How does Zetia (Ezetimibe) Work? (+ Pharmacology)

Рет қаралды 62,832

5 жыл бұрын

How does Zetia Work? How does Ezetimibe work?
Zetia (Ezetimibe) is used to treat Hypercholesterolemia or high LDL levels. Anti-hyperlipidemia therapy seeks to prevent the complications heart attack, stroke and other ASCVD risks.
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Answers:
1.)C
2.)B
3.)C
4.)D
Statin Video Here: • How do Statins Work? (...
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This pharmacology lecture covers topics such as dyslipidemia drugs, they block the NPC1L1 receptors in the intestine to lower cholesterol absorption. Also we talk about the pathophysiology of LDL cholesterol, regulation of LDL, HDL, LDL and other complications of bad cholesterol buildup. Mechanism of action of Zetia and their side effects. Drugs mentioned include; Zetia, Ezetimibe, Vytorin.
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Пікірлер: 96

@HughSommer 3 ай бұрын

I took Crestor and Zetia for six months. I’m 82 and a diabetic. My total cholest is 105, ldl is 48, hdl is 40, tri is 88. No problems. Good look

@rhondagregory5253 4 жыл бұрын

These video are a great resource for studying for pathopharm exams!

@nazzib3657 4 жыл бұрын

Pls don’t stop making videos!!! They are super helpful

@DrugChug 4 жыл бұрын

More videos are planned to come!

@maxine.celeste 4 жыл бұрын

I literally cannot thank you enough! You break it down and make it so easy to understand! :)

@DrugChug 4 жыл бұрын

Thank you for the support!!😁

@fatimaezzeddine1918 Жыл бұрын

your videos are life savers! thank you for being very detailed

@christellekankalian7824 5 жыл бұрын

I really liked how detailed you were in this video otherwise I wouldn’t have understood it as well as I did. The way you thought it will always stick in my head from the examples you gave us. Also, It’s really cool how zetia’s dosage is only 10mg’s. Now I know that Zetia helps lower the LDL cholesterol.

@Happy-Trails-To-You 2 жыл бұрын

Nice, simple and clear. Thank you.

@maedorasmith33 Жыл бұрын

Thank you for your knowledge I found it very informative and easy to understand

@DrugChug 5 жыл бұрын

Hope you guys Enjoyed! Did you get the Quiz questions right at the end? Let me know!

@CarolineBeautyInc 5 жыл бұрын

Drug Chug yes!! Thank you for another great video

@karlvillaluz7933 4 жыл бұрын

Are you still making videos? You should make a education website, I’ll totally subscribe!! Your videos are straight forward and very helpful!!!

@gregstuart5903 Жыл бұрын

@@karlvillaluz7933 - I agree. Informative yet concise. Just subscribed, will follow from now on. A website will be great, then we can search when needs arise.

@abc_cba 4 жыл бұрын

This channel is the best one on drugs of the hundreds there are on YT. I have three things to talk about or express : 1) You mentioned Ezitimibe blocking the *dietary cholesterol* what about the one created by the liver automatically, does that mean that ezetimibe can't block the cholesterol that our livers produce ? 2) It's funny how easily we at India can grab any drug without any prescription at 1/50th the price in US. I self change and try drugs on myself being a testing space. I got a combination of Rosuvastatin and Ezetimibe (10 mg each) for $1.50 for a strip of ten tablets. So, Simvastatin is the only drug that is used in combination with Zetia alone. Lastly, 3) You have an amazingly sexy voice and I am not actually hiting on you ( I think i am !) , And Thank you very much for this elaborate explanation. God bless you.

@DrugChug 4 жыл бұрын

Great Questions! 1.) That is correct. Ezetimibe only affects dietary cholesterol. That is why we typically use it with a statin. That way the ezetimibe blocks the dietary absorbtion, while the statin blocks the production of cholesterol (we target both pathways). 2.) Yeah that is crazy about the price of drugs around the world. And the only combo product is Vytorin in America (Ezetimibe + Simvastatin). You can take Ezetimibe with any other statin, but the drug companies have only done trials with simvastatin to be able to make this combo product specifically. 3.) And thank you! I'll keep making more of these videos then!

@user-xu8pt6uy8h 2 жыл бұрын

To tell the truth you have the best channel ♥️♥️♥️

@tinatam6205 2 жыл бұрын

Very clear explanation.

@tnleung1 2 жыл бұрын

love it. thanks!!

@alburybeverly359 6 ай бұрын

Clear and easy to understand

@rubaabazid6737 3 жыл бұрын

Your method in explain is very simple and useful . Thank you very much

@DrugChug 3 жыл бұрын

Glad you enjoyed it! Thanks for watching!

@fumikosteiger 2 жыл бұрын

Wow, I like this video!

@tenniskinsella7768 7 ай бұрын

Why if its so good do i still have to take statin morecside effects taking both why cant i just take the one tablet

@kharesiddharth2526 2 жыл бұрын

Very useful .. thank you

@SongbirdRanch2005 11 ай бұрын

My trouble is that my body produces cholesterol a LOT , blocking the dietary cholesterol absorption doesn’t really help.

