How Does Fish Oil Work? (+ Pharmacology)

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How Does Fish Oil Work? (+ Pharmacology)

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Күн бұрын

How Fish Oils work? How Omega 3's work? How do Omega 3 Fatty Acids work? All of these questions are asking the same thing! Fish Oils = Omega 3 Fatty Acids. Fish Oils are used to treat Hypertriglyceridemia or high triglyceride levels. Anti-hyperlipidemia therapy seeks to prevent the complications heart attack, stroke and other ASCVD risks.
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Answers:
1.)B 2.)D 3.)C 4.)A (Check out our MUST HAVE Shirt designs!)
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This pharmacology lecture covers topics such as Fish Oils , Omega 3's, pathophysiology of hypertriglyceridemia, regulation of LDL, HDL, Triglycerides and other complications of bad cholesterol buildup. Mechanism of action of fish oil drugs and their side effects. Drugs mentioned include; Lovaza, Vascepa and over the counter fish oils.
Other theorized Mechanism of Actions for Fish oils:
The mechanism of action of LOVAZA is not completely understood.
Potential mechanisms of action include inhibition of acyl CoA:1,2-diacylglycerol acyltransferase, increased mitochondrial and peroxisomal β-oxidation in the liver, decreased lipogenesis in the liver, and increased plasma lipoprotein lipase activity. Fish Oils may reducethe synthesis of triglycerides (TGs) in the liver because EPA and DHA are poor substrates for the enzymes responsible for TG synthesis, and EPA and DHA inhibit esterification of other fatty acids.
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Пікірлер: 212

@DrugChug 4 жыл бұрын

Thank you for watching! People keep asking which Fish Oil to get. I recommend this one: amzn.to/3dYBUQh (Because they remove the bad stuff like mercury)

@sweetrain50 4 жыл бұрын

Your recommended fish oil is "Nature's Bounty Fish Oil 1200 mg Omega-3, Heart Health, 200 Rapid Release Softgels "? Is this correct?

@DrugChug 4 жыл бұрын

@Lorraine May Yes Lorraine, its a big company and can be found at any pharmacy!

@ChosenJudaHiTess_TheShemiTess 4 жыл бұрын

1. B 2. D 3. C 4. A

@MAYBE673 3 жыл бұрын

I am taking part in a study to test the effectiveness of Vasepa medication in helping with covid 19 patients.. I am 31 year old healthy male who is covid positive. Do you think I should take this medication at all??

@brandonk8948 3 жыл бұрын

I hate science, it typically bores me...you made this video slow enough to understand and cool enough to appreciate. Thank you for sharing this video, you helped me in a college class online. Oh, and you gained a subscriber. ;)

@ReelX4U 4 жыл бұрын

I tried to get my health insurance to cover my prescription for “Lovaza”. I tried and my cardiologist tried and it was next to impossible. The health insurance said I must first try over the counter fish oil supplements and proof that they don’t work by providing supporting Documentation that the brand purchased and the dose taken and I had to give it at least four weeks of failure to reduce my triglycerides and then they would cover it. So I did my research and I found a company that extracted and packaged pharmaceutical grade fish oil by the name of “Omegavia” and their gel capsules were quite concentrated. I took 3 grams for a month and did another blood test and “Triglycerides” were now within normal range. And they weren’t even that expensive, something like “$26.00” for a month’s supply. So I didn’t bother with the “Lovaza”, I found something just as good over the counter.

@DrugChug 4 жыл бұрын

That's awesome!!

@THE-HOLY-SPIRIT Жыл бұрын

I think you mean "LAVAZA" 😏 .... grab a cuppa ☕

@ethicalathlete8520 Жыл бұрын

Honestly Omegavia is far better quality than Lovaza! For starters Lovaza is an ethyl esther form that our bodies dont absorb well. Also it's produces from salmon and mackerel that are both cheap and consistently report higher levels of mercury and other heavy metals. Omegavia on the other is produced from small anchovees that have far less heavy metal exposure, omegavia also gets third party tested for heavy metals and its produced using co2 extraction so the omega 3s arent getting denatured.

@gabrielolsen7555 Жыл бұрын

I personally produced the oil for lovaza, in norway😏

@tmc1564 9 ай бұрын

Cool

@larissapatrocinio3285 4 жыл бұрын

This was so helpful!!!! I really appreciate you for doing all the visuals, and explaining it so well.

@DrugChug 4 жыл бұрын

Glad it helped! Thanks for watching!😄

@morrism2388 4 жыл бұрын

I should be sleeping. But I just found your channel and I cannot stop watching the videos. I think I only have a few left to watch, then what am I gonna watch?? Seriously, I've watched so many pharmacology videos and these are by far the best. Thank you very much!

