). So why would I, at these low pain medication levels, become tolerant to acetaminophen and NSAIDS to the point where they don't work? Are my white blood cells producing different COX enzymes that NSAIDS just can't bind to because of having previously taken NSAIDS? Are the receptors in my brain that acetaminophen binds to being downregulated even though it is usually only once a month that I take it?

Hey dnews make a video about aspirin and aleve. Where do these go in all the pain meds?

The difference between ibuprofen and acetaminophen is that ibuprofen is an anti-inflammatory and acetaminophen a fever reducer. Acetaminophen reduces pain by cooling down the body which raises the pain threshold. So I would say that ibuprofen is better for pain specifically compared to acetaminophen, but it does reduce pain. But acetaminophen is definitely better for fevers and headaches.

Naproxen sodium seems to work the best for me. But acetaminophen works just as well.

As a pharmacist for pain, I prefer aspirin so long I know my kidney function is fine. At adequate doses, close to 3gm split every 4 to 6 hrs is equipotent to codeine as I recall from my pharmacology classes at UF. We are backing off from Ibuprofen because it may have undesirable cardiovascular effects and few benefits are gained at doses higher than 600mg every 8 hrs (or TID) in the lingo of the US. Acetaminophen I had learned to be a selective cox3 produced solely in the brain. It is a good pain reliever when used at the correct dose, but the FDA is recommending to back of bcz of the opiod epidemic. Still, at 1000mg every 6 hrs it relieves pain very well without affecting renal flow nor risking people that are likely to bleed... Those with ulcers, warfarin or newer direct anticoagulants like rivaroxaban.

around 2:48 u mentioned researchers say they can actually activate pain instead of reduce it, for me and tooth pain, it absolutely for sure hurts worse when i smoke bud, its definitely noticeable and the m.o.a. or way i smoke doesnt make any bit of difference at all, it has nothing to do with smoke touching the teeth or a vacuum being pulled.

Were is Naproxen Sodium (Aleve) in all this?

its situational for me whether i use one or the other

If you take a mix of both it works REALLY well, just don't go overboard.

I have never taken either, especially not for headaches. I'm one of those few who very rarely get headaches.

Putting up with it is my pain killer of choice.. But for when that's not an option; Aspirin for less serious pain, Codeine for anything more severe.

0:27 and send a signal slow* to the brain. nociceptors are C type fibers and are actually the slowest type of nerve impulse. depending on how tall you are, it could take a full second or more for pain signals to reach your brain from your feet.

Is it true you can take a dose of each simultaneously without particularly adverse effects?

Please be sure to check with your pharmacist. I cannot take Advil due to contra-indications with the other medicines I take. Whether it is an RX or over the counter, always check with your pharmacist.

Hey DNews! Make a video similar to this but about cough medicine. I'm confused as to how it works but i know that it works in a very indirect way that just relieves symptoms and not the root cause. At least that's what i remember

what about naproxen sodium? (aleve)

What about paracetamol possible working on COX-3 in the CNS?

Hi D News. I have some suggestions on possible topics to discuss. Why haven't we cured gout yet? There is a lot of conflicting information on causes and cures. That led me to question why the FDA takes so long to approve new drugs? Europe seems to Excell at new meds, what are they doing right and why aren't we (the US) mimicking that system? Thank you for your consideration!

I've always used Advil because it works better for my dad so it's what my parents kept around the house. Watching this video made me realize that I'm in my twenties, yet I don't think I've ever taken Tylenol. Weird...

I don't like either and in general I don't like taking meds unless needed. When i get headaches I literally go to bed and relax. That usually helps.

it depends on the pain right? i tried taking ibuprofen for a wisdom tooth im getting in and it didn't do anything, while acetaminophen stopped that pain significantly. And with head aches for me, ibuprofen works better than acetaminophen

Tylenol works good for my leg pain which is believed to be cyatic nerve.But is it safe to take after having 3 heart stents out in 6 months ago.so Do I deal with possible heart problem ,or severe pain.?help

Now, can you explain how allergies to anti-inflammatory and other medications arise?

I'm now convinced on ibuprofen myself

Make videos about Cymbalta

I have both rn for a filling I have and the IB works better for me with blocking pain. The Tylenol 3 has acetaminophen/codeine and it’s not working well for me.

How about Naproxen vs. Ibuprofen??

depends on side effects, one of those you mentioned have adverse effects on the liver... i would prefer to not take pain meds at all... except for a short time after surgery until it's at a point i can tolerate it.

In Argentina we only consume ibuprofen, and for very bad pains we use diclofenac. I've never seen tylenol here.

I can't take ibuprofen with my dabigitran etexilate but I'm allowed to take cocodamol however I do sometimes cold filter out the acetaminophen

I generally find that Ibuprofen is the one I end up taking the most, although I personally would almost always take them in combination, because that's fine. But the one hang up I have about acetaminophen (paracetamol where I'm from) is the fact that it is metabolised through one of the enzymes which metabolises alcohol, making it more likely to have an overdose effect of the paracetamol when you're drinking or hungover, making you feel much worse than just that hangover (because Woohoo Pharmacology!). Just make sure you know the circumstances for each drug and you'll be fine :)

ok, this episode had a lot of big words. i dont really understand it, but I'll accept the challenge!

