Lmao funny.

What in blazes does that even mean.

You are out to lunch.

Thanks for all you do Dave! Can't wait for lmhr study this year on plaque.

What about LEM decreases the risk of ApoB? Even if turnover of any given particle is higher, endothelial intrusion is a diffusion process so concentration dependent, not dependent on the lifecycle of any given particle (the probability is not dependent on the history of a particle).

@scotbradesteems The LEM is seeking to explain this phenomenon in the context of high LDL/ApoB where seemingly metabolically healthy, fat-adapted. The specific risk association of high LDL/ApoB in this context is what we're researching with the LMHR Study out of Lundquist.

It seems to be doing that. ( 4:16 )

@@erastvandoren, "… then he can show us his biomarkers." He did show us the only one he was interested in for this experiment -- LDL-c. It took less than "at least a couple of weeks on Oreos" to see the effect on that one, so why should he be concerned about any others? If he was not, why are you? (Have you even seen his video explaining what this was all about?")

@@erastvandoren, So design and conduct a study to show the effects you are interested in. I would still suggest that you watch (or re-watch) Dr. Norwitz's video where he explains his intent for his experiment.

​@erastvandoren you must not be a LMHR, it's okay fatty

there is nothing to watch in Norton's videos then. Firstly, Layne himself admitted to errors while replying to this and suggested it's because he was dealing with his mother's surgery. Which is awkward because he sells Data>Feelings and yet he uses feelings to try to explain his deficiencies. As someone who follows the science myself, there is a reason why I follow both these guys, because getting 2 opposing views is essential for science. In fact I got to know Norwitz because of the study, bravo to him for using Oreos, that was provocative of him and it brought out the attention. Norton refusing to debate Norwitz is proving frustrating because I need to hear both opposing views with arguments for each. I didn't want to say this, but on this, as even Layne points out so clearl, Norwitz has his science and data correct, and we science followers should try to see beyond the superficial data and get beyond. Because that study raises more questions. And I appreciate even Layne saying the study raises questions. If Layne and his character sees the study as important, I wonder what type of person you are, really.@@erastvandoren

Yes. It seems odd that so many people would be so resistant to that.

need to get a prescription from your doc ;-)

​@@JoeS97756😂😂😂He is joking about insurance.

😅😅use Medicare!

😂

@@saintjulien6126 I know, as was I. lol

You mean, Layne-man's explanation! Aha! 😂

nice one bro hah@@rixxlx

You mean explanation to a layman? Because Layne-man is not a layman.

I fit LMHR as well after years of high fat keto/carnivore diet. 37 year old male very muscular and fit with 10% BF. Blood markers very similar to yours. I’ve tried reintroducing carbs around workouts with some success but beyond 100g/day gives me awful brain fog. I just feel so damn good without carbs I’m torn on this. Really hope some more conclusive data comes out soon.

Has your weight training performance increased since you brought carbs back in?

Can you say something about your performance and hormonal levels? Did they change? How do you feel better?

@@bcjammer87can you say something about your performance and hormonal levels in both situations? How do you feel about?

@@bcjammer87have you tested possible food sensitivities? Not all carbs are equal.

Eat some carbs

It is not shown whether this high LDL is harmless. Maybe it is healthier if you had a lower LDL by eating some carbs.

@@MmartinL I think that is likely correct. I do not eat this way now, I was just experimenting with those diets to see how I responded.

@@MmartinL The lower you can get your LDL the better.

@@MmartinL On the other hand, if some carbs lead to elevating A1C, that could be bad too. It'd be nice to have low glucose/cholesterol/triglycerides, but it seems nearly impossible for some people to get all three in the low range unless they have great genetics. I can choose to lower either cholesterol or glucose, but not both. Triglycerides are low no matter what.

mg/dL*

Yea buddy, I think eligibility criteria also includes you need to be "natty". You cholesterol is sky high not because you're a LMHR, you're using PEDs 😂

I wouldn't be surprised if it was because of fiber. Soluble fiber is useful for the body to shed excess cholesterol. And high fiber diets are often considered to be overall quite healthy.

Sounds like an awesome doctor!