@DrugChug 4 жыл бұрын

Glad you like them! I truly appreciate the support! 😁

@davidrobinson7112 Жыл бұрын

Extremely informative and well presented thank you so much. You diligence is impressive.

@BushMann731 Жыл бұрын

Very informative. Thanks. But why no mention of the benefits for brain function?

@annie011955 4 жыл бұрын

Please keep update more and more!! It is very helpful 🧡

@DrugChug 4 жыл бұрын

More videos are on the way!

@pauliepaul3408 Жыл бұрын

I had moderate To high LDL, started taking fish oil and it caused my LDL to go much higher. 136 to 180 and I was dieting. Didn’t work for me but it could still work for you. I did feel more calm. I’m not a doctor.

@paulendry6398 9 ай бұрын

You should highlight retina and Macular health. Also vegan variety from algae avoids fish smell, rancidity and over-fishing

@delishme2 2 жыл бұрын

Great info, thanks 🙏. The International Fish Oil Standard or IFOS, rates EVERY fish oil and rates according to quality, purity, heavy metals, stability and dosage etc Worth a look to know you are getting the best you can for the price you have. 😊

@yeahrightkashi Жыл бұрын

thank you so much please add more topics... I will watch all your lectures.. thank you

@martin-1965 4 жыл бұрын

Loving your videos. Amazed not more subscribers yet. Came here for the beta blockers video and just stayed for more. Nice relaxed style with great graphics and detailed scientific information that even a layperson can understand. Would love one on metformin if you get the time.

@DrugChug 4 жыл бұрын

Thank you so much for the support! Yes there are a lot of videos planned. Diabetes is one of my favorite topics, so there will be videos on metformin and everything else!

@libbylife7161 Жыл бұрын

I am taking Niacinamide 500mg by Solaray with Aloe Vera. No problem flushing ( this is derivative). I take Nordic ultra omega 3, I also take Mega coQ10 ubiquinol 100mg super absorption.

@learneasypharm4524 Жыл бұрын

Your videoes are so useful. Easy to understand. Please do more videoes on pharmacology...

@bnutgishrit3 Жыл бұрын

What I didn't understand is how Omega 3 lowers Triglyceridine and at the same time raises levels of LDL As you explained in the hands of vitamin B3 that preventing the production of triglycerides will lead to a decrease in LDL

@shendendc7547 2 ай бұрын

Yah you right so what is important to reduce the triglycerides or the LDL 😂

@FlySkyGurl 3 жыл бұрын

Hi Doctor, will the otc fish oils work. I've been doing some research & I see it was stated that ethyl ester was bad & I saw videos on KZfaq showing that it ate through Styrofoam. I purchased someone nature made fish oils, but it listed the omega 3s as ethyl ester, so I returned it. I just tried this test using some spring valley fish oil pills. it says it includes 1060mg of omega 3 fats acids as triglycerides & the epa/dha are also showing as EE & it ate through the Styrofoam cup. So I wanted to know are ethyl esther & triglycerides are the same?

@rhadoo8745 9 ай бұрын

Great video! There is so much confusion about how to pick the best Omega 3 (regardless if it's from fish or from algae), as most people are looking at the products with the highest EPA and DHA. I find out that doesn't matter how much EPA+DHA has a product, but matter most how well is protected that product against OXIDATION. Personally, I use an fish oil that comes with blood tests that measures the Omega 3 levels every 4th month, so in this way I make sure that I receive the right amount

@aaronwatson7795 4 жыл бұрын

Awesome knowledge towards my health in healing from strong holds of bad foods very encouraging on the road too a healthy way of living thank you keep posting on this journey

@DrugChug 4 жыл бұрын

Glad I could Help! Keep up the healthy journey! You got this! :)

@aaronwatson7795 4 жыл бұрын

😄thank you :)

@philip4569 4 жыл бұрын

Thanks so much for these videos! I have been looking for a channel like this for awhile

@DrugChug 4 жыл бұрын

Thank you for the support! I appreciate it!😁

@eduardobravo-leon3894 5 жыл бұрын

Great video. Have to check the quality of my fish oil now.

@CarolineBeautyInc 5 жыл бұрын

Eduardo Bravo-Leon same here!

@curcumin417 Жыл бұрын

Awesome channel, love these professional, to the point vids!

@bijaymalla8290 Жыл бұрын

I am taking Omega-3 for nine months every year starting from September till May. So far every thing remains under control.

@battleroyalepros6471 Жыл бұрын

What remains under control exactly?

