How does Niacin (B3) Work? (+ Pharmacology)

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How does Niacin (B3) Work? (+ Pharmacology)

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Күн бұрын

How does Niacin work? How does Vitamin B3 work? How does nicotinic acid work? All of these questions are asking the same thing! Niacin = B3 = Nicotinic Acid. This vitamin is used to treat dyslipidemia. Anti-hyperlipidemia therapy seeks to prevent the complications heart attack, stroke and other ASCVD risks.
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Answers:
1.)C 2.)A 3.)C 4.)B
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This pharmacology lecture covers topics such as Niacin, pathophysiology of dyslipidemia, regulation of LDL, HDL, Triglycerides and other complications of bad cholesterol buildup. Mechanism of action of Vitamin B3 drugs and their side effects. Drugs mentioned include; Niacin, Vitamin B3, Slo Niacin, Niaspan, Flush Free Niacin and their brand names.
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Пікірлер: 861

@hahaaxd4041 11 ай бұрын

The first time I took niacin I did not know you were meant to flush so I started panicking, then started googling it to find out it is a normal reaction and harmless. Ever since I really actually value the feeling of the flush, when the peak of it ends I start becoming deeply relaxed and free of anxiety and just overall tiredness, it makes me very calm and energetic. I'm taking 500mg every day now in the evening and it also helps me with insomnia from past benzodiazepine use. It's almost like my brain and chest are taking a really deep breath.

@rayvac7743 5 ай бұрын

So you must have taken the jab. Do your research 😅

@ABhd84 Ай бұрын

@@rayvac7743 Incorrect. Im jab free and the Niacin flush is relaxing once the redness goes. Using it to increase HDL

@Balingy 25 күн бұрын

"You must have taken the jab."

@SilviePaul 4 жыл бұрын

*Thanks for updating,God bless you. Anothers benefits Vitamin B3 1. Regulated digestion 2. Treats pellagra 3. Improves skin 4. Reduces the symptoms of Arthritis 5. Prevents the risk of heart disease 6. Mental health 7. Diabetes*

@leximohamed9532 2 жыл бұрын

Thank you

@HBToastedAlmond 2 жыл бұрын

Thank u! Do you have information about B3 regulating digestion? Which dosage? I want to take it to improve my stomach acidity on the long run

@leximohamed9532 2 жыл бұрын

@@HBToastedAlmond it's D3

@thetahexhodlhands4550 2 жыл бұрын

@@leximohamed9532 We are talking about B3. not D3.

@leximohamed9532 2 жыл бұрын

@@thetahexhodlhands4550 thank you so much

@ivysummers5649 4 жыл бұрын

Fishermen in Alaska take b3 the night that the herring fishing season opens. it's so cold they take it to stay warm in the wee hrs of the morning

@manp1039 3 жыл бұрын

That is interesting. I noticed when i take niacin or high dose multi B vitamins.. I regain warmth to my feet and hands. and i have a warm relaxing feeling when sleeping

@Mohammad-qr1vc 3 жыл бұрын

Thank you. My feet always cool. It may help me

@Pajtim2023 3 жыл бұрын

@@manp1039 same me I feel erected too lol

@megja1812 3 жыл бұрын

I don’t need the electric blanket after taking niacin and my sleep is so much better

@magma9138 2 жыл бұрын

That may be flushing niacin. You can get non flushing too. High doses of Niacin improve depression.

@eligreg99 Жыл бұрын

To everyone asking about harmful dosage it works like any other drug. You start off with a small dose to build up your tolerance. You don’t immediately start with 2000mg. I recommend taking 250 mg to start off with for a couple days and then bump it up to 500 mg ONLY if you feel your body is ready. Remember everybody is different.

@or6144 Жыл бұрын

I started at a 1000mg. I was fine with the flush but my legs swell and if I take it a day after or consecutively for 2 days or a day after I still get that swelling. I'll restart next month and start with 100mg and increase it from there after a few months to get my body used to it.

@hannaishak7206 Жыл бұрын

@@or6144 see your uric acid

@or6144 Жыл бұрын

@@hannaishak7206 Uric Acid not bad. I guess it was because I jumped the gun by taking 1000mg before saturating from a low dose or it can also be due to the brand of Nicotinic Acid I used which was Piping Rock. I'm up to 600mg now Nature's Way brand twice a day (Morning/Evening) working my way to 1000mg. I suppose my body is adjusting better to it since asides from the expected flush that clears up I've no other side effects. I take this with Bilberry (eyes) and Vitamin C for the Arteries along with my 2 Tbs of Sea Moss in the morning since your vasodilating your arteries no better time to infuse it with other nutrients.

@no_country_for_real_men 7 ай бұрын

You are absolutely irrefutably spot on correct. I could not have said it any better.

