Intriguing Vitamin K2 study: www.jacc.org/doi/10.1016/j.jacadv.2023.100643 💊 MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin 📜 Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap

5 years ago I had a calcification on my neck artery. I started to take K2 mk7 (200 μg) After 2 years of taking it with vitamin D3 on daily basis, the doctor told me that he couldn’t find any calcifications anymore.

We've been taking the MK7 type K2 with D3 and using Colloidal Magnesium and Zinc with some Iodine as well as Taurine, Choline and Magtein, Magnesium L Threonate, B Complex with C, Selenium and Cod Liver Oil. We're 70 & 75 yo. I hope we're moving in the right direction. Still on no other drugs. Thanks, we'll keep watching.

Great!!! I was waiting your detailed input on K2, Doc.

Dr Brad, people can say anything on this platform because you’re not face to face. I have been watching your videos for sometime. I think that you should not have to explain yourself like this. You always explain your intentions and views very well. Keep up the good work!

Awesome!! Thanks Brad!

2:18 : « The study was funded by Nattopharma ASA (Høvik, Norway). » I think it’s an information you should have mentionned.

Very interesting, thank you!

I love your content.

Well done!

Good info, as usual. Thanks Doc!

Thank you Dr Stanfield.

Thanks for explaining the research. My doctor was very happy when I started taking Vit. K2 Mk7.

It would be interesting to see a study with K2 combined with nattokinase

Excellent video on K2. Encouraging information regarding the slow down of soft plaque build up, which is the real problem, not calcium.

I have 6 stents and have taken K2 and D3 pill once a day for the 4 years since the attack. I am glad to hear I likely have helped myself!

I take 180mcg of K2 MK7 and 1000iu of D3 daily for both cardiovascular health and osteopathic health, and I have seen improvements in blood exams and feel better, which is anecdotal, but I trust how I feel. I get more than enough calcium in my diet and do not take Ca supplements. K2 MK7 is an excellent supplement and works synergistically with D3 and Ca and has shown improvements in my blood exams and my general health on my Samsung Pro 5 smartwatch readings (lead 1 ECG, BIA, monthly calibrated blood pressure, etc.) Great video on an excellent supplement.

I found natto being sold at Korean and Japanese grocery stores. Check the freezer section. I love it, eat it every day.

Thanks for presenting the evidence which to me seems hypothesis generating at best as you indicate. It would be interesting if a study was done on the interaction of MK-7 and statin medication (which stabilizes plaque) on plaque progression and cardiovascular event outcomes. It would seem for now for those who have high calcium scores taking MK-7 may be risky until more RCT studies are done.

My 50 gm of natto every day contains about 900 mcg of K2-MK7. It also contains several mg of polyamines. Thanks for the update.

I just found the study (Following on from my comment below ). It turns out that the majority of the participants WERE on statins in addition to the usual range of other drugs used by patients with heart disease, high blood pressure etc. This gives me a lot of confidence that the supplementation of Vit D3 and K2 still gives favorable results (and certainly no negative ones) when used with the "normal" range of drugs used by patients with heart and associated conditions (ACE inhibitor or ARB, Beta-blocker ,Mineralocorticoid-receptor antagonist, Antiplatelet therapy, DOAC and Statin therapy).

I listened to many health influencers talk about how Vitamin K2 reduces hard plaque, which made me ask myself whether that means instead of the plaque calcifying does it remain as the more dangerous soft plaque. Dr. Stanfield is the first I came across who talks about this. Kudos to him.

I would strongly recommend adding enough magnesium which is known to activate vitamin D3. And its known that the activity of Vitamin D3 interacts with K2 to make this work more efficiently!

Hey this is great information! Thank you! Do older individuals need to take more than a microvitamin supplement? Thanks!

Cheers Brad. Wifey n I have been taking this for K2 mk7 for years now and as nothing seems to have happened to either of us I really can't have any opinion as to efficacy:) AtB

I know as a disclaimer, you say talk to your health care professional, but to be quite honest, I have lost faith in them. They don't even know the information that's out there. They are stuck on their old ways that they were taught from medical information from 60 years ago And I don't see any sign of it changing, especially when medical journals now are being falsified to such great degree.

Dr. Stanfield, can you PLEASE do a video on what to take for OSTEOPOROSIS? There is SO much confusion about that out there! Thank you 😊

Great video. Hope studies are contemplated using K2 with statins alone or in combination with Ezetimibe or other non-statins such as PCSK9 inhibitors on soft or new plaque regression. Looks potentially promising.

