Forgot to say! I don’t work/cooperate/affiliated with any supplement company. Get FREE updates about my supplement research as long as you subscribe to this habit formation app at: wellnessmessiah.com/app.

🎯 Key Takeaways for quick navigation: 00:00 🌱 *Taurine shows strong potential in protecting against aging, with suggested doses increasing with age, but its effects on neurotransmitters warrant caution and individualized approaches.* 04:33 💊 *Niacin (B3) and NAD boosters like NMN and NR have potential in age-related health, with NMN showing promise in muscle health and exercise performance in older individuals.* 09:30 🌿 *Ashwagandha may help regulate cortisol levels, aiding stress management, particularly during periods of chronic stress or intense physical activity.* 11:50 💪 *ALCAR (Acetyl-L-Carnitine) supports muscle health by aiding fat metabolism and reducing reliance on glucose, potentially preserving muscle function with age.* 14:49 ☀️ *Vitamin D supplementation needs to be tailored based on individual conversion rates and genetic factors, with a recommended starting dose of 4,000 to 5,000 units per day.* 17:24 💊 *B vitamins can enhance energy and reduce anxiety but should be taken cautiously to avoid excess, with a preference for obtaining them from food sources or low-dose supplementation during fasting.* 19:27 🦴 *Glucosamine and chondroitin may support joint health and longevity, although further research is needed to fully understand their impact and optimal dosages.* 20:51 💊 *Glucosamine and chondroitin supplementation may be associated with reduced total mortality risk, particularly in higher doses, according to research findings.* 22:00 🎯 *Individuals over the age of 65 may benefit from tailored supplement regimens to mitigate the risk of accelerated aging, including hormonal support, antioxidant defense, and enhanced protein intake.* 23:09 🔄 *Cycling DHEA cream usage and integrating antioxidants like quercetin may help support hormonal balance and protect against oxidative damage, particularly in individuals over 65.* 26:18 🍖 *Increased protein intake, particularly in powdered or collagen form, may be beneficial for individuals over 65 to compensate for reduced protein absorption and support soft tissue health.* Made with HARPA AI

many people know the longevity effect of taurine but they do not understand the mechanism. here it is: in the mitochondria there are two primary types of fuels to be burned: glucose and fatty acids. and there is a difference in ROS production between burning fat or glucose. if burning glucose, ROS production is going up. if you understand ROS then you understand, that it is very very damaging. sometimes the body needs it as a defense mechanism against a virus of bacteria or a cancer cell that is gone rouge. but of course ROS is damaging also organelles, cell walls etc. so, if ROS is not needed, it should be avoided. staying in fat burning mode is key for that. one factor - besides many other factors - is making sure that fat burning is running smoothly and fast enough. if it is too slow to produce enough ATP, the mitochondria is switching to glucose burning mode. what is making sure that fatty acids are oxidized ( =burned) fast enough? ==> the speed of the enzymes that are involved in that (krebs cycle etc.) is depending on the pH level of the surrounding. if the pH level is going down ( lower pH = more acidic ) then the fat burning enzymes are slowing down. this is a usual effect from a chemical reaction. the speed looks like an S-curve, or mathematically like a sigmiod-function. it this case this sigmoid function describes how fast the chemical reaction is. AN THIS IS WHERE TAURINE IS COMING IN: taurine is a pH buffer. that means it keeps the acidity from changing fast. and there is a chain of pH buffers from taurine in the mitochondria to carnosine in the cell to bicarbonate in the blood. in legal sports doping where the body should stay in fat burning in long endurance sport (cycling, running over many hours etc.) they supplement with sodium bicarbonate, beta-alanine (to make carnosine) and taurine to have enough of these pH buffers. so, now the anti aging mechanism should be clear. in one sentence, taurine optimizes fat burning which lowers ROS which is one cause of aging.

Vit D3 with K2

Thanks for addressing those over 65. I have changed up my supplement routine since I hit retirement to target those aging issues. It has clearly made a difference.

I find your comments some of the best on the web. You deliver things directly.

Thank you for your incredible work!

We appreciate your sharing your thoughts on these supplements!! Thank you 👍🙄

Thanks for your opinions and research on all of that. I hope that your wife continues to improve.

Thank you very much for you proposals, which I apricate a lot

Great advice Rimon and very much appreciated here in China. Thank you

I appreciate your efforts and valuable informations,thanks a lot

Congratulations, Rimon. I haven't been here for a while and on watching this, I observed with joy, the astronomical growth in your number of subscribers. I used to feel bad when your numbers were still low because I never quite understood why such an informative channel would be under subscribed. The only way is up for you now. I hope your wife continues to make a good recovery. Best wishes.