@DaddyElfMan Ай бұрын

I bought some Niacin from GNC in the last year, to help with blood pressure, (as it is a vasodilator), I bought the 500mg tablets, did not know about the flushing part, took me a couple days to figure out what I was taking (was also taking a prebiotic, may have been past expire date, so thought that was what was making me flush and my skin to tingle, mine did not actually itch, just tingled a bit) both the flush and tingling subsided after about 20 mins or so. I was not sure on how much to take daily, found some evidence to not take too much, so I quartered the tablets and take 1/4 every day. Did not know about taking at night before bed, to help with the flushing (not noticing as much at night), so I found this video informative. I was worried about taking too much and it causing damage to my liver or kidneys... so am opting for a lower dosage. I also found that taking with applesauce can help to reduce/negate the flushing/tingly itchy skin.

@ketocajun7451 Жыл бұрын

You should inform people (since you state it several times) that LDL is not bad because it is the same as HDL just with higher concentration of fatty acids (same protein structure) just the phenotype of LDL is something to watch. Differentiate the LDL into it's 7 components and see if you have high glycated end products. Maybe that is beyond this video but people should not be afraid of LDL. You cannot live without it.

@chrisdell5679 3 жыл бұрын

Cholesterol dropped 86 points after taking Niacin.

@outofthebox5441 Жыл бұрын

Are you still taking it? What's your mg dosage?

@christymartinez2078 Жыл бұрын

@@outofthebox5441 once your LDL is stabilize you can take 3 times a week. You don't need to take it everyday. It should keep your LDL at a good place

@outofthebox5441 Жыл бұрын

@@christymartinez2078 sounds good. Thanks

@dzim8822 Ай бұрын

Wow, that's great.. I have a prescription for a statin, but I think I'm gonna try taking Niacin instead. Is your dosage above 1,000 mg?

@dlg5485 Жыл бұрын

I've been taking 500mg 2x daily for at least 10 years. Heart disease runs deep in my family history so I decided in my early 40s that I wanted to protect my vascular health as much as possible. Niacin, fish oil, D3/K2, CoQ10, and a few other supplements have really helped me preserve my overall health, along with exercise and regular fasting. I only take full flushing niacin because it's the only one that really works. I've been taking it for so long that I almost never experience the flush anymore, only when I take it on empty stomach.

@Chaitanyaworld2692 10 ай бұрын

You have Hypocholestromia

@ReflectedMiles 10 ай бұрын

That much taken for that long, especially, may increase your chances of developing Type II diabetes according to a couple of studies, unfortunately.

@dlg5485 10 ай бұрын

@@ReflectedMiles I've never heard that in my life. I research every supplement that I take once or twice every year to keep up with the latest data and there is virtually no risk with 1000mg/day of B3, as long as you also fast regularly and take CoQ10, Omega3 which protect the liver. My metabolic profile is perfect and has been for as long as I can remember. I'm not concerned.

@ReflectedMiles 10 ай бұрын

@@dlg5485 That is certainly your choice, but social media sources are rarely scientifically literate and thorough--including many who are supposedly in healthcare in one form or another--and many GP's don't have the time to be. So it's just important to be aware of the current evidence on the subject, and that is why I mentioned it. Certainly not everyone who takes significant amounts regularly will then develop Type II, but current evidence shows that there is an increased risk. It is probably the single significant downside of using it for its benefits--it seems there are nearly always some risks or trade-offs.

@ash9x9 9 ай бұрын

Good to know, I am starting with Niacin from tom and was a little bid concerned about this developing into TypeII diabetes. Anyhow what other benefits have you seen over the years of consp. of 1000mg/day niacin?@@dlg5485

@marcosta183 Жыл бұрын

I kinda like the flush. It increases circulation and it also renews dead cells...😊

@alwayscuriousalwayslearnin Жыл бұрын

I used to regularly take large does of Niacin just before my weightlifting at the gym( 1970s-80s) it seemed to help with many things even though I was flushing, now decades later I am taking it to hopefully lower my cholesterol levels instead of taking stains

@Meow-ds7pr Жыл бұрын

take fish oil high in EPA see iherb. minimum 2g epa per day or more, in few months will lower tryglicerides and cholesterol nicely. dont get on statins

@Test7017 Жыл бұрын

How much are you taking? Also try taking large constant doses of vitamin C. Your body uses it to repair arterial walls. If your low on C your body will use a poor version of LDL to repair arteries

@bojax3434 Жыл бұрын

@@Test7017what is a high dose of C? I pretty regularly take 2-3 grams/day.

@rayvac7743 5 ай бұрын

Carnivore, no problem .😅

@rluo462 2 жыл бұрын

very very succinct! Just the way an explanatory video should be! No BS, no fluffy stuff, just the useful content. One of the very few on youtube who really aims to educate, not marketing or showing off. Love the animation!

@kevino6756 Жыл бұрын

YOU DID NOT GIVE THE ANSWERS

@suepalmer4726 Жыл бұрын

You have really done an excellent job with this video. I am a nutritional therapist and this was even a reminder to me about niacin

@urseldoran2991 Жыл бұрын

Good video sir. I have been taking it for years. Getting the flush is desirable as it indicates it is working to dilate the capillaries on the skin, but MOST importantly the capillaries around the heart and in the brain. Obviously very desirable to dilate one's capillaries for enhanced blood flow!!