You also mention the risk of vit K to blood thinner medicine. Well done!!

My n-1 anecdata. After the vaccine i got what I assume is undiagnosed myocarditis, tightness in the chest and palpitations become stronger and more frequent. As soon as i started taking K2 ( I was already taking vitamin D and zinc daily) I felt a difference that is hard to explain, palpitations have mostly dissapeared and the intensity reduced, sleep better as well. Strange how some supplements work for some and not others. Good luck with your journey.

K2-4 is the form the body uses, but only lasts about 4 hours in the body. So you are best to get it threw food during the day. K2-7 lasts 24 hour but needs conversation. Which is why it is better as a supplement. I have had 2 bone density scans. A baseline one at age 51. Went low carb a few years later. Started eating real food like meat, eggs and cheese. Had another bone density at age 56. It had increased. Did not start take K2-7 until I was 59. But moved to a province that starts at age 65, but well behind. So not sure when I will get another. Took a fall down the ramp at age 62. Black ice and I was carrying things. Suddenly facing straight up on my back. Not even a bruise.

Thank you

In the summer of 2018 i started to take a pretty high dose of K2, with NO additional D3. I did this for about 5 or 6 weeks. I was then 58 years old. After a few months I noticed I was feeling a little weaker. By Christmas I felt exhausted. I was finding it difficult to turn over in bed. I started to sleep badly. Then I began to stay downstairs as it was a strain and tiring to walk up them. I saw a Dr in February and he sent me for a scan which found nothing. By March I had a much reduced appetite and was starting to find it hard to swallow. The Dr thought I had a problem with my appetite and prescribed vit d3 and fortified drinks. Gradually i could not straighten up and stand tall and it was hard to lift my head. I was admitted to hospital in April 2019, and spent 10 weeks there. Most of it in ICU, on pressurised oxygen, i was intubated, and put on a feeding tube. I could not swallow and my voice was also lost. I had pneumonia twice. Via a muscle biopsy I was diagnosed with poly myositis. I needed IV steroids, antibiotics and IV immunoglobulin therapy. I then needed speech and language physiotherapy and more help to get me walking again. I was given more steroids and immune suppressants. I would recommend to anyone that wants to take k2 to please keep up a high level of D3, as they work synergistically. I had taken nothing else that would send my D3 level into a downward spiral. It is potentially extremely dangerous to take K2 alone. Thank you.

Have you looked at Natto studies RE: osteoporosis protective effects? The amount of MK-7 in about 2 oz of Natto is about 1,000 mcg. Hence taking only 180 mcg, is likely under-intaking and missing out on maximal benefits. The addition of phytoestrogens likely also benefits aging bones.

Dr. Stanfield - is the Low-Dose MultiVitamin that you are taking methylated? Do you believe that methylated vitamins are necessary for people with DNA defects that prevent/inhibit full metabolism of certain vitamin compounds? This is a topic that I don't fully understand. BTW, I have and maintain full confidence in your analysis of the topics that I've seen you cover.

Among the study links, I'm unable to figure out which one goes with which part of the video. Are they listed in order of appearance? Or order of verbal mention? It would be great if they were listed as clickable titles instead of URLs, or maybe give each one a number then show a subtitle during the video saying "see study 2" like Gil Carvalho does. As it is I find I just ignore them and when they are shown in the video I manually google the title, its quicker than trying to figure out which link is which. Sorry to be a complainer! Thanks for the videos Brad.

Can you make a video with all of the supplements which you take on a daily basis and the supplements which you take from time to time?

Bone mineral density loss contributes to facial aging so I'm very interested in safe supplements that address that issue.

Please make a video ferritin levels in body and iron supplements ❤

The JACC study appears to be a republication of Circuation study, using same patient base, but slightly different statistics. What is strange, is that first study was using solely noncontrast cardiac CT, whereas results in the reevaluation study included contrast CT scans. It seems like the authors disregarded contrast CT scans in the first approach...

Great information, I take 100 mk7 daily.