Good stuff...appreciate the info on taking care of our older parents. My mother so far has been fairly receptive to my suggestions. She's on medications so I don't want to overload her with supplements so suggestions such as bone brother are helpful. Being 65 myself..this stuff is important to me as well. Your work is appreciated.

Beautiful research thanks for Sharing

I also avoid all prescriptions if I can. I even turned down statins and I'm using nattokinase instead. Some study actually found it far more effective at removal of plaque. I don't care for nmn too pricey and I didn't notice any benefits personally.

Re: Taurine. Recommend getting an amino acid profile which includes taurine. Then module diet, exercise and supplementation over time to get to high end of reference range. Makes no sense to just gobble many grams a day without testing. I'm 69 yo and have levels of a 30 to 40 yo according to data in studies and I only use 500 mg/d which I've taken for about 10 years for other reasons (vascular). Now taking 1 gram a day and will retest again soon. Same idea with Vitamin D (I take 5000 IU /d), Omega 3 index, test and modulate diet and supplementation and as needed. My D3 level is in 40 to 50 ng/ml range. Omega 3 index 7.8%, almost ideal ( i take about 600 mg of EPA and DHA, eat flaxseed and nuts and a little fish). Test when testing is available.

Couple of things, Taurine taken on the empty stomach in the morning will stimulate your gllbladder and improve bile flow. This will help to prevent stones from forming also a good easy way to jump start your day. Second, vitamin E should be in tocotrienol form - this is important. I also add CaAKG and some other amino acids before workout, and creatine. Creatine not just gor musvle growth but for stress and mental health actually which was surprising to me…different doses for men and women because of the way it’s processed, gender specific things…also a quick note on micro-dosing melatonin after 40. A few more things I had really good success with if it’s interesting, I can write later! 😊👍

Thanks ! Very interesting!

Very good advices, very good and wise, thank you

Thanks for this. You’ve convinced me to start taking Taurine for the first time. I didn’t fully understand when you take it and why and how to stop it interfering with sleep

Good information.

Like your channel very much ❤

Love your content Rimon! Can you comment on the latest data on Niacin's metabolites (4PY) being linked to heart risk and inflammation? Does this also impact NMN/NR users? A video on this would be very helpful! Thank you for all you do

Thank u, great information

Wonderful presentation and presenter , comments out of this world, kicks ss, Peace

That was great and thank you very much ❤

I took ashwaganda for a long time, 3..4 days per week. I liked the effect on psychology and regulation of sex drive. However, and that's a big one: It caused inflammation of the liver, AST got as high as 40. When I took it off, all other things roughly the same, AST returned to 28 after 8 months. So, if you start taking it, observe your liver enzymes. In order to support the healing i ramped up the vitamin A, by food and by supplement

10:50 iirc l-ornithine does reduce cortisol as well

Hey Ramon Love your channel.❤ What is best to mix the taurine powder with? The taste is pretty bad. I cannot swallow capsules either. Thank you

There's a lot of hype towards NMN and NR. Probably it's due to commercial interests. Niacin has been on the market for a long time and isn't a good business for labs

Great Video and Glad You addressed 'over 65's'❤! Could You kindly share the Brand of Collagen You give Your parents.😊

You should look over Tulsi - holy basil. It’s so wonderful against stress and more.

Thank you so much Rimon for this video. I am a 70 yrs. old African American female in GOOD general health but do not feel the energy I used to since turning 70. I am on bio-Identical hormone replacement cream (16 yrs. now)--not due to any disease. It was elective for me as a way to manage aging. Is it OK for me to add DHEA cream? Also do I understand correctly that I can try either Niacin OR NMN? I don't need both? Thank you.

Good info.

I thought B12, like other B vitamins, was water soluble. Therefore, any excess would be harmlessly excreted. Is that not so?

Thank you so much for the Great content, I trust you more than any one ,could you please share which brand of vitamin b3 ( niacin) and collagen do you use ?! Are you recommending whey protein for people over 55 or 60 it has all the amino acids especially for those who don't eat red meat alot maybe once a week?! Greatly appreciated 🙏❤😊

Great information, thank you! I was researching into the NOW brand super antioxidants, and it seems that the bottle used to be $17, then the price was increased to almost $40, which does not really matter because it is not currently available; so I am thinking I may try to get quercetin on its own, and less you have a different suggestion.

Good video! Thanks for dividing supplement analysis into age groups (65). This is important for some supplements. I'm surprised you didn't do that for NMN, though. NMN is mostly used by older people to restore NAD levels to closer to youthful levels. I don't know if niacin can do as good of a job in older people. It is a good example of a supplement that doesn't make sense to use when younger, especially since it's expensive, but can be justified in older people.