@billbob7982 8 ай бұрын

It seems to improve my scalp hair growth, as my hair is thicker(?). Perhaps, someone may research this hypothesis?

@kcpoodlesofpa 2 жыл бұрын

I’m so glad I found this channel! Someone shares my love of pharmacology 😀

@davelelonek Жыл бұрын

Last week I started taking non flushing Nature’s Bounty brand but unlike video, it has 400 mg of niacin with inositol hexanicotinate for flushing. I’ve thus far had no flushing. Was taking it at night and found interrupted sleep and mild stomach issues. Started taking in morning and wow super energy. Noticeable lowering of BP too.

@mrofnocnon 10 ай бұрын

Non flushing niacin is not effective for cholesterol control.

@itsatrap4986 Жыл бұрын

For first timers, get B3 500mg in tablet form and break it in half. Start off low and work your way up. It also helps to eat first and drink lots of water before taking it.

@pattyloader8013 Жыл бұрын

Because I had a bad flushing reaction years ago when I took 500 mg, now I started off at only 100 mg...and will increase a bit at a time.....That flush reaction can be scary the first time.

@jimdale6476 Жыл бұрын

I enjoy that niacin "flush" when I hit the hay. It feels cool & refreshing ... as if I'd just completed a steam bath (even when that's far from the case). People are always startled, scared and misjudge it when they don't know to expect the flush. When they DO know ahead of time, however, they can enjoy its uplifting effects ... presented at the RIGHT time & environment . Best to take it just before you go to sleep. It's so comfortable while you just lay there motionless, you won't feel like moving. Even feels like it reboots the mind ... feeling more rested afterward ... both physically & mentally. (Just be prepared for its slightly extra cooling effect ... with an adequate sheet or light blanket.) :)

@Chip_eater48 Жыл бұрын

I agree , how comes I don’t get the flush every time I take it ?

@mcr3105 11 ай бұрын

Do you feel the itch on the chest and arms too?

@mcr3105 11 ай бұрын

@@Chip_eater48 You could be taking the flush free niacin

@MaxAmerica.Freedom 2 ай бұрын

Thanks for letting us know to avoid flush free. No wonder it didn't work. At about 7:00

@royjhamlin 7 ай бұрын

Awesome content! Great useful information. I love the way you simplified the science and understanding of how to use Niacin, Vit B3 and how it works. Do you have any more video's on the Vitamin supplement topics? I am preparing to teaching nursing students Fundamentals and nutrition and you were right. We basically tell them B, metabolism and nerves. But you get to the science on how this works simplified to understand why. Love the presentation and I will guide students to this video in case they want info to the point and clearly presented. I will look to your other pharmacology videos when I get to those topics. Thank you.

@wilburadams9848 Жыл бұрын

Thank you. Your explanation was absolutely informative, and comprehensive.

@MAGZIVE 4 жыл бұрын

Watching this video while my ears are magma hot from the flush lmao

@DrugChug 4 жыл бұрын

Hahaa hopefully the video helped!

@abc_cba 4 жыл бұрын

Lol

@XWDaniel 4 жыл бұрын

I definitely popped 2 pill first day not reading the label. I know the feeling 1000mg at once ain't it. 😂

@intelligentdesignmorty8112 3 жыл бұрын

@@XWDaniel 500 mg already white me hard xD

@HopeAndrea_HFG 3 жыл бұрын

Same

@ninawildr4207 4 жыл бұрын

Get rid of vegetable oils and most sugars

@Ntbjp 4 ай бұрын

What about peanut oil filtered at home?

@Mulazim. 2 жыл бұрын

Some people claim that Niacin increases Nitric oxide and could be used as an alternative of L-arginine and L-Citrulline

@lancer717 2 жыл бұрын

It does. Take it before sex and viola

@edmitchell9307 Жыл бұрын

Niacin is a vitamin you must start slowly and gradually work your way up to your desired dose. The first time I took it it startled me because I wasnt expecting the side effects. The flushing doesn't last long and as you increase your dose the flushing can eventually go away completely. I have found all the "Take with X and you wont flush" to be bogus. The only thing that worked for me was dosage saturation. I am currently on 4grams and I no longer flush at all. I had debilitating arthritis and am mostly pain free now. I also noticed an increase in cognitive function. 3 years now and no down side except peeing a lot. Stay hydrated.

@jamescalifornia2964 Жыл бұрын

Ha ! Same with me. The first dose was a doozy ! I now use _SloNiacin_ .

@dwaynemorris3079 Жыл бұрын

@@jamescalifornia2964 i take Endur-acin and very little flushing. i took Nialor prior to that.

@jamescalifornia2964 Жыл бұрын

@@dwaynemorris3079 - Sustained release niacin should not cause flushing 👌

@osopapi Жыл бұрын

@@jamescalifornia2964 but it does. Go figure.

@jamescalifornia2964 Жыл бұрын

@@osopapi ~ Sustained release does not cause the uncomfortable flush for me. Try splitting the does 2 - 3 times daily. _SloNiacin_ comes in 500 & 750 mg.

