Thank you for discussing the effect of fasting on organs.Most people on here are focused on weight loss.I'm a tiny person that is fasting to strengthen my heart and kidneys.I actually need to be careful not to lose too much weight.

Great presentation!! Thank you for your work!! I have fasted a lot throughout my life and know it has healed me significantly. I will subscribe to see the future videos you spoke about. I like your style and speaking so clear I was able to follow without having to go back over. God Bless your work!!

Finally! Really interesting findings, thank you Nicolas for review of this study. I really looking forward for another part! Such a a great job!!!

I really enjoy your paper analyses and discussions. Thank You! Great Video!

Thank you for the precious information, that's fantastic!

Please keep on doing this vlog. It saved my health.

Absolutely excellent! This is a well thought out analysis.

Nicolas, great input. Invaluable in restoring health. God bless you forever.

Could organ shrinkage and rapid regrowth be better explained by mostly glycogen loss and replacement than cell destruction and regrowth, which would probably take longer?

Wow…packed with great information, many questions answered so thank you very much for this video!

Watching your channel grow over the years has been an absolute treat

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Love the west coast gangsta music in the background. I can just imagine a '64 bouncing up and down, bending a corner on 3 wheels.

Thank you, Nicolas! I just stumbled on your Chanel. Love it! This video is inspiring me to do fasting again. I am sixty, and didn’t wanted to loose the muscles 😁. Well, 4 days of fasting!… starting tomorrow!!

Thank you for the scientific paper discussion of fasting.

Wow brilliant the human body is amazing 🥰 thankyou for sharing all your knowledge Nicolas ☺️

Perhaps by now you have information on intermittent fasting ( OMAD ) and bone density ?? Thanks

Thankyou so much for this video. Amazing 😍

Props y'all brought it back as requested. Y'all are awesome. Go Blue Jays 💙

I loved the music in this video! Very original 😊

Love the video! Have you studied Tryptase levels and what they mean?

A good one. Thanks 👍

Well done. Thanks

Thank you, I was worried about fasting!Now,not so much.

Thank you, very interesting

At the very least, observations look promising for treating connective tissue disorders with fasting regimens improving quality of collagen tissues. I could see refeeds using controlled amounts of highly accessible, or bioavailable, aminos being wonderful for enhancing collagen lattice and other connective tissues. I'd love to see the mechanism quantified.

Very interesting to see what you said there about scar tissue and fibrosis. I have myleofibrosis and have been feeling drawn to fasting...

I'm currently doing a 7 day water fast, I've done a few before as well. I lift weights usually and continue to do so while doing these longer fast. It's just that the workouts are not as intense. I only go to stimulate the muscles to further prevent muscle tissue catabolism. The pituitary gland increases the amount of HGH produced to preserve muscles as well.

Love the tunes, lol, this video is flame

the organ regeneration is amazing!

Thanks!

My colon was surgically removed (colitis) over 30 years ago. Is it possible to regenerate a new one through fasting?

A video on bone mass and IF would be helpful and rarely covered. Thanks. Hard to find truly objective unbiased sources. Hopefully you’ll stay this way. I stopped watching others who didn’t. New subb.

I know this is an old video but I just stumbled upon you channel. I also just watched a newer video regarding how keto affects the heart. So I have following questions: 1. Does fasting also supposedly damage the heart? Fasts are time restricted whereas a diet is a constant thing but still… 2. What happens to the heart when fasting? Does it also shrink (and regenerate)? From I have read/watched it is one of the organs that almost don’t regenerate at all. TIA

Would be great to know what happened to the lifespan of these mice and how long did they subjected them to Fast Mimicking Cycling?

Any research on autophagy and CKD?

Interesting, I'm a t1d with a continuous glucose monitor. I am profoundly interested in nutritional science, endocrinology and energy systems. I have done many fasts 24-36 hours, the odd 72 but just finished a 5day water only. Much of your ascertions in mice studies I concur with myself. After day 4 I found weakness in muscle and strength plus shortness of breath. No lack of energy or tiredness, hunger wasnt an issue tbh. At refeed day 5 I could have continued. Most Interesting I found was Initially I felt that going over 4 days for me was perhaps detrimental to my muscle protein and catabolism of muscle BUT regrowth of muscle in the subsequent days after refeed concurs with the study and actually a substantial improvement in muscle strength over usual pre fast training (my exercise regime was unaffected by the fast) Weight loss was 7lbs but the mirror suggests it was visceral, again suggest similarity to mice study. It's difficult to find extended fasts in humans and more so in diabetics and people of my age (over 50). So I did it myself. Very very glad I did.

How much of organ rebound is water weight?

how many days are recommended for the organ registration benefits?

Does body organs shrink in first 24hrs of water fasting. Will it be same in dry fasting too.

Do you know the duration (days / hours) required for a water fast for humans to experience a non-trivial loss of visceral fat?

Those changes make lots of sense in lab animals

I love your videos! Thanks a lot! Based on your research what is the best way to reduce subcutaneous fat while maintaining or increasing muscle mass, being someone who lift weights regularly?

Moin :) aufschlussreiches Video! Gut gemacht. ☺ Hast du eigentlich dieses Wasserstoffwasser aus einem Wasserionisierer schon mal recherchiert? Dieses Getränk ist wirklich mega genial! :) Wir trinken es vor allem arbeiten !! 🌱

I have attempted to maximize Autophagy and noticed that feast and famine has positive outcomes. Have the cells only in Grow Mode or Repair Mode. Intentionally gained 30 pound last August to October (Vitamin D???) and in mid January started to lose it all, and then some. My right shoulder, top of my head, and then neck, down the back is now shedding massive amounts of skin. Not pretty, but the new cells seem baby fresh, and because they are staring to tan, gaining pigment, they can not be scar tissue.