Thank you for sharing your insights, informative and much appreciated. I may be wrong, but you may want to double check the units Vit D (40-70 nmol/L ?). I think you meant ng/mL (?)

Anyone have any recs for a good DHEA cream? I’m on the capsules but need to switch. Or do folks get an rx & have it compounded? Thanks!

Hi Rimon, Happy to see you again. Very informative another podcast. Most appreciated. But lately after eating my first b/ fast my blood pressure is dropping. Normally I was on OMAD. But I’m afraid so much from low pressure so divided my meal into two, one is B/ fast am & dinner is latest 3 pm. If I eat protein I'm ok if not it drops to 80 / 59 or 85/59 Because of carbs, rare but & 102/ 56 or 90/59 mostly. something to do with my cortisol levels, they are low But is there a relationship with the molecules, I don't know🤷‍♀️ Once I went to a private clinic but couldn't find time to talk with the doctor, I had a flight to catch so wanted doc to give me the results on the phone but she refused it😢This was years ago. Also Next week they will monitor my BP 😛. Lack of protein caused some of these problems but now started to eat Turkey meat etc♥️ also began to take 500 of metamorfine. ( bought from abroad) Listen to our valuable Scientist Prof David Sinclair🙏 Thank you, Rimon most trustful and helpful videos., I keep on praying for your lovely wife🙏🌹♥️ God Bless you & your wife🙏🙏

Huge Thank-you ! All Great Info. ! One Full Body/Brain , Natural Supplement that You Did Not Mention, I take Daily as well as My Mother in her Late 80's Is Creatine Monohydrate ! Your body produces Naturally but as We Age it is Imperative for Good Health and Longevity ! Cheers !

im 84 .Loved this.

For CVD prevention, I’m taking 100mg of Niacin along with bergamot. I used to wash my supplements down with a protein smoothie that included banana, but I replaced the banana with apple because there’s a compound in banana that blocks the benefits of polyphenols found in berries and bergamot.

Awesome content... awesome knowledge! I take over 50 Supplements. NMN is by far my favorite. It really makes a difference with me. THX

Thanks for the medical advice and personal recommendation 😂🎉

The pro-longevity and pro-divorce hormone part cracked me up 😂 Great content

I can not easily mix Taurine with water. It floats on the top, makes a cork, very light, doesn't want to dissolve or mix in any way. I take capsules therefore.

Lifted weights till now, ( 50 years ,l 1 gram nmn has helped rotator cuff pain shoulder pain and the lack of pain has helped reverse gradually loss of strength

I need metholated B Vitamins. Other wise on deficiency. I have a metholated issue. The same with NAC I'm low on glutathione. So I have to take liposomal Glutathione

Interested to find out if you’ve heard Chris Masterjohn’s warning of NMN supplementation leading to excessive filling of the niacin pool and epethial damage to vascularature. I need to try and read his post again because he’s incredibly technical. But he cautions against high dose NMN.

Was hoping resveratrol , apigenin, astraxanthin and tumerec would also be covered

I take magnesium citrate in the morning and take magnesium taurate just before bed. Taurate is the salt of taurine, so the magnesium/taurine combo is great for many reasons, including healthy sleep. I also munch on some pumpkin seeds sometimes before bed because those are a good source of magnesium.

Thanks to you, I take Niacin instead of NMN because of cost. I take a 500 mg capsule and just drink it throughout the day little at a time. I find that the body got used to the flush over time. I take resveratrol 3-500 mg every two days on days I dont work out. GlyNAC 3 grams every morning, Taurine 2,5 gr x 2 times a day. Thats it for now, until I get more money.

Great info. If worried about TMAO, take about 500mg of a garlic extract with your food. It will lower TMAO.

Are you aware that tocotrienol is 50 times more protective of fat oxidation than tocopherol? I learned this from an hour long interview on Modern HealthSpan about six months ago. I apologize for not knowing the doctor's name, but he spend most of his life studying tocotrienol. He also said that tocopherol diminishes the effect of tocotrienol, so they should not be taken together. For those who have had radiation treatment, I use tocotrienol together with pentoxyfilline to reduce fibrosis from radiation (see the papers of Dr. Sylvie Delanian for dosages.) This combination, although I used tocopherol until recently, has kept my throat open for decades. It is common for fibrosis to keep growing and fill the throat so that a feeding tube is required. Many ENT doctors know about this cocktail now, but not about tocotrienol.