@carlsapartments8931 4 жыл бұрын

BEFORE TAKING SLOW RELEASE OR NO FLUSH OPTIONS INSTEAD OF REGULAR NIACIN DO YOUR RESEARCH ABOUT THE DOWNSIDE . Regular niacin will not cause flushing if you slowly build up your dose over days or weeks ---- FLUSHING DOES NOT HARM YOU --- ITS JUST UNCOMFORTABLE FOR A SHORT PERIOD --- YOU FEEL HOT AND ITCHY FOR 15-30-60 MIN OR SO. it depends how sensitive you are to it so start with the low dose maybe 50mg/day and build up.

@deedee2218 3 жыл бұрын

Great suggestion, thanks!

@anxietina_ 2 жыл бұрын

first time taking niacin, i experienced flushing for about 2 hours and days after that just 20mins max

@bradleyparis5821 2 жыл бұрын

I always take with food about half way through a meal and chew up the tablet completely, no flushing, If flushing occurs drink lots of liquid.

@josephinelai4638 2 жыл бұрын

I experienced flushing(scary red all over the face and hands) right away after taking 50mg of Niacin the first tiime!

@arthurdolle5257 Жыл бұрын

I enjoy gentle scratching, just be careful to keep it gentle

@micaonyx5301 Жыл бұрын

I took a pretty good amount of niacin last year when I had covid, because my body wanted to get out and breath fresh air. It was an average of 10-15 degrees in my area. I had just watched Andrew Saul and he seems to think niacin and vitamin C can cure everything except death. I didn't take it for covid I was taking it to keep me warm which it did. I'm anemic and I felt so good I walked on average two hours every day. I barely had any symptoms of covid. This year had a severe case of covid forgot to take niacin because I try to cycle my supplements. First week too sick to get out of bed least of all go walking. Took me 3-4 weeks to recover taking the same supplements except niacin. . Coincidence I don't know, what I do know no matter what I'm keeping niacin in my supplements stack 🤣

@debbietaylor20 3 жыл бұрын

It relaxes me helps for anxiety Better then an antidepressant or valium Im on keto and HDL gone up and tryglicerades gone down LDL is still high.

@Shurmash 3 жыл бұрын

How much do you normally take at a time?

@peacewins3281 2 жыл бұрын

check dr. Berg's "why your LDL is high on keto",,,,,then you would relaxxxxxx.

@johanitalouw9315 Жыл бұрын

Totally agree!

@GreenCheese500 Жыл бұрын

What dose do you take?

@kiaratoves9472 2 жыл бұрын

Hi, please post more content!! Your videos are literally the only ones i can find on here that properly explain each topic with perfect visuals!

@enmukeeenmukee3254 2 жыл бұрын

Be careful when taking Niacin. I took regular flush 500mg of Niacin and within 30 mins, the flush effects were crazy, my heart rate went to 120 and I felt dizzy and blacked out for 5 mins. Luckily, I did not hurt myself. Effects were gone in an hour but it was a torture. So start with a small dose to see how your body tolerates it.

@meme-tf8ih 2 жыл бұрын

Wow, u r brave...when taking any supplements, start with small dose, and then up it. At lease you didn't stop taking with the bad experience you had. Smart move. B3 is very good for the body.

@Foxterrier 2 жыл бұрын

If you are interested, there is a video how flushing occurs. kzfaq.info/get/bejne/eL6FZppht6eVc2g.html&ab_channel=Foxterrier

@enmukeeenmukee3254 2 жыл бұрын

@@Foxterrier Thanks. One lesson I learnt the hard way is to be very well hydrated when taking Niacin and never take Niacin if there is any significant alcohol in your blood as it greatly exacerbates flushing.

@Foxterrier 2 жыл бұрын

@@enmukeeenmukee3254 Also antibiotics and even grapefruit juice can potentiate niacin effect. So be aware of such drug interactions.

@meghanzoll6447 2 жыл бұрын

same! had an awful reaction and i didn’t even realize jt was the niacin just thought it was the hot sauce i had lol. so i took it again and ended up crying in the school bathroom. side effects are awful!!!

@lonnieke 2 жыл бұрын

BEST VIDEO I FOUND ON KZfaq ON THIS SUBJECT

@makarov138 6 ай бұрын

A no-flush type of niacin is inositol hexanicotinate, which I take daily. It is a slow-release form that ensures the body always has niacin in the bloodstream.

@justinadamo6480 Жыл бұрын

Welp, I guess I’ll be adding your vids to my binge list. Great stuff. 👍🏻

@herbertvonsauerkrautunterh2513 Жыл бұрын

I've been taking a B3 supplement for years and not for cholesterol. I take it for skin and DNA repair. No side effects at all

@khristianswandychandra Жыл бұрын

It was niacin or other form called niacinamide?

@herbertvonsauerkrautunterh2513 Жыл бұрын

Both

@howto3739 11 ай бұрын

so how was it?does it gives you nice skin?how old are you?