Thank you for your comment! I'm a nutrition student and we have spent a lot of time on this issue. The fiber found in carbohydrates have a wonderful ability to help lower LDL by binding to it so it can be excreted from the body. That's likely what happened for you. I'm glad you were able to find a good balance.

There are so many vegans with LDL of 50-70. So carbs definitely help.

@@taylorhillard4868I agree. My TC was 8.0 ( New Zealand values). 1 month on high fibre foods with very low saturated fat and it dropped to 6.6. On whole foods. No statin yet ( I do have Pattern B) and hope its continuing its downward trajectory

Dairy, not diary. Oops

Calcium score is a late-stage finding. If you find calcium you are very close to a hear attack.

You should probably go see a Dietitian

@@troy3423 LOL. Go to a dietitian? Wow, I NEVER thought of that. Or probiotics. Or prebiotics. Or fiber. Or yogurt. Or butyrate. Or kombucha. Or other fermented foods. Or FMT. (Fecal microbiota transplant) Or low salicylate. Or SIBO. Or bone broth. Or any other suggestion that presumes I am uninformed and have not already tried everything and was left to manage this problem with no assistance from “experts.” Because someone has an RD after their name, are they gonna wave a wand and render me able to suddenly digest the things I cannot? Telling me to eat things I cannot digest won’t fix the problem. I once asked a dietitian for help with a low FODMAP diet and she had never heard of it. Fired more gastroenterologists than most people have seen, because the only thing they do is give you the same canned advice, over and over again, even after you have reiterated that you have ALREADY TRIED THESE THINGS and THEY DO NOT WORK. The worst was the time I was in the ER for uncontrollable hemorrhaging and the advice was to “eat more fiber”. Or perhaps the time a doctor put me on medication for intestinal cramps and I could not swallow as a result, and when I reported that she said she hoped I would not stop the drug because that was not a side effect. I stopped the drug, regained the ability to swallow, and needless to say, didn’t waste my time with her again.

@@kostisapostolidis1821 my score was zero.

That doesn't mean the high LDL caused the MI. That's like saying you can't be involved in a car accident if you're not in a car. The idea of the study is to eventually disprove that LDL is a factor with the calcification of arteries leading to heart disease. There are many factors that can lead to a heart attack, and it isn't just heart disease. As there are other studies that show high LDL is associated with longevity, I am very interested to see where this study of LMHR's goes.

Did she happen to be vaccinated

​@@LucidAmethyst that wasn't the point of the study. Its stating that there is a subsection of the population, lean people on extremely low carb diets, who use LDL as a transporter in the lipid energy model. There is a hope that that does not lead to coronary plaque. However we know for certain that LDL is involved in the pathogenesis of coronary plaque development. It's not the only factor I agree.

@@LucidAmethyst You are wrong. I don't think they have any intention of trying to prove anything like that. They only care about LMHR. I'm also unaware of any study showing high LDL is associated with longevity. If you mean that there is data collected where old people developed high LDL and then died because of a ton of other factors, then yes that probably exists. Did they have high LDL their whole lives and that's why they lived long? No. Just look at people with Familial hypercholesterolemia. They tend to have cardiac events very young. They did not live extra due to high LDL. They died very young. It makes no sense to say high LDL is associated with longer life when all the data shows otherwise.

​@@LucidAmethystafaik the association between high LDL and longevity is due to diseases like cancer, hepatitis, malnutrition etc which among other symptoms cause lower LDL. When researchers take care to exclude subjects with undiagnosed diseases from prospective studies, the association between high LDL and longevity disappears.