@alz732 4 жыл бұрын

Can i take ashwagandha 500mg and vitamin d3 5000iu at the same time daily?? My vitamin d3 result is 10.52 insufficiency. Please let me know thank you.

@ginamorrell4426 4 жыл бұрын

Great explanation! I take fish oil among lots of other over the counter supplements all in an effort to lower my RX meds, improve my eyesight, help me with stress and body aches and to improve my mood. Please keep going and also include your opinion on the added ingredients in supplements and what is an ineffective supplement. Thank you!

@DrugChug 4 жыл бұрын

Thank you Gina! 😁

@romacannon7235 Жыл бұрын

What other supplements do you take?

@csbaseball9826 Жыл бұрын

What dose and brand please??

@omegabalance63 Жыл бұрын

Great video, thanks for sharing. Have you heard of Zinzino BalanceOil? It helps balance the Omega 6:3 Ratio close to a ratio of 3:1 and comes with a before and after dry-blood test to show the results. Most people have an Omega 6:3 ratio of 20:1 or more and from the tests done we can see that most fish oil products don't do the work when it comes to obtaining a healthy balance.

@judithocasio3367 Жыл бұрын

Thank you that was very informative, now I know why my LDL is high because I was advised to take fish oil twice per day morning and evening a total of four capsule per day so my blood work LDL came out high now I know why.

@kO_EC Жыл бұрын

Can you provide details about the EHA and DHA values of your fish oil supplement? Also which brand you prefer .

@xavier417 2 жыл бұрын

Fish oil supplements usually advertise some kind of cognitive benefit as well. Is there a well-known mechanism of action for these benefits too?

@kasimirb5155 4 жыл бұрын

Is it possible that the increase of LDL is caused by the carrier oil (usually sunflower), not the fish-component itself?

@gregstuart5903 Жыл бұрын

I wonder about this as well. Hope we get an answer on this !!!

@rookmove Жыл бұрын

Sunflower oil!!

@mariaadanalian6943 4 жыл бұрын

Thank you so much for these videos♥️

@DrugChug 4 жыл бұрын

Thank you for watching! 😁

@arslanzafar8701 Жыл бұрын

please make more videos. I really love your videos. please cover more topics.

@pelangos 2 жыл бұрын

Excellent! Great explanation thanks

@gregstuart5903 Жыл бұрын

I learned something new - fish oil lowers triglyceride levels, yet it raises LDL levels. My LDL is high, (182), my triglyceride is very low (108). Fish oil is not for me then ?? I've been taking it for 6-7 years, 2 g/day. Should I stop ? By the way my HDL is very high (108). Your advice will be greatly appreciated.

@battleroyalepros6471 Жыл бұрын

High hdl means your metabolic health is very good. What is your exercise routine ?

@battleroyalepros6471 Жыл бұрын

Did you try to cut saturated fats from your diet. It helps a lot in reducing ldl cholesterol

@vulcan4d Жыл бұрын

Omega 3 competes with 6 and 9 which are inflammatory and bad for you. This means you have to also cut out 6 and 9 to see the benefit of 3. This can be easily done by not consuming vegetable seed oils, Canola, Soy, etc.

@timothyarnold7670 Жыл бұрын

Walnut hazelnuts have omega 6

@spacejamgaming Жыл бұрын

Taking fish oil almost everyday!! ❤️

@yeahrightkashi Жыл бұрын

I am a struggling med student I need this thank you!

@PolPotsPieHole Жыл бұрын

if you make it as doctor and I hope you do, please don't be a pill pushing pharma shill like so many are

@yeahrightkashi Жыл бұрын

@@PolPotsPieHole thank you so much! I want to take Family Medicine in the future. I need to master Pharmacology. I am now done with my Internship and will be studying soon for boards. thank you thank you

@DrAzmir Ай бұрын

Short quiz answer 1.a 2.c 3.c 4.a

@artsoto5459 2 жыл бұрын

Great video! How long from when taking do you start seeing results? OTC?

@AlexandreLollini Жыл бұрын

Is it that 4g of fish oil gives about 2.5g of Omega-3 ? Omega3s are mostly triglycerides, but do reduce triglycerides. The most important point being as you can not reduce omage6 intake, take omega3 to balance them out. And there are relationships with Vitamin E. Those are also important for the eyes comfort.