@lewis20002000 4 жыл бұрын

VERY WELL DONE....great narration and graphics

@DrugChug 4 жыл бұрын

Thank you Lewis! Appreciate the support!😁

@MichaelCzajka Ай бұрын

Niacin has been known to spike liver enzymes in the first week or so... but then they drop down back into the normal range. Niacin has been known to spike blood glucose... but that also returns to normal after a few days: Niacin helps improve carbohydrate metabolism. 🙂

@ReflectedMiles 10 ай бұрын

Several older clinical studies have demonstrated that IHN may have a beneficial effect on endothelium-dependent vasodilatation. The clinical research literature includes several positive studies on the use of IHN for improving blood flow in conditions where blood flow is compromised (Ring and Bacon 1977; Head 1986; O’Hara et al. 1988).

@florramirez6744 4 жыл бұрын

thanx for these videos. You make everything so easy to comprehend. Love ur voice btw!

@DrugChug 4 жыл бұрын

Thanks for watching! Glad it helped😁

@71160000 11 ай бұрын

My doctor prescribed niacin years ago. I took one pill. In an hour by arms were on fire, my legs were both vibrating. An hour and a half later it subsided and then within the next hour it started over again. It was so painful I was ready to go to the emergency room when it finally quit hurting. It was like the worse sunburn of my life. I don't remember turning very red though. Just a burning sensation.

@phil.1 11 ай бұрын

I love the flush now. I take 2-4g a day. My neck burns and my chest itches so bad if i take it at night. I mix more than 1g in my citrus flavor fiber powder drink. After a nice hot shower before bed with the niacin flush, it's super rejuvenating. Once you get used to it, it's a game-changer. Like my brain fogs completely disappears after the flush, it is super sauna-like and relaxing in a good way... something about opening up the capillaries and flushing fresh oxygenated blood to my brain and under my skin makes the post-flush feeling really youthful. Biggest plus is my HDL went from 52 -> 84 and VLDL 102 -> 83.

@TinaRossetti-ty6zy 3 ай бұрын

This made me laugh. I would have had a major panic attack with those symptoms. It sounds as bad as my atrial fibrillation, which is why I'm looking into niacin....

@davidtrindle6473 Жыл бұрын

Don’t take 1000mg!! Start at 50mg and gradually increase as body adjusts.

@thunderjoy7250 Жыл бұрын

That's exactly how I've started 👌

@yoshiytt2834 3 жыл бұрын

Niacin helps with tinnitus, lowers the ringing big time especially if you're fit and are No Fap

@Littleprinceleon Жыл бұрын

Research study on the correlation of tinnitus with fapping?

@augustmosco Жыл бұрын

This is wonderful information for the concerned novice. Thank you.

@juanitahardy8583 2 жыл бұрын

My radiologist recommended 500 mg regular release to treat skin cancer. This is common practice in other countries. My Bowens skin cancer has virtually disappeared but other skin cancers are down but not as significantly. I understand this is a common recommendation in Australia where skin cancer is prevalent. Flushing becomes less with regular use. I do use low dose aspirin but I will try homemade no sugar applesauce. I do not eat sugars.

@morpheusbott3370 2 жыл бұрын

How do u avoid sugars in fruits? I’m guessing u mean other types of sugars but I’m curious how u do it as I’m interested in cutting out sugar. Thank you

@katesun2957 2 жыл бұрын

My son thinks that's so funny when he hears that from people. He always says, almost everything breaks down to sugar in your system.

@supermariiio 2 жыл бұрын

@@katesun2957 then we dont need to add sugars in the products if our body converts it to sugar anyway

@hbh4276 Жыл бұрын

Thank you so much for your post. I didn’t know it helps with skin cancer which I got. I came here for high cholesterol but found this piece of information by chance. 😊

@hopenunyahbiz Жыл бұрын

Supposedly "CrabApples" are the ones to go to all others are full of sugar..

@steveamor8103 3 жыл бұрын

Life saver! Need more content !

@steveamor8103 3 жыл бұрын

I leave a comment for the algorithm gods!

@DrugChug 3 жыл бұрын

Thank you some much for the support! 😁

@jackjones4043 3 жыл бұрын

twitter.com/3PIDEMIOLOGY Dmitry Kats, Ph.D., M.P.H. he will lead you to tons of research papers.

@dauseanadoingme3824 2 жыл бұрын

I take niacin regulary. It makes me feel extremely warm. Too dark to flush lol. But it really helped lower my high cholesteral.

@texanboiii562 2 жыл бұрын

Lucky you 😭

@hazeboy8981 2 жыл бұрын

Didn’t knew grabbed a mtn dew kickstart And I’m like wtf is that just by curious but still drank it

@dauseanadoingme3824 2 жыл бұрын

@@texanboiii562 🤣🤣🤣🤣🤣🤣

@vinlondon8904 2 жыл бұрын

@@dauseanadoingme3824 how much did it lower your cholesterol and how fast it did it ?