Glucosamine and Chondroitin are considered to be anti-cholinergic. Since anti-cholinergics are believed to increase dementia risk, I stopped taking them. What is your opinion about the risk of taking these supplements?

🎯 Key Takeaways for quick navigation: 00:00 🌟 *Cutting-edge longevity updates:* - Taurine, NMN, ashwagandha, and stress customization impact aging defense. - Personal insights on dosage and effects of various supplements. - Focus on optimizing aging defense protocols for individuals over 65. 01:23 💡 *Taurine benefits and dosage:* - Taurine shows strong potential in protecting against aging. - Dosage recommendation: around 1 gram per decade of age. - Individual responses vary; experimentation and cautious approach advised. 04:48 🔄 *NMN insights and dosing:* - Limited data on NMN's lifespan extension effects in humans. - Focus on muscle benefits and exercise performance over 60. - Recommended dose: 1 gram daily; individual response and quality of life improvements matter. 09:45 🌿 *Ashwagandha's role in stress management:* - Ashwagandha's potential to reduce cortisol levels during high-stress periods. - Importance of balanced cortisol levels for longevity. - Personal experimentation and cautious approach recommended. 11:50 💪 *ALCAR for muscle health:* - ALCAR aids in burning fat and reducing dependence on sugar for energy. - Personal experience suggests preservation of muscle vitality and youthfulness. - Dosing adjustment to 500 milligrams twice a day for a conservative approach. 14:49 ☀️ *Vitamin D supplementation:* - Importance of understanding vitamin D activation and conversion in the body. - Recommendations for dosage based on individual testing and genetic factors. - Addressing concerns about vitamin D toxicity and optimizing blood levels for health benefits. 17:24 🅱️ *B vitamins and aging:* - Adequate B vitamin levels linked to increased longevity and vitality. - Caution against excessive B vitamin intake, which may increase mortality. - Timing of supplementation during fasting and dosage adjustments for optimal results. 19:27 🦴 *Glucosamine for joint health:* - Glucosamine and chondroitin as building blocks for joint and ligament repair. - Potential benefits for preventing joint damage and promoting longevity. - Limited data on mortality reduction associated with glucosamine and chondroitin use. 20:51 ⚕️ *Glucosamine and chondroitin intake linked to 70% lower mortality risk according to a study.* 22:00 🦴 *Modification of supplements for individuals over 65 aims to counteract "runaway aging" by customizing longevity protocols.* 23:09 🧴 *Hormonal support recommended for individuals over 65, including DHEA cream for hormone production.* 24:05 🧠 *Antioxidant support becomes more crucial after age 65 to protect brain, eyes, and ears from oxidative damage.* 26:18 🍖 *Protein absorption decreases with age, particularly after 65, leading to a recommendation for extra collagen intake to support soft tissues and antioxidant defense system.* Made with HARPA AI

I'm 92 with no medical problems or prescriptions, but my vitamins are getting out of hand. So many to take!

Great, thanks

Opinion: Yes, protein absorption may drop a bit with age, but exercising is best way to prevent muscle loss aside from many other benefits as we age. Get a scale which measures lean muscle mass and body fat and start tracking. If you start loosing lean mass on a good diet and exercise then consider a little more protein in the form of higher protein real food, Things like nuts and beans. Avoid the powders.

Nmn is absorbed better with tmg also take it with glycine and I take quercintin with it to activate mtor

Yooo you gotta do intracellular NAD+ (powered form) water soluble and raised me levels from 27 to 50 in a week

I took 10,000 IU’s of quality Vit D throughout the pandemic. Never got sick BUT the skin on my hands and feet literally started peeling off because of Vit D toxicity. Taking powder form as opposed to natural sunlight will obviously be Absorbed differently. Like he said starting at 4000 IU’s should be fine.

What do you put that 5g of taurine into, Rimon? I've been taking capsules but will probably switch to the powder. 💠

Good info, hard to understand sometimes though. So you only take 50mg of niacine per day or 50mg a few times per day?

HI Rimon: i take niacin, first few days I got the flush but soon developed tolerance to it no longer have any flush with it, I suggest start with a low dose for a week and gradually increase , I take anywhere from 500 to 1500 mg Niacin flush per day, both for Mitochondria health and lipid profile.

Hi Rimon, do you still drink coffee or matcha? what do you think is best if I ever to choose only one?

What did you say around 2:44? It was something about timing Taurine to prevent sleep disturbance?

I’m surprised that you didn’t add GlyNac to your 65+ supplement routine. It’s better than exogenous antioxidants.

Maybe it's the afternoon when you want to exercise, and not take a nap. I have taken taurine straight. But I had to take it separate from meals. Currently I take Magnesium Taurate with meals, twice a day.