If your TG went up significantly in response to carbohydrates maybe you have not fixed the problem with insulin resistance yet. You just treated the symptoms. Which is ok, that‘s what meds do as well. We know that diabetes remission is not caused by cutting out carbs. It has been done on various diets and even happens after weight loss surgery. It is probably due to loosing fat. Why are you so sure your high LDL-C is not harmful and your doctors worries are nonsensical? What harm would be taking meds to be on the safe side? That‘s what I don‘t get tbh. I think it is dangerous to put a study, that excluded every LMHR with plaque and also is lacking a control group above randomized controlled trials and mendelian randomization studies. There needs to be more research to come to a proper conclusion and definitely of higher quality. One big question would be how many of the LMHR do not develop plaque and how many do not and if it’s more then people with low BMI and normal or slightly elevated LDL-C not on a low carb diet. There are people that do get no cardiovascular problems despite high LDL-C and not being metabolically healthy. My grandma for example. LDL-C in the 300eds elevated TG‘s and fasting glucose. No heart disease with 88. So should we not care about LDL-C and metabolic health then? There are always outliers. And a study cherry picking what might be outliers is largely used to depict all of the group. I see that very critical. What‘s also stange is you could predict their studies outcome - plaque does not build up over one year, but several or even decades. Don‘t get me wrong, I‘m fascinated with the phenomenon. But I do not think the lipid energy model is correct. It makes no sense. It proposes that LDL-C is high because of higher traffic of Triglycerides in LDL particles. But triglycerides are very low in LMHR and they do not have much small LDL typically carrying TG’s. No it is the reverse cholesterol transport, that is the issue in my opinion, where HDL but mostly LDL is involved. Both HDL-C and LDL-C increase in LMHR, indicating they are full of cholesterol. Reverse cholesterol transport is increased in fat loss, as not only the stored triglycerides leave the cells. This happens on low carb/keto more then on a carb rich diet. Fat tissue somehow protects from high cholesterol. If you look at BMI and LDL-C, you see only a rising linear relationship up to a BMI of 30, and then even a drop. I bet there is something wrong with the fat tissues in LMHR.

I do similar, 7 mg simvastatin and 3mg Ezetimbe and 500 mg L Carnitine (for LP(a)). But I do not get anywhere near the reduction you do, I am at about 60-70mg/DL LDL. Mine started at 60 then bounced up to 70 six months later, I would expect yours will do the same.

@@robertdaymouse3784, maybe the Lp(a) is the point. Mine is below 1. Or maybe not. I have bloodwork scheduled for next week. We'll see.

@@robertdaymouse3784 Maybe the point is the Lp(a). Mine is below 1 mmol/L. Or maybe not. I have blood work scheduled for next week. We'll see.

I’m curious why you’d want to take the statins, but not just increase carb consumption a bit?

@@Chris_P_, two reasons. The first one is a matter of control. When you start being permissive with something, at least in my case, it's very easy to slip down the slope. The second reason is that I had digestive issues (gastritis, GERD) that have improved significantly. Besides (I don't know if this is real or just suggestion, but just in case), my concentration and memory have also improved. I don't want to take risks. I'm not afraid of statins and have no side effects, apart from a couple of points increase in AST and ALT, but both are still below 24.

I think is a pretty Bad one, that on this one he basically tried to insult someone who actually wanted him to collaborate on a ver interesting research. Layne showed that he has no scientific mind on this one . Layne showed that he is too, a zealot

Actually it does because this lipid energy model predicts exactly what you're describing.

Feldman and norwitz are grifters

Only thing this study is being falsely used for is by the ketotards who are now claiming statins are useless, and that high LDL in keto is safe.

Anticipating the buy in from legacy media

@@SandyBatten1962 Lol, I can just see the new marketing label. “clinically proven to reduce high cholestoral” with a big asterisk. Then, further super fine print somewhere on the bottom or back of the package somewhere referencing the asterisk stating: “ Individual results may greatly vary and results were based on a N of 1 study. We do not endorse our product as a substitution for medical advice, prescribed treatment or the consumption of oreos to prevent or treat high LDL. Please consult with your doctor.”. Having said that I have to confess as a side note, I am super jealous of the LMHR phenotype. I love me oreos, but cannot stop at one only, so find I need to totally avoid them. If I could eat 13 Oreos a day with impunity. Now, that would be heaven,,and a dream come true 🙂

FDA won't allow it.

I'm glad to hear you get such significant results from a reasonable dose. At my last physical I found myself in nearly exactly the same situation (LDL 180 and everything else pretty good). I'm currently at the end of a six-month test to see if I can get results with 10 lbs weight loss and a higher-fiber, lower saturated fat diet, but I'm expecting to have to start statins next month.