@johnnyflores1978 2 жыл бұрын

Just take omega 3 krill oil and healthy fats also take soluble fiber for cholesterol

@nsgreen1796 Жыл бұрын

Thank you very much for the clearest valuable information ❤

@luckyhanger1326 4 жыл бұрын

Nicotinic acid also has a pathway to help recharge the NAD+ which powers the mitochondria. It is a cheap version of NMN or NR. Not sure about the dosing but I take 200 mg in my daily STAC.

@kerzhemanov 4 жыл бұрын

Perhaps 500 mg will be closer to optimal. I am not an expert though

@itsmeforsure5475 Жыл бұрын

I just started taking 300mg of Niacin and I've never taken any vitamin or drug, that had that big of an effect. Even at 300mg, I got the face flushing and tingling skin. I didn't know this lowers triglycerides and mine are high so I will probably take it most nights. I don't want to walk around looking like I spent 2 hrs too long in a tanning bed.

@elvisgarciadejesus 4 жыл бұрын

Thanks bro, a brilliant presentation without the bullshit, excellent.

@DrugChug 4 жыл бұрын

Thanks man! Appreciate the support!

@2394Joseph 10 ай бұрын

After one dose, my blood pressure went from 175 (top number to 135. Crazy burn though.

@MichaelCzajka Ай бұрын

The inositol version of niacin has a niacin molecule at each of the 6 corners. Enzymatic action breaks down the bond to the niacin releasing it. Inositol hexanicotinate is the most effective form of niacin because of this slow release mechanism. :-)

@ruebenshaw 4 жыл бұрын

I don't care if people see me as being red And I like the feeling of itching and burning and heat!!!

@PandaA-cv3mm 4 жыл бұрын

👍 Same here! Love it 😉

@tarwamccound5308 4 жыл бұрын

Lmao

@AK-kv2fl 3 жыл бұрын

Bloody love ya

@fightcrime4216 3 жыл бұрын

Same me I bloody love it if I don't get the flush sm piss off 🤣🤣🤣🤣

@chejvasquez5202 3 жыл бұрын

Oh. I have dark skin and my skin turn purple 😈😈😈😁😁

@LindaSparks813 Ай бұрын

Good information great video love your graphics. 😊

@afh1695 Жыл бұрын

Natures Way nicotinic acid 100mg capsules is the easiest to split into 50mg starting dose on empty stomach first thing in the morning before coffee. Allow yourself the chance to see if you are sensitive to the flushing/heat effects before upping the dosage.

@MichaelCzajka Ай бұрын

Inositol hexanicotinate most certainly improves your cholesterol. HDL goes up and LDL goes down. It also appears to help reduce homocysteine, free fatty acids and many markers of inflammation. :-)

@TheSilverlover999 4 жыл бұрын

I took swansons 100mg Niacin within 10 mins i feel like i have taken a shot of brandy but a little milder. my body feels hot but nice to take in cold weather.

@intheworldbutnotofit8002 3 жыл бұрын

The Irony is that brand makes their products from harmful to toxic ingredients. They use an ingredient that are found in cement compounds. You toot and praise them all the way to your grave.

@AlbionRising 3 жыл бұрын

Was it nicotinic acid?

@josephinelai4638 2 жыл бұрын

Glad to find your channel. I have been taking flush free niacin for years and didnt know the effect until now! Thanks for sharing.

@seanoconnor1731 Жыл бұрын

Flush free does NOT reduce triglycerides - refer to end of video.

@no_country_for_real_men 7 ай бұрын

Hands down best short lecture on Niacin I have ever seen

@masoodabbas3144 Жыл бұрын

Well explained and very informative

@Bulldoghartl 4 жыл бұрын

Been waiting for this! Found it today!

@DrugChug 4 жыл бұрын

Woohoo! Glad it helped!😀

@Bulldoghartl 4 жыл бұрын

Slow ride.... slow ride........ sloe ride

@SableFox72 6 ай бұрын

I was having some liver pains yesterday, then intuitively felt to take 500mgs of B3 before bed. My entire upper body got very itchy while my entire body swelled a bit & my every single hair felt like a spike in my body. I felt like a hedgehog. My heartbeat quickened as my blood pressure & temperature rose. Woke up this morning feeling refreshed. Not sure why my body reacted so strongly but Im guessing its because Im riddled with spike protiens from touching the vaxed public at work which is inflaming my joints terribly after each shift.

@manalalzubi671 3 жыл бұрын

How much is the dose of niasin that could harm the liver? Is there any tests that I should do first for my liver to see if it is safe to take this vitamin?

@tootienottoofruitie1726 2 жыл бұрын

250 mg to start. ,500 mg per day once you can handle the flushing.. when I take it I skin brush that feels so good

@Littleprinceleon Жыл бұрын

Basic liver enzymes levels (which are routinely checked) should suffice.... If you (or your genetic relatives) haven't had problems with liver, then 250mg should be safe... Start with lower doses though

@Droidzi Жыл бұрын

nice one - any views on the better versions (least man-made "natural"/less chemical) versions of B3?

@marcosta183 Жыл бұрын

In the shopping, a few years ago, Niacine was the threefold price of Niacinamide. Later on, this difference went the other way around and today, Niacinamide is the one which price is the highest. Any one there to explain this change?