@user-br3sw4tm2c 3 ай бұрын

It will

@jupiterthesun3217 3 ай бұрын

I'm the same . Best wishes

@user-br3sw4tm2c 3 ай бұрын

increase soluble fiber and add Amla and Niacin a day and it will go down@@jupiterthesun3217

@tesos2866 2 ай бұрын

The first thing you must do is find out if you are a hyper absorber, or a hyper producer If you are a hyper producer you use statins, pcsk9 inhibitors, bempedoic acid.

@user-br3sw4tm2c 2 ай бұрын

@@tesos2866 are pcsk9 safe?

@zsuzsannavarga9370 3 жыл бұрын

love this video very informative thx

@DrugChug 3 жыл бұрын

Thank you for watching!😁

@AquariusShero Ай бұрын

Wow this is awesome! I passed the quiz btw 😂 My doctor is putting on this medication as of today and I needed to know what was up with it. I’m already taking Cholestyramine and I guess it not working because my LDL’s are elevated . I’m allergic to the Statins. We tried that first my body was so sore, thought I aged in 3 days to about 99 years old 😢 I was like absolutely not. Trash this medication immediately 😥 But this was a great video. Praying I don’t get that fatigue side effect 🤞🏾🤞🏾

@jamesbirch6522 Ай бұрын

how you finding it so far? ive just been prescribed this + 180mg bempedoic acid

@andyc9982 Жыл бұрын

Can you use this as a preventive measure? and would it block Omega oils or Vitamin E supplements?

@atiqrehman8562 3 жыл бұрын

Very good explanation thank you

@DrugChug 3 жыл бұрын

Thank you for watching Atiq!

@mrcharlesjohnson 4 жыл бұрын

Cool video, very helpful.

@DrugChug 4 жыл бұрын

Thank You! Glad you enjoyed it!

@lucilledabney2340 Жыл бұрын

He makes a lot of sense this is the best video I have watch but I do have pains in my knee in my nick while taking this medicine I don’t like that part I can’t tell if it working or not I’m not for sure🤦🏽‍♀️💁🏽‍♀️

@Zahraa.Fadhil 3 жыл бұрын

You are amazing !

@DrugChug 3 жыл бұрын

Thank you for the support! 😁

@joyceelmer131 2 жыл бұрын

Just subscribed

@cg-pj8mj 4 жыл бұрын

Please make more you make the best pharmacology videos on KZfaq!

@DrugChug 4 жыл бұрын

Thank you! @Colton More videos will come in the future, thanks for your support!😁

@ayobabalola8657 4 жыл бұрын

Absolutely, I agree

@darlenecaton4032 Жыл бұрын

Also raises Alt and Ast at least for me and some others. Had to get get off this drug immediately.

@johnsullivan8129 9 ай бұрын

Does it help prevent strokes or heart attacks

@Ke-qv3md Жыл бұрын

Can you take Ezetimbe (Zetia) if you donate blood platlets?

@vigienaidoo7413 11 ай бұрын

Wow I have just started this tab today came across this video today beautiful was a pleasure to watch have peace of mind taking it thank you ❤

@subhash7408 Ай бұрын

What about a combination of retrovastatin + fenofibrate. Sir.

@tenniskinsella7768 7 ай бұрын

Why have i read this tablet increases risk of deme tia. Is tbis true or notv

@mary-elizabethcoetzee685 5 ай бұрын

Ezetimbe made me ill. Stopped it. Got all side effects. Thought i was dying.

@hanialabed9100 4 жыл бұрын

Very nice job really 👍👍👍

@DrugChug 4 жыл бұрын

Thank you for the support! 😁

@hanialabed9100 4 жыл бұрын

@@DrugChug you welcome I am going to watch all your videos 😊

@messelnoinoi6971 5 жыл бұрын

Nice bro

@DrugChug 5 жыл бұрын

Thank You!

@tom-dr1ym 2 жыл бұрын

so what are the side effects

@AM-qw9cv 2 жыл бұрын

Does Zetia reduce the chances of getting a stroke or heart attack? Is Lipitor better than Zetia? Please advise.

@tenniskinsella7768 7 ай бұрын

Ipitir has lots of side effects invading lip and face swelli g. I had to come off

@erieviewer148 17 күн бұрын

Good video actually eating cholesterol can only raise cholesterol in a small way it is eating saturated fat that raises it.

@tesos2866 2 ай бұрын

Zadia dropped my APO b 41% I am a hyperabsorber not a hyper producer. And ZERO side effects. I also take a very low dose statin to avoid a bounce back. Less than 5mg.

@NeetaAgarwal-mn3dk 11 ай бұрын

When to take ezitimibe tab Best time Night Before dinner/After dinner Or in breakfast/lunch Suggest best time in whole day for 10 mg ezitimibe to minimise any meal cholesterol absorbtion ??