I’ve been checking out Niacin by Now Supplements and noticed they have one without the flush. Is it just as good or is the one with the flush better? Also should you take TMG if you take Niacin?

My natural factors b complex is in 50 mg. What's the conversion to pmol/L .

I read about the B 12 problem. I have a question though. Did they they make a distinction between those who supplemented methylcobalamine and those who supplemented with cyanocobalamine? It's my bet there is a difference.

I am trying to find out if NICOTINAMIDE or NIACINAMIDE is a a more economical alternative to NMN. Would you know?

Carnatine - 1 to 1.5g, not 1g to 1.5mg. Just a mistake, of course. But worth pointing out, so nobody gets confused.

I believe I watched one of your videos thot covered which supplements we should take together but now I can’t find it………..someone help please

Are you at all concerned about the recent study showing cardiovascular inflammation from excess niacin intake? The metabolite of concern will likely be impacted by NMN as well. What are your thoughts? Thanks!

NMN has incredibly improved my eczema on my hands which I have year round. I started NMN last week. Also, I was having crazy inflammation in my body which led to incredible hair loss and NMN has helped my hair to stop falling out. I take it with TMG. So far it’s a miracle supplement. PS I’m 31 years old.

I have never heard any expert suggest that NMN prevents cancer. I have experienced numerous benefits from NMN which I have been taking for five years and feel 10-20 years younger than my 70+ years.

The comment about exercise and joints is valid. However not all exercise is equal on our joints. I swim & often use training aids like paddles and flippers. Increasing the load on my muscles but not joints. Win win

Don't forget about your creatine monohydrate.

Ashwagandha may be a solution to my deadly lowering of blood pressure after eating my first meal 😞 Can I take it with NMN & Resveratrol & Supermedine together? Or a different time? I read in the article this Ashawanga may drop blood pressure so it may cause danger in my case. My problem may be because of my lower cortisol levels. I will check them hopefully. But in meanwhile I can order this supplement. Which company you advise, please?Thank you. Lately, they keep on sharing in the news this OMAD diet may kill us. Can you pls make a video about it pls? Many thanks. God Bless your wife & you🙏🙏

Can you do video for young people, like what supplements they should start taking?

Error in your vitamin D blood test target: I think you mean 40-70 ng/mL, not nmol/L, because 40-70 nmol/L is only 16-28 ng/mL.

Rimon, what do you think of Ray Peat's approach that advises to keep metabolic rate high including to prolong life?.

have you tried higher doses choline in liquid form? like phspatidyl choline? I'm gonna try that now. I've struggled with inflammation for years and my daughter too :/ and I don't even have her myself, but I have her more now so trying to give her high doses clean c vitamin powder and nac in powder form mixed in a daily smoothie ++++

How about rapamycin and fisetin? Wouldn’t you recommend these?

Collagen doesn’t have a complete amino acid profile. It doesn’t count towards your protein for the day.

Is there a fish oil u recommend?❤

You said we need to take a gram of MNM a day. But how about taking Niacin (I take 500 mg of sustained release) + 500 mg of NMN?

I've been taking all of these and many more, over 100 different supplements every day.

surprised on the Vitamin D info. I've been taking 5k iu of K2 & D3 (cholocalciferal) and I get my Vitamin D measured since I've got osteoporosis. My last measure showed an increase in my bone density! I take a lot of supplements, but I thought it would have been due to the Vitamin D or NMN(?).

Thanks for this video. What is the meaning of runaway ageing? Thanks

NMN is just a derivative of Vitamin B3, shouldn't be too hype over the substance. Anyway thank you for your information.

DHEA has been around for decades. About 15 years ago I would talk supplements with a friend/bartender who was taking DHEA. He died in his sleep from sleep apnea? But I always wondered if the oral DHEA had anything to do with it as it was know to cause heart palpitations. He was in his 60s. Rimon's suggestions as a cream & cycling seem safer.

Taurine is a GABA precursor which will calm you unless you have some genetic difference. You should take a smaller dose if there's a wakefulness effect. I only need 500mg per day which is enough to help with sleep but not change my brain too much. But cycling is important with any amino acid that can change neurotransmitters because that's a fragile balance

The antioxidant blend you're feeding to your parents contains a solid wallop of dried green tea leaf, which can cause acute liver injury, as can ashwagandha (noted by other commentators) and niacin.

Just like inrermittent fasting and muscle buikding tigether has it's place, so should intermittent supplements. Ritation Is a key practice your liver will thank you for. Also, space out supplements so as not to overwhelm your liver, brain, and kidneys..