@17mazes17 Жыл бұрын

Does it spike blood sugar? My FBS is consistently between 5.3 to 5.7. I took niacin the night before and had a considerably higher FBS in the morning!

@johanitalouw9315 Жыл бұрын

Why no mention of dr Abram Hoffer's work on niacin for schizophrenia? Also use for ADHD?

@huseyinmuhtar3095 7 ай бұрын

Hi, does nicotinamide(no flush niacin) 500mg is good for improving NAD level?

@kyberuserid Жыл бұрын

Inspires confidence in medical education.

@eduardobravo-leon3894 5 жыл бұрын

Great job bro!

@joseanker2059 4 жыл бұрын

Flushing is not harmful and with use it actually disappears

@Pajtim2023 3 жыл бұрын

I see flushing like detox bro Colesterol and metal detox My brain start working better Memorizing better thinking better My erection are better Blood flow is rocking

@mrofnocnon Жыл бұрын

Thank you for this video. A few tips, the flush lasts only about 15 mins and reduces a great deal in a short time, the Niaspan is a disgusting rip off of what is basically niacin in a slow release form sold with the word play "extended release" it should never have been allowed a patent. Slo-Niacin is just as effective for a fraction of the price. these slow release forms of niacin have stronger effect and can be a strain on the liver, so try the regular niacin first.

@Erikacarriel1982 Жыл бұрын

The med pharma people said that niacin (Nicotinic Acid) raises blood sugar levels on people with diabetes. I have pre diabetes, but it does not affect me. It only raises it from the time frame of the flush beginning to end, and it doesn't go that high, does not harm you like pharma people say. I really live the flush.

@mrofnocnon Жыл бұрын

@@Erikacarriel1982 Me too.

@sadiqakhan2545 3 жыл бұрын

Wow thank you its great video n thanks for doing the quiz in the end .Thank you so much

@didgeridooblue 2 жыл бұрын

If B3 blocks the decomposition of adipose tissue how can someone lose weight (fat) while taking B3?

@Littleprinceleon Жыл бұрын

Niacin is transforned into NAD which is part of the basic cellular metabolism... If there is enough NAD in the cells perhaps they burn more calories... Although they should also work more efficiently (meaning less waste, so less energy needed... so maybe the excess is stored as fat 🤔😉): I would say that under 50 one should NOT normally need extra B3 uptake. Perhaps it helps with muscle building with regular exercise. If you start to search after how complicated are the networks affected by most of the supplements, you'll realise that one can only rely on good quality clinical studies: even those produce many times more or less contradictory results. But those are at least explained after some more investigation, while most of the problematic issues found via basic or epidemiologic research have no satisfactory answers even after three decades and hundreds of studies

@nassermj7671 Жыл бұрын

Be good if you can give answers at end though we get the idea.

@sheilamore3261 Жыл бұрын

Thank you so very much for explaining what niacin does🥰💕

3 жыл бұрын

I need to know WHAT İSTHE DIFFERENCE in between of Niacin and Niacin hexagonite?

@Littleprinceleon Жыл бұрын

Hexagonite? Surely? Non-flush version has six (=hexa) niacin molecules chemically bonded to one inositol molecule... The nicotinic acid (= niacin) is slowly and not very efficiently stripped off of the inositol.

@LoveOCOC Жыл бұрын

B3 is not a drug. It is a nutrient that works as a co-enzyme. You seem to be categorizing nutrient constituents as drugs. They are not.

@CAdams93 6 ай бұрын

Facts

@wqmanawqke3375 3 ай бұрын

Omg I did it today 500 mg... and I thought I was having a stroke with the facial drooping, skin felt like it was on FIRE. My feet got very cold then hot. I was down on the floor with tunnel vision... my speech was a little slurry. I have slightly elevated bad cholesterol... oh boy... this was intense.

@theoriginalmungaman Жыл бұрын

I took a 500 mg without knowing what flush was, It was like a third degree sunburn on every part of my body, fun!

@ameliagarcia1483 10 ай бұрын

😵‍💫

@nikolagolub9668 5 ай бұрын

AVANTURA

@edj2745 Жыл бұрын

Can niacin be taken with other vitamin supplements like magnesium and cod liver oil?

@MichaelCzajka Ай бұрын

Inositol B3 is very good at reducing hypertension because it increases NO production. 🙂

@baljitsingh8394 Жыл бұрын

Very informative 👍

@sophiebuzora9616 2 жыл бұрын

I have Atrial Fibrillation, SVT. I really would like to take B3 Niacin, but I have a feeling that my heart rate will go up and triggers an episode which I really afraid of. Does anybody have any suggestions about this? Thanks.

@ResearcherJournalist 2 жыл бұрын

Hey Did you try Niacin in the end? If so how was your Afib response? Or have you found any guidance or advice on using Niacin with Afib??

@johnnyflores1978 2 жыл бұрын

Hello hows your afib? Did you get an ablation or are on beta blockers?