Thanks

I'm wondering how many pharmacists, nurses, doctors and/or allied health professionals watched this video out of morbid curiosity...

Something worth noting is that Ibuprofen is way worse for your kidneys than Acetaminophen while Acetaminophen is worse for the liver. I had a kidney removed a few years ago and was told I shouldn't take Ibuprofen anymore.

Headache --> Aspirin (enteric coated) Pain --> Ibuprofen Tylenol isn't as effective as pain reliever as ibuprofen for me. Naproxen works excellent for pain, but I no longer take it because it makes me extremely dizzy.

My migraines are caused by high intracranial blood pressure which can be triggered by anomalies in caffeine intake, stress, changes in barometric pressure, and ambient heat, among other things. I treat mine during early onset with a combination ibuprofen and cannabis which lowers my blood pressure and relieves the pressure on the arteries and nerves in my brain which are responsible for the pain.

I prefer ibuprofen but for severe pain I usually use Norco or Percocet which has acetaminophen in it to strengthen the drug’s effect

Acetaminophen (Paracetamol) coz I mostly have headaches that's why now I'm planning to experiment.

Because of decades of having to deal with inflammatory injuries due to athletics, I became a fan of ibuprofen and the other NSAIDs depending on a specific need where one was a better choice than another. Acetaminophen never seemed to help, even as an analgesic, nearly as well. Add in acetaminophen's relatively higher risk of overdose and I tend to stay away from it unless it's an included ingredient in another medication.

This is wisdom from my mom and she seems to be right. You take acetaminophen for fevers, headaches, and pain if your wound is bleeding. You take ibuprofen for muscle pain or injuries to reduce swelling. For headaches you can also take ibuprofen if it is a tension or sinus headache. If it's a bad headache or migraine, I take 2 of each.

Acetaminophen doesn't do anything for me by itself, but I'm at a loss because I can't take Ibuprofen or any other NSAID for that matter, so I usually just have to deal with the pain unless I take Acetaminophen w/ Codeine.

Which on do you take for period cramping? Ibuprofen? I am quite sure it is not asprin.

Ibuprofen does not work as well for me as Acetaminophen. Plus I can only take medications that contain Acetaminophen. I will not take any generics right now as I am on blood thinners I even have certain pain medications hidden from myself that have NSAIDS in them because of it such as asprin and and aleve

I have been diagnosed with Fibromyalgia and arthritis and the pain medications the doctors prescribe seem to always have Acetaminophen in them. I dont take very much Ibuprofen. If I werent allergic to Naproxin Id prefer to take it as a pain reliever.

Naproxen ftw!

Naproxen (Aleve) is my go to over the counter pain reliever. Nothing is better than Aleve for me.

My brain started hurting when she started to try to explain acetaminophen lol

As a child I was able to take acetaminophen, as I got older however I became allergic to acetaminophen so now I have to take ibuprofen.

my mom prefers advil because tylenol doesn't work for her but she's allergic to advil. :( she has a prescription to tramadol instead to use sparingly.

I use both with no preference for headaches. But for migraines it's Acetaminophen all the way.

Ibuprofen is the only one that works on me. I never knew why but Acetaminophen makes me feel nauseated and sometimes increases the pain I've felt. This video left me the question though - if we don't know now acetaminophen even works :| why is it an over the counter drug? If we don't know how it works how do we know what the long term side effects would be.

Acetaminophen works better for me, but I can't take it anymore because of liver issues, so I'm stuck with Ibuprofen, which is now killing my stomach instead.

I love them cox 2!

I grew up with acetaminophen, which has worked. I dont know which one works best though

Acetaminophen, not because I think it's better, but because it was always in my house. My mother is allergic to Ibuprofen [and related drugs].

What about aspirin or naproxen?

Where I'm from, we've got a drug that contains both ibuprofen and paracetamol (acetaminophen) in reasonable doses, but I prefer to just take ibuprofen.

While sure Ibuprofen works slightly better for me, Paracetamol (Acetaminophen) works quite good as well. For really strong pain (like a really nasty migraine) I'd take Ibuprofen though. Actually Paracetamol is fine in this case too but then I'd take 2x500mg of that to be sure that it's working really good (or 400mg Ibuprofen. There are very few cases when I take 800mg). My body reacts quite positively with those medicine, like I don't really have to take much and after 20 minutes I feel pretty relieved after having quite strong pain (especially headache and migraine).

Ibuprofen is really good if you have nausea caused by your monthly period. I also prefered it when the lymph nodes in my neck swelled up and became painful. For a fever, tylenol is okay, but even then, ibuprofen seems better. So, for me, Ibuprofen it is!

I have a blood disease, Von Willebrands, and when i was a baby the doctor told my mom that I cant take ibuprofen but I CAN take acetaminophen... why is that?

Tylenol has always made my headaches worse. Ibuprofen is the only thing that works for headaches and migraines (for me) but, when it comes to physical pain somewhere else in my body, tylenol seems to help more.