Why do researchers don't give a complete combination of vitamins and minerals which work together? They should know that vitamin K2 activates the vitamin K Dependent proteins which have been created by vitamin D. Or rsther, would have been created if they gave enough of vitamin D3. 25 ug (1000 IU) doesn’t do much. Somewhere between 5000 and 10000 IU during a couple of months would give optimal levels for most people. And furthermore, most people are deficient in magnesium, which is needed for vitamin D to work, and is important for bones too. They also equates bone density with bone quality. That's not really true. Vitamin D3 and K2 remodels bone. It doesn’t just add minerals to them, Why would the body build bones when it hasn't got all the ingredients it need for that? That would be weak bones, and the body probably avoid building those! It wouldn't hurt to supplement with collagen and boron either, if they really cared for bone health. This tendency researchers have to give just one thing makes it hard to show effects when several things work together. It requires large groups to compensate for the missing ingerediens in the general population. If they wanted real results, they would supply all the ingredients, with the one they researched in three different doses. And meassure the level they got, because some people actually get enough of it from food and not from the researchers.

Dr. Stanfield, can you comment on recent studies showing higher dosing on Niacin (Vit B3) association with vascular inflammation and increased vascular events (stroke, MI).

i would like to see if this supplement helps with rebuilding teeth i heard it did K2 MK7 version i wished this was mentioned

Any promise for nattokinase? I have been taking it for bone density for a number of years. At 69, my coronary calcium score is 0.

There are also longer chain k2 versions. The Mk-4 isn't long enough, Mk-7 is a long enough in Natto. There are some even longer like Mk-8, Mk-9, ...Mk-12. So, the longer chain mk-9 has just become available as a supplement. Will be interesting to see in the future if the longer mk-9, 10 11, 12 is more effective

Thankfully i have been fermenting my own natto for the past 7 years and i consume a lot of it almost everyday!

K2 jacked me up 😢

If you could please do a video on HMB that would be awesome. Many thanks

@3:42 -- Good grief, 25 mcg of Vit-D is just 1000 IU, which is an utterly pathetic dose, especially when paired with a Herculean dose of K2 like 720 mcg! The D is needed to mobilize the calcium, otherwise the K2 has nothing to work with. No wonder it didn't work!

Never heard of a study termed “tantalizing “ Highly scientific Gonna have to look that word up in double blind randomized studies Australian Ribeye Steak is “tantalizing “ yes - let’s get EXCITED about a FAILED study !! Good thumbnail ❤😂

Any thoughts on the link between Omega-3 supplementation and prostqte cancer. Thank you.

If a randomized study on smoking had been conducted over a period of 2 years in the 1950s, no significant differences would probably have been seen. These are such long-term effects (decades) that such short-term studies are virtually useless to prove anything.

Dr. Stanfield - Curious what your opinion is on taking D3 & K2 together, or separating them? I've read numerous claims that they compete for absorption and that it's better to take them separately. Thanks!

Started 5K of D3 plus K2 yrs ago. My doc said that was perhaps too much D3. After two yrs he said he was taking 2K per day. Asked for a blood test and I tested only just above the mid range! Looking at old blood work I was just above the min so it was not flagged. Watch your own blood work folks….took 5K to get me mid range.

I hv taken k2 mk7 with d3 for 4 years, dosage 200- 300 micro gram k2mk7 + 3000- 5000 iu d3 it does reduce my swollen shouder, perhaps due to calcium build up. But the effects are minor in comparison to taking much higher dosages of k2 mk4, i started taking 5 mg in jul 2023, and moved up in 2 months to 20 mg a day. It removed the deep pains in my neck and my arms joints, as well as the stiffness in my whole upper body when I have to lie down on my stomach. I believe k2 mk4 is much more effective. The 4 hours half life cud means that our body absorbed it much more effectively, and cus used it right away. I cud feel the effects almost daily, that all my body pains just fades a way on daily basis. Eventually I will moved yp to 45 mg a day for few weeks to few months, depending on how I feel. That I might reduce it to 5 to 10 mg daily untill new research findings. The only reason I slowly increasing the dosages is to avoid whatever calcium in my arteries from reducing to fast, and melting into pieces, such that some cud flow to my heart.

Consistent with the USPSTF and the US National Institutes of Health (NIH) consensus statement, in otherwise healthy people who have adequate dietary intake and no risk factors for inadequate vitamin status as discussed above, we suggest not taking multivitamin supplementation for primary prevention of chronic diseases because of insufficient evidence of benefit

Where do you get it?

hello, If we take 1 pill d3 10,000 IU weekly, how many pills of k2 120 micrograms should be taken per week?