@christymartinez2078 Жыл бұрын

Magnesium will help for A fib

@melaniebooth9703 4 жыл бұрын

' Niacin The Real Story ' by Abram Hoffer MD PHD / Andrew Saul PHD / Harold Foster PHD. To find out loads of benefits! For anyone interested.

@s.m.3608 4 жыл бұрын

Melanie Booth Thanks buddy! God bless you!

@PandaA-cv3mm 4 жыл бұрын

Thank you 😊

@carlsapartments8931 4 жыл бұрын

Good point, my mother was a patient of Dr Hoffer.

@razvedka9979 9 ай бұрын

@@carlsapartments8931 really ??? Thats amazing. Was she treated for depression / schizo / alcoholism ? He is missed

@raymondsanders6588 2 жыл бұрын

Love the flush!!!

@erandeser5830 Жыл бұрын

Why is the very slow release drug prescription only ? How slow can be bad ?

@creepycrawler4690 Жыл бұрын

I recently started 500mg. Been having some extreme side effects. My whole body turns red with burning and stinging for a couple of hours. I'm thinking it could be the fact that I'm taking with all of my other vitamins at the same time. I mean it's almost unbelievable.

@mrofnocnon Жыл бұрын

Take it with food to reduce the flush.

@Skinny_Pimp Жыл бұрын

Get in hot water with Epsom salt Or a hot tub. The water will soothe your skin and allow it to be more tolerable.

@paulharrisonadventuregearm5457 Жыл бұрын

Totally normal...it's nothing to be concerned with

@mrofnocnon Жыл бұрын

@@Skinny_Pimp Totally false.

@pattyloader8013 Жыл бұрын

Start off at a low dose!!!! you can get 100 mg to start... Very uncomfortable side effects at higher doses.......and after meals

@Darkedge361 2 жыл бұрын

Well I came here to learn about the vitamins I randomly started putting in my body because of a hunch, Would like to say thanks!! Turns out it does more than I thought it would, I'm starting with a 250mg per day for 30 days then I'll increase to 500mg for the long term, I was honestly looking for something to help with erectile disfunction that wasn't a $38 per pill solution because I knew it dilated blood vessels, and I deduced that it maybe a solution because my legs feeling cold on occasions. it's been working as I expected, and your video gives me a much better understanding of why.

@eligreg99 Жыл бұрын

Try Ashwagandha pills brother.

@Darkedge361 Жыл бұрын

@@raulbeck3722 i feel pretty good, i don't get the flush very often unless i take a double dose

@Darkedge361 Жыл бұрын

@@raulbeck3722 A1c actually dropped a bit,no issues on blood screens though

@andrewfinlay5160 Жыл бұрын

Marc Cuban cost plus pharmacy..tadalifil is cheap with prescription...25$. 90 days supply

@naomimara3340 Жыл бұрын

I started taking 250-500mg B3 for anxiety (trying to reduce Benzo Clonazepam 0.5mg).I realised it's a Nicotinamide, the no-flush-kind. Will I still be getting anti anxiety effects?

@exteriorized Жыл бұрын

Excellent video !!!!!

@tttony9426 Жыл бұрын

my ldl has been very high for years,over 350,doctor put me on avorstatin,it made me donkey dumb,i couldnt think,my memory was terrible,i had to stop taking it,why did it effect my mind like it did,would b3 be a better choice for high ldl ???

@AZ-tt1lw 4 жыл бұрын

I hope to get a response... I purchased a flush free niacin, by accident (flush free is in small print), and I’m using it to help my vascularity in transporting other nutrients throughout my body. Towards the end of this video it was mentioned to avoid those products. Is the flush free version entirely useless especially for what I am trying to do with my diet? I’m not too concerned with lowering or raising cholesterol at this time.

@DrugChug 4 жыл бұрын

You may be able to use it for that purpose, but I havent seen much evidence for helping vascularity. Give it a shot and see if you feel any improvements, we still need more well designed studies!

@Happiness-fp5dl 2 жыл бұрын

any progress?

@Littleprinceleon Жыл бұрын

Some news?

@FlickSh0tt Жыл бұрын

I feel like the flushing has its purpose. Reducing it or taking a slow release might take away form of the benefit

@shineaenn2642 4 жыл бұрын

Wowwww. Saw ur first video and enjoyed the presentation effects .good info and a subscriber too now .gd job n gd luck 👍

@DrugChug 4 жыл бұрын

Thank you for watching! 😁

@bobcocampo 2 жыл бұрын

Does Niacin have an effect on Vitamin D3

@zacharyzetts7395 4 жыл бұрын

This video answered my question. I wanted to know if flush free niacin worked as well as regular niacin. The answer is no. ❤ I definitely feel a better difference when I take regular niacin than when I take flush free niacin. I have dyslipidemia.

@DrugChug 4 жыл бұрын

Glad it helped! Thank you for watching 😁

@allboutthemojo Жыл бұрын

@Drug Chug I'm very active, doing Intermittent fasting for 5 yrs. No doctor can explain why I have low triglycerides, good hdl but still very high ldl and they want to put me on statin. I refuse. Will Naicin help?