Cognitive function I guess. I did try a statin for a while and my feeling was decreased Cognitive function, so much so, I couldn't compile data. Lol. I used to get gout bad. Meds looked like a life long thing, so I made better connections to what was good and rectified the issue. A side effect was much better numbers with ldl, hdl, triglyceride. Old habits started coming back and the numbers got worse again and that's when I tried a statin. Since then I have tried to make better habits easier to follow from making even better connections. I actually have optimal metabolic health now. If you can, it is clearly better to work with nature than fight against nature, such as using a statin. Not going to be possible with everyone, I guess.

There's concern about mental cognition if you have familiars with Alzheimer's disease bit if not I think your safe

I'm glad you're solving your statin deficiency so succesfully. Layne is truly an amazing guy right!

Yes, it is interesting he used foods he objects/rejects and is now using them to promote his work/science and popularity. Maybe he finally saw the light and that all "foods" can be incorporated into a healthy diet.

@@markhaubphd You... you don't understand whats happening do you?

@@markhaubphdhe purposely used Oreos because almost no one would think they are healthy at all. Any carbs will cause lower LDL in LMHS.

​@markhaubphd ahh no you missed the whole point, just like 90% of Layne fan base. 😂😂 fucking bots

Endothelial penetration? 😅 🤡 Transcytosis of LDL is absolutely normal and happens in everyone.

​​​@@erastvandoren Layne says it in the video..... aging Is normal and happens in everyone, but who wants to accelerate that process??

@@erastvandoren so then, every ldl that passes through is detrimental?

@@davidflorez1196 yes, we don't want to accelerate LDL transcytosis. That's why we need to keep inflammation, blood glucose and pressure down.

@@yoso585 Every LDL that crosses endothelium can be gulped down by a macrophage. As far as I know, this process (fluid phase macrophage pinocytosis) is unregulated. We also know that inhibition of LDL transcytosis prevents atherosclerosis completely.

Yep, so true

Full disclosure: Layne is on statins

​@SullivanKelly85 so are a lot of cardiologist and longevity Drs...

@@brownshit1 the irony there is not lost on me 😆

No it's because LDL is used to transport fatty acids through the blood to be used as energy. When you're obese your cells have more than enough fuel so your LDL stays the same or even goes down on low carb but if you're very lean all that fat has to come from dietary fat which is transported in LDL to the cells. The reason the addition of carbs from oreo lower the LDL is because the body now also has extra glucose for fuel, meaning that it has to transport less fat to the cells for fuel.

Nick has IBD. He has to be in a keto state to avoid serious gut issues. He was probably grossed out and stressed when he had to eat Oreos.

FHC includes higher clotting.

How does it get into the blood?

Nick made it clear Oreos were added it to the diet without and taking anything out. That means his saturated fat intake actually increased on Oreo phase

💯

No, triglycerides dont raise in 2 weeks. It takes longer

It's not independent of cholesterol. It's an accelerator of cholesterol.

I would experiment with other foods, that would appear better than oreos and see if you can keep everything the same, but reduce ldl. Jerusalem artichoke for a period would be interesting to see the results.

I was very similar on low carb, but my cholesterol was around 290. Low triglycerides, excellent insulin sensitivity and A1C. My doctor suggested taking my carbs from 20-40 up to at least 100, and it made a huge difference. I’m still just barely in the “high” range, but it’s just outside of normal. Not sure what your diet is like- but some suggested my improvement might be due to more fiber with more carbs. You could give it a try- it’s almost never a bad idea to add more fiber!

Of course you need to be concerned. Literally every study has shown that high LDL is bad. The keto grifters won't tell you this

The free version of Google's AI bard can do this for you. As it to summarize this video (you'll need to give it the link), and then take that text and ask the AI to make the wording so simple you could explain it to a 12 years old.

@@Feed_Bleed_Read Yes he did, I have confirmation of this now. He used ketone supplements to stay in ketosis. However, even Nick states that some people, if they strategize correctly, may be able to carb cycle without supplements.