One time the British Army took camels across the desert. All of camels died even though they were each given a 2 cups of water for the journey. The next time all the camels died again even though the water was increased by 100% to 4 cups. Therefore, it must be concluded that water has no effect on the death rate of camels in the desert. But, the curious link between water and camel mortality continues and should receive further study of the random controlled double blind kind.

have you seen any supplements or studies that help prevent AS?

Hi dr.stanfield.you have provided useful information by providing evidence from the leading medical journals.Please let me know if someone can take vitamin k2 with aspirin. Furthermore, please let me know the side effects of vitamin k2.from your accent you seem to be either from Australia or new Zealand. Thanks

I would like to hear clarification on why MK7 is preferred over MK4. One source implied that MK7 is preferred because it seems to stay in the blood longer. Yet, it seems to have been shown that all forms of vitamin K convert to MK4 and that the body takes MK4 up faster. This would imply that the body prefers MK4. This was said to be shown by a recent study, but I'm not involved on checking the source documents for this kind of thing.

Warfarin (aka rat poison) blocks Vitamin K1 and has an anticoagulant effect, but WORSENS atherosclerosis. So cardiologists are sometimes prescribed a medicine which has known negative cardiovascular effects. Fortunately there are newer anticoagulants which can be used much of the time.

Great video Dr. Stanfield. If you had to design a Multivitamin for vegans. What would it look like?

For 5 years now taking D3/K2(180mcg), but also C,Mag,Q10,Omega3 etc....65y,BMI 25, Cholsterol :HDL 46, LDL 230, Total 281. CAC : 0......

How do you detox Chlormequat out of your body?

Hello, can you tell me how long can you take K2? Are there any dangers after some time? Many thanks for your informative videos.

Please make video for IGG4RD, we have a very low quality of life with less clinical data

I had doubts before the video and now they increase. At one point k2 does harm...then he says it can do good but the clinical test reveals that it does harm...but he is excited to reveal that in the other clinical test the results are inconclusive..

I eat blueberries every day, I try to also get a good amount of spinach in my smoothies and I eat perhaps 200g of broccoli at least every week. My wife is starting to make beef and chicken liver more often as well. Does all this have enough k2 per week? Are organ meats ok?

With or without D3?

Where can I buy K2 only in the UK?

Safer, cheaper, and healthier to eat natto! You also get protein, fiber, probiotics and the proven benefits of beans. You can use any beans to make them and it's easy in an insta pot. I often use black soybeans or black beans or red beans.

Can anyone tell me, if it’s recommended to take K2 (or MK7) without D3 in the summer time?

What? No. K2 stabilized the soft plaque but had no statistically significant effect on calcification. That’s what you read aloud. Or did I miss something? This feels like click-bait.

Wich is better K2 mk4 or K2 mk7? Some people say mk7 increase Blood pressure as side effects

This might be one of the more intriguing supplement; and after reading a short snippet - "Vitamin K2-7, also known as menaquinone-7 (MK-7) is a form of vitamin K that has health-beneficial effects in osteoporosis, cardiovascular disease, inflammation, cancer, Alzheimer's disease, diabetes and peripheral neuropath" I'm curious whether this is fitting a specific age group (e.g. elderly)?

Since statins stabilize soft plaques, I wonder if K2 would be particularly beneficial for someone taking a statin.

Dr Brad. Thank you for alerting me to the dangers attached to following the David Sinclair Resveratrol regime. However, I note in your own case you are a supplement taker and also you change your regime as the evidence changes. I find that difficult, for the obvious reason. Is there anything beneficial (you don’t get enough of through a balanced diet) you take where the evidence in support has not changed for decades? We laymen are faced every year or so with headlines like “University tests now say up to 5 cups of coffee per day are beneficial.” Next year they are not. So the rolling evidence supporting or otherwise the fad of the day makes it very confusing.

Interesting, my bottle of K2 MK7 arrived yesterday, lol

I make non traditional natto at home, TVP with 1% sodium chloride, 2% sucrose. The γ-PGA biofilm is so thick after @35 stirs it's Impossible to stir. No idea the nattokinase or k2-m7 content, judging by the biofilm, at least 10x traditional natto. Eat @100g/day. The mega FUNK taste is faint, and essentially no smell at all.😊

Diane Kruger, A list German actress and star in Inglourious Basterds, listed as a study author at 1:33 😅 !?

I recently started taking Eloquis bloodthinner for blood clots. Is it safe to take K2 MK7 with it? I started eating natto because it has the K2 MK7, along with other 'healthy' things.