@DeepuCEO 2 жыл бұрын

*The best healthy form of fish oil is Triglyceride form. Ethyl Ester form is cheap to make so most companies use that but it is very harmful for your health. When you consume Ethyl Ester form it create all kind of side effects on your body. I end up getting heart burn pain on tummy, discomfort and anxiety after consuming Ethyl Ester form even though the company said it is Salmon fish oil with high EPA DHA. When I got those side effects I did the thermocol test and find out the brand that made me sick is using Ethyl Ester form. So I am staying away from that brand. Also swallow the capsule do not break it in your mouth while consuming fish oil supplements especially if it is in Ethyl Ester form. Ethyl Ester form burn everything inside*

@gregstuart5903 Жыл бұрын

Good to know. Thanks M J.

@ian632 Жыл бұрын

I'll just stick to the ether

@gabrielolsen7555 Жыл бұрын

What u are describing is a side effect, that affects a minority.

@mathaipaul1743 Жыл бұрын

Helpful videos Expect more Thanks

@fabianc77 4 жыл бұрын

Would it be a double protection in getting Triglycerides by taking Vitamin B3 and Fish Oil.

@lovelylayla4978 3 жыл бұрын

I love these videos.

@DrugChug 3 жыл бұрын

Thank you so much for your support!😁

@Davethreshold Жыл бұрын

Thank you so much Doctor!

@xapxap1811 3 жыл бұрын

At the fish spots they fry the fish in canola oil or vegetable oil. What is healthier in oils to cook the fish and preserve the omega 3? Baked fish is undercooked.

@trianglebook3616 3 жыл бұрын

I’ve been taking it for two weeks and have noticed my nails are growing faster and I’m losing less hair

@user-fg1li6iv1i 3 жыл бұрын

Hi, wich one are you using

@hfe1833 3 жыл бұрын

The secret of long life

@rico99586 Жыл бұрын

What about the omega 3 from plants, such as purslane. Purslane is a common weed to most people but I raise a lot of plants, and the purslane just kept coming up in the pots so i researched it. It has the highest known concentration of omega 3 of any plant on the planet, as far as currently known. I like it raw but it contain oxalates and I have a kidney problem, so I cook it with other veggies to eliminate the oxalates.

@wanihazman6544 4 жыл бұрын

do we need stop taking statin medicine when start consume omega-3?

@DrugChug 4 жыл бұрын

In practice we can see patients with poor lipid levels be on both

@shashawillaw 2 ай бұрын

Hi, I was wondering where you got the 13-63% fish oil concentration range from. Is there an article I can read on that?

@leehansen3450 Жыл бұрын

Will eating one can of sardines give me the omega 3 I need?

@orenshalev3881 Жыл бұрын

How does it affect the hdl? And how does it protect the heart and blood vessels? Thanks in advance

@noryatijavier6235 3 жыл бұрын

Can you make videos about Cod liver oil? How it works in our body, I really want to know...

@suthasinnathurai2253 Жыл бұрын

I had chest pain and my heart doctor said me to take fish oil and my chest pain gone

@suecanada2313 Жыл бұрын

luv it, basic info for me + a quiz i answered correctly 🙂YES i have subscribed, pls stay well

@CraigMullins1 2 жыл бұрын

IS there a certain food to take this with? Fatty food? Anything?

@ldgillette Жыл бұрын

I get insomnia from taking Omega 3 tablets, regardless if it is Algae based or fish oil based. I've tested this multiple times over the years. I can handle it if I take low doses. For example I can't take even one tablet of Lovaza every day without it affecting my sleep. Seems like one tablet every other day is tolerable.

@345kobi Жыл бұрын

I am very curious why You don't mention algae, where the fish get the omega 3.

@ahmedahm1 2 ай бұрын

The forget the ⬆️ increased atrial fibrillation

@padwah Жыл бұрын

my ldl is through the roof and i cold not understand why, now i know

@Mohammed-dd8jm 4 жыл бұрын

Great video thank you

@azander1958 2 жыл бұрын

Fish oil: lowers triglycerides but increase LDL So is fish oil good for the heart: YESN'T

@ahmedahm1 2 ай бұрын

50% ⬆️ increase in atrial fibrillation with O3

@jesperjee 3 жыл бұрын

So Fishoil can treat high triglyceride levels but also raise LDL? Which means.....does it matter if we take it at all if it´s doing both good and bad for the heart!?

@MarkSmith-js2pu 2 жыл бұрын

Yeah, that may explain why my Triglycerides are 70 and my LDL is 210

@gregstuart5903 Жыл бұрын

My triglycerides are low (108), my LDL is high at 182. But my HDL is high at 108. I've been taking wild Salmon oil for 6-7 years. My primary care dr now wants to put me on Atorvastin 40mg. Im not convinced her recommendation is right for me.