@nenadcubric2663 7 ай бұрын

It doesnt matter

@canadacalling6892 4 жыл бұрын

If the drug is blocking intestine uptake of LDL, why is it taken at bedtime? Breakfast, lunch and dinner are long gone by then. A sincere question.

@DrugChug 4 жыл бұрын

Great Question! @ Canada Calling Yes you can take this medication at anytime because the half life of Zetia is about 22 hours, which means it only requires once a day dosing. However, if a patient is also taking a statin (which is a high probability) it is best to take this medication with the statin and this is where we can see a preference on when to take the medication: If a patient takes a night time statin, such as simvastatin, then they should take Zetia + Simvistatin at bedtime (Again only because the Simvastatin has a short half-life and cholesterol synthesis happens at night. We even see the combo product Vytorin which has Zetia + Simvastatin. But if a patient takes Zetia with a long acting statin (Like Atorvastatin) then they may take it at any time of the day! Hope this clears things up! :)

@canadacalling6892 4 жыл бұрын

@@DrugChug thx for the reply. I am refusing to take the statin because previously it was wrecking my brain and a few other unmentionable things. I am about to take Ezetimibe today. I am hoping all the side effects listed will not occur. Thanks again for the reply.

@DrugChug 4 жыл бұрын

@@canadacalling6892 No problem! Zetia usually has a better side effect profile! Hopefully it works well for you!

@gregstuart5903 Жыл бұрын

@@DrugChug - Indeed this answer is important but no other source mentions it that I've noticed - Simvastation and Atorvastation have different acting half-lifes. Thank you for the clarification.

@nenadcubric2663 7 ай бұрын

I take Crestor and Zetia 20/10

@user-ti4tf6ud3s Жыл бұрын

❤️❤️

@cdinaz 26 күн бұрын

So a phytosterol hyperabsorber would not benefit from zetia then - someone with variations in the SNPs for ABCG5 and G8 receptors? Fatigue, loose stool and nausea may be common but those are NOT small side effects. If you had those without the meds you would be trying to figure out WTH is wrong. HMG CoA reductase (mevalonate pathway) being disrupted also reduces production of MK4, geranylgeraniol and CoQ10. So perhaps doubling down on living better should prevail over meds.

@DK-pr9ny Жыл бұрын

Can it be mixed with Crestor?

@nenadcubric2663 7 ай бұрын

Yes 20 mg / 10 mg

@datmeme8967 2 жыл бұрын

OK, pay big pharma for the rest of your life instead of improving your diet.

@markthurlow6223 Жыл бұрын

It’s not a dietary issue for everyone. I have a family history and have always had hi ldl and low hdl. I have always been a healthy eater and exercised. Not happy about getting out on this medication but going to try it and see what happens.

@datmeme8967 Жыл бұрын

@@markthurlow6223 Sorry to hear that, but we all know that the medical industrial complex does very little in the way prevention. My cardiologist told me to start taking statins. I told him I wanted to try lifestyle changes first or else I'll never know if they did anything or if it was the statins. I'm muscular, 6' 195, so not obese or out of shape and always ate a "clean" diet. I changed my diet and lowered my LDLs over 25% in 3 months. There are foods that raise cholesterol and others that help lower it. Red meat, whole eggs, whole dairy, etc. are all "healthy" foods, but I reduced my intake of them by 90% added ground flax seed to my daily oatmeal, started using plant stanol spread instead of butter and increased the amount of cardio over a day that I was doing. Everyone is different, but I wanted to see if the changes would work for me before committing to a life of drug use. Glad I did.

@ameliahelmerfalcao5559 9 ай бұрын

Cometa o remédio que chama zete em português

@951NewNow Жыл бұрын

I thought the diatary cholesteral myth was debunked.

@littleartist9043 3 жыл бұрын

Then if this drug help us by make foods not digested whe we don't use it to prevent obesity 🤔

@dougwood1658 8 ай бұрын

I was on Zetia several years ago...I was noticing a weight reduction, so I kept a daily log...lost 17 pounds in one month !!.. Doctor took me off Zetia and the weight came back on within 2 weeks ! .. Apparently it absorbed all the fat (cholesterol) so my body then took it elsewhere to maintain metabolism....just things I noticed...

@jupiterthesun3217 3 ай бұрын

I've been a vegan for many years and I don't used cooking oils at all and then only cooking oil is use is avocado oil and as my lover can't process oils I am used to no fat diet but my cholesterol is off the charts ! I think it's mainly bad genes.

@yolandasalone7949 3 жыл бұрын

What if the patient is on a healthy diet and have been on a healthy diet for years for instant they don't eat any animal products What about that Sometimes I think they just wanna put you on drugs you don't need

@gregstuart5903 Жыл бұрын

There are those doctors around unfortunately.

@tenniskinsella7768 7 ай бұрын

A completely vegetarian diet not necessary a good all my life have eaten good diet so dhy ha e I got diabetes and high colestral is it because I'm old