Does vitamin K2 increase the risk for blot clots? Does it affect blood coagulation the same way as vitamin K?

Is 90mcg really enough?

Does Vitamin K decrease blood circulation (functioning as the opposite of a blood thinner)?

Sorry what is Nato and cheese in reference to fermented products

I have been taking VitK2 & D for many years right after my heart attack

How does nattokinase compare with vitamin k supplements?

How many different supplements can a man take before it turns to cement

These studies are so plagued with confounding variables that they are doomed to remain in terminal "hypothesis generating" land. At the very minimum, I would think that a study like this would look look at least (3) minerals, K2 (MK-7), D3, and Mg (bisglycinate?). Plus you would also want to closely assess dietary intake patterns (to include what, when, how). Calcium co-supplementation in these studies is very concerning to me in that iit will subvert the benefits of the minerals being testing for. Thanks for the review.

Resveratrol is a beauty by preventing the nick in the arterty in the first place .

Make your own K2. it is easy. Warm a cup of milk in microwave. drop a grain of Natto in cup. Cover and leave cup for a day. Drink "fermented milk" Milk tastes a bit "muddy" but nice.

Can you talk about the difference between mk-7 Menaquinone in the cis and all-trans forms? From what I'm seeing the all-trans form is more stable and bio-active. The reading I'm seeing is that the cis form can leave the mk-7 inactive and unable to act on different proteins and enzymes.

Is it safe to eat natto while on Warfarin? What is its effect on the INR?

Vitamin K2 mk4 is far more beneficial then mk7. The Superiority of MK-4 over MK-7 Only MK-4 is the only K2 in the brain. MK-7 is absent in the brain. MK-4 manages inflammation in the brain. MK-7 does not. MK-4 has the highest concentration in human tissues. MK-9, MK-8 and MK-7 in that order, are in tissues. So you could say that MK-7 is the 4th most important K2. MK-4 crosses the placenta. For pregnant women this is important for the health of the fetus. MK-7 does not pass to the fetus. Human breast milk contains MK-4. It does not contain MK-7. MK-4 protects against over a dozen different cancers. MK-7 has no anti-cancer benefit. MK-4 prevents calcium buildup in the arteries "better" than MK-7. MK-4 protects against cirrhosis of the liver. MK-7 does not. MK-4 protects against Alzheimer's disease. MK-7 does not. MK-4 protects against Parkinson’s disease. MK-7 does not. Promotes healthy platelet, white and red blood cell production in people with leukemias. MK-7 does not The "trans" form of MK-7 is the only beneficial isomer. In "food," such as Natto, MK-7 is 100% in the trans form. In MK-7 "supplements," the majority of the supplement are "not" in the pure trans form. The trans form of MK-7 is the only active form of menaquinone able to act as a cofactor for carboxylation. The majority of MK-7 supplements also have the "CIS" form. The CIS form is 100% useless and does not act as a cofactor for carboxylation. In the majority of MK-7 tested, despite claims of being mostly in the trans form, the independent testing showed they were not. They were in the CIS form. The CIS form has an "unknown toxicity profile." (is it any wonder why so many have side effects?) Some manufacturers are dishonest in their "trans" claims. The CIS form can be there "from the start" in MK-7 supplements. The CIS form can also "convert" from the "trans" form over time and by "oxidation." Which means, over time, MK-7 supplements become more "CIS like." Most manufacturers of MK-7 use "cheap processing" to make this, and that is why there is a large issue with "impurity" with the supplements. As this does not impact MK-7 "from food." It is 100% in the trans form. You will not have the issue with potential toxicity with food, BUT if you are sensitive to soy, you can still have side effects from food in the trans form, as "soy" is a stimulant. When it comes to "MK-4" supplements, the supplement form is "bio-identical" to what is in food. There is no issues in terms of impurity or toxicity or getting "something different" in the supplement form compared to what is in food. In Japan, where they are one of the largest consumers of "natto," they only recommend "MK-4" as a supplement for the treatment of osteoporosis, and have been doing so since 1995.

According to Chronometer, K2 is very easy to get from diet alone. I can well-excede the daily reccomended amount from a healthy diet. No need to supplement.

is it good to takes K2 if you have high hemoglobin and hematocrite?

I don't know what's going on here. He talks in circles all the time. I dont know if its click bait. The video and the title are very disconnected.