When does fasting start to catabolise lean tissue

Seems evolutionarily sensible for our bodies to boost stem cells at refeeding after significant (deep) fasting. That would be a cool mechanism to know (more) about.

I've done prolonged water fasts for as long as 2 weeks and noticed that my strength remains constant when I exercise during the fast while my muscles seem denser likely because they are. Doctors often warn about losing muscle tissue when doing a water fast. They may not know and repeat what seems to make sense.

Episode should be called Organ and Bone Regeneration, Fatness and Autophagy after Cycling between Severe Calorie Restricted Diet or Fast Mimicking Diet and Refeeding which is strictly speaking still not Fasting in a true sense on Water which has no Food to impact extra Calories, Glucose Rising, Insulin Rising. Would be interesting to know the number of days for people (60-100 Years life) versus mice (2-13? Years) which would have this incredible Autophagy effect.

Any mention of FMD / fasting messing up metabolism?

hehehhe, cool dancing cell 😊 love the information you provide and the way you re doing it, nice done. Thank you!

It sounds like fasting for 4 days followed by 3 days of refeeding is optimal for organ “shrinking/growing” (wasn’t sure how to word the refeed stem cell phenomenon 😊). Edit : sorry about asking questions on old videos

is the autophagy making organs smaller

Does autophagy only occur during a dry fast? Or can it also occur during a water fast? I only do water fasting...I drink water during my fast.

What is the 4 day equivalent in humans, since mouse metabolism is so much faster?

So, I have minimal knowledge about epigenetic processes. One of the main concepts that I remember is that it is sensitive to environmental factors. I now wonder if individual cells within the same tissue have variances in their epigenetic settings. If so, I surmise that fasting may result in certain cells surviving based on epigenetic supremacy while others die off. It would be akin to natural selection on a microscopic scale. This would contribute to that rapid regrowth you see during refeeding. In a sense, the modern environment of plentiful food (much of which is not healthful) creates a low stress environment at the microbiological level which sustains weaker epigenetic traits. A macro scale analogy would be the domestication of the grey wolf. Dogs regress, genetically, due to the more comfortable existence (generally speaking) they have been accustomed to coevolving with humans. Ultimately, stress builds strength by killing off the weak to make room for the strong, but humans stopped evolving (progressively) because physical evolution is driven by limited resources in a wild environment that pits trait against trait until one fails, and the other propagates. Humans have entered a new kind of evolution that is mnemtic instead of genetic because the physical environment that drove genetic evolution has been conquered with intellect. The wild environment that drives mnemetic evolution is the free market. Ideas that are free to compete with each other creates higher quality and lower costs. Environments where one idea is artificially sustained through subsidy or regulation negates the inherent value of competitive struggle, and better ideas are unable to supplant older and obsolete ideas. Anyway. Sorry I went all over the place there. Thanks for the video. +1 Like +1 Subscribe And I will be sharing.

Was this Valter Longo's study?

Thanks Nicholas for an interesting video. 4 days extrapolated to humans would be about about 15 days.

I wonder how this would compare to eating a small low carb meal of 500 calories in humans, or to doing some 'fat fasting'. Too bad they don't have more human studies with fasting-like diets.

Hi, I had a hysterectomy in 09, after seeing several specialist i was told the surgery was not only barbaric and unnecessary. After 4 surgeries to try to correct the mistakes, im riddled with scar tissue internally, any suggestions? Thank you.

G-funk background music?

Does this include brain organ?

What about hair loss? I'm a 43 year old male who has been intermittent fasting for years so hard to tell the wood through the trees, but I've been experiencing unusual heavy hair fall (mild Telogen Effluvium). Any chance fasting is causing it?

Can fasting help me heal a damaged tendon?

Schön das du da bist :) spannende Erklärung! Danke! 🌱 Hast du schon mal zufällig vielleicht das Jungbrunnenwasser aus einem Wasserionisierer jemals kennenlernen können? Dieses Wasser ist echt beeindruckend! ☘ und Wasserstoff kann helfen Schmerzen zu reduzieren

"fastmimicking" I've probably improved my health and fitness knowledge enormously since subscribing to this channel.

Every time I heard “fast mimicking” I imagined Task Master and heightened mirror neurons. Monkey See. Monkey Do. SSJ4.

Timestamps would help your nice videos! 🙂

Just came off of a 5-day fast ... 😏👌

Nicholas, I do prolong fasting while working out. Do you know of any studies that need humans?

Reason for not showing that fasting helps with fat loss that we want to lose in order to get ripped, its not long enough fast, showing that it helps with fat around organs, its because thats where body starts to look for calories once that is used then goes into fat that is around your body and finally belly fat, its long process but thats how it works Body does not use muscles for energy not until you have enough fat around you.

Liver does well with fasting What about kidneys?

*****

Some timestamps would have been nice tbh....

What about dry fasting (no food or water)? I did DF for 3 days (1 day DF = 3 days WF supposedly) but wondering if the few Russian studies on this is inconclusive

fasting saved my kidneys

Congrats! You were clear to my Darwinian layman monkey brain.

I just want to know how to lose weight, but get all of the essential nutrients. Can humans maintain excellent health on a whole food plant based diet? And what about water? What is the ideal diet for humans? I'm so confused.

17:00

Scientist high five.

Regeneration seems like a good idea

Yep, fasting has no benefit in terms of health to simple caloric restriction.

This is very informative, but the horrendous background music is too distracting

damn u looked like a baby 4 years ago....

I don’t really like this guy, he’s really boring as hell and he is monotone But He has good logic and although his presentation could be better: i can trust what he says