@johncostello3174 3 жыл бұрын

Is it ok to take Omega 3 fish oil supplement (one per day) with Clopidogrel (one a day) ?? if it's not ok then is it ok to eat oily fish (Salmon, Sardines etc) while on clopidogrel??

@user-te3mh6mc2n 2 жыл бұрын

Hi there. That's what i found on the internet, if it's still any help for you. "...In conclusion, high-dose fish oil is safe in combination with aspirin and clopidogrel and does not increase the risk of bleeding compared with that seen with aspirin and clopidogrel alone..... Taking fish oil at the same time as blood thinners may cause problems with bleeding. Talk with your doctor first if you want to take more than 3 grams a day of a fish oil supplement. Doses this high can also increase the risk of bleeding..". And personally i believe it is OK to eat oily fish with your medication since it doesn't have as much Omega 3 acids as fish oil supplements.

@Jag1lit 3 жыл бұрын

Great video!

@stevo6891 Жыл бұрын

How does it raise LDL???

@Mark-te8ky 2 жыл бұрын

thanks for the video! 🤠

@saml8894 3 жыл бұрын

thanks for the video love it very good jobs

@DrugChug 3 жыл бұрын

Thank you for watching!!

@wdadwawdadawdwdwa4133 3 жыл бұрын

what does the data show on health outcomes for people supplementing with fish oil vs people who don't? are there any studies?

@wifagelhaj6392 4 жыл бұрын

Can u please make a video about antibiotics..all about..

@DrugChug 4 жыл бұрын

Yes! It is planned, and will be made in the future!

@aliarahaman4998 Жыл бұрын

Very good

@Aman.singh_08 3 жыл бұрын

Omega 3 good for Fatty liver?

@Lonjemoco 4 жыл бұрын

Is the MAV nutrition omega 3 brand good for a 22 year old male?

@lindasheung237 3 жыл бұрын

very good explanation of fish oil, thx

@mrcharlesjohnson 4 жыл бұрын

Awesome vids!

@DrugChug 4 жыл бұрын

I appreciate the support! @Typhon 😁

@erickb4355 2 ай бұрын

Can you do Zyrtec or anti histamine drugs

@ishimwepayiroti6651 2 жыл бұрын

Thank you

@Lisalee5469 Жыл бұрын

Ahh seems like you all just touch the surface of these supplements…but I’m enjoying the Physiology portion of this…

@mountolympusvitamins5488 3 жыл бұрын

Wonderful

@macdermesser Жыл бұрын

Can one take more than 4g of OTC omega 3? Since the concentrations of the OTC products are not regulated, would it hurt to take a little extra just to be sure?

@chrislee6890 2 жыл бұрын

Thank you it work 4g per days for 2 months my blood test came out so normal for my chorlestorol but how long continue now after the perfect blood test look so good? And continue 4g each day for how long now? Please advise, thank you so much.

@lostboi3974 3 жыл бұрын

So cool. I eat wild caught canned sardines.

@otakusenpai3737 Жыл бұрын

So unless the doctor recommends we shouldnt take the over the counter fish oil capsules? u know like a source of omega -3 that we hear so much of?

@thomasevans1728 Жыл бұрын

I take fish oil , my LDL has increased ,should l stop the fish oil?

@dig1035 Жыл бұрын

Help, I take Carlson fish oil (Omega 3). 1 teaspoon contains 800/500mg EPA/DHA. How many tsp do I need to get 4grams dose? Thumbs up and subscribed!

@gymjoedude 11 күн бұрын

The EPA/DHA stated is in how much fish oil? What does the bottle say. He is talking about total fish oil not counting the EPA/DPA. If each capsule is 1000mgs and it states on the bottle to take 2 you'll get 2000mg fish oil and your 800/500 EPA/ DHA from your 2 capsules.

@gymjoedude 11 күн бұрын

Just take the number of capsules to get 4 grams of fish oil and neglect the EPA/DHA. I'm your next blood test get an omega index done and you'll find out your ALA EPA DHA DPA with an indeed number and a table to compare where you're at with the dose you're taking. Any changes in fish oil get another index. Always test for the drugs you are taking to be sure you're in the right range. The showing said I'd bet you high, you want an index around 7-8.

@techguy0927 Жыл бұрын

How about a person with fatty acid on liver is it advisable to take fish oil?

@danielgriff2659 2 жыл бұрын

Cod Liver Oil is another oil high in those.

@dvonders8469 3 жыл бұрын

Everyday seems scary. I don’t know a lot about anything but I was told too much of anything is bad for you. If you stop taking it will ur body be dependent on it and therefore have negative side affects? I want to better my body but scared to throw it out of wack.

@dvonders8469 3 жыл бұрын

Very